DE69232086D1 - Elektrochemilumineszente label für dna-sonde l nachweis - Google Patents
Elektrochemilumineszente label für dna-sonde l nachweisInfo
- Publication number
- DE69232086D1 DE69232086D1 DE69232086T DE69232086T DE69232086D1 DE 69232086 D1 DE69232086 D1 DE 69232086D1 DE 69232086 T DE69232086 T DE 69232086T DE 69232086 T DE69232086 T DE 69232086T DE 69232086 D1 DE69232086 D1 DE 69232086D1
- Authority
- DE
- Germany
- Prior art keywords
- detection
- dna probe
- electrochemiluminescent label
- electrochemiluminescent
- label
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001514 detection method Methods 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S428/00—Stock material or miscellaneous articles
- Y10S428/917—Electroluminescent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/801—Electron dense compounds, e.g. ferritin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/905—Photochemical activation of reactions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80553791A | 1991-12-11 | 1991-12-11 | |
| PCT/US1992/010480 WO1993012256A1 (en) | 1991-12-11 | 1992-12-07 | Improved electrochemiluminescent label for dna probe assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69232086D1 true DE69232086D1 (de) | 2001-10-31 |
| DE69232086T2 DE69232086T2 (de) | 2003-09-11 |
Family
ID=25191844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69232086T Expired - Lifetime DE69232086T2 (de) | 1991-12-11 | 1992-12-07 | Elektrochemilumineszente label für dna-sonde l nachweis |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5610017A (de) |
| EP (1) | EP0667919B1 (de) |
| JP (1) | JP3067030B2 (de) |
| KR (1) | KR0169755B1 (de) |
| AT (1) | ATE206170T1 (de) |
| AU (1) | AU661757B2 (de) |
| CA (1) | CA2123808C (de) |
| DE (1) | DE69232086T2 (de) |
| ES (1) | ES2164069T3 (de) |
| IL (1) | IL103960A (de) |
| WO (1) | WO1993012256A1 (de) |
| ZA (1) | ZA929351B (de) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451225B1 (en) * | 1986-04-30 | 2002-09-17 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US6890712B1 (en) * | 1993-09-22 | 2005-05-10 | Bioveris Corporation | Cycling DNA/RNA amplification electrochemiluminescent probe assay |
| US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| JP2000500342A (ja) * | 1995-11-15 | 2000-01-18 | ジェン−プローブ・インコーポレーテッド | ヒトパピローマウイルス核酸に相補的な核酸プローブおよび関連する方法およびキット |
| ATE346165T1 (de) * | 1995-11-29 | 2006-12-15 | Anthony Nolan Bone Marrow Trus | Verfahren zur trennung und/oder erkennung von dns-molekülen |
| DE19627290A1 (de) * | 1996-07-06 | 1998-01-08 | Boehringer Mannheim Gmbh | Bestimmung von Analyten unter Verwendung zweier Markierungen |
| US7314711B2 (en) * | 1997-05-23 | 2008-01-01 | Bioveris Corporation | Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers |
| JP3785517B2 (ja) * | 1997-06-05 | 2006-06-14 | 東ソー株式会社 | 核酸融解温度測定法 |
| WO1999018438A1 (en) * | 1997-10-02 | 1999-04-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
| NZ504214A (en) * | 1997-10-24 | 2003-06-30 | Invitrogen Corp | Recombination cloning using nucleic acids having recombination sites |
| WO1999037820A1 (en) * | 1998-01-26 | 1999-07-29 | Saigene Corporation | An exponential nucleic acid amplification method using a single primer of opposing polarity |
| DE19811582A1 (de) * | 1998-03-17 | 1999-09-23 | Roche Diagnostics Gmbh | Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen |
| US6391544B1 (en) * | 1998-05-15 | 2002-05-21 | Abbott Laboratories | Method for using unequal primer concentrations for generating nucleic acid amplification products |
| US8445664B2 (en) * | 1998-06-24 | 2013-05-21 | Enzo Diagnostics, Inc. | Kits for amplifying and detecting nucleic acid sequences |
| US6743605B1 (en) * | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
| US6288221B1 (en) | 1998-08-20 | 2001-09-11 | Duke University | Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction |
| US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
| US6214552B1 (en) | 1998-09-17 | 2001-04-10 | Igen International, Inc. | Assays for measuring nucleic acid damaging activities |
| AU2180200A (en) * | 1998-12-14 | 2000-07-03 | Li-Cor Inc. | A heterogeneous assay for pyrophosphate detection |
| EP1035214B1 (de) * | 1999-03-05 | 2005-12-21 | Tosoh Corporation | Eine am 3'-Ende modifizierte Nukleinsäuresonde, geeignet zur Hybridisierung und Detektion über Fluoreszenz |
| US6410255B1 (en) * | 1999-05-05 | 2002-06-25 | Aurora Biosciences Corporation | Optical probes and assays |
| US7141436B2 (en) * | 1999-11-03 | 2006-11-28 | Science And Technology Corp. | Immunoassay and reagents and kits for performing the same |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US20030082549A1 (en) * | 2000-08-30 | 2003-05-01 | Xiangjun Liu | Method for determining alleles |
| US7029919B2 (en) * | 2001-05-04 | 2006-04-18 | Agilent Technologies, Inc. | Electro-optical device and methods for hybridization and detection |
| US7223483B2 (en) | 2001-06-25 | 2007-05-29 | Showa Denko K.K. | Light-emitting material and organic light-emitting device |
| JP4628594B2 (ja) * | 2001-06-25 | 2011-02-09 | 昭和電工株式会社 | 有機発光素子および発光材料 |
| WO2003001889A2 (en) | 2001-06-29 | 2003-01-09 | Meso Scale Technologies, Llc. | Assay plates reader systems and methods for luminescence test measurements |
| US6808939B2 (en) * | 2001-06-29 | 2004-10-26 | Igen International, Inc. | ECL labels having improved non-specific binding properties, methods of using and kits containing the same |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| JP4355214B2 (ja) | 2001-07-30 | 2009-10-28 | メソ スケイル テクノロジーズ，エルエルシー | 発光試験測定用の固定化された脂質／タンパク質層を有するアッセイ用電極、その作製法、及びその使用法 |
| DE50207516D1 (de) * | 2001-08-10 | 2006-08-24 | Roche Diagnostics Gmbh | Verfahren zur herstellung von protein-beladenen mikropartikeln |
| EP1451348B1 (de) | 2001-09-10 | 2015-08-12 | Meso Scale Technologies, LLC | Verfahren, reagentien, kits und vorrichtungen zur proteinfunktionsanalyse |
| US20030086165A1 (en) * | 2001-11-05 | 2003-05-08 | Cross John W. | Illuminated reticle |
| US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
| JP2006506644A (ja) * | 2002-11-15 | 2006-02-23 | アプレラ コーポレイション | 核酸配列検出 |
| US20040161737A1 (en) * | 2003-02-14 | 2004-08-19 | Yang Dan-Hui D. | Novel luminescent metal chelates and methods for their detection |
| EP2390352A1 (de) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren |
| US7727752B2 (en) * | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) * | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) * | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| WO2005014796A2 (en) | 2003-08-08 | 2005-02-17 | Invitrogen Corporation | Methods and compositions for seamless cloning of nucleic acid molecules |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| JP2007505315A (ja) * | 2003-09-12 | 2007-03-08 | インヴィトロジェン コーポレーション | 多重結合および活性アッセイ |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| EP1697534B1 (de) | 2003-12-01 | 2010-06-02 | Life Technologies Corporation | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
| NZ549384A (en) | 2004-02-19 | 2008-08-29 | Univ Alberta | Leptin promoter polymorphisms and uses thereof |
| US20060270922A1 (en) | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
| US20060020192A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
| JP2008521007A (ja) * | 2004-11-17 | 2008-06-19 | バイオヴェリス コーポレイション | 電気化学発光測定法 |
| US7354719B2 (en) | 2004-12-08 | 2008-04-08 | Gen-Probe Incorporated | Detection of nucleic acids from multiple types of human papillomaviruses |
| US20060275841A1 (en) * | 2004-12-20 | 2006-12-07 | Martin Blankfard | Assay method and apparatus with reduced sample matrix effects |
| EP3228624A3 (de) * | 2005-02-10 | 2017-11-01 | Yeda Research And Development Co., Ltd. | Redox-aktive chromophore moleküle und damit ausgestattete vorrichtungen |
| EP3167900B1 (de) | 2006-03-29 | 2018-11-21 | Merial Limited | Impfstoff gegen streptokokken |
| GB0701444D0 (en) * | 2007-01-25 | 2007-03-07 | Iti Scotland Ltd | Detecting analytes |
| PL2271938T3 (pl) | 2008-04-11 | 2014-07-31 | Univ Texas | Sposób i urządzenie do wzmacniania elektrogenerowanej chemiluminescencji nanocząsteczek |
| KR101603356B1 (ko) | 2008-05-08 | 2016-03-14 | 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 전기발생 화학발광에 사용되는 발광 나노구조 물질 |
| US20100261292A1 (en) * | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
| WO2011017094A2 (en) | 2009-07-27 | 2011-02-10 | Ian Chamberlin | Assay apparatuses, consumables and methods |
| JP2011072222A (ja) * | 2009-09-29 | 2011-04-14 | Kitasato Otsuka Biomedical Assay Kenkyusho:Kk | 標的核酸の検出方法 |
| US20140038834A1 (en) | 2010-07-07 | 2014-02-06 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Novel biomarkers for detecting neuronal loss |
| EP4300100A2 (de) | 2010-10-14 | 2024-01-03 | Meso Scale Technologies, LLC | Reagenzienlagerung in einer assay-vorrichtung |
| MX336940B (es) | 2010-10-25 | 2016-02-08 | Hoffmann La Roche | Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia. |
| EP2673335B1 (de) * | 2011-02-11 | 2014-12-10 | Fábrica Nacional de Moneda Y Timbre - Real Casa de la Moneda | Leuchtpigmentstoffe und deren nutzung in sicherheitsanwendungen |
| EP2776833B1 (de) | 2011-11-11 | 2018-09-05 | Eli N. Glezer | Cobinder-unterstützte testverfahren |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| CA3107353A1 (en) | 2013-01-04 | 2014-07-10 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
| DK2972353T3 (da) | 2013-03-11 | 2023-03-27 | Meso Scale Technologies Llc | Forbedrede fremgangsmåder til udførelse af multipleksanalyser |
| JP6408552B2 (ja) | 2013-03-13 | 2018-10-17 | メソ スケール テクノロジーズ エルエルシー | 改善されたアッセイ方法 |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| US10202500B2 (en) | 2013-03-15 | 2019-02-12 | Lubrizol Advanced Materials, Inc. | Heavy metal free CPVC compounds |
| WO2015070173A1 (en) * | 2013-11-08 | 2015-05-14 | Isis Pharmaceuticals, Inc. | Compounds and methods for detecting oligonucleotides |
| IL229525A0 (en) | 2013-11-20 | 2014-01-30 | Yeda Res & Dev | Metal complexes of tris-bipyridyl and their uses in electrochromic applications |
| CA3229509A1 (en) | 2014-05-09 | 2015-11-12 | Meso Scale Technologies, Llc. | Graphene-modified electrodes |
| WO2015175856A1 (en) | 2014-05-15 | 2015-11-19 | Meso Scale Technologies, Llc. | Improved assay methods |
| BR112018001956A2 (pt) | 2015-08-20 | 2018-09-11 | Hoffmann La Roche | ?método de medição de analitos e kit? |
| BR112018017336A2 (pt) | 2016-03-07 | 2018-12-26 | Hoffmann La Roche | método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão |
| EP3426398B1 (de) | 2016-03-11 | 2024-01-24 | Roche Diagnostics GmbH | Verzweigtkettige amine in der elektrochemilumineszenzdetektion |
| EP3577460B1 (de) | 2017-02-02 | 2021-01-20 | Roche Diagnostics GmbH | Immunoassay mit mindestens zwei pegylierten analyt-spezifischen bindungsmitteln |
| FI3756009T3 (fi) | 2018-02-23 | 2023-12-01 | Meso Scale Technologies Llc | Menetelmiä antigeeniä sitovien molekyylien seulontaan normalisoimalla antigeeniä sitovan molekyylin pitoisuus |
| CN111936522A (zh) | 2018-04-18 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 新型抗胸苷激酶抗体 |
| EP3844503A1 (de) | 2018-08-31 | 2021-07-07 | F. Hoffmann-La Roche AG | Thymidinkinase (tk-1) in prognostischen indizes für dlbcl |
| CN109232663B (zh) * | 2018-11-08 | 2020-09-25 | 云南大学 | 一种钌配合物的制备方法及其艾滋病毒逆转录酶抑制应用 |
| CN113366313A (zh) | 2019-01-03 | 2021-09-07 | 中尺度技术有限责任公司 | 实施分析测量的组合物及方法 |
| CN114144422A (zh) | 2019-03-01 | 2022-03-04 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| BR112021024624A2 (pt) | 2019-06-07 | 2022-01-18 | Hoffmann La Roche | Métodos para selecionar e fornecer um par de ligação de oligonucleotídeos de fita simples, para formar um duplex antiparalelo e para realizar um ensaio, par de ss-oligonucleotídeos complementares separados, duplex antiparalelo, uso de um par de ss-oligonucleotídeos separados, kit para realizar um ensaio e composição líquida |
| KR20220024782A (ko) | 2019-07-22 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a8 |
| EP4004555A1 (de) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a6 als blutbiomarker zur nichtinvasiven diagnose von endometriose |
| CN114144674A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物 |
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| CN114144671A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a12作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物 |
| KR20220100883A (ko) | 2019-11-15 | 2022-07-18 | 에프. 호프만-라 로슈 아게 | 환자 샘플의 질량분석법 측정을 위한 베타-락탐 항생제의 유도체화 |
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| CN116113830A (zh) | 2020-07-01 | 2023-05-12 | 中尺度技术有限责任公司 | 用于测定测量的组合物和方法 |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| CN116635083A (zh) | 2020-12-22 | 2023-08-22 | 豪夫迈·罗氏有限公司 | 用于检测样品中的目标分析物的方法 |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| JP2024511867A (ja) | 2021-04-01 | 2024-03-15 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｐｓｐ９４ |
| CN117337394A (zh) | 2021-05-17 | 2024-01-02 | 豪夫迈·罗氏有限公司 | sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断 |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| WO2023129884A1 (en) | 2021-12-30 | 2023-07-06 | Meso Scale Technologies, Llc. | Methods for electrochemiluminescence detection |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023156510A1 (en) | 2022-02-18 | 2023-08-24 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3329892A1 (de) * | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| FR2557836B1 (fr) * | 1983-11-17 | 1988-08-05 | Legrand Pierre | Equipement de vehicules de transport en commun et de lieux de transit, et application particuliere |
| DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| JPS6228549A (ja) * | 1985-07-30 | 1987-02-06 | Teijin Seiki Co Ltd | 駆動源付き減速装置 |
| WO1987006706A1 (en) * | 1986-04-30 | 1987-11-05 | Igen, Inc. | Electrochemiluminescent assays |
| DK564086A (da) * | 1986-11-25 | 1988-06-17 | Novo Industri As | Enzymatisk detergent-additiv |
| US5135717A (en) * | 1986-12-24 | 1992-08-04 | British Technology Group Usa Inc. | Tetrabenztriazaporphyrin reagents and kits containing the same |
| ATE142622T1 (de) * | 1987-11-04 | 1996-09-15 | Igen Inc | Elektrochemilumineszente rhenium-fraktionen und verfahren |
| US4951878A (en) * | 1987-11-16 | 1990-08-28 | Casey Gary L | Pico fuel injector valve |
| US4835214A (en) * | 1987-11-23 | 1989-05-30 | Eastman Kodak Company | Polymer blends useful for hot fillable containers having improved gas barrier properties |
| AU622899B2 (en) * | 1988-05-04 | 1992-04-30 | F. Hoffmann-La Roche Ag | Rutheniumcomplex-compounds |
| US5247243A (en) * | 1988-11-03 | 1993-09-21 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| US5061445A (en) * | 1988-11-03 | 1991-10-29 | Igen, Inc. | Apparatus for conducting measurements of electrochemiluminescent phenomena |
| AU637775B2 (en) * | 1988-11-03 | 1993-06-10 | Igen, Inc. | Electrochemiluminescent assays |
| CA2033692A1 (en) * | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
| IL100867A (en) * | 1991-02-06 | 1995-12-08 | Igen Inc | Method and device for improved luminescence testing |
-
1992
- 1992-12-02 ZA ZA929351A patent/ZA929351B/xx unknown
- 1992-12-03 IL IL10396092A patent/IL103960A/xx not_active IP Right Cessation
- 1992-12-07 EP EP93900868A patent/EP0667919B1/de not_active Expired - Lifetime
- 1992-12-07 AU AU32388/93A patent/AU661757B2/en not_active Ceased
- 1992-12-07 AT AT93900868T patent/ATE206170T1/de not_active IP Right Cessation
- 1992-12-07 KR KR1019940702034A patent/KR0169755B1/ko not_active IP Right Cessation
- 1992-12-07 DE DE69232086T patent/DE69232086T2/de not_active Expired - Lifetime
- 1992-12-07 ES ES93900868T patent/ES2164069T3/es not_active Expired - Lifetime
- 1992-12-07 WO PCT/US1992/010480 patent/WO1993012256A1/en active IP Right Grant
- 1992-12-07 CA CA002123808A patent/CA2123808C/en not_active Expired - Fee Related
- 1992-12-07 JP JP5510980A patent/JP3067030B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/461,038 patent/US5610017A/en not_active Expired - Lifetime
- 1995-06-05 US US08/461,645 patent/US5686244A/en not_active Expired - Lifetime
- 1995-06-07 US US08/479,817 patent/US5597910A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3067030B2 (ja) | 2000-07-17 |
| EP0667919A1 (de) | 1995-08-23 |
| AU3238893A (en) | 1993-07-19 |
| US5686244A (en) | 1997-11-11 |
| EP0667919A4 (de) | 1996-01-17 |
| WO1993012256A1 (en) | 1993-06-24 |
| IL103960A0 (en) | 1993-05-13 |
| ATE206170T1 (de) | 2001-10-15 |
| IL103960A (en) | 2000-08-31 |
| CA2123808A1 (en) | 1993-06-24 |
| US5610017A (en) | 1997-03-11 |
| JPH07503947A (ja) | 1995-04-27 |
| US5597910A (en) | 1997-01-28 |
| KR0169755B1 (ko) | 1999-01-15 |
| ES2164069T3 (es) | 2002-02-16 |
| EP0667919B1 (de) | 2001-09-26 |
| KR940703926A (ko) | 1994-12-12 |
| CA2123808C (en) | 2003-05-27 |
| ZA929351B (en) | 1993-06-04 |
| DE69232086T2 (de) | 2003-09-11 |
| AU661757B2 (en) | 1995-08-03 |
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