DE69322272D1 - Substituierte arginine und substituierte homoarginine und ihre verwendung - Google Patents

Substituierte arginine und substituierte homoarginine und ihre verwendung

Info

Publication number
DE69322272D1
DE69322272D1 DE69322272T DE69322272T DE69322272D1 DE 69322272 D1 DE69322272 D1 DE 69322272D1 DE 69322272 T DE69322272 T DE 69322272T DE 69322272 T DE69322272 T DE 69322272T DE 69322272 D1 DE69322272 D1 DE 69322272D1
Authority
DE
Germany
Prior art keywords
methyl
arginine
omega
alpha
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69322272T
Other languages
English (en)
Other versions
DE69322272T2 (de
Inventor
Owen W Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Application granted granted Critical
Publication of DE69322272D1 publication Critical patent/DE69322272D1/de
Publication of DE69322272T2 publication Critical patent/DE69322272T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
DE69322272T 1992-05-28 1993-05-19 Substituierte arginine und substituierte homoarginine und ihre verwendung Expired - Fee Related DE69322272T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/889,345 US5281627A (en) 1992-05-28 1992-05-28 Substituted arginines and substituted homoarginines and use thereof
PCT/US1993/004544 WO1993024126A1 (en) 1992-05-28 1993-05-19 Substituted arginines and substituted homoarginines and use thereof

Publications (2)

Publication Number Publication Date
DE69322272D1 true DE69322272D1 (de) 1999-01-07
DE69322272T2 DE69322272T2 (de) 1999-04-22

Family

ID=25394938

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322272T Expired - Fee Related DE69322272T2 (de) 1992-05-28 1993-05-19 Substituierte arginine und substituierte homoarginine und ihre verwendung

Country Status (7)

Country Link
US (2) US5281627A (de)
EP (1) EP0649303B1 (de)
JP (1) JPH07507306A (de)
AT (1) ATE173621T1 (de)
DE (1) DE69322272T2 (de)
ES (1) ES2123653T3 (de)
WO (1) WO1993024126A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
JPH09501918A (ja) * 1993-08-12 1997-02-25 アストラ・アクチエボラーグ 酸化窒素合成酵素活性を有するアミジン誘導体
PT724435E (pt) * 1993-10-21 2002-11-29 Searle & Co Derivados amidino uteis como inibidores de oxido nitrico sintase
EP0897912A1 (de) * 1993-10-21 1999-02-24 G.D. Searle & Co. Amidinoderivate als NO-Synthetase-Inhibitoren
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
US5695761A (en) * 1993-12-23 1997-12-09 Rutgers University Suppression of nitric oxide production by osteopontin
WO1995024382A1 (en) * 1994-03-10 1995-09-14 G.D. Searle & Co. L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
DK0751930T3 (da) * 1994-03-24 2000-04-17 Searle & Co Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer
MX9605366A (es) * 1994-05-07 1997-12-31 Astra Ab Derivados de amidina biciclicos como inhibidores de la oxido nitrico sintetasa.
FR2722507B1 (fr) * 1994-07-12 1996-08-14 Rhone Poulenc Rorer Sa Adenovirus comportant un gene codant pour une no synthase
US20030099945A1 (en) * 1994-09-20 2003-05-29 Invenux, Inc. Parallel selex
US6239172B1 (en) * 1997-04-10 2001-05-29 Nitrosystems, Inc. Formulations for treating disease and methods of using same
US5543430A (en) * 1994-10-05 1996-08-06 Kaesemeyer; W. H. Method and formulation of stimulating nitric oxide synthesis
US20110196039A9 (en) * 1994-10-05 2011-08-11 Kaesemeyer Wayne H Controlled release arginine formulations
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
FR2727111B1 (fr) * 1994-11-21 1997-01-17 Hoechst Lab Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
FR2730930B1 (fr) 1995-02-27 1997-04-04 Oreal Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
NZ305799A (en) * 1995-04-20 1999-01-28 Searle & Co Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US6127420A (en) * 1997-08-22 2000-10-03 The Medical College Of Wisconsin Research Foundation, Inc. L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6489323B1 (en) 1998-06-10 2002-12-03 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6784178B2 (en) 2000-04-12 2004-08-31 Cornell Research Foundation, Inc. Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AU2002359761A1 (en) * 2001-12-18 2003-06-30 Invenux, Inc. Antibiotic compounds
CA2478089A1 (en) * 2002-03-06 2003-09-18 Duke University Methods and composition based on discovery of metabolism of nitroclycerin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2663668A (en) * 1951-08-09 1953-12-22 Permanente Foundation Process for producing arginase
US2834713A (en) * 1952-11-22 1958-05-13 Armour & Co Preparation of enzyme extracts from liver
DE2126181C3 (de) * 1970-05-27 1975-04-24 Kyowa Hakko Kogyo K.K., Tokio Biotechnisches Verfahren zur Herstellung von L-Arginase
US4061542A (en) * 1976-03-08 1977-12-06 Hoffmann-La Roche Inc. 2-Methyl-L-arginine produced by cultivating streptomyces strain
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
US4499068A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -alkyl derivatives of arginine
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine
US4499067A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -acyl derivatives of arginine
US4477428A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α,NG -diacyl derivatives of arginine
US4698442A (en) * 1982-12-21 1987-10-06 Syntex (U.S.A.) Inc. ω-Guanidino-substituted-α-amino acids
US4734438A (en) * 1983-04-26 1988-03-29 Macri Frank J Norepinephrine potentiated compositions and method of use
DE3838461A1 (de) * 1988-11-12 1990-05-23 Krebsoege Gmbh Sintermetall Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
AU636713B2 (en) * 1990-02-26 1993-05-06 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof

Also Published As

Publication number Publication date
US5281627A (en) 1994-01-25
ES2123653T3 (es) 1999-01-16
DE69322272T2 (de) 1999-04-22
EP0649303B1 (de) 1998-11-25
JPH07507306A (ja) 1995-08-10
US5453441A (en) 1995-09-26
EP0649303A4 (de) 1995-07-05
EP0649303A1 (de) 1995-04-26
WO1993024126A1 (en) 1993-12-09
ATE173621T1 (de) 1998-12-15

Similar Documents

Publication Publication Date Title
DE69322272T2 (de) Substituierte arginine und substituierte homoarginine und ihre verwendung
HUP0001383A1 (hu) N-(Aril/heteroaril)-aminosav-származékok, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
KR880700668A (ko) 특정 생체조직 부위로의 전달을 위한 아미노산 킬레이트의 조성물
HUP0004529A2 (hu) VLA-4 által mediált leukocita adhéziót gátló szulfonilezett dipeptid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint alkalmazásuk
CA2008108A1 (en) Bis-aza-bicyclic anxiolytic agents
ATE64396T1 (de) Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
MX9801716A (es) Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
CA2437983A1 (en) Transporters comprising spaced arginine moieties
TR199802102T2 (xx) Antifungal madde ve asetat tampon maddesi i�eren bile�imler.
ATE147272T1 (de) Pharmazeutische zubereitungsformen
CA2215695A1 (en) .beta.-sheet mimetics and use thereof as protease inhibitors
HUP9802372A2 (hu) Szomatosztatin gyűrűs peptid analógjai
KR930701415A (ko) 약학적으로 활성인 벤조퀴나졸린 화합물
EP0966975A3 (de) Diagnostikum für die exocriene Pankreasfunktion
CA2250861A1 (en) Cyclic adhesion inhibitors
TW427906B (en) Antifungal compositions
SI9420001B (sl) Polipeptidni antagonisti bombezina
HUP0203117A2 (hu) Semleges kationos lipid nukleinsav és hatóanyag szállítására
KR920014778A (ko) 헤테로사이클릭 하이드록실아민
CA2193460A1 (en) 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation
ATE10836T1 (de) Peptide und ihre anwendung in der therapeutik.
KR900006308A (ko) 중추 신경계에 작용하는 치환된 방향족 화합물
ATE73660T1 (de) 9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel.
HUP9901290A2 (hu) Trombin inhibitor hatású polifluor-alkil-triptofánt tartalmazó tripeptidek
AU1843097A (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee