DE69232952T2 - Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1 - Google Patents
Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1Info
- Publication number
- DE69232952T2 DE69232952T2 DE69232952T DE69232952T DE69232952T2 DE 69232952 T2 DE69232952 T2 DE 69232952T2 DE 69232952 T DE69232952 T DE 69232952T DE 69232952 T DE69232952 T DE 69232952T DE 69232952 T2 DE69232952 T2 DE 69232952T2
- Authority
- DE
- Germany
- Prior art keywords
- receptors
- antibodies
- stem cells
- hematopoietic stem
- pluripotent hematopoietic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67966691A | 1991-04-02 | 1991-04-02 | |
US72891391A | 1991-06-28 | 1991-06-28 | |
US79306591A | 1991-11-15 | 1991-11-15 | |
US07/813,593 US5185438A (en) | 1991-04-02 | 1991-12-24 | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
PCT/US1992/002750 WO1992017486A1 (en) | 1991-04-02 | 1992-04-02 | Totipotent hematopoietic stem cell receptors and their ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232952D1 DE69232952D1 (de) | 2003-04-17 |
DE69232952T2 true DE69232952T2 (de) | 2003-10-02 |
Family
ID=27505386
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233788T Expired - Lifetime DE69233788D1 (de) | 1991-04-02 | 1992-04-02 | Verfahren zur Isolierung von Zellen die FLK-1-Rezeptoren auf ihrer Oberfläche exprimieren |
DE69233746T Expired - Lifetime DE69233746D1 (de) | 1991-04-02 | 1992-04-02 | Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren |
DE69232952T Expired - Lifetime DE69232952T2 (de) | 1991-04-02 | 1992-04-02 | Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1 |
DE69232687T Expired - Lifetime DE69232687T2 (de) | 1991-04-02 | 1992-04-02 | Rezeptor flk-2 von pluripotenten hämatopoetischen Stammzellen |
DE69233676T Expired - Lifetime DE69233676T2 (de) | 1991-04-02 | 1992-04-02 | Rezeptor Protein Tyrosin-Kinase (FLK-1) |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233788T Expired - Lifetime DE69233788D1 (de) | 1991-04-02 | 1992-04-02 | Verfahren zur Isolierung von Zellen die FLK-1-Rezeptoren auf ihrer Oberfläche exprimieren |
DE69233746T Expired - Lifetime DE69233746D1 (de) | 1991-04-02 | 1992-04-02 | Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232687T Expired - Lifetime DE69232687T2 (de) | 1991-04-02 | 1992-04-02 | Rezeptor flk-2 von pluripotenten hämatopoetischen Stammzellen |
DE69233676T Expired - Lifetime DE69233676T2 (de) | 1991-04-02 | 1992-04-02 | Rezeptor Protein Tyrosin-Kinase (FLK-1) |
Country Status (7)
Country | Link |
---|---|
US (3) | US5185438A (de) |
EP (6) | EP1231261B1 (de) |
KR (3) | KR100261465B1 (de) |
AU (1) | AU1924892A (de) |
CA (1) | CA2107463C (de) |
DE (5) | DE69233788D1 (de) |
WO (2) | WO1992017486A1 (de) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030206899A1 (en) * | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5270458A (en) * | 1991-04-02 | 1993-12-14 | The Trustees Of Princeton University | Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 |
US5367057A (en) | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
US6331302B1 (en) | 1992-01-22 | 2001-12-18 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
US5861301A (en) * | 1992-02-20 | 1999-01-19 | American Cayanamid Company | Recombinant kinase insert domain containing receptor and gene encoding same |
US6228609B1 (en) * | 1992-07-09 | 2001-05-08 | Systemix, Inc. | Soluble Flk-2 sequence |
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
US5776755A (en) * | 1992-10-09 | 1998-07-07 | Helsinki University Licensing, Ltd. | FLT4, a receptor tyrosine kinase |
US6107046A (en) * | 1992-10-09 | 2000-08-22 | Orion Corporation | Antibodies to Flt4, a receptor tyrosine kinase and uses thereof |
US5712395A (en) * | 1992-11-13 | 1998-01-27 | Yissum Research Development Corp. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
CN1701814A (zh) * | 1992-11-13 | 2005-11-30 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US6872699B2 (en) | 1992-11-13 | 2005-03-29 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. | Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein |
AU6117294A (en) * | 1993-02-16 | 1994-09-14 | Auckland Uniservices Limited | Developmental tyrosine kinases and their ligands |
WO1994026891A2 (en) * | 1993-05-19 | 1994-11-24 | Schering Corporation | Purified mammalian flt3 ligands and agonists and antagonists thereof |
US7534867B1 (en) | 1993-05-19 | 2009-05-19 | Schering Corporation | Purified mammalian Flt3 ligands; agonists; antagonists |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US6630143B1 (en) * | 1993-05-24 | 2003-10-07 | Immunex Corporation | Antibodies against flt3 ligand |
US7045128B2 (en) | 1993-05-24 | 2006-05-16 | Immunex Corporation | Antibodies against flt3-ligand |
NZ314644A (en) | 1993-05-24 | 2000-11-24 | Immunex Corp | Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue |
AU7210394A (en) * | 1993-06-18 | 1995-01-17 | Trustees Of Princeton University, The | Totipotent hematopoietic stem cell receptors and their ligands |
US5516658A (en) | 1993-08-20 | 1996-05-14 | Immunex Corporation | DNA encoding cytokines that bind the cell surface receptor hek |
CA2171112A1 (en) * | 1993-09-08 | 1995-03-16 | Neil I. Goldstein | Monoclonal antibodies that recognize flk-2 receptors and the isolation of primitive hematopoietic stem cell populations |
CA2175893C (en) * | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
US6001621A (en) * | 1993-11-23 | 1999-12-14 | Genetech, Inc. | Protein tyrosine kinases |
US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
US5618709A (en) * | 1994-01-14 | 1997-04-08 | University Of Pennsylvania | Antisense oligonucleotides specific for STK-1 and method for inhibiting expression of the STK-1 protein |
US5573935A (en) * | 1994-01-18 | 1996-11-12 | The United States Of America As Represented By The Department Of Health And Human Services | Protein tyrosine kinase A6 |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US5840301A (en) * | 1994-02-10 | 1998-11-24 | Imclone Systems Incorporated | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
US5861499A (en) | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
US6448077B1 (en) * | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
US7294331B2 (en) * | 1994-03-07 | 2007-11-13 | Immunex Corporation | Methods of using flt3-ligand in hematopoietic cell transplantation |
US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6734285B2 (en) * | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US7109308B1 (en) * | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US7186688B1 (en) * | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
DK0751992T3 (da) * | 1994-03-08 | 2006-03-06 | Human Genome Sciences Inc | Karendotelvækstfaktor 2 |
US6140119A (en) * | 1994-09-16 | 2000-10-31 | Michigan State University | Expression of estrogen receptors in type I and type II human breast epithelial cells |
US5650317A (en) * | 1994-09-16 | 1997-07-22 | Michigan State University | Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics |
US5731425A (en) * | 1994-10-28 | 1998-03-24 | Eastman Kodak Company | Polypeptide surface marker for cells |
WO2002060950A2 (en) * | 1994-11-14 | 2002-08-08 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
EP0854185A3 (de) * | 1994-12-23 | 1998-10-21 | Ludwig Institute For Cancer Research | Rezeptor-Proteine zu Bestimmungszwecke und Liganden |
US7070972B1 (en) | 1995-01-13 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Janus family kinases and identification of immune modulators |
IL117645A (en) * | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
US5824789A (en) * | 1995-06-07 | 1998-10-20 | Systemix, Inc. | Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof |
AU710696C (en) * | 1995-09-08 | 2002-10-24 | Genentech Inc. | VEGF-related protein |
US20020034517A1 (en) * | 1995-10-04 | 2002-03-21 | Kenneth Brasel | Dendritic cell stimulatory factor |
US7150992B1 (en) | 1995-10-04 | 2006-12-19 | Innunex Corporation | Methods of preparing dendritic cells with flt3-ligand and antigen |
US7361330B2 (en) * | 1995-10-04 | 2008-04-22 | Immunex Corporation | Methods of using flt3-ligand in the treatment of fibrosarcoma |
AU1116297A (en) * | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
US6994989B1 (en) | 1995-11-08 | 2006-02-07 | Immunex Corp. | FLK-1 binding proteins |
US5869243A (en) * | 1996-03-05 | 1999-02-09 | Rhode Island Hospital | Immortalized hepatocytes |
US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US6750044B1 (en) * | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
WO1999037751A1 (en) * | 1998-01-23 | 1999-07-29 | Imclone Systems Incorporated | Purified populations of stem cells |
US6908898B1 (en) * | 1998-06-15 | 2005-06-21 | Lars Holmgren | Angiogenesis related molecules |
CA2345276C (en) * | 1998-10-09 | 2011-03-29 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy |
US8124630B2 (en) * | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000041698A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US20020064528A1 (en) * | 2000-01-28 | 2002-05-30 | Zhenping Zhu | Antibodies specific to KDR and uses thereof |
US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
US6379903B1 (en) | 1999-10-08 | 2002-04-30 | Sigma-Aldrich Co. | Purification of recombinant proteins fused to multiple epitopes |
NZ523386A (en) | 2000-06-07 | 2004-07-30 | Ortho Mcneil Pharm Inc | Method to measure phosphorylation using a fusion protein, such as the carboxy terminal amino acids of rat VEGF-R2 fused with an affinity tag |
WO2002011769A1 (en) * | 2000-08-04 | 2002-02-14 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
WO2002083849A2 (en) * | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
AU2002256172A1 (en) * | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
DE60236646D1 (de) * | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
US20050232921A1 (en) * | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
US7402312B2 (en) * | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
EP1515707A4 (de) * | 2001-06-20 | 2005-10-19 | Imclone Systems Inc | Verfahren zur behandlung von atherosklerose und anderer entzündlicher erkrankungen |
US20050026220A1 (en) * | 2001-08-10 | 2005-02-03 | Shahin Rafii | Isolation and mobilization of stem cells expressing vegfr-1 |
US20080108672A1 (en) * | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
AU2003209116A1 (en) * | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
DE602004007382T2 (de) * | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
DE602004010407T2 (de) | 2003-07-23 | 2008-10-16 | Bayer Pharmaceuticals Corp., West Haven | Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden |
CA2590671A1 (en) * | 2004-11-18 | 2006-05-26 | Imclone Systems Incorporated | Antibodies against vascular endothelial growth factor receptor-1 |
US7495383B2 (en) * | 2005-08-01 | 2009-02-24 | Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. | Phosphor based on a combination of quantum dot and conventional phosphors |
KR100883430B1 (ko) * | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
AR071891A1 (es) | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
CA2728215A1 (en) * | 2008-06-18 | 2010-06-24 | Innovative Biotherapies, Inc. | Methods for enhanced propagation of cells |
DK2956476T3 (da) | 2013-02-18 | 2020-02-17 | Vegenics Pty Ltd | Ligandbindende molekyler og anvendelser deraf |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2035317T5 (es) * | 1987-11-09 | 1998-03-16 | Becton Dickinson Co | Metodo para analizar celulas hematopoyeticas en una muestra. |
HUT53672A (en) * | 1988-02-25 | 1990-11-28 | Gen Hospital Corp | Quick immunoselective cloning process |
US5081030A (en) * | 1989-04-25 | 1992-01-14 | The Johns Hopkins University | Release of cells from affinity matrices |
US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
-
1991
- 1991-12-24 US US07/813,593 patent/US5185438A/en not_active Expired - Lifetime
-
1992
- 1992-04-02 DE DE69233788T patent/DE69233788D1/de not_active Expired - Lifetime
- 1992-04-02 EP EP02004001A patent/EP1231261B1/de not_active Expired - Lifetime
- 1992-04-02 EP EP02004002A patent/EP1231265B1/de not_active Expired - Lifetime
- 1992-04-02 CA CA002107463A patent/CA2107463C/en not_active Expired - Lifetime
- 1992-04-02 EP EP07001970A patent/EP1808445A3/de not_active Withdrawn
- 1992-04-02 DE DE69233746T patent/DE69233746D1/de not_active Expired - Lifetime
- 1992-04-02 AU AU19248/92A patent/AU1924892A/en not_active Abandoned
- 1992-04-02 WO PCT/US1992/002750 patent/WO1992017486A1/en active IP Right Grant
- 1992-04-02 EP EP98119396A patent/EP0909813B1/de not_active Expired - Lifetime
- 1992-04-02 DE DE69232952T patent/DE69232952T2/de not_active Expired - Lifetime
- 1992-04-02 DE DE69232687T patent/DE69232687T2/de not_active Expired - Lifetime
- 1992-04-02 KR KR1019930702936A patent/KR100261465B1/ko not_active IP Right Cessation
- 1992-04-02 EP EP92911275A patent/EP0580760B1/de not_active Expired - Lifetime
- 1992-04-02 EP EP02004000A patent/EP1231260B1/de not_active Expired - Lifetime
- 1992-04-02 DE DE69233676T patent/DE69233676T2/de not_active Expired - Lifetime
- 1992-04-02 KR KR10-2000-7000871A patent/KR100407010B1/ko not_active IP Right Cessation
- 1992-06-26 US US07/906,397 patent/US5621090A/en not_active Expired - Lifetime
- 1992-06-26 WO PCT/US1992/005401 patent/WO1993000349A1/en active Application Filing
- 1992-09-17 US US07/946,507 patent/US5283354A/en not_active Expired - Lifetime
-
1999
- 1999-09-15 KR KR1019990039635A patent/KR100406832B1/ko not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69232952D1 (de) | Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1 | |
DE69008891D1 (de) | Lagerung von Materialien. | |
DE59109220D1 (de) | Plattform zur nutzung von sonnenenergie | |
FI833088A0 (fi) | Avslipande agglomerat foer anvaendning i skurande tvaettblandningar | |
DE3587154D1 (de) | Immunoaerztliche verfahren und zusammensetzungen unter verwendung von gegen maligne neoplasmen spezifischen antigenen. | |
NO162698C (no) | Ryggsekk | |
LU81411A1 (fr) | Recipient de conservation et de service | |
DE3382390D1 (de) | Zellinien und ihre verwendung in der herstellung von proteinen. | |
NO151338C (no) | Membranventil | |
DK334484D0 (da) | Belaegnings- eller stoebematerialer | |
FI834049A0 (fi) | Baeranordning foer artiklar | |
BR8108883A (pt) | Composicoes anti-estaticas e elementos revestidos com as mesmas | |
FI841284A (fi) | Anordning foer samtidig styrning av luftfloedesmaengden och blaossnabbheten i en reglerbar luftfloedesmaengden om omfattande luftkonditioneringsinstallation. | |
FI811311L (fi) | En saos bildande i genomsnitt fuktig djurfoeda | |
DK24085D0 (da) | Sproejtebeholder | |
FR2560582B1 (fr) | Recipient portatif non reutilisable | |
ATA25381A (de) | Rucksack | |
FR2547483B1 (fr) | Composition insecticide pour peinture et peinture la contenant | |
ES495131A0 (es) | Perfeccionamientos en la construccion de habitaculos trans- portables | |
KR860001197U (ko) | 다용도 등산용 배낭 | |
FR1255279A (fr) | Additifs empêchant le développement d'organismes nuisibles pour les peintures et les matériaux de constructions sous-marins | |
ES493938A0 (es) | Mejoras introducidas en la construccion de contenedores | |
ES248009Y (es) | Envase plegable | |
KR840005389U (ko) | 다목적용기 | |
KR860003374U (ko) | 다용도 배낭골격 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |