DE69233746D1 - Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren - Google Patents

Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren

Info

Publication number
DE69233746D1
DE69233746D1 DE69233746T DE69233746T DE69233746D1 DE 69233746 D1 DE69233746 D1 DE 69233746D1 DE 69233746 T DE69233746 T DE 69233746T DE 69233746 T DE69233746 T DE 69233746T DE 69233746 D1 DE69233746 D1 DE 69233746D1
Authority
DE
Germany
Prior art keywords
receptors
cells expressing
isolating cells
expressing flk
flk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233746T
Other languages
English (en)
Inventor
Ihor R Lemischka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of DE69233746D1 publication Critical patent/DE69233746D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69233746T 1991-04-02 1992-04-02 Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren Expired - Lifetime DE69233746D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67966691A 1991-04-02 1991-04-02
US72891391A 1991-06-28 1991-06-28
US79306591A 1991-11-15 1991-11-15
US07/813,593 US5185438A (en) 1991-04-02 1991-12-24 Nucleic acids encoding hencatoporetic stem cell receptor flk-2

Publications (1)

Publication Number Publication Date
DE69233746D1 true DE69233746D1 (de) 2008-10-30

Family

ID=27505386

Family Applications (5)

Application Number Title Priority Date Filing Date
DE69233788T Expired - Lifetime DE69233788D1 (de) 1991-04-02 1992-04-02 Verfahren zur Isolierung von Zellen die FLK-1-Rezeptoren auf ihrer Oberfläche exprimieren
DE69232687T Expired - Lifetime DE69232687T2 (de) 1991-04-02 1992-04-02 Rezeptor flk-2 von pluripotenten hämatopoetischen Stammzellen
DE69233676T Expired - Lifetime DE69233676T2 (de) 1991-04-02 1992-04-02 Rezeptor Protein Tyrosin-Kinase (FLK-1)
DE69233746T Expired - Lifetime DE69233746D1 (de) 1991-04-02 1992-04-02 Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren
DE69232952T Expired - Lifetime DE69232952T2 (de) 1991-04-02 1992-04-02 Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69233788T Expired - Lifetime DE69233788D1 (de) 1991-04-02 1992-04-02 Verfahren zur Isolierung von Zellen die FLK-1-Rezeptoren auf ihrer Oberfläche exprimieren
DE69232687T Expired - Lifetime DE69232687T2 (de) 1991-04-02 1992-04-02 Rezeptor flk-2 von pluripotenten hämatopoetischen Stammzellen
DE69233676T Expired - Lifetime DE69233676T2 (de) 1991-04-02 1992-04-02 Rezeptor Protein Tyrosin-Kinase (FLK-1)

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69232952T Expired - Lifetime DE69232952T2 (de) 1991-04-02 1992-04-02 Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1

Country Status (7)

Country Link
US (3) US5185438A (de)
EP (6) EP1808445A3 (de)
KR (3) KR100261465B1 (de)
AU (1) AU1924892A (de)
CA (1) CA2107463C (de)
DE (5) DE69233788D1 (de)
WO (2) WO1992017486A1 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206899A1 (en) * 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
US6582959B2 (en) * 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
US5270458A (en) * 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
US5185438A (en) * 1991-04-02 1993-02-09 The Trustees Of Princeton University Nucleic acids encoding hencatoporetic stem cell receptor flk-2
US5367057A (en) 1991-04-02 1994-11-22 The Trustees Of Princeton University Tyrosine kinase receptor flk-2 and fragments thereof
US6331302B1 (en) 1992-01-22 2001-12-18 Genentech, Inc. Protein tyrosine kinase agonist antibodies
US5861301A (en) * 1992-02-20 1999-01-19 American Cayanamid Company Recombinant kinase insert domain containing receptor and gene encoding same
US6228609B1 (en) * 1992-07-09 2001-05-08 Systemix, Inc. Soluble Flk-2 sequence
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US6107046A (en) * 1992-10-09 2000-08-22 Orion Corporation Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5792771A (en) * 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
US5763441A (en) * 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
CN1173991C (zh) * 1992-11-13 2004-11-03 马克斯普朗克科学促进协会 作为血管内皮生长因子受体的f1k-1
US6872699B2 (en) 1992-11-13 2005-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein
US5712395A (en) * 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5981569A (en) * 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
AU6117294A (en) * 1993-02-16 1994-09-14 Auckland Uniservices Limited Developmental tyrosine kinases and their ligands
US7534867B1 (en) 1993-05-19 2009-05-19 Schering Corporation Purified mammalian Flt3 ligands; agonists; antagonists
JPH09501822A (ja) * 1993-05-19 1997-02-25 シェリング・コーポレーション 精製哺乳動物ｆｌｔ３リガンド並びにそのアゴニストおよびアンタゴニスト
US7045128B2 (en) 1993-05-24 2006-05-16 Immunex Corporation Antibodies against flt3-ligand
US6630143B1 (en) * 1993-05-24 2003-10-07 Immunex Corporation Antibodies against flt3 ligand
US5554512A (en) * 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
NZ314644A (en) 1993-05-24 2000-11-24 Immunex Corp Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue
AU7210394A (en) * 1993-06-18 1995-01-17 Trustees Of Princeton University, The Totipotent hematopoietic stem cell receptors and their ligands
US5516658A (en) 1993-08-20 1996-05-14 Immunex Corporation DNA encoding cytokines that bind the cell surface receptor hek
EP1734053A3 (de) * 1993-09-08 2009-04-22 Imclone Systems, Inc. Monoklonale Antikörper die Flk-2 Rezeptoren erkennen und die Isolierung von primitiven hematopoietischen Stammzellpopulationen
EP0730646A1 (de) * 1993-11-23 1996-09-11 Genentech, Inc. Rse, protein tyrosin kinasen
US6001621A (en) * 1993-11-23 1999-12-14 Genetech, Inc. Protein tyrosine kinases
US6190655B1 (en) 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
US5618709A (en) * 1994-01-14 1997-04-08 University Of Pennsylvania Antisense oligonucleotides specific for STK-1 and method for inhibiting expression of the STK-1 protein
US5573935A (en) * 1994-01-18 1996-11-12 The United States Of America As Represented By The Department Of Health And Human Services Protein tyrosine kinase A6
US5861499A (en) 1994-02-10 1999-01-19 Imclone Systems Incorporated Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
US6448077B1 (en) * 1994-02-10 2002-09-10 Imclone Systems, Inc. Chimeric and humanized monoclonal antibodies specific to VEGF receptors
US20030108545A1 (en) * 1994-02-10 2003-06-12 Patricia Rockwell Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
US5840301A (en) * 1994-02-10 1998-11-24 Imclone Systems Incorporated Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
US6811779B2 (en) * 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
US7294331B2 (en) * 1994-03-07 2007-11-13 Immunex Corporation Methods of using flt3-ligand in hematopoietic cell transplantation
CA2184584C (en) 1994-03-08 2003-04-08 Jing-Shan Hu Vascular endothelial growth factor 2
US6040157A (en) * 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US7153827B1 (en) * 1994-03-08 2006-12-26 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 and methods of use
US7186688B1 (en) * 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
US7109308B1 (en) 1994-03-08 2006-09-19 Human Genome Sciences, Inc. Antibodies to human vascular endothelial growth factor 2
US5932540A (en) 1994-03-08 1999-08-03 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US6734285B2 (en) 1994-03-08 2004-05-11 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 proteins and compositions
US5650317A (en) * 1994-09-16 1997-07-22 Michigan State University Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics
US6140119A (en) * 1994-09-16 2000-10-31 Michigan State University Expression of estrogen receptors in type I and type II human breast epithelial cells
US5731425A (en) * 1994-10-28 1998-03-24 Eastman Kodak Company Polypeptide surface marker for cells
EP0854185A3 (de) * 1994-12-23 1998-10-21 Ludwig Institute For Cancer Research Rezeptor-Proteine zu Bestimmungszwecke und Liganden
US7070972B1 (en) * 1995-01-13 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Janus family kinases and identification of immune modulators
IL117645A (en) * 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5824789A (en) * 1995-06-07 1998-10-20 Systemix, Inc. Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
DE69628652T3 (de) * 1995-09-08 2012-05-03 Genentech, Inc. Vegf-verwandtes protein
US7150992B1 (en) 1995-10-04 2006-12-19 Innunex Corporation Methods of preparing dendritic cells with flt3-ligand and antigen
US7361330B2 (en) * 1995-10-04 2008-04-22 Immunex Corporation Methods of using flt3-ligand in the treatment of fibrosarcoma
US20020034517A1 (en) * 1995-10-04 2002-03-21 Kenneth Brasel Dendritic cell stimulatory factor
WO1997017442A1 (en) * 1995-11-08 1997-05-15 Immunex Corporation Flk-1 binding protein
US6994989B1 (en) 1995-11-08 2006-02-07 Immunex Corp. FLK-1 binding proteins
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US6750044B1 (en) * 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids
US20060171907A1 (en) * 1996-11-21 2006-08-03 The Procter & Gamble Company Oral care compositions providing enhanced whitening and stain prevention
EP1060242A4 (de) * 1998-01-23 2003-09-17 Imclone Systems Inc Aufbereitete stammzell-populationen
US6908898B1 (en) * 1998-06-15 2005-06-21 Lars Holmgren Angiogenesis related molecules
EP1119371B1 (de) * 1998-10-09 2010-11-24 Vegenics Limited Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie
US8124630B2 (en) * 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
IL144144A0 (en) * 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US20020064528A1 (en) * 2000-01-28 2002-05-30 Zhenping Zhu Antibodies specific to KDR and uses thereof
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
US6379903B1 (en) 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
NZ523386A (en) 2000-06-07 2004-07-30 Ortho Mcneil Pharm Inc Method to measure phosphorylation using a fusion protein, such as the carboxy terminal amino acids of rat VEGF-R2 fused with an affinity tag
US7273751B2 (en) * 2000-08-04 2007-09-25 Human Genome Science, Inc. Vascular endothelial growth factor-2
AU2002248372B8 (en) * 2001-01-19 2008-03-20 Vegenics Limited FLT4(VEGFR-3) as a target for tumor imaging and anti-tumor therapy
AU2002256172A1 (en) * 2001-04-13 2002-10-28 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US20050232921A1 (en) * 2001-04-13 2005-10-20 Rosen Craig A Vascular endothelial growth factor 2
JP2004536579A (ja) 2001-04-13 2004-12-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 血管内皮増殖因子２
EP1385862A4 (de) * 2001-04-13 2005-03-02 Human Genome Sciences Inc Vaskulärer endothelwachstumsfaktor 2
US7402312B2 (en) * 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1515707A4 (de) * 2001-06-20 2005-10-19 Imclone Systems Inc Verfahren zur behandlung von atherosklerose und anderer entzündlicher erkrankungen
DE60223556T2 (de) * 2001-08-10 2008-09-18 Imclone Systems, Inc. Medizinische verwendung von stammzellen, die vegfr-1 exprimieren
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
JP4636486B2 (ja) * 2002-02-11 2011-02-23 バイエル、ファーマシューテイカルズ、コーポレイション 脈管形成阻害活性を有するアリール尿素
US7557129B2 (en) * 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
ES2305808T3 (es) * 2003-05-20 2008-11-01 Bayer Healthcare Llc Diarilureas con actividad inhibidora de quinasas.
CL2004001834A1 (es) 2003-07-23 2005-06-03 Bayer Pharmaceuticals Corp Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
PT1819358E (pt) * 2004-11-18 2014-11-17 Imclone Llc Anticorpos contra o recetor-1 do factor de crescimento endotelial vascular
US7495383B2 (en) * 2005-08-01 2009-02-24 Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. Phosphor based on a combination of quantum dot and conventional phosphors
KR100883430B1 (ko) * 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
AR071891A1 (es) 2008-05-30 2010-07-21 Imclone Llc Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
AU2009327485A1 (en) * 2008-06-18 2010-06-24 Cytopherx, Inc. Methods for propagation of renal precursor cells
RS60026B1 (sr) 2013-02-18 2020-04-30 Vegenics Pty Ltd Molekuli koji vezuju ligande i njihove upotrebe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317156B2 (de) * 1987-11-09 1997-11-12 Becton, Dickinson and Company Verfahren zur Analyse hämatopoietischer Zellen in einer Probe
HUT53672A (en) * 1988-02-25 1990-11-28 Gen Hospital Corp Quick immunoselective cloning process
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5185438A (en) * 1991-04-02 1993-02-09 The Trustees Of Princeton University Nucleic acids encoding hencatoporetic stem cell receptor flk-2

Also Published As

Publication number Publication date
US5621090A (en) 1997-04-15
EP1231265A3 (de) 2003-12-03
EP0580760B1 (de) 2003-03-12
EP1231260B1 (de) 2008-09-17
DE69232952T2 (de) 2003-10-02
EP1808445A2 (de) 2007-07-18
US5283354A (en) 1994-02-01
DE69232952D1 (de) 2003-04-17
DE69233676T2 (de) 2007-11-15
EP0580760A1 (de) 1994-02-02
EP1808445A3 (de) 2007-09-26
DE69232687T2 (de) 2002-11-21
AU1924892A (en) 1992-11-02
WO1992017486A1 (en) 1992-10-15
US5185438A (en) 1993-02-09
EP1231265A2 (de) 2002-08-14
EP1231261B1 (de) 2010-06-23
EP1231261A2 (de) 2002-08-14
EP0580760A4 (en) 1997-04-09
CA2107463C (en) 2008-06-17
DE69232687D1 (de) 2002-08-22
EP1231260A3 (de) 2003-12-03
KR100407010B1 (ko) 2003-11-28
WO1993000349A1 (en) 1993-01-07
EP1231265B1 (de) 2007-01-31
DE69233788D1 (de) 2010-08-05
KR100261465B1 (ko) 2000-07-01
CA2107463A1 (en) 1992-10-03
EP0909813B1 (de) 2002-07-17
EP0909813A1 (de) 1999-04-21
EP1231260A2 (de) 2002-08-14
EP1231261A3 (de) 2003-12-03
DE69233676D1 (de) 2007-03-22
KR100406832B1 (ko) 2003-11-21

Similar Documents

Publication Publication Date Title
DE69233746D1 (de) Verfahren zur Isolierung von Zellen die FLK-2-Rezeptoren auf ihrer Oberfläche exprimieren
DE69618464D1 (de) Verfahren zur produktzuführung
ATA77981A (de) Hydraulisch abbindende zusammensetzung zur herstellung von faserverstaerkten formkoerpern sowie verfahren zu ihrer herstellung
DE69319389D1 (de) Verfahren zur herstellung dünner zellen
DE69311944D1 (de) Verfahren zur Bestimmung der Anzahl lebender Mikroorganismen
AT381902B (de) Verfahren zur herstellung von hohlkoerpern
ATE204120T1 (de) Verfahren zur vermehrung von pflanzenmaterial
DE59108784D1 (de) Mehrlagenleiterplatte und verfahren zu ihrer herstellung
AT387235B (de) Menschliche t-zellen-linien und verfahren zu ihrer herstellung
DE69505120D1 (de) Verfahren zur selektiven hydrierung von epoxyalkenen zu epoxyalkanen
DE59205061D1 (de) Verfahren zur Herstellung keilförmiger Strukturen
DE68917642D1 (de) Verfahren zur kontinuierlichen Züchtung von haftenden tierischen Zellen.
AT389530B (de) Verfahren zur altpapieraufbereitung
DE59301973D1 (de) Pipettierhilfe und verfahren zu ihrer herstellung
ATA163888A (de) Kathodisch abscheidbare elektrotauchlacke und verfahren zu ihrer herstellung
ID22832A (id) Metode pembuatan asam formilfosfonat
DE3855429T2 (de) Verfahren zur Elektrophorese
DE69305208D1 (de) Verfahren zur Herstellung von alkalischen Zellen
AT364667B (de) Kuenstliche fliege fuer fischereizwecke und verfahren zu ihrer herstellung
DE69800114D1 (de) Verfahren zur Hydrierung von Cyanopropanaldehyden enthaltend Cyanopropionaldehydacetalen
DE69624730T2 (de) Verfahren zur selektiven spaltung von naphthalin-ringen
DE59010363D1 (de) Membran zum austrag ungesättigter kohlenwasserstoffe sowie verfahren zu ihrer herstellung
DE69229915D1 (de) Verfahren zur herstellung von magnetostriktivem material
ATA7087A (de) Schalldaemmplatte und verfahren zu ihrer herstellung
AT388888B (de) Verfahren zur herstellung von zylinderfoermigen hohlkoerpern

Legal Events

Date Code Title Description
8364 No opposition during term of opposition