DE69331387T2 - Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika - Google Patents

Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika

Info

Publication number
DE69331387T2
DE69331387T2 DE69331387T DE69331387T DE69331387T2 DE 69331387 T2 DE69331387 T2 DE 69331387T2 DE 69331387 T DE69331387 T DE 69331387T DE 69331387 T DE69331387 T DE 69331387T DE 69331387 T2 DE69331387 T2 DE 69331387T2
Authority
DE
Germany
Prior art keywords
matricates
localane
aesthetics
local anesthetic
biodegradable polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69331387T
Other languages
English (en)
Other versions
DE69331387D1 (de
Inventor
Charles B Berde
Robert S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Original Assignee
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Application granted granted Critical
Publication of DE69331387D1 publication Critical patent/DE69331387D1/de
Publication of DE69331387T2 publication Critical patent/DE69331387T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
DE69331387T 1992-09-10 1993-09-10 Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika Expired - Fee Related DE69331387T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94328792A 1992-09-10 1992-09-10
PCT/US1993/008568 WO1994005265A1 (en) 1992-09-10 1993-09-10 Biodegradable polymer matrices for sustained delivery of local anesthetic agents

Publications (2)

Publication Number Publication Date
DE69331387D1 DE69331387D1 (de) 2002-01-31
DE69331387T2 true DE69331387T2 (de) 2002-08-22

Family

ID=25479379

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331387T Expired - Fee Related DE69331387T2 (de) 1992-09-10 1993-09-10 Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika

Country Status (11)

Country Link
US (1) US5618563A (de)
EP (2) EP0659073B1 (de)
JP (1) JP3007687B2 (de)
AT (1) ATE210969T1 (de)
AU (1) AU683022B2 (de)
CA (1) CA2144407C (de)
DE (1) DE69331387T2 (de)
DK (1) DK0659073T3 (de)
ES (1) ES2170074T3 (de)
PT (1) PT659073E (de)
WO (1) WO1994005265A1 (de)

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CA2144407A1 (en) 1994-03-17
WO1994005265A1 (en) 1994-03-17
CA2144407C (en) 2000-05-30
JPH08503695A (ja) 1996-04-23
DE69331387D1 (de) 2002-01-31
DK0659073T3 (da) 2002-03-11
EP0659073A1 (de) 1995-06-28
EP0659073B1 (de) 2001-12-19
AU683022B2 (en) 1997-10-30
PT659073E (pt) 2002-06-28
ES2170074T3 (es) 2002-08-01
EP1132080A3 (de) 2001-10-17
JP3007687B2 (ja) 2000-02-07
AU5126993A (en) 1994-03-29
ATE210969T1 (de) 2002-01-15
EP1132080A2 (de) 2001-09-12
US5618563A (en) 1997-04-08

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