DE69329594T2 - Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung - Google Patents

Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung

Info

Publication number
DE69329594T2
DE69329594T2 DE69329594T DE69329594T DE69329594T2 DE 69329594 T2 DE69329594 T2 DE 69329594T2 DE 69329594 T DE69329594 T DE 69329594T DE 69329594 T DE69329594 T DE 69329594T DE 69329594 T2 DE69329594 T2 DE 69329594T2
Authority
DE
Germany
Prior art keywords
oligomers
controlled release
biodegradable
hydrogels
polymerized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329594T
Other languages
English (en)
Other versions
DE69329594D1 (de
Inventor
Jeffrey A Hubbell
Chandrashekhar P Pathak
Amarpreet S Sawhney
Neil P Desai
Jennifer L Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE69329594D1 publication Critical patent/DE69329594D1/de
Publication of DE69329594T2 publication Critical patent/DE69329594T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0042Materials resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06Polymers provided for in subclass C08G
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F291/00Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D153/00Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J153/00Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012Cell encapsulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0677Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017Lysozyme (3.2.1.17)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21068Tissue plasminogen activator (3.4.21.68), i.e. tPA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424Anti-adhesion agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • C12N2533/32Polylysine, polyornithine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • C12N2533/40Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/74Alginate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913Rod, strand, filament or fiber
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913Rod, strand, filament or fiber
    • Y10T428/2933Coated or with bond, impregnation or core
    • Y10T428/2964Artificial fiber or filament
    • Y10T428/2967Synthetic resin or polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31786Of polyester [e.g., alkyd, etc.]
DE69329594T 1992-02-28 1993-03-01 Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung Expired - Lifetime DE69329594T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84348592A 1992-02-28 1992-02-28
PCT/US1993/001773 WO1993017669A1 (en) 1992-02-28 1993-03-01 Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers

Publications (2)

Publication Number Publication Date
DE69329594D1 DE69329594D1 (de) 2000-11-30
DE69329594T2 true DE69329594T2 (de) 2001-05-31

Family

ID=25290128

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329594T Expired - Lifetime DE69329594T2 (de) 1992-02-28 1993-03-01 Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung

Country Status (15)

Country Link
US (5) US5567435A (de)
EP (1) EP0627911B1 (de)
JP (1) JP3011768B2 (de)
KR (1) KR100266912B1 (de)
AT (1) ATE197125T1 (de)
AU (1) AU673160B2 (de)
BR (1) BR9306038A (de)
CA (1) CA2117588C (de)
DE (1) DE69329594T2 (de)
DK (1) DK0627911T3 (de)
ES (1) ES2153378T3 (de)
GR (1) GR3035172T3 (de)
NZ (1) NZ249770A (de)
PT (1) PT627911E (de)
WO (1) WO1993017669A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427415B2 (en) 2002-10-11 2008-09-23 Novocell, Inc. Implantation of encapsulated biological materials for treating diseases

Families Citing this family (453)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
EP0572526A4 (en) * 1991-02-13 1995-12-06 Interface Biomedical Lab Corp Filler material for use in tissue welding
US5669934A (en) * 1991-02-13 1997-09-23 Fusion Medical Technologies, Inc. Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets
CA2117588C (en) 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US20020095164A1 (en) * 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5749968A (en) * 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
US5800373A (en) * 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6004547A (en) 1997-09-29 1999-12-21 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
JP3579052B2 (ja) * 1993-03-23 2004-10-20 フォーカル,インコーポレイテッド 重合材料の生体組織への局部付与のための装置
US6037329A (en) 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
US5665063A (en) 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
CA2202511A1 (en) * 1994-10-12 1996-04-25 Laurence A. Roth Targeted delivery via biodegradable polymers
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
US5618850A (en) * 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
AU709527B2 (en) 1995-03-23 1999-09-02 Board Of Regents, The University Of Texas System Redox and photoinitiator systems for priming for improved adherence of gels to substrates
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
EP0814774B1 (de) * 1995-03-24 2005-10-19 Genzyme Corporation Verminderung von adhäsionen durch gesteuerte verabreichung von aktivsauerstoffinhibitoren
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
EP0842209B1 (de) 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
AU7398196A (en) * 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
DE69734060T2 (de) 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
ES2198579T3 (es) 1996-07-01 2004-02-01 Universiteit Utrecht Hidrogeles hidrolizables para liberacion controlada.
US20080131512A1 (en) * 1996-07-01 2008-06-05 Wilhelmus Everhardus Hennink Biodegradable hydrogels
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5945100A (en) * 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
AU728281B2 (en) * 1996-09-23 2001-01-04 Genzyme Corporation Polymerizable biodegradable polymers including carbonate or dioxanone linkages
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19646782C2 (de) * 1996-11-13 2000-05-25 Merck Patent Gmbh Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
AU5522798A (en) 1996-12-31 1998-07-31 Kimberly-Clark Worldwide, Inc. Water-responsive polymer compositions and method of making the same
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US20040176801A1 (en) * 1997-03-12 2004-09-09 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US20030191496A1 (en) 1997-03-12 2003-10-09 Neomend, Inc. Vascular sealing device with microwave antenna
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6127520A (en) * 1997-04-15 2000-10-03 Regents Of The University Of Michigan Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles
GB2325467B (en) * 1997-05-21 2000-11-01 Dainippon Ink & Chemicals Process for producing material with hydrophilic surface
EP0986402A2 (de) 1997-06-06 2000-03-22 Battelle Memorial Institute Reversibles gelbindendes copolymer und verfahren
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
EP1512395A1 (de) * 1997-07-18 2005-03-09 Azopax Therapeutics LLC Biologisch abbaubare Makromere zur kontrollierten Abgabe biologisch aktiver Substanzen
JP2001510151A (ja) 1997-07-18 2001-07-31 インファイムド,インク. 生理活性物質の制御放出のための生分解性マクロマー
US5952433A (en) * 1997-07-31 1999-09-14 Kimberly-Clark Worldwide, Inc. Modified polyactide compositions and a reactive-extrusion process to make the same
US5945480A (en) * 1997-07-31 1999-08-31 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method for making the fibers
US6096303A (en) * 1997-07-31 2000-08-01 Medical College Of Georgia Research Institute, Inc. Method to enhance treatment of cystic tumors
US6552162B1 (en) 1997-07-31 2003-04-22 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same
AU8681098A (en) 1997-08-01 1999-03-08 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ZA987019B (en) * 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6306642B1 (en) 1997-11-24 2001-10-23 Quidel Corporation Enzyme substrate delivery and product registration in one step enzyme immunoassays
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
WO1999052469A1 (en) 1998-04-10 1999-10-21 Wm. Marsh Rice University Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
US6350518B1 (en) 1998-06-01 2002-02-26 Kimberly-Clark Worldwide, Inc. Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
WO2000012018A1 (en) * 1998-08-26 2000-03-09 Advanced Closure Systems, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers or covering structures
US6994686B2 (en) 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
US6458147B1 (en) 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6949114B2 (en) 1998-11-06 2005-09-27 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US7279001B2 (en) * 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US6830756B2 (en) * 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
WO2000033764A1 (en) * 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US7001400B1 (en) 1999-03-04 2006-02-21 Abbott Laboratories Articulating suturing device and method
US7235087B2 (en) 1999-03-04 2007-06-26 Abbott Park Articulating suturing device and method
US8137364B2 (en) 2003-09-11 2012-03-20 Abbott Laboratories Articulating suturing device and method
US6964668B2 (en) 1999-03-04 2005-11-15 Abbott Laboratories Articulating suturing device and method
US7842048B2 (en) 2006-08-18 2010-11-30 Abbott Laboratories Articulating suture device and method
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6692738B2 (en) 2000-01-27 2004-02-17 The General Hospital Corporation Delivery of therapeutic biologicals from implantable tissue matrices
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
ATE386075T1 (de) 1999-04-12 2008-03-15 Cornell Res Foundation Inc Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
WO2000062630A1 (en) 1999-04-16 2000-10-26 Wm. Marsh Rice University Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol)
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6579951B1 (en) * 1999-06-08 2003-06-17 Life Medical Sciences, Inc. Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
JP2003516810A (ja) * 1999-11-15 2003-05-20 バイオキュア・インコーポレーテッド 分解性ポリ(ビニルアルコール)ヒドロゲル
ATE460951T1 (de) 2000-01-25 2010-04-15 Edwards Lifesciences Corp Freisetzungssysteme zur behandlung von restenose und anastomotischer intimaler hyperplasie
WO2001055360A1 (en) * 2000-01-28 2001-08-02 Infimed Therapeutics, Inc. Slow release protein polymers
US6547806B1 (en) 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
US7039453B2 (en) * 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
DE60119906T2 (de) * 2000-03-13 2007-01-11 Biocure, Inc. Zusammensetzungen zur erhöhung des gewebevolumens und beschichtungszusammensetzungen
US8697137B2 (en) 2000-03-24 2014-04-15 Biosphere Medical, Inc. Methods of using microspheres for active embolization
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
US6800671B1 (en) 2000-04-21 2004-10-05 Britesmile, Inc. Low peak exotherm curable compositions
AU2001261300A1 (en) * 2000-05-09 2001-11-20 Pearl Technology Holdings, Llc Biodegradable fiber optic
WO2001088025A1 (en) * 2000-05-16 2001-11-22 Biocure, Inc. Membranes formed from amphiphilic copolymers
USRE43612E1 (en) 2000-10-10 2012-08-28 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7427394B2 (en) * 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6686431B2 (en) * 2000-11-01 2004-02-03 Avery Dennison Corporation Optical coating having low refractive index
US7625580B1 (en) 2000-11-28 2009-12-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
CA2433861A1 (en) 2000-12-27 2002-07-04 Genzyme Corporation Controlled release of anti-arrhythmic agents from a biodegradable polyethylene oxide hydrogel for local application to the heart
US6537569B2 (en) * 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
JP2004523624A (ja) * 2001-02-26 2004-08-05 デューク ユニバーシティ 新規なデンドリティックポリマー、およびその生物医学的使用
WO2002074354A1 (en) * 2001-03-16 2002-09-26 Delsitech Oy Treatment of sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US6685956B2 (en) 2001-05-16 2004-02-03 The Research Foundation At State University Of New York Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
WO2003031483A1 (en) 2001-10-10 2003-04-17 The Regents Of The University Of Colorado Degradable thiol-ene polymers
DE10152407A1 (de) * 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
US7112361B2 (en) * 2001-10-25 2006-09-26 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
US7842498B2 (en) * 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
ATE434184T1 (de) * 2001-11-20 2009-07-15 Univ Duke Grenzflächen-biomaterialien
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
KR100527408B1 (ko) * 2002-01-03 2005-11-09 한국과학기술원 카프로락톤과 락티드의 랜덤공중합체와 폴리에테르를이용한 생분해성 블록공중합체의 제조방법 및 이의 응용
US7163557B2 (en) * 2002-01-16 2007-01-16 D Eredita Riccardo Biodegradable auricular prosthetic device
US20030147958A1 (en) * 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
EP1469893A1 (de) * 2002-02-01 2004-10-27 Sustech GmbH & Co. KG Sternformige prapolymere fur die herstellung ultradunner hydrogel-bildender beschichtungen
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7056901B2 (en) * 2002-03-29 2006-06-06 The Regents Of The University Of California Microgel particles for the delivery of bioactive materials
US7329414B2 (en) * 2002-05-03 2008-02-12 Biopsy Sciences, Llc Biodegradable polymer for marking tissue and sealing tracts
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
JP2005532393A (ja) * 2002-07-02 2005-10-27 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 眼の障害についての処置
US20040137039A1 (en) * 2002-07-22 2004-07-15 Trustees Of Stevens Institute Of Technology Methods for controlled release of molecules from layered polymer films
US20050008828A1 (en) * 2002-07-25 2005-01-13 Trustees Of Stevens Institute Of Technology Patterned polymer microgel and method of forming same
EP1534191A4 (de) * 2002-08-20 2010-11-03 Exactech Inc Zusammensetzung zum tragen und abgeben von das knochenwachstum induzierendem material und verfahren zur herstellung und applikation der zusammensetzung
KR100552954B1 (ko) * 2002-09-04 2006-02-20 주식회사 바이오레인 열감응성 유착방지용 조성물, 용액, 필름, 스폰지 및 분말
US7217254B2 (en) 2002-09-20 2007-05-15 Genzyme Corporation Multi-pressure biocompatible agent delivery device and method
US7862831B2 (en) 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
US8105652B2 (en) * 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
DE10253391A1 (de) * 2002-11-15 2004-06-03 Mnemoscience Gmbh Amorphe polymere Netzwerke
US7816316B2 (en) * 2002-11-21 2010-10-19 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
US7160309B2 (en) 2002-12-31 2007-01-09 Laveille Kao Voss Systems for anchoring a medical device in a body lumen
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US7223826B2 (en) 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040151691A1 (en) 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
WO2004073563A2 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
US7585499B2 (en) * 2003-04-10 2009-09-08 Surmodics, Inc. Method for encapsulation of cellular material using a charged initiator polymer
US7273896B2 (en) * 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
US20060014003A1 (en) * 2003-07-24 2006-01-19 Libera Matthew R Functional nano-scale gels
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US7462188B2 (en) 2003-09-26 2008-12-09 Abbott Laboratories Device and method for suturing intracardiac defects
EP1691791A2 (de) * 2003-10-02 2006-08-23 Trustees of Stevens Institute of Technology Kapseln aus mehrschichtigen neutralen polymerfilmen, die durch hydrogenverbindung verbunden sind
WO2005044309A1 (en) 2003-11-05 2005-05-19 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
EP2289567A3 (de) * 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrix aus natürlich vorkomendem vernetztem Protein
US7842667B2 (en) * 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
US7449024B2 (en) 2003-12-23 2008-11-11 Abbott Laboratories Suturing device with split arm and method of suturing tissue
US20050180957A1 (en) * 2004-01-16 2005-08-18 Scharp David W. Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
FR2865737B1 (fr) * 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
US20050202096A1 (en) * 2004-03-09 2005-09-15 Jun Li Microcapsules for encapsulation of bioactive substances
US20080241262A1 (en) * 2004-03-29 2008-10-02 The University Of Houston System Nanoshells and Discrete Polymer-Coated Nanoshells, Methods For Making and Using Same
WO2005105172A1 (en) 2004-04-20 2005-11-10 Genzyme Corporation Surgical mesh-like implant
KR20070011557A (ko) * 2004-05-07 2007-01-24 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 근시 치료
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006036969A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Formation of barrier layer
US8367099B2 (en) 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
US8312836B2 (en) 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
WO2006036982A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Drug delivery coating for use with a stent
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US20060135725A1 (en) * 2004-12-21 2006-06-22 Scimed Life Systems, Inc. New balloon materials
EP1846505B1 (de) * 2005-02-09 2015-11-11 Covidien LP Synthetische dichtungsmittel
WO2006089267A2 (en) 2005-02-18 2006-08-24 Synthasome Inc. Synthetic structure for soft tissue repair
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
US20060276859A1 (en) * 2005-06-02 2006-12-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Photopatterning of skin
US8157807B2 (en) 2005-06-02 2012-04-17 The Invention Science Fund I, Llc Skin treatment including patterned light
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US8343710B1 (en) 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US8431226B2 (en) 2005-03-30 2013-04-30 Biomet Manufacturing Corp. Coated medical device
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
EP1712903B1 (de) * 2005-04-11 2015-07-15 Roche Diagnostics GmbH Verfahren für integrierte 2D-Gelelektrophorese
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
WO2006118330A1 (en) * 2005-04-28 2006-11-09 Nippon Shokubai Co., Ltd. Composition of n-alkenyl carboxylic acid tertiary amide
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
KR101429774B1 (ko) 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
EP1898955A2 (de) * 2005-06-17 2008-03-19 Nektar Therapeutics AL, Corporation Zusammensetzungen auf polymerbasis und konjugate von nichtsteroidalen antirheumatika
US20070038270A1 (en) * 2005-07-05 2007-02-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step photopatterning of skin
US7666963B2 (en) * 2005-07-21 2010-02-23 Akzo Nobel N.V. Hybrid copolymers
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US7883517B2 (en) 2005-08-08 2011-02-08 Abbott Laboratories Vascular suturing device
US8083754B2 (en) 2005-08-08 2011-12-27 Abbott Laboratories Vascular suturing device with needle capture
WO2007019016A1 (en) 2005-08-08 2007-02-15 Abbott Laboratories Vascular suturing device
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US20070060895A1 (en) 2005-08-24 2007-03-15 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US20070048340A1 (en) * 2005-08-31 2007-03-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step patterning of a skin surface
JP2009507103A (ja) * 2005-09-02 2009-02-19 コルバー・ライフサイエンス・リミテツド 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法
ES2377479T3 (es) * 2005-09-27 2012-03-28 Universite Joseph Fourier - Grenoble 1 Hidrogel funcionalizado con una porción polimerizable y sus utilizaciones como biosensores o biorreactores.
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US8574627B2 (en) 2006-11-06 2013-11-05 Atrium Medical Corporation Coated surgical mesh
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
CN105582523B (zh) 2005-10-08 2022-04-15 阿佩利斯制药公司 用于眼部病症的补体抑制素和其类似物
CA2626030A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
WO2007065074A2 (en) * 2005-11-29 2007-06-07 Indiana University Research And Technology Corporation Biodegradable implant polymers and composites
EP1801573A1 (de) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Vorrichtung und Verfahren für Parallele Zweidimensional-Elektrophorese
WO2007084878A1 (en) * 2006-01-13 2007-07-26 Fell Barry M Surgically implantable prosthesis with active component
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
CN101378766B (zh) * 2006-02-01 2013-05-01 株式会社三养生物制药 用于抑制粘连的组合物
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
EP2010796B1 (de) * 2006-04-04 2016-06-01 Saint-Gobain Abrasives, Inc. Infrarotgehärtete schleifartikel und herstellungsverfahren
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US7597882B2 (en) 2006-04-24 2009-10-06 Incept Llc Protein crosslinkers, crosslinking methods and applications thereof
WO2007143659A2 (en) * 2006-06-05 2007-12-13 Massachusetts Institute Of Technology Crosslinked, degradable polymers and uses thereof
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
BRPI0711784B8 (pt) 2006-06-15 2021-06-22 Microvention Inc dispositivo de embolização construído de polímero expansível e seu método de preparação
WO2008005371A2 (en) * 2006-06-29 2008-01-10 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8674021B2 (en) * 2006-07-21 2014-03-18 Akzo Nobel N.V. Sulfonated graft copolymers
NO20073821L (no) * 2006-07-21 2008-01-22 Akzo Nobel Chemicals Int Bv Podede kopolymerer med lav molekylvekt
CA2658768C (en) * 2006-07-21 2016-05-17 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
CA2659612A1 (fr) 2006-08-02 2008-02-07 Khorionyx Preparation implantable, utilisable notamment pour le complement tissulaire et la cicatrisation
CN101522133B (zh) 2006-08-08 2012-08-08 伊纳斯米特基金会 可植入的光学系统,其开发和应用的方法
AU2007284002B2 (en) * 2006-08-18 2013-12-19 Commonwealth Scientific And Industrial Research Organisation Polymeric coatings and methods for forming them
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
WO2008070863A2 (en) 2006-12-07 2008-06-12 Interventional Spine, Inc. Intervertebral implant
US7935363B2 (en) 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
US20080154233A1 (en) 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
AU2008214359B2 (en) 2007-02-05 2014-01-16 Apellis Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20100196492A1 (en) * 2007-03-08 2010-08-05 Green Jordan J Electrostatic coating of particles for drug delivery
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
EP2537539B1 (de) * 2007-04-13 2019-04-03 Kuros Biosurgery AG Polymergewebeversiegelungsmittel
EP2155165A1 (de) * 2007-04-20 2010-02-24 BioCure, Inc. Arzneiabgabevehikel mit vesikeln in einer hydrogel-basis
KR100838809B1 (ko) 2007-05-03 2008-06-17 성균관대학교산학협력단 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체
US20080311177A1 (en) 2007-06-14 2008-12-18 Massachusetts Institute Of Technology Self Assembled Films for Protein and Drug Delivery Applications
US8574244B2 (en) 2007-06-25 2013-11-05 Abbott Laboratories System for closing a puncture in a vessel wall
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
JP5441922B2 (ja) 2008-01-17 2014-03-12 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 膨張可能な椎間インプラント及び関連するその製造方法
US20090192554A1 (en) * 2008-01-29 2009-07-30 Confluent Surgical, Inc. Bioabsorbable block copolymer
WO2009099552A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated Cell culture article and screening
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
CN101939362A (zh) * 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的少突胶质细胞前体细胞的合成表面
AU2009209157B2 (en) 2008-01-30 2015-06-11 Asterias Biotherapeutics, Inc. Synthetic surfaces for culturing stem cell derived cardiomyocytes
WO2009099539A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated (meth)acrylate surfaces for cell culture, methods of making and using the surfaces
AU2009215175B2 (en) 2008-02-11 2014-07-17 The Johns Hopkins University Compositions and methods for implantation of adipose tissue and adipose tissue products
US20090238815A1 (en) * 2008-03-18 2009-09-24 Medtronic Vascular, Inc. Nondegradable Hydrogels For Medical Device Application
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
EP2262449B1 (de) 2008-04-05 2020-03-11 Synthes GmbH Expandierbares bandscheibenimplantat
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
CN102026599A (zh) 2008-05-12 2011-04-20 犹他大学研究基金会 眼内药物递送装置及相关方法
WO2009148579A2 (en) 2008-06-03 2009-12-10 Qlt Usa, Inc. Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
AU2009279716A1 (en) * 2008-08-05 2010-02-11 Biomimedica, Inc Polyurethane-grafted hydrogels
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
WO2010021973A2 (en) * 2008-08-17 2010-02-25 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
US9889230B2 (en) 2008-10-17 2018-02-13 Covidien Lp Hemostatic implant
US20110212179A1 (en) * 2008-10-30 2011-09-01 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
WO2010060485A1 (de) 2008-11-28 2010-06-03 Zetascience Gmbh Bioaktives hydrogel
WO2010068295A2 (en) * 2008-12-11 2010-06-17 The Board Of Trustees Of The Leland Stanford Junior University Three-dimensionally shaped interpenetrating network hydrogels
KR101040561B1 (ko) 2008-12-26 2011-06-16 아주대학교산학협력단 효소촉발형 생체주입형 하이드로젤과 그 생의학적 용도
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
CA2750242C (en) 2009-02-12 2018-05-22 Incept, Llc Drug delivery through hydrogel plugs
US20100227799A1 (en) * 2009-03-09 2010-09-09 Medtronic Vascular, Inc. Simultaneous photodynamic therapy and photo induced polymerization
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US10639396B2 (en) * 2015-06-11 2020-05-05 Microvention, Inc. Polymers
US8362144B2 (en) * 2009-05-21 2013-01-29 Corning Incorporated Monomers for making polymeric cell culture surface
KR101091028B1 (ko) 2009-07-02 2011-12-09 아주대학교산학협력단 체내 주입형 하이드로젤 및 이의 생의학적 용도
JP2011016896A (ja) * 2009-07-08 2011-01-27 Nippon Bee Chemical Co Ltd 光硬化型植物由来コーティング剤およびそのコーティング物
DK2459171T3 (en) 2009-07-31 2017-09-25 Sanofi Aventis Deutschland Long-acting insulin composition
US9597430B2 (en) 2009-07-31 2017-03-21 Synthasome, Inc. Synthetic structure for soft tissue repair
SI2459220T1 (sl) 2009-07-31 2020-12-31 Ascendis Pharma A/S Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola
BR112012002168A2 (pt) 2009-07-31 2016-05-31 Sanofi Aventis Deutschland profármacos compreendendo um conjugado ligador de insulina
BR112012001605B1 (pt) 2009-07-31 2021-02-23 Akzo Nobel Chemicals International B.V composição de formulação, composição método de inibição da sistema aquoso 1/102 co polímero inibidora formação de híbrido aniônico, de incrustação e incrustação em um sistema aquoso
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
US20110077216A1 (en) * 2009-09-30 2011-03-31 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
US8470355B2 (en) 2009-10-01 2013-06-25 Covidien Lp Mesh implant
KR101220047B1 (ko) * 2009-10-12 2013-01-08 금호석유화학 주식회사 액정 표시 소자용 실란트 조성물
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
CN102695500A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 多糖基水凝胶
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2011119059A1 (en) 2010-03-26 2011-09-29 Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
US9132209B2 (en) 2010-05-07 2015-09-15 Howmedia Osteonics Corp. Surface crosslinked polyethylene
US8845733B2 (en) 2010-06-24 2014-09-30 DePuy Synthes Products, LLC Lateral spondylolisthesis reduction cage
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
TW201215379A (en) 2010-06-29 2012-04-16 Synthes Gmbh Distractible intervertebral implant
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
WO2012027675A2 (en) 2010-08-26 2012-03-01 Massachusetts Institute Of Technology Poly(beta-amino alcohols), their preparation, and uses thereof
US20130217829A1 (en) 2010-08-27 2013-08-22 David Myung "hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same"
US9370353B2 (en) 2010-09-01 2016-06-21 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US8663252B2 (en) 2010-09-01 2014-03-04 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
WO2012039979A2 (en) 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP2438930A1 (de) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrug mit einem exendinbindenden Konjugat
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US20120121718A1 (en) * 2010-11-05 2012-05-17 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
CN103635198A (zh) 2010-11-12 2014-03-12 阿勒根公司 经代谢的经调节的生长培养基和使用方法
WO2012103445A2 (en) 2011-01-28 2012-08-02 The Regents Of The University Of Colorado, A Body Corporate Convalently cross linked hydrogels and methods of making and using same
US9102914B2 (en) 2011-02-03 2015-08-11 Empire Technology Development Llc 3D trophoblast matrix for preparing organ-specific stem cells
EP2683753B1 (de) * 2011-03-09 2016-08-03 Occlugel Implantierbares bioresorbierbares polymer, das mit fragilen makromolekülen beladen ist
GB2489320A (en) * 2011-03-21 2012-09-26 Univ Reading Transport of cells by encapsulating in a hydrogel
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
US8636918B2 (en) 2011-08-05 2014-01-28 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of controlling hard water scale
US8679366B2 (en) 2011-08-05 2014-03-25 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of controlling hard water scale
US8853144B2 (en) 2011-08-05 2014-10-07 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of improving drainage
US8841246B2 (en) 2011-08-05 2014-09-23 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of improving drainage
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
MX2014005094A (es) 2011-11-04 2014-08-08 Akzo Nobel Chemicals Int Bv Copolimeros de dendrita hibridos, composiciones de los mismos y metodos para producirlos.
JP2014532792A (ja) 2011-11-04 2014-12-08 アクゾ ノーベル ケミカルズ インターナショナル ベスローテン フエンノートシャップAkzo Nobel Chemicals International B.V. グラフト樹状コポリマー及びそれを製造する方法
AU2012340699A1 (en) 2011-11-21 2014-06-19 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
KR101269423B1 (ko) 2011-12-22 2013-05-30 오스템임플란트 주식회사 체내 분해 속도 조절이 가능한 수화젤 및 그 제조 방법
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
US9321030B2 (en) 2012-01-04 2016-04-26 The Trustees Of The Stevens Institute Of Technology Clay-containing thin films as carriers of absorbed molecules
EP2822533B1 (de) 2012-02-02 2021-01-20 Mosaic Biosciences, Inc. Biomaterialien zur abgabe von blutextrakten und verwendungsverfahren dafür
US20150056158A1 (en) * 2012-02-03 2015-02-26 Commonwealth Scientific And Industrial Research Organisation Branched polymers
US9005286B2 (en) 2012-02-21 2015-04-14 Thierry Giorno PLGA/HA hydroxyapatite composite bone grafts and method of making
JP5883539B2 (ja) 2012-03-16 2016-03-15 ザ・ジョンズ・ホプキンス・ユニバーシティー Hif−1阻害剤の送達のための放出制御製剤
EA030318B1 (ru) 2012-03-16 2018-07-31 Дзе Джонс Хопкинс Юниверсити Конъюгаты нелинейного мультиблочного сополимера с лекарственным средством для доставки активных агентов
US8864778B2 (en) 2012-04-10 2014-10-21 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US8858573B2 (en) 2012-04-10 2014-10-14 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
WO2013163234A1 (en) 2012-04-23 2013-10-31 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2871745C (en) 2012-05-03 2023-01-24 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
KR102140989B1 (ko) 2012-05-03 2020-08-04 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
AU2013256008B2 (en) 2012-05-04 2016-02-25 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
US9241707B2 (en) 2012-05-31 2016-01-26 Abbott Cardiovascular Systems, Inc. Systems, methods, and devices for closing holes in body lumens
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
WO2015009992A1 (en) 2013-07-18 2015-01-22 The General Hospital Corporation Vessel treatment systems, methods, and kits
US10549112B2 (en) 2012-07-20 2020-02-04 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
US10292381B2 (en) 2012-07-20 2019-05-21 The General Hospital Corporation Vessel treatment systems, methods, and kits
WO2014015274A1 (en) 2012-07-20 2014-01-23 The General Hospital Corporation Methods for tissue passivation
US8945314B2 (en) 2012-07-30 2015-02-03 Ecolab Usa Inc. Biodegradable stability binding agent for a solid detergent
EP2922919B1 (de) 2012-11-21 2020-03-25 University Of Louisville Research Foundation, Inc. Zusammensetzungen und verfahren zur reduzierung von oxidativen schäden
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
WO2014126837A2 (en) 2013-02-12 2014-08-21 Eipi Systems, Inc. Continuous liquid interphase printing
EP3358405A1 (de) 2013-02-12 2018-08-08 Carbon, Inc. Verfahren und vorrichtung für dreidimensionale herstellung
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
CN114957564A (zh) 2013-04-26 2022-08-30 生物相互作用有限公司 生物活性涂层
BR112016005768B1 (pt) 2013-09-19 2021-09-21 Microvention, Inc Películas de polímero
BR112016005770B1 (pt) 2013-09-19 2021-07-27 Terumo Corporation Partículas de polímero
WO2015070094A1 (en) 2013-11-08 2015-05-14 Microvention, Inc. Polymer particles
US10232605B2 (en) 2014-03-21 2019-03-19 Carbon, Inc. Method for three-dimensional fabrication with gas injection through carrier
WO2015164234A1 (en) 2014-04-25 2015-10-29 Carbon3D, Inc. Continuous three dimensional fabrication from immiscible liquids
JP6599361B2 (ja) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド 活性剤を含むポリマー
US9365805B2 (en) 2014-05-15 2016-06-14 Ecolab Usa Inc. Bio-based pot and pan pre-soak
US10569465B2 (en) 2014-06-20 2020-02-25 Carbon, Inc. Three-dimensional printing using tiled light engines
MX2016017099A (es) 2014-06-20 2017-08-07 Carbon Inc Impresion tridimensional con alimentacion reciproca de liquido polimerizable.
US10661501B2 (en) 2014-06-20 2020-05-26 Carbon, Inc. Three-dimensional printing method using increased light intensity and apparatus therefor
JP6720092B2 (ja) 2014-06-23 2020-07-08 カーボン,インコーポレイテッド 多様な硬化機構を有する材料からのポリウレタン三次元物体製造方法
IL282559B (en) * 2014-07-17 2022-07-01 Univ California Self-reinforced and controllable microgel particles for biomedical applications
WO2016025579A1 (en) 2014-08-12 2016-02-18 Carbon3D, Inc. Three-dimensional printing with build plates having a smooth or patterned surface and related methods
EP3011952A1 (de) * 2014-10-24 2016-04-27 Centre National De La Recherche Scientifique -Cnrs- Zeitgesteuerte, glucosefreisetzende Hydrogels und Anwendungen davon
TW201625754A (zh) * 2014-11-21 2016-07-16 艾倫塔斯有限公司 單一成份、儲存穩定、可硬化之聚矽氧組成物
CN105131315B (zh) 2014-11-27 2017-08-29 上海戴云化工科技有限公司 非自由基光化学交联水凝胶材料制备方法、其产品及应用
EP3240671B1 (de) 2014-12-31 2020-12-16 Carbon, Inc. Dreidimensionales drucken von objekten mit belüftungsöffnungen
US20160193786A1 (en) 2015-01-06 2016-07-07 Carbon3D, Inc. Three-dimensional printing with build plates having a rough or patterned surface and related methods
WO2016112090A1 (en) 2015-01-07 2016-07-14 Carbon3D, Inc. Microfluidic devices and methods of making the same
US20160200052A1 (en) 2015-01-13 2016-07-14 Carbon3D, Inc. Three-dimensional printing with build plates having surface topologies for increasing permeability and related methods
US10485757B2 (en) 2015-01-27 2019-11-26 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
WO2016123499A1 (en) 2015-01-30 2016-08-04 Carbon3D, Inc. Build plates for continuous liquid interface printing having permeable base and adhesive for increasing permeability and related methods, systems and devices
EP3250368A1 (de) 2015-01-30 2017-12-06 Carbon, Inc. Bauplatten für clip-druckverfahren mit durchlässigen folien und zugehörige verfahren, systeme und vorrichtungen
WO2016126779A1 (en) 2015-02-05 2016-08-11 Carbon3D, Inc. Method of additive manufacturing by fabrication through multiple zones
WO2016130478A1 (en) 2015-02-09 2016-08-18 University Of Louisville Research Foundation, Inc. Ophthalmic compositions and methods for reducing oxidative damage to an eye lens
WO2016130573A2 (en) 2015-02-09 2016-08-18 Mosaic Biosciences, Inc. Degradable thiol-ene polymers and methods of making thereof
WO2016133759A1 (en) 2015-02-20 2016-08-25 Carbon3D, Inc. Methods and apparatus for continuous liquid interface printing with electrochemically supported dead zone
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
WO2016140888A1 (en) 2015-03-05 2016-09-09 Carbon3D, Inc. Fabrication of three dimensional objects with variable slice thickness
US20180029292A1 (en) 2015-03-05 2018-02-01 Carbon, Inc. Continuous liquid interface production with sequential patterned exposure
WO2016140886A1 (en) 2015-03-05 2016-09-09 Carbon3D, Inc. Fabrication of three dimensional objects with multiple operating modes
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
WO2016145050A1 (en) 2015-03-10 2016-09-15 Carbon3D, Inc. Microfluidic devices having flexible features and methods of making the same
WO2016145182A1 (en) 2015-03-12 2016-09-15 Carbon3D, Inc. Additive manufacturing using polymerization initiators or inhibitors having controlled migration
WO2016149151A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with concurrent delivery of different polymerizable liquids
WO2016149097A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with reduced pressure build plate unit
WO2016149104A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with flexible build plates
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
EP4279064A3 (de) 2015-05-12 2024-02-28 Incept, LLC Arzneimittelabgabe aus hydrogelen
CN106620893B (zh) * 2015-07-23 2021-07-30 爱博诺德(北京)医疗科技股份有限公司 用于眼部疾病光治疗的材料
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
JP6889155B2 (ja) 2015-09-25 2021-06-18 カーボン,インコーポレイテッド ライティングパネルを有する継続的液体相間印刷用のビルドプレートアセンブリー、及び関連した方法、システム並びにデバイス
WO2017059082A1 (en) 2015-09-30 2017-04-06 Carbon, Inc. Method and apparatus for producing three-dimensional objects
GB201519811D0 (en) * 2015-11-10 2015-12-23 Univ Belfast Ocular compositions
US10350823B2 (en) 2015-12-22 2019-07-16 Carbon, Inc. Dual precursor resin systems for additive manufacturing with dual cure resins
WO2017112521A1 (en) 2015-12-22 2017-06-29 Carbon, Inc. Production of flexible products by additive manufacturing with dual cure resins
WO2017112483A2 (en) 2015-12-22 2017-06-29 Carbon, Inc. Accelerants for additive manufacturing with dual cure resins
WO2017112571A1 (en) 2015-12-22 2017-06-29 Carbon, Inc. Dual cure additive manufacturing of rigid intermediates that generate semi-rigid, flexible, or elastic final products
US10639844B2 (en) 2015-12-22 2020-05-05 Carbon, Inc. Fabrication of compound products from multiple intermediates by additive manufacturing with dual cure resins
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
EP3458119B1 (de) 2016-05-17 2021-01-27 Leibniz-Institut für Polymerforschung Dresden e.V. Verfahren zur bildung eines funktionellen netzwerkes von humanen neuronalen und glialen zellen
US11465339B2 (en) 2016-05-31 2022-10-11 Northwestern University Method for the fabrication of three-dimensional objects and apparatus for same
WO2018002711A2 (en) 2016-06-28 2018-01-04 Eit Emerging Implant Technologies Gmbh Expandable, angularly adjustable intervertebral cages
WO2018002715A2 (en) 2016-06-28 2018-01-04 Eit Emerging Implant Technologies Gmbh Expandable and angularly adjustable articulating intervertebral cages
EP3423256B1 (de) 2016-07-01 2022-02-23 Carbon, Inc. Verfahren zum dreidimensionalen drucken und vorrichtung zur reduzierung von blasen durch entgasung durch eine bauplatte
GB2562443B (en) * 2016-08-05 2021-01-13 Lancaster Univ Business Enterprises Limited Injectable composition
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
EP3518983B1 (de) 2016-09-28 2024-04-24 Terumo Corporation Polymerpartikel
US11135790B2 (en) 2016-11-21 2021-10-05 Carbon, Inc. Method of making three-dimensional object by delivering reactive component for subsequent cure
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
CN117582559A (zh) 2016-12-29 2024-02-23 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
US10426449B2 (en) 2017-02-16 2019-10-01 Abbott Cardiovascular Systems, Inc. Articulating suturing device with improved actuation and alignment mechanisms
US10239255B2 (en) 2017-04-11 2019-03-26 Molecule Corp Fabrication of solid materials or films from a polymerizable liquid
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
EP3700965A1 (de) 2017-10-27 2020-09-02 Massachusetts Institute of Technology Poly(beta-aminoester) und deren verwendungen
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN107875444B (zh) * 2017-11-03 2021-01-05 西安工业大学 用于心脏修复的生物降解性的水凝胶支架材料的制备方法
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
JP7264222B2 (ja) * 2017-11-27 2023-04-25 東洋紡株式会社 光硬化性爪被覆剤
JP7000819B2 (ja) * 2017-11-27 2022-01-19 東洋紡株式会社 光硬化性爪被覆剤
AU2019247467B2 (en) 2018-04-06 2023-01-19 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US11608412B2 (en) 2018-10-26 2023-03-21 Massachusetts Institute Of Technology Polymer-lipids and compositions
CN109777340B (zh) * 2019-01-24 2020-03-13 中国科学院兰州化学物理研究所 一种水中和空气中均能使用的胶黏剂及其制备方法
SG11202110863TA (en) 2019-04-09 2021-10-28 Azul 3D Inc Methodologies to rapidly cure and coat parts produced by additive manufacturing
KR102267782B1 (ko) * 2019-05-09 2021-06-24 창신리빙(주) 욕조에 넣어 사용하는 반신욕 좌대
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
WO2024047045A1 (en) 2022-08-31 2024-03-07 Mimetis Biomaterials Synthetic bone grafts and methods for their preparation

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
BE785858A (fr) * 1971-07-06 1973-01-05 Union Carbide Corp Procede chimique de reticulation de poly (oxyde d'alkylene)
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
GB1446709A (en) * 1972-07-06 1976-08-18 Nat Patent Dev Corp Tooth root canal filling composition
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4193845A (en) * 1973-11-15 1980-03-18 Japan Atomic Energy Research Institute Immobilization of enzymes or bacterial cells
AR205997A1 (es) * 1973-11-21 1976-06-23 American Cyanamid Co Resina de poliester normalmente solida biodegradable e hidrolizable
JPS5126285A (en) * 1974-08-30 1976-03-04 Japan Atomic Energy Res Inst Koso mataha kintaiofukunda soseibutsu no seizohoho
US4076800A (en) * 1975-01-13 1978-02-28 The Procter & Gamble Company Protein-containing detergent compositions for protecting keratinous materials
DE2633259C3 (de) * 1975-07-23 1984-11-15 Japan Atomic Energy Research Institute, Tokio/Tokyo Verfahren zum Unbeweglichmachen von Enzymen oder enzymhaltigen Zellen
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
US4095600A (en) * 1976-06-01 1978-06-20 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4118470A (en) * 1976-06-01 1978-10-03 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4298839A (en) * 1978-03-31 1981-11-03 Westinghouse Electric Corp. Programmable AC electric energy meter having radiation responsive external data interface
JPS5589314A (en) * 1978-12-27 1980-07-05 Dainichi Nippon Cables Ltd Method of crosslinking polyvinyl chloride
JPS55110105A (en) * 1979-02-19 1980-08-25 Japan Atom Energy Res Inst Preparation of polymer composition containing physiologically active material
US4295762A (en) * 1979-02-21 1981-10-20 Nalco Chemical Company Grouting-soil conditioning systems using polyoxyethylene diacrylates
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
JPS5611916A (en) * 1979-07-10 1981-02-05 Chisso Corp Production of vinyl chloride copolymer
JPS5622306A (en) * 1979-07-31 1981-03-02 Nitto Kasei Kk Ultraviolet ray-curable resin composition having antistatic effect
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4376839A (en) * 1980-01-21 1983-03-15 Technicon Instruments Corporation Heat stable, polymer-forming composition
NL8001885A (nl) * 1980-03-31 1981-11-02 Akzo Nv Intiator-systeem voor door straling hardbare composities.
JPS56142038A (en) 1980-04-07 1981-11-06 Chisso Corp Extrusion molding of vinyl chloride copolymer
JPS57113118A (en) * 1980-12-30 1982-07-14 Fanuc Ltd Robot control system
US4434150A (en) * 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
US4512910A (en) * 1982-01-28 1985-04-23 Morton Thickol, Inc. Photocurable compositions
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
JPS59184029A (ja) 1983-03-31 1984-10-19 Kanegafuchi Chem Ind Co Ltd 自動車用シフトレバ−ブ−ツ
JPS59191750A (ja) 1983-04-13 1984-10-30 Chisso Corp 塩化ビニル系樹脂組成物
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4533445A (en) * 1983-07-06 1985-08-06 Shipley Company Inc. U.V. Curable composition
JPS6028950A (ja) 1983-07-27 1985-02-14 T Hasegawa Co Ltd シス−3−アルケン酸類、その製法および利用
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4511478A (en) * 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
US4605622A (en) * 1983-11-15 1986-08-12 Kansai Paint Co., Ltd. Process for producing granular fixed enzymes or microorganisms
JPS60127342A (ja) 1983-12-14 1985-07-08 Chisso Corp 塩化ビニル樹脂組成物
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4749620A (en) * 1984-02-15 1988-06-07 Massachusetts Institute Of Technology Encapsulated active material system
US4744933A (en) * 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
US4650488A (en) * 1984-05-16 1987-03-17 Richards Medical Company Biodegradable prosthetic device
FR2565233B1 (fr) * 1984-05-30 1986-09-12 Rhone Poulenc Rech Copolymere greffe de silicone et de polylactone lie par une liaison urethanne
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
CA1267618A (en) * 1985-03-04 1990-04-10 Roberta C. Cheng Stabilization of intracellular enzymes
US4950596A (en) * 1985-03-04 1990-08-21 The Dow Chemical Company Stabilization of intracellular enzymes
US4741337A (en) * 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
CS255758B1 (en) * 1985-12-11 1988-03-15 Frantisek Rypacek Preparat for the diagnostic of transportion function of oviduct and process for preparing thereof
US4889722A (en) * 1985-12-16 1989-12-26 Ethicon, Inc. Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
US4741872A (en) * 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US4744365A (en) * 1986-07-17 1988-05-17 United States Surgical Corporation Two-phase compositions for absorbable surgical devices
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4913903A (en) * 1987-02-04 1990-04-03 Alza Corporation Post-surgical applications for bioerodible polymers
JPS63199208A (ja) * 1987-02-12 1988-08-17 Chisso Corp 塩化ビニル樹脂の製造方法
US4933430A (en) * 1987-03-05 1990-06-12 S. C. Johnson & Son, Inc. Process for producing polymers useful in thermoset coatings and polymer so produced
DE3716544A1 (de) * 1987-05-16 1988-11-24 Basf Ag Verwendung von wasserloeslichen copolymerisaten, die monomere mit mindestens zwei ethylenisch ungesaettigten doppelbindungen einpolymerisiert enthalten, in wasch- und reinigungsmitteln
IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
JPH0192386A (ja) * 1987-10-05 1989-04-11 Hitachi Ltd 密閉循環型吸収式冷凍機及び吸収式冷凍機用吸収液
US5129889A (en) * 1987-11-03 1992-07-14 Hahn John L Synthetic absorbable epidural catheter
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4891263A (en) * 1987-12-17 1990-01-02 Allied-Signal Inc. Polycarbonate random copolymer-based fiber compositions and method of melt-spinning same and device
US5185408A (en) * 1987-12-17 1993-02-09 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5120802A (en) * 1987-12-17 1992-06-09 Allied-Signal Inc. Polycarbonate-based block copolymers and devices
US4921934A (en) 1987-12-23 1990-05-01 S. C. Johnson & Son, Inc. Alkali-soluble polymers and process for producing same
US4888413A (en) * 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
DD277454A1 (de) * 1988-12-02 1990-04-04 Akad Wissenschaften Ddr Verfahren zur beschichtung von glas- und keramikoberflaechen mit elektronenstrahlhaertbaren ueberzuegen
GB8903464D0 (en) * 1989-02-15 1989-04-05 Joint Replacement Instrumentat Coated femoral prosthesis
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
CA2016740A1 (en) * 1989-05-26 1990-11-26 Shih-Chung Chen Anti-fog coating
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US4994277A (en) * 1989-10-31 1991-02-19 Pfizer Hospital Products Group, Inc. Use of xanthan gum for preventing adhesions
US5049138A (en) 1989-11-13 1991-09-17 Boston Scientific Corporation Catheter with dissolvable tip
JP2651516B2 (ja) * 1989-12-13 1997-09-10 国立循環器病センター総長 ハイブリッド型人工膵臟
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
DE59106464D1 (de) * 1990-07-12 1995-10-19 Ciba Geigy Ag Verfahren zum Fixieren von Farbstoffen.
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5206303A (en) * 1990-12-27 1993-04-27 Exxon Chemical Patents Inc. Entanglement-inhibited macromolecules
US5153002A (en) * 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
JP3184555B2 (ja) 1991-05-28 2001-07-09 松下電工株式会社 吸湿器
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5405366A (en) * 1991-11-12 1995-04-11 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
US5270400A (en) * 1991-12-31 1993-12-14 Maria Spinu L-Dpolylactide copolymers with controlled morphology
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5417983A (en) * 1992-02-19 1995-05-23 Sagami Chemical Research Center Drug release controlling material responsive to changes in temperature
CA2117588C (en) * 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
GB9326511D0 (en) * 1993-12-29 1994-03-02 Solvay Interox Ltd Macromonomer preparation
EP0842209B1 (de) * 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5633342A (en) * 1995-10-27 1997-05-27 Chronopol, Inc. Method for the synthesis of environmentally degradable block copolymers
DE19718520C1 (de) 1997-05-02 1998-10-01 Daimler Benz Ag Jalousierahmenanordnung
JP2001510151A (ja) * 1997-07-18 2001-07-31 インファイムド,インク. 生理活性物質の制御放出のための生分解性マクロマー
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
JP3294835B2 (ja) 2000-01-31 2002-06-24 ニチハ株式会社 木質セメント板およびその製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427415B2 (en) 2002-10-11 2008-09-23 Novocell, Inc. Implantation of encapsulated biological materials for treating diseases

Also Published As

Publication number Publication date
PT627911E (pt) 2001-04-30
CA2117588C (en) 1998-08-25
JP3011768B2 (ja) 2000-02-21
US5567435A (en) 1996-10-22
NZ249770A (en) 1996-09-25
EP0627911B1 (de) 2000-10-25
EP0627911A4 (de) 1995-07-26
US6306922B1 (en) 2001-10-23
ES2153378T3 (es) 2001-03-01
ATE197125T1 (de) 2000-11-15
DE69329594D1 (de) 2000-11-30
US20020091229A1 (en) 2002-07-11
US6060582A (en) 2000-05-09
DK0627911T3 (da) 2000-11-20
CA2117588A1 (en) 1993-09-16
GR3035172T3 (en) 2001-04-30
KR100266912B1 (ko) 2000-12-01
US5986043A (en) 1999-11-16
BR9306038A (pt) 1998-01-13
AU673160B2 (en) 1996-10-31
WO1993017669A1 (en) 1993-09-16
KR950700053A (ko) 1995-01-16
JPH07507056A (ja) 1995-08-03
US6602975B2 (en) 2003-08-05
EP0627911A1 (de) 1994-12-14
AU3735393A (en) 1993-10-05

Similar Documents

Publication Publication Date Title
DE69329594D1 (de) Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
BR9711537A (pt) Pol¡meros polimeriz veis biodegrad veis incluindo cadeias de carbonato ou dioxanona
DK1077952T3 (da) Polymeriserbare hydrofile monomerer, der absorberer ultraviolet lys
ES2139394T3 (es) Polimeros absorbedores de agua con una mejores propiedades, procedimiento para su produccion y su empleo
BR9811793A (pt) MacrÈmeros biodegradáveis para a liberação controlada de substâncias biologicamente ativas.
EP0872275A3 (de) Durchsichtiges Zellulosehydrogel und dessen Verwendung
BR9707794A (pt) Composição monomérica biocompatível processo para união entre si in vivo de duas superfícies viventes de tecido para aplicação em tecido vivente de uma composiç o adesiva e para formação de uma película biocompatível e película
CA2121577A1 (en) Novel UV Curable Crosslinking Agents Useful in Copolymerization
DE69013833T2 (de) Zusammensetzung und methode zur verhütung von verklebungen zwischen körpergewebe.
DE60226768D1 (de) Monofunktionelle aromatische siloxan-makromonomere mit hohem brechungsindex
WO2001044307A2 (en) Degradable poly(vinyl alcohol) hydrogels
DE69015775T2 (de) Chitinderivate enthaltende Zusammensetzungen zur Verhütung der Adhäsion.
WO2005107828A3 (en) Implantable or insertable medical articles having covalently modified, biocompatible surfaces
ES2122353T3 (es) Hidrogeles hidrofilos, con una alta capacidad de hinchamiento.
DE69721750D1 (de) Hydrogele mit hohem brechungsindex, hergestellt aus polymeren und copolymeren von n-benzyl-n-methylacrylamid
CO5031270A1 (es) Polimeros lineales injertados de silicona endurecidos
BR9813338A (pt) Processo para a preparação de polieletrólitos catiÈnicos
AR013273A1 (es) SISTEMA MATERIAL VISCOELÁSTICO GELIFICABLE FORMADO POR DOS PARTES CON POLíMEROS DE GALACTOMANANO Y BORATO.
AR031056A1 (es) Composicion cosmetica que proporciona buenas propiedades de estabilidad y que incluye un copolimero de unidad acido
CA2396229A1 (en) Compliant polymeric materials formed from macromers
BR9510286A (pt) Adjuvante para vacinas vacina utilização de um polímero e processo para preparar uma vacina
Ata Effect of Chitosan pretreatment of the demineralized dentin surface on the durability of resin dentin bonding. An in vitro study
GB2284821A (en) Polymer products
MX9700169A (es) Composiciones de monomero y polimero biocompatibles modificadas en el ph.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition