DE69301916T2 - 5-0-desosaminylerythronolid a derivate - Google Patents

5-0-desosaminylerythronolid a derivate

Info

Publication number: DE69301916T2
Authority: DE; Germany
Prior art keywords: desosaminylerythronolide; derivative; oxo; substituted; alkyl
Prior art date: 1992-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69301916T

Other languages

English (en)

Other versions

DE69301916D1 (de

Inventor

Toshifumi Asaka

Masato Kashimura

Yoko Misawa

Shigeo Morimoto

Katsuo Hatayama

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taisho Pharmaceutical Co Ltd

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-22

Filing date

1993-04-21

Publication date

1996-08-08

1993-04-21 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1996-04-25 Publication of DE69301916D1 publication Critical patent/DE69301916D1/de

1996-08-08 Application granted granted Critical

1996-08-08 Publication of DE69301916T2 publication Critical patent/DE69301916T2/de

2013-04-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

DE69301916T 1992-04-22 1993-04-21 5-0-desosaminylerythronolid a derivate Expired - Fee Related DE69301916T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP10149292		1992-04-22
PCT/JP1993/000516 WO1993021199A1 (en)	1992-04-22	1993-04-21	5-o-desosaminylerythronolide a derivative

Publications (2)

Publication Number	Publication Date
DE69301916D1 DE69301916D1 (de)	1996-04-25
DE69301916T2 true DE69301916T2 (de)	1996-08-08

Family

ID=14302174

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69301916T Expired - Fee Related DE69301916T2 (de)	1992-04-22	1993-04-21	5-0-desosaminylerythronolid a derivate
DE69305987T Expired - Fee Related DE69305987T2 (de)	1992-04-22	1993-04-21	5-0-desosaminylerythronolide a derivate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69305987T Expired - Fee Related DE69305987T2 (de)	1992-04-22	1993-04-21	5-0-desosaminylerythronolide a derivate

Country Status (12)

Country	Link
US (2)	US5631355A (de)
EP (2)	EP0638585B1 (de)
KR (2)	KR0166996B1 (de)
AT (2)	ATE135707T1 (de)
AU (2)	AU662420B2 (de)
BR (1)	BR1100235A (de)
CA (2)	CA2118488C (de)
DE (2)	DE69301916T2 (de)
DK (2)	DK0638584T3 (de)
ES (2)	ES2087737T3 (de)
GR (2)	GR3019787T3 (de)
WO (2)	WO1993021200A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2739620B1 (fr) *	1995-10-09	1997-12-19	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
USRE38426E1 (en)	1995-10-09	2004-02-10	Aventis Pharma S.A.	5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
US5747466A (en) *	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
US6274715B1 (en)	1995-11-08	2001-08-14	Abbott Laboratories	Tricyclic erythromycin derivatives
ES2218604T3 (es) *	1995-11-08	2004-11-16	Abbott Laboratories	Derivados triciclicos de eritromicina.
US5750510A (en) *	1997-04-04	1998-05-12	Abbott Laboratories	3-descladinose-2,3-anhydroerythromycin derivatives
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
PT1291352E (pt) *	1996-09-04	2005-09-30	Abbott Lab	Cetolidos 6-o-substituidos possuindo actividade antibacteriana
CN1238777A (zh)	1996-11-27	1999-12-15	大正制药株式会社	红霉素a衍生物
FR2757168B1 (fr) *	1996-12-12	1999-06-11	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
WO1998040392A1 (fr) *	1997-03-10	1998-09-17	Taisho Pharmaceutical Co., Ltd.	Derives d'erythromycine a
US6140479A (en) *	1997-03-24	2000-10-31	Taisho Pharmaceuticals Co., Ltd.	Erythromycin a derivatives
AU6932098A (en) *	1997-05-09	1998-12-08	Pfizer Products Inc.	Erythromycin derivatives
US5922683A (en) *	1997-05-29	1999-07-13	Abbott Laboratories	Multicyclic erythromycin derivatives
AU7591298A (en) *	1997-05-29	1998-12-30	Abbott Laboratories	Multicyclic erythromycin derivatives
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
US5780604A (en) *	1997-09-26	1998-07-14	Abbott Laboratories	11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
PA8461401A1 (es) *	1997-10-29	2000-05-24	Pfizer Prod Inc	Derivados de eritromicina triciclicos
CO4990960A1 (es) *	1997-10-29	2000-12-26	Abbott Lab	Derivados de cetolidos 2-halo-6-o sustituidos
HN1998000159A (es) *	1997-10-29	1999-02-09	Monsanto Co	Derivados de 9- amino - 3 ceto eritromicina
US6124269A (en) *	1997-10-29	2000-09-26	Abbott Laboratories	2-Halo-6-O-substituted ketolide derivatives
FR2777282B1 (fr) *	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
ES2199524T3 (es)	1998-04-24	2004-02-16	Pfizer Products Inc.	Derivados 9a,11b-deshidro de 9-oxima-3-ceto-6-o-metileritromicina.
US6248719B1 (en)	1998-06-03	2001-06-19	Pfizer Inc	Tricyclic 3-keto derivatives of 6-O-methylerthromycin
FR2784682B1 (fr) *	1998-10-15	2002-12-06	Hoechst Marion Roussel Inc	Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
US6355620B1 (en)	1999-05-14	2002-03-12	Abbott Laboratories	C-2 modified erythromycin derivatives
US6569836B2 (en)	1999-12-02	2003-05-27	Abbott Laboratories	6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1146051A3 (de) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A-Derivate
US7135573B2 (en) *	2002-05-13	2006-11-14	Enanta Pharmaceuticals, Inc.	Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
CN1659178A (zh) *	2002-05-13	2005-08-24	英安塔制药有限公司	6、11二环红霉素衍生物
US6764998B1 (en)	2003-06-18	2004-07-20	Enanta Pharmaceuticals, Inc.	6,11-4C-bicyclic 9a-azalide derivatives
US6841664B2 (en) *	2002-07-25	2005-01-11	Enanra Pharmaceuticals, Inc.	6,11-4-carbon bridged ketolides
US6753318B1 (en)	2002-07-25	2004-06-22	Enanta Pharmaceuticals, Inc.	6,11-4-carbon bridged erythromycin derivatives
US7064110B2 (en) *	2002-05-13	2006-06-20	Enanta Pharmaceuticals, Inc.	6-11 bicycle ketolide derivatives
US6878691B2 (en) *	2002-05-13	2005-04-12	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US7910558B2 (en) *	2002-05-13	2011-03-22	Enanta Pharmaceuticals, Inc.	Bridged macrocyclic compounds and processes for the preparation thereof
WO2005070918A1 (en) *	2002-05-13	2005-08-04	Enanta Pharmaceuticals, Inc.	Process for the preparation of t-11 bicyclic erythromycin derivatives
US7273853B2 (en) *	2002-05-13	2007-09-25	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US6645941B1 (en)	2003-03-26	2003-11-11	Enanta Pharmaceuticals, Inc.	6,11-3C-bicyclic 9a-azalide derivatives
US7276487B2 (en) *	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005067564A2 (en) *	2004-01-07	2005-07-28	Enanta Pharmaceuticals, Inc.	6-11 bicyclic erythromycin derivatives
WO2005070113A2 (en) *	2004-01-09	2005-08-04	Enanta Pharmaceuticals, Inc.	9n-substituted 6-11 bicyclic erythromycin derivatives
US7163906B2 (en) *	2004-11-04	2007-01-16	Chevron Phillips Chemical Company, Llp	Organochromium/metallocene combination catalysts for producing bimodal resins
US7419962B2 (en)	2004-12-07	2008-09-02	Enanta Pharmaceuticals, Inc.	3,6-bicyclolides
US7229972B2 (en)	2004-12-07	2007-06-12	Enanta Pharmaceuticals, Inc.	3,6-Bicyclolides
US7312201B2 (en)	2004-12-13	2007-12-25	Enanta Pharmaceuticals, Inc.	Tetracyclic bicyclolides
WO2006065721A2 (en)	2004-12-13	2006-06-22	Enanta Pharmaceuticals, Inc.	11, 12-lactone bicyclolides
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
CN101454334B (zh)	2006-05-01	2013-04-10	大正制药株式会社	大环内酯衍生物
US20070298811A1 (en) *	2006-06-21	2007-12-27	Lockheed Martin Corporation	System for predicting bandwidth capacity
US8871728B2 (en)	2007-06-29	2014-10-28	Georgia Tech Research Corporation	Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
WO2009006403A2 (en) *	2007-06-29	2009-01-08	Georgia Tech Research Corporation	Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
US8354383B2 (en) *	2007-09-17	2013-01-15	Enanta Pharmaceuticals, Inc.	6,11-bridged biaryl macrolides
US8273720B2 (en) *	2007-09-17	2012-09-25	Enanta Pharmaceuticals, Inc.	6,11-bicyclolides: bridged biaryl macrolide derivatives
KR20120132577A (ko) *	2007-09-17	2012-12-05	이난타 파마슈티칼스, 인코포레이티드	6,11-다리걸친 바이아릴 매크로라이드
TW200946109A (en) *	2008-05-09	2009-11-16	Enanta Pharm Inc	Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175150A (en) *	1985-08-31	1992-12-29	Kitasato, Kenkyusho	Erythromycin derivative
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
ATE157368T1 (de) *	1990-11-28	1997-09-15	Taisho Pharmaceutical Co Ltd	6-0-methylerythromycin a-derivat
US5523399A (en) *	1991-12-27	1996-06-04	Taisho Pharmaceutical Co., Ltd.	5-O-desosaminylerythronolide derivatives

1993
- 1993-04-21 AT AT93909403T patent/ATE135707T1/de not_active IP Right Cessation
- 1993-04-21 ES ES93909403T patent/ES2087737T3/es not_active Expired - Lifetime
- 1993-04-21 CA CA002118488A patent/CA2118488C/en not_active Expired - Fee Related
- 1993-04-21 DK DK93909403.3T patent/DK0638584T3/da active
- 1993-04-21 EP EP93909404A patent/EP0638585B1/de not_active Expired - Lifetime
- 1993-04-21 DE DE69301916T patent/DE69301916T2/de not_active Expired - Fee Related
- 1993-04-21 CA CA002118489A patent/CA2118489C/en not_active Expired - Fee Related
- 1993-04-21 AU AU40223/93A patent/AU662420B2/en not_active Ceased
- 1993-04-21 AT AT93909404T patent/ATE145212T1/de not_active IP Right Cessation
- 1993-04-21 AU AU40222/93A patent/AU661585B2/en not_active Ceased
- 1993-04-21 US US08/318,862 patent/US5631355A/en not_active Expired - Fee Related
- 1993-04-21 US US08/318,795 patent/US5591837A/en not_active Expired - Fee Related
- 1993-04-21 WO PCT/JP1993/000517 patent/WO1993021200A1/ja active IP Right Grant
- 1993-04-21 EP EP93909403A patent/EP0638584B1/de not_active Expired - Lifetime
- 1993-04-21 ES ES93909404T patent/ES2096915T3/es not_active Expired - Lifetime
- 1993-04-21 DE DE69305987T patent/DE69305987T2/de not_active Expired - Fee Related
- 1993-04-21 KR KR1019940703541A patent/KR0166996B1/ko not_active IP Right Cessation
- 1993-04-21 KR KR1019940703540A patent/KR100244729B1/ko not_active IP Right Cessation
- 1993-04-21 DK DK93909404.1T patent/DK0638585T3/da active
- 1993-04-21 WO PCT/JP1993/000516 patent/WO1993021199A1/ja active IP Right Grant
1996
- 1996-04-29 GR GR960401167T patent/GR3019787T3/el unknown
- 1996-12-11 GR GR960403431T patent/GR3021992T3/el unknown
1997
- 1997-04-07 BR BR1100235-2A patent/BR1100235A/pt active IP Right Grant

Also Published As

Publication number	Publication date
WO1993021199A1 (en)	1993-10-28
GR3021992T3 (en)	1997-03-31
US5591837A (en)	1997-01-07
KR950700920A (ko)	1995-02-20
EP0638584B1 (de)	1996-03-20
DE69301916D1 (de)	1996-04-25
US5631355A (en)	1997-05-20
KR950700921A (ko)	1995-02-20
EP0638584A4 (de)	1994-12-23
KR0166996B1 (ko)	1999-01-15
DE69305987T2 (de)	1997-03-06
DK0638584T3 (da)	1996-04-15
CA2118488A1 (en)	1993-10-23
WO1993021200A1 (fr)	1993-10-28
KR100244729B1 (ko)	2000-02-15
ATE135707T1 (de)	1996-04-15
AU662420B2 (en)	1995-08-31
ES2096915T3 (es)	1997-03-16
BR1100235A (pt)	2002-04-30
EP0638585A1 (de)	1995-02-15
DE69305987D1 (de)	1996-12-19
CA2118489C (en)	1999-07-13
ATE145212T1 (de)	1996-11-15
EP0638585B1 (de)	1996-11-13
AU4022393A (en)	1993-11-18
ES2087737T3 (es)	1996-07-16
EP0638584A1 (de)	1995-02-15
CA2118489A1 (en)	1993-10-23
AU661585B2 (en)	1995-07-27
GR3019787T3 (en)	1996-07-31
CA2118488C (en)	2002-11-05
EP0638585A4 (de)	1995-04-19
DK0638585T3 (da)	1996-12-02
AU4022293A (en)	1993-11-18

Legal Events

Date	Code	Title	Description
1997-04-17	8364	No opposition during term of opposition
2004-02-12	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69301916D1 (de)	1996-04-25	5-0-desosaminylerythronolid a derivate
DE69127457T2 (de)	1998-01-22	6-0-methylerythromycin a-derivat
ATE153341T1 (de)	1997-06-15	5-o-desosaminylerythronolid derivate
ATE271557T1 (de)	2004-08-15	Dc-89 derivat
DE69505470D1 (de)	1998-11-26	Pyrrolocarbazol
DE69423339T2 (de)	2000-07-27	Epoxycyclohexendionderivat
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ES2115816T3 (es)	1998-07-01	Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.
FI883507A (fi)	1989-02-01	Naftotiazepinderivat och deras framstaellning.
ATE284402T1 (de)	2004-12-15	Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung