DE69333785D1 - Anordnung zum Aufbau eines Proben- und Reagenzien-Aufnahmesystems für in situ PCR auf einer Lamelle - Google Patents

Anordnung zum Aufbau eines Proben- und Reagenzien-Aufnahmesystems für in situ PCR auf einer Lamelle

Info

Publication number
DE69333785D1
DE69333785D1 DE69333785T DE69333785T DE69333785D1 DE 69333785 D1 DE69333785 D1 DE 69333785D1 DE 69333785 T DE69333785 T DE 69333785T DE 69333785 T DE69333785 T DE 69333785T DE 69333785 D1 DE69333785 D1 DE 69333785D1
Authority
DE
Germany
Prior art keywords
retaining assembly
slide
base
situ pcr
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333785T
Other languages
English (en)
Other versions
DE69333785T2 (de
Inventor
John G Atwood
Larry Haff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Publication of DE69333785D1 publication Critical patent/DE69333785D1/de
Application granted granted Critical
Publication of DE69333785T2 publication Critical patent/DE69333785T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers
DE69333785T 1993-02-16 1993-09-30 Anordnung zum Aufbau eines Proben- und Reagenzien-Aufnahmesystems für in situ PCR auf einer Lamelle Expired - Lifetime DE69333785T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17721 1993-02-16
US08/017,721 US5364790A (en) 1993-02-16 1993-02-16 In situ PCR amplification system

Publications (2)

Publication Number Publication Date
DE69333785D1 true DE69333785D1 (de) 2005-04-28
DE69333785T2 DE69333785T2 (de) 2005-09-01

Family

ID=21784183

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69323720T Expired - Fee Related DE69323720T2 (de) 1993-02-16 1993-09-30 In situ PCR Vermehrungsverfahren System
DE69333785T Expired - Lifetime DE69333785T2 (de) 1993-02-16 1993-09-30 Anordnung zum Aufbau eines Proben- und Reagenzien-Aufnahmesystems für in situ PCR auf einer Lamelle

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69323720T Expired - Fee Related DE69323720T2 (de) 1993-02-16 1993-09-30 In situ PCR Vermehrungsverfahren System

Country Status (12)

Country Link
US (4) US5364790A (de)
EP (2) EP0884394B1 (de)
JP (1) JPH06245771A (de)
KR (1) KR100286792B1 (de)
CN (1) CN1072725C (de)
AT (2) ATE291635T1 (de)
AU (2) AU673397B2 (de)
CA (1) CA2106360A1 (de)
DE (2) DE69323720T2 (de)
DK (1) DK0611598T3 (de)
IL (3) IL107131A (de)
NZ (1) NZ248835A (de)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) * 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7273749B1 (en) * 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5843640A (en) * 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
ATE193465T1 (de) * 1994-01-06 2000-06-15 Johnson & Johnson Clin Diag Vorrichtung zum erwärmen einer flüssigkeitsführenden kammer von einer reaktionscuvette
GB9402205D0 (en) * 1994-02-04 1994-03-30 Ray Ronnie A Enclosed reaction container
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
JP3537194B2 (ja) * 1994-10-17 2004-06-14 オリンパス株式会社 光学顕微鏡
US5721136A (en) * 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
DK0739423T3 (da) * 1994-11-14 2002-05-06 Univ Pennsylvania Indretning til amplifikation af polynukleotider i mesoskala
US5935825A (en) * 1994-11-18 1999-08-10 Shimadzu Corporation Process and reagent for amplifying nucleic acid sequences
US5804366A (en) * 1995-02-09 1998-09-08 Baxter International Inc. Method and apparatus for sodding microvessel cells onto a synthetic vascular graft
WO1996028537A1 (en) * 1995-03-09 1996-09-19 University Of Utah Research Foundation Long qt genes and method for diagnosing or preventing the occurrence of long qt syndrome
US5599673A (en) * 1995-03-09 1997-02-04 University Of Utah Research Foundation Long QT syndrome genes
US5566021A (en) * 1995-03-23 1996-10-15 Pettingell; James T. Microscope stage having a sliding grease interface
GB9506312D0 (en) 1995-03-28 1995-05-17 Medical Res Council Improvements in or relating to sample processing
US6022689A (en) * 1995-04-07 2000-02-08 University Of New Mexico Situ hybridization slide processes
ATE196322T1 (de) * 1995-05-05 2000-09-15 Perkin Elmer Corp Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
GB9516636D0 (en) * 1995-08-14 1995-10-18 Univ London In-situ nucleic acid amplification and detection
BR9606634A (pt) * 1995-09-12 1997-11-11 Becton Dickinson Co Aparelhagem para realização de uma amplificação de ácido nucleico homogenea aparelhagem para realização de um processo biológico sobre uma amostra biológico líquida aparelhagem para realização de uma titulação de polarização de fluorescência de ácido nucleico sobre uma amostra biológica líquida processo para realização de uma amplificação de ácido nucleico e titulação de polarização de fluorescência de ácido nucleico e processo para realização de uma reação de amplificação de ácido nucleico sobre uma amostra biológica liquida
US6091842A (en) * 1996-10-25 2000-07-18 Accumed International, Inc. Cytological specimen analysis system with slide mapping and generation of viewing path information
US5930732A (en) * 1995-09-15 1999-07-27 Accumed International, Inc. System for simplifying the implementation of specified functions
US6118581A (en) * 1995-09-15 2000-09-12 Accumed International, Inc. Multifunctional control unit for a microscope
US5963368A (en) * 1995-09-15 1999-10-05 Accumed International, Inc. Specimen management system
CA2174279C (en) * 1995-09-26 2001-01-30 Francis J. Walker Anti-bleed coating for silicone automobile gaskets
AU7262696A (en) * 1995-10-10 1997-04-30 Regents Of The University Of California, The Detection of allele-specific mutations by allele-specific in situ reverse transcriptase polymerase chain reaction
US6004512A (en) * 1995-12-08 1999-12-21 Mj Research Sample cartridge slide block
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
JPH1052300A (ja) * 1996-06-03 1998-02-24 Kyowa Hakko Kogyo Co Ltd 細胞内テロメラーゼ活性の測定法
ATE318327T1 (de) 1996-06-04 2006-03-15 Univ Utah Res Found Fluoreszenz-donor-akzeptor paar
US5795748A (en) * 1996-09-26 1998-08-18 Becton Dickinson And Company DNA microwell device and method
US5882903A (en) * 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
US5958341A (en) * 1996-12-23 1999-09-28 American Registry Of Pathology Apparatus for efficient processing of tissue samples on slides
US6703247B1 (en) 1996-12-23 2004-03-09 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US6074868A (en) 1997-03-03 2000-06-13 Regents Of The University Of Minnesota Alumina plate method and device for controlling temperature
US7133726B1 (en) * 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
US5939329A (en) * 1997-05-14 1999-08-17 Serim Research Corporation Test strip incubation device and method
US5812312A (en) * 1997-09-04 1998-09-22 Lorincz; Andrew Endre Microscope slide
US6239906B1 (en) 1997-09-04 2001-05-29 Andrew E. Lorincz Flexible microscope slide
US6567214B2 (en) 1997-09-04 2003-05-20 Andrew E. Lorincz Microscope slide having culture media and method for use
DE19753598C1 (de) * 1997-12-03 1999-07-01 Micronas Intermetall Gmbh Vorrichtung zum Messen physiologischer Parameter
WO1999043434A1 (en) * 1998-02-27 1999-09-02 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US20090111101A1 (en) * 1998-05-09 2009-04-30 Ikonisys, Inc. Automated Cancer Diagnostic Methods Using FISH
CA2331508A1 (en) * 1998-05-09 1999-11-18 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US7901887B2 (en) * 1998-05-09 2011-03-08 Ikonisys, Inc. Automated cancer diagnostic methods using fish
US20080241848A1 (en) * 1998-05-09 2008-10-02 Ikonisys, Inc. Methods for prenatal diagnosis of aneuploidy
US6358475B1 (en) * 1998-05-27 2002-03-19 Becton, Dickinson And Company Device for preparing thin liquid for microscopic analysis
US6180314B1 (en) * 1998-05-27 2001-01-30 Becton, Dickinson And Company Method for preparing thin liquid samples for microscopic analysis
DE69935230T2 (de) * 1998-08-10 2007-12-20 Genomic Solutions, Inc., Ann Arbor Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren
USD418228S (en) * 1998-09-03 1999-12-28 Harry Fisch Microscope slide assembly
US6413780B1 (en) 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
CA2348782A1 (en) * 1998-11-02 2000-05-11 The Brigham & Women's Hospital, Inc. A method for genomic substractive hybridization
US20060216744A1 (en) * 1998-12-23 2006-09-28 American Registry Of Pathology Armed Forces Institute Of Pathology Apparatus and methods for efficient processing of biological samples on slides
EP1154858A1 (de) * 1998-12-23 2001-11-21 American Registry of Pathology Apparat und methoden zur effizienten verarbeitung biologischer proben auf laborschlitten
US6411434B1 (en) 1999-02-17 2002-06-25 Lucid, Inc. Cassette for facilitating optical sectioning of a retained tissue specimen
ES2520140T3 (es) * 1999-02-17 2014-11-11 Lucid, Inc. Portador de muestras de tejido
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6555361B1 (en) * 1999-03-24 2003-04-29 Corning Incorporated Hybridization chamber for high density nucleic acid arrays
USD423678S (en) * 1999-05-26 2000-04-25 Harry Fisch Microscope slide assembly
US6258593B1 (en) * 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
DE19941905C2 (de) * 1999-09-02 2002-06-06 Max Planck Gesellschaft Probenkammer zur Flüssigkeitsbehandlung biologischer Proben
USD431300S (en) * 1999-09-27 2000-09-26 Harry Fisch Microscope slide assembly
USD431301S (en) * 1999-09-27 2000-09-26 Harry Fisch Microscope slide assembly
DE19948087B4 (de) * 1999-10-06 2008-04-17 Evotec Ag Verfahren zur Herstellung eines Reaktionssubstrats
US6403931B1 (en) * 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
US6300124B1 (en) 1999-11-02 2001-10-09 Regents Of The University Of Minnesota Device and method to directly control the temperature of microscope slides
WO2001032934A2 (en) * 1999-11-04 2001-05-10 Arcturus Engineering, Inc. Hybridization station
US6309889B1 (en) * 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
WO2001081892A2 (en) 2000-04-26 2001-11-01 Arcturus Engineering, Inc. Laser capture microdissection (lcm) extraction device and device carrier and method for post-lcm fluid processing
FR2808888B1 (fr) * 2000-05-15 2003-06-20 Trophos Dispositif d'observation sequentielle d'echantillons et procedes l'utilisant
JP2002010777A (ja) * 2000-06-30 2002-01-15 Precision System Science Co Ltd 反応容器、反応装置および反応液の温度制御方法
US6511277B1 (en) 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
US6422249B1 (en) 2000-08-10 2002-07-23 Affymetrix Inc. Cartridge washing system and methods
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6939516B2 (en) * 2000-09-29 2005-09-06 Becton, Dickinson And Company Multi-well plate cover and assembly adapted for mechanical manipulation
ES2169701B1 (es) * 2000-12-21 2003-11-01 Univ Jaen Reactor microcristalografico.
JP2002262854A (ja) * 2001-03-06 2002-09-17 Hitachi Software Eng Co Ltd ハイブリダイゼーション器具
KR100916074B1 (ko) * 2001-03-09 2009-09-08 바이오마이크로 시스템즈, 인크. 어레이에 대한 마이크로유체 인터페이스 방법 및인터페이스용 시스템
WO2003015923A1 (en) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Fluid mixing in low aspect ratio chambers
CA2441163A1 (en) * 2001-03-16 2002-09-26 Memorec Biotec Gmbh Analysing device for analysing chemical and/or biological samples
DE10116938C1 (de) * 2001-03-30 2002-11-07 Univ Dresden Tech Zellkammer für die Lichtmikroskopie
US6677131B2 (en) * 2001-05-14 2004-01-13 Corning Incorporated Well frame including connectors for biological fluids
EP1818402A3 (de) * 2001-05-31 2008-04-02 Fuso Pharmaceutical Industries, Ltd. Verfahren zur Beurteilung der Phagozytenfunktion und dessen Anwendung
JP3934605B2 (ja) * 2001-05-31 2007-06-20 扶桑薬品工業株式会社 感染症原因微生物の検出および同定のための改良された方法
US6485918B1 (en) * 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
WO2003093168A2 (en) * 2001-07-26 2003-11-13 Motorola, Inc. System and methods for mixing within a microfluidic device
WO2003015922A1 (en) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Laminated microarray interface device
US6767733B1 (en) 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
US7943093B2 (en) * 2001-12-12 2011-05-17 Erie Scientific Company Cover slip
US20040020993A1 (en) * 2001-12-28 2004-02-05 Green Larry R. Method for luminescent identification and calibration
WO2003066907A1 (en) * 2002-02-05 2003-08-14 Genome Therapeutics Corporation Seal for microtiter plate and methods of use thereof
ATE467115T1 (de) 2002-03-15 2010-05-15 Affymetrix Inc System und verfahren zur abtastung von biologischen materialien
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
DE10218988C1 (de) * 2002-04-24 2003-11-20 Horst Dieter Becker Vorrichtung und Verfahren zum Benetzen von Objekten
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
JP2004028694A (ja) * 2002-06-24 2004-01-29 Canon Inc 核酸プローブ・アレイ基板の温度制御装置、及び、これを用いた遺伝子検出方法
KR100855996B1 (ko) * 2002-07-02 2008-09-02 유재천 Pcr 디스크 장치, pcr 디스크 드라이버 장치 및 그를 이용한 분석 방법
US20050123924A1 (en) * 2002-08-05 2005-06-09 Ayoub Rashtchian Compositions for in vitro amplification of nucleic acids
JP2006522582A (ja) * 2002-09-05 2006-10-05 インヴィトロジェン コーポレーション 核酸を合成するための組成物および方法
US6730883B2 (en) * 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
US20040120861A1 (en) * 2002-10-11 2004-06-24 Affymetrix, Inc. System and method for high-throughput processing of biological probe arrays
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
EP2390352A1 (de) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren
WO2004083824A1 (en) * 2003-03-20 2004-09-30 Dakocytomation Denmark A/S System for establishing a sample cover on a substrate
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
US7517498B2 (en) * 2003-08-19 2009-04-14 Agilent Technologies, Inc. Apparatus for substrate handling
US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism
US20050226779A1 (en) 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
DE10352716A1 (de) * 2003-11-05 2005-06-16 Einsle, Xaver Plattform
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US7122799B2 (en) * 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US7615371B2 (en) * 2003-12-23 2009-11-10 Ventana Medical Systems, Inc. Method and apparatus for treating a biological sample with a liquid reagent
AU2005244673B2 (en) 2004-02-19 2009-12-10 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
US20050183976A1 (en) * 2004-02-19 2005-08-25 Brothers John G. Cryogenic canister assembly
DE102004022263A1 (de) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US20050282270A1 (en) * 2004-06-21 2005-12-22 Applera Corporation System for thermally cycling biological samples with heated lid and pneumatic actuator
US7700281B2 (en) * 2004-06-30 2010-04-20 Usb Corporation Hot start nucleic acid amplification
ATE377194T1 (de) * 2004-07-02 2007-11-15 Hoffmann La Roche Vorrichtung zur zuverlässige analyse
KR100601966B1 (ko) 2004-10-07 2006-07-18 삼성전자주식회사 마이크로 칩 유니트 및 상기 마이크로 칩 유니트를이용하여 생화학 반응을 수행하는 방법
US20060109467A1 (en) * 2004-11-24 2006-05-25 Evans Richard W Devices, methods, and systems for measuring an optical property of a sample
KR100612879B1 (ko) * 2004-12-06 2006-08-14 삼성전자주식회사 폐쇄 시스템에서 펌프와 밸브의 제어를 통한 혼성화 장치
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
DE102005044021A1 (de) * 2005-09-14 2007-03-15 Eppendorf Ag Labortemperiereinrichtung mit Oberseite
US20070092403A1 (en) * 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
EP1829613B1 (de) * 2006-03-02 2022-03-30 Nexus Biosystems, Inc. Aufbewahrungseinheit und Transfersystem zum Aufbewahren und Bereitstellen von Biologischen proben
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
BRPI0709282B8 (pt) 2006-03-29 2021-05-25 Merial Ltd vacina contra estreptococos
GR1005943B (el) * 2006-05-15 2008-06-19 Γ. Παπανικολαου & Σια Ε.Ε. Τρυβλιο μικροσκοπιου με στερεωμενη αντικειμενοφορο πλακα και με στεγανοποιητικο καλυμμα καθως και διαταξη για τη στερεωση βασης συστοιχιας σωληναριωνμικροβιολογικων εξετασεων.
JP5286261B2 (ja) * 2006-07-17 2013-09-11 ブランディーズ・ユニバーシティ 特殊化オリゴヌクレオチドならびに核酸の増幅および検出でのその使用
US20110031139A1 (en) * 2006-07-26 2011-02-10 James Joseph Macor Protection, authentication, identification device for a physical object specimen
DE102006048264B4 (de) * 2006-10-12 2011-03-24 Bundesrepublik Deutschland, vertreten durch das Bundesministerium der Verteidigung, vertreten durch das Bundesamt für Wehrtechnik und Beschaffung Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen
FI20075191A0 (fi) 2007-03-23 2007-03-23 Bioinnovations Oy Väline ja menetelmä analyysiä varten
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
US20110212491A1 (en) * 2007-08-03 2011-09-01 Enigma Diagnostics Limited Reaction vessel
GB0715170D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
GB0715171D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
US20090055243A1 (en) 2007-08-21 2009-02-26 Jayson Lee Lusk Systems and methods for predicting a livestock marketing method
EP2255010B1 (de) * 2008-02-20 2018-05-30 Streck Inc. Thermocycler und probengefäss zur schnellen amplifikation von dna
US8062861B2 (en) 2008-02-21 2011-11-22 George Mason Intellectual Properties, Inc. Tissue sample preprocessing methods and devices
US20100055733A1 (en) * 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
JP2012502660A (ja) * 2008-09-22 2012-02-02 エフ．ホフマン−ラ ロシュ アーゲー マイクロアレイ基板上の生体物質の選択的プロセシング
US20100119454A1 (en) * 2008-11-03 2010-05-13 Ping Shen Use of the conserved Drosophila NPFR1 system for uncovering interacting genes and pathways important in nociception and stress response
EP2356423A1 (de) 2008-11-12 2011-08-17 Ventana Medical Systems, Inc. Verfahren und vorrichtungen zum erwärmen von präparate tragenden objektträgern
WO2010078176A1 (en) * 2008-12-31 2010-07-08 Ventana Medical Systems, Inc. Automated staining apparatus
US20100288059A1 (en) * 2009-05-14 2010-11-18 Streck, Inc. Specimen container, system, and method
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
WO2010147654A2 (en) 2009-06-15 2010-12-23 Netbio Inc. Improved methods for forensic dna quantitation
GB2471856A (en) * 2009-07-14 2011-01-19 Mantis Deposition Ltd Sample holder
JP5610313B2 (ja) * 2009-07-21 2014-10-22 国立大学法人 岡山大学 光学的観察用チャンバー及び試料の光学的観察方法、並びに下側透明板の製造方法
JP5280984B2 (ja) * 2009-10-23 2013-09-04 株式会社日立ハイテクノロジーズ 保温装置及びそれを備えた分析装置
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
IN2012DN03245A (de) 2009-11-13 2015-10-23 Ventana Med Syst Inc
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
GB201005357D0 (en) * 2010-03-30 2010-05-12 Menai Medical Technologies Ltd Sampling plate
IT1400868B1 (it) * 2010-06-23 2013-07-02 Torino Politecnico Dispositivo microfluidico integrato per la purificazione, amplificazione e rivelazione di acidi nucleici per la diagnostica
WO2012018741A2 (en) * 2010-08-02 2012-02-09 Weight Brent L Pressurizable cartridge for polymerase chain reactions
GB2482726A (en) * 2010-08-13 2012-02-15 Invicta Plastics Ltd Specimen slide for microscope
WO2012033914A1 (en) * 2010-09-09 2012-03-15 Battelle Memorial Institute Heating a short section of tape or wire to a controlled temperature
CN102445368B (zh) * 2010-10-13 2013-05-01 青岛市市立医院 检验载玻片
CA2835654A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
CN103946398B (zh) 2011-09-15 2019-08-13 健能泰格技术公司 探针：反义探针组合物对高特异性dna或rna的检测
IN2014CN04294A (de) * 2011-11-16 2015-09-04 Leica Biosystems Melbourne Pty
CN104254767B (zh) 2012-02-26 2016-10-26 克力博成像诊断股份有限公司 用于光学切片显微镜的组织样本工作台
US9932632B2 (en) 2012-08-10 2018-04-03 Streck, Inc. Real-time optical system for polymerase chain reaction
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
CN107233945B (zh) 2013-03-19 2019-10-11 生命科技股份有限公司 热循环仪封盖
EP3495803A1 (de) 2013-06-28 2019-06-12 Streck, Inc. Vorrichtungen für echtzeit-polymerasekettenreaktionen
KR101502434B1 (ko) * 2013-08-21 2015-03-24 영동제약 주식회사 세포 도말용 슬라이드 챔버
CN103642674A (zh) * 2013-12-11 2014-03-19 苏州东胜兴业科学仪器有限公司 一种原位聚合酶链反应板
CN105960282A (zh) * 2014-01-07 2016-09-21 达克雷诊断器材有限公司 流体输送装置、系统和方法
CN103743899B (zh) * 2014-01-13 2015-04-15 南通大学 可拆卸并可调容积的载玻片孵育器
CN103743896B (zh) * 2014-01-13 2015-04-15 南通大学 可拆卸、可调容积和防蒸发的载玻片孵育器
CN103952301B (zh) * 2014-04-11 2015-12-16 珠海美路得企业发展有限公司 一种医学检测设备的加热系统
WO2017049609A1 (en) * 2015-09-25 2017-03-30 Trane Air Conditioning Systems (China) Co., Ltd. Fixing device for heat exchanger
EP4067503A1 (de) * 2015-12-28 2022-10-05 Nihon Rikagaku Kaihatsu LLC. Vorrichtung zur bestimmung des lebendig/tot-zustands von mikroorganismen und verfahren zur bestimmung des lebendig/tot-zustands von mikroorganismen unter verwendung der vorrichtung
KR20170099737A (ko) * 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 패치 및 이를 이용하는 염색 방법
WO2018099918A1 (en) * 2016-11-29 2018-06-07 Koninklijke Philips N.V. Slide holding in digital pathology
US10328147B2 (en) 2017-03-24 2019-06-25 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herpes simplex virus type-1(HSV-1) vaccine strain VC2 generating an anti-EHV-1 immune response
KR102037411B1 (ko) * 2018-02-09 2019-10-28 광주과학기술원 측방 유동 분리 기반의 dna 추출 디바이스
WO2021064758A1 (en) * 2019-10-04 2021-04-08 Biosigma S.P.A. Containing device for cell culture
CN111774115B (zh) * 2020-05-29 2021-09-07 东南大学 一种用于固定带电极微流控芯片的夹具装置
WO2022140479A1 (en) * 2020-12-21 2022-06-30 Conservaton X Labs, Inc. Systems and methods using hand-held devices for detecting a target analyte loaded on a cartridge
FR3130844A1 (fr) 2021-12-22 2023-06-23 Bforcure Composition et procédé d’amplification de séquences d’acides nucléiques

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1620351A (en) * 1925-10-30 1927-03-08 Hnilo Frank Microscopic-slide staining and drying apparatus
US2623301A (en) * 1949-08-18 1952-12-30 Technicon International Ltd Drier for microscope slides
US2748495A (en) * 1953-06-25 1956-06-05 Burton Mfg Company Means for drying microscope slides, pipettes, and similar types of laboratory instruments
US3029695A (en) * 1960-05-02 1962-04-17 Frank E Wolf Microscope slides
US3158447A (en) * 1961-04-27 1964-11-24 Polaroid Corp Method for drying photographic sheet materials
US3220300A (en) * 1961-06-09 1965-11-30 California Inst Res Found Specimen holder
US3233975A (en) * 1962-03-05 1966-02-08 Ames Lab Tek Inc Prothrombin reaction chamber
GB1064244A (en) * 1965-01-05 1967-04-05 Ici Ltd Cell culture slides
DE1284118B (de) * 1967-04-25 1968-11-28 Leitz Ernst Gmbh Heiztisch fuer Mikroskope
US3667088A (en) * 1970-10-29 1972-06-06 Frank David Kurtz Slide holder method and apparatus
JPS4924296B1 (de) * 1970-12-24 1974-06-21
US3701201A (en) * 1971-02-10 1972-10-31 James A Drury Microscope slide dryer
US3879106A (en) * 1973-04-11 1975-04-22 Pelam Inc Microscope slide cover slip
US3883398A (en) * 1973-05-07 1975-05-13 Bellco Glass Inc Microculture slide chamber
US4384193A (en) * 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
EP0122772B1 (de) * 1983-04-15 1988-08-17 Science and Technology Agency, Minister's Secretariat, Director of Finance Division Chemischer Manipulator
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5038852A (en) * 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4814279A (en) * 1986-03-17 1989-03-21 Fuji Photo Film Co., Ltd. Incubator for chemical-analytical slide
GB8722902D0 (en) * 1987-09-30 1987-11-04 Shandon Southern Prod Tissue &c processing
US4974952A (en) * 1988-03-31 1990-12-04 Focht Daniel C Live cell chamber for microscopes
US5281516A (en) * 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
DE3924701A1 (de) * 1989-07-26 1991-01-31 Buehler Edmund Gmbh & Co Mikroskopinkubator
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5062697A (en) * 1990-08-08 1991-11-05 Mitchell Phillip R Portable microscope apparatus
GB9026517D0 (en) * 1990-12-05 1991-01-23 Cox Smith Peter J Temperature control apparatus
US5246665A (en) * 1991-06-03 1993-09-21 Abbott Laboratories Heat and air flow control for assay carrier
CA2218875C (en) * 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system

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DE69323720T2 (de) 1999-07-01
IL120847A0 (en) 1997-09-30
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ATE177024T1 (de) 1999-03-15
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