DE69418595T2 - Verfahren und vorrichtung zur erzeugung von biopolymermatrizen auf einer festphasenträgeroberfläche - Google Patents

Verfahren und vorrichtung zur erzeugung von biopolymermatrizen auf einer festphasenträgeroberfläche

Info

Publication number
DE69418595T2
DE69418595T2 DE69418595T DE69418595T DE69418595T2 DE 69418595 T2 DE69418595 T2 DE 69418595T2 DE 69418595 T DE69418595 T DE 69418595T DE 69418595 T DE69418595 T DE 69418595T DE 69418595 T2 DE69418595 T2 DE 69418595T2
Authority
DE
Germany
Prior art keywords
matricates
solid phase
support surface
phase support
generating biopolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69418595T
Other languages
English (en)
Other versions
DE69418595D1 (de
Inventor
Robert Matson
Peter Coassin
Jang Rampal
Edwin M Southern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of DE69418595D1 publication Critical patent/DE69418595D1/de
Publication of DE69418595T2 publication Critical patent/DE69418595T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1072—Multiple transfer devices with provision for selective pipetting of individual channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/0043—Means for dispensing and evacuation of reagents using masks for direct application of reagents, e.g. through openings in a shutter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
DE69418595T 1993-10-28 1994-10-28 Verfahren und vorrichtung zur erzeugung von biopolymermatrizen auf einer festphasenträgeroberfläche Expired - Lifetime DE69418595T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/144,954 US5429807A (en) 1993-10-28 1993-10-28 Method and apparatus for creating biopolymer arrays on a solid support surface
PCT/US1994/012443 WO1995011748A1 (en) 1993-10-28 1994-10-28 Method and apparatus for creating biopolymer arrays on a solid support surface

Publications (2)

Publication Number Publication Date
DE69418595D1 DE69418595D1 (de) 1999-06-24
DE69418595T2 true DE69418595T2 (de) 1999-09-16

Family

ID=22510923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418595T Expired - Lifetime DE69418595T2 (de) 1993-10-28 1994-10-28 Verfahren und vorrichtung zur erzeugung von biopolymermatrizen auf einer festphasenträgeroberfläche

Country Status (5)

Country Link
US (1) US5429807A (de)
EP (1) EP0675760B1 (de)
JP (1) JPH08505407A (de)
DE (1) DE69418595T2 (de)
WO (1) WO1995011748A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008021364A1 (de) * 2008-04-29 2009-06-25 Siemens Aktiengesellschaft Verfahren zum Einbringen von Trockenreagenzien in eine Analyseeinheit und Kit
DE102014105437A1 (de) * 2014-04-16 2015-10-22 Amodia Bioservice Gmbh Mikrofluidik-Modul und Kassette für die immunologische und molekulare Diagnostik in einem Analyseautomaten

Families Citing this family (292)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US20050032048A1 (en) * 1988-05-03 2005-02-10 Oxford Gene Technology Limited Analyzing polynucleotide sequences
DE4027675C2 (de) * 1990-08-31 1997-05-07 Biotechnolog Forschung Gmbh Verfahren zur parallelen Herstellung von trägergebundenen oder freien Peptiden, trägergebundene Peptide und ihre Verwendung
AU675054B2 (en) * 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
JPH0622798A (ja) * 1992-07-07 1994-02-01 Hitachi Ltd 塩基配列決定法
GB9401833D0 (en) * 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
AU5253496A (en) * 1995-03-15 1996-10-02 City Of Hope Disposable reagent storage and delivery cartridge
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
DE59700294D1 (de) * 1996-01-23 1999-09-02 Novartis Ag Vorrichtung und verfahren zum synthetisieren von makromolekülen
US5744102A (en) * 1996-01-30 1998-04-28 Chugai Biopharmaceuticals, Inc. Solid phase synthesizer
WO1997029212A1 (en) * 1996-02-08 1997-08-14 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6924094B1 (en) 1996-02-08 2005-08-02 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP1958955B1 (de) * 1996-02-09 2013-09-04 Cornell Research Foundation, Inc. Räumlich adressierbare Oligonukleotidarrays und eine Methode zu deren Herstellung
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU2320597A (en) 1996-03-19 1997-10-10 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
US6458530B1 (en) * 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US5733509A (en) * 1996-04-17 1998-03-31 Motorola, Inc. Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars
EP0912761A4 (de) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Bestimmung von unterschieden in der nukleisäuresequenz mittels einer kombination von ligasebestimmung und polymerase-kettenreaktion
WO1997046313A1 (en) * 1996-06-07 1997-12-11 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
DE19625397A1 (de) * 1996-06-25 1998-01-08 Deutsches Krebsforsch Verfahren zur Kombination von paralleler Oligonukleotidsynthese und Darstellung von Oligomer-Chips
US20050214827A1 (en) * 1996-07-08 2005-09-29 Burstein Technologies, Inc. Assay device and method
JP2002514046A (ja) 1996-07-08 2002-05-14 バースタイン テクノロジーズ，インコーポレイティド 切断可能なシグナル因子の装置および方法
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
CA2301230A1 (en) 1996-09-20 1998-03-26 Digital Drives, Inc. Spatially addressable combinatorial chemical arrays in cd-rom format
US6875620B1 (en) * 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
US20010022950A1 (en) * 1996-11-18 2001-09-20 Jonathan Hall Device for polymers synthesis
AU5322798A (en) * 1996-11-18 1998-06-10 Novartis Ag Device for polymers synthesis
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
DE19706570C1 (de) * 1997-02-19 1998-02-26 Inst Physikalische Hochtech Ev Verfahren zur Herstellung von strukturierten, selbstorganisierten molekularen Monolagen einzelner molekularer Spezies, insbesondere von Substanzbibliotheken
PT969919E (pt) 1997-02-21 2003-04-30 Merckle Gmbh Dispositivo e processo para a sintese automatica de macromoleculas.
US6028189A (en) * 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
US6419883B1 (en) 1998-01-16 2002-07-16 University Of Washington Chemical synthesis using solvent microdroplets
WO1998041531A2 (en) 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6210880B1 (en) 1997-09-19 2001-04-03 Third Wave Technologies, Inc. Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides
EP0983292A4 (de) 1997-05-05 2005-05-18 Third Wave Tech Inc Zielabhängige reaktionen mittels strukturüberbrückender oligonukleotide
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6214545B1 (en) 1997-05-05 2001-04-10 Third Wave Technologies, Inc Polymorphism analysis by nucleic acid structure probing
US6194149B1 (en) 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US6969488B2 (en) * 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
EP1012331B1 (de) 1997-07-01 2006-03-29 Isis Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6290685B1 (en) 1998-06-18 2001-09-18 3M Innovative Properties Company Microchanneled active fluid transport devices
US5985567A (en) * 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
WO1999013313A1 (en) * 1997-09-11 1999-03-18 Genovations, Inc. Method of making high density arrays
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
WO1999040434A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US7399589B2 (en) * 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
WO1999042605A1 (en) * 1998-02-21 1999-08-26 Schwabacher Alan W One dimensional chemical compound arrays and methods for assaying them
US7108968B2 (en) * 1998-04-03 2006-09-19 Affymetrix, Inc. Mycobacterial rpoB sequences
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
DE19827754C1 (de) 1998-06-23 2000-02-10 Graffinity Pharm Design Gmbh Einrichtung für eine nahezu gleichzeitige Synthese einer Vielzahl von Proben
DE29907804U1 (de) * 1998-04-30 1999-10-07 Graffinity Pharm Design Gmbh Vorrichtung für den Transport von Flüssigkeiten entlang vorgegebener Leitwege
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6316229B1 (en) 1998-07-20 2001-11-13 Yale University Single molecule analysis target-mediated ligation of bipartite primers
WO2000005582A2 (en) * 1998-07-21 2000-02-03 Burstein Laboratories, Inc. Optical disc-based assay devices and methods
JP3562968B2 (ja) * 1998-08-14 2004-09-08 富士写真フイルム株式会社 試験片、その製造方法および装置並びにその読取方法および装置
US6461812B2 (en) * 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
EP1114184A2 (de) * 1998-09-15 2001-07-11 Yale University Klonierung mittels "rolling circle" amplifizierung
JP2002525078A (ja) 1998-09-15 2002-08-13 イェール ユニバーシティ 人工的長末端反復配列
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ， エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU778438B2 (en) 1999-04-06 2004-12-02 Yale University Fixed address analysis of sequence tags
US6518056B2 (en) 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
DE19919607A1 (de) 1999-04-29 2000-11-16 Mets Ion Gmbh Ges Fuer Angewan Verfahren und Vorrichtung zur parallelen Herstellung von wenigstens 4n Oligonukleotiden
AU4988600A (en) * 1999-05-04 2000-11-17 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US6395559B1 (en) * 1999-05-04 2002-05-28 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US6589791B1 (en) 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
EP1206577B1 (de) 1999-08-13 2006-03-01 Yale University Binär kodierte sequenzmarker
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
DE29921606U1 (de) * 1999-12-03 2001-04-19 Mwg Biotech Ag Kartusche für eine Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
US6482638B1 (en) * 1999-12-09 2002-11-19 3M Innovative Properties Company Heat-relaxable substrates and arrays
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US6368801B1 (en) 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
CA2405412A1 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
IL152634A0 (en) * 2000-05-04 2003-06-24 Univ Yale High density protein arrays for screening of protein activity
US20090075256A1 (en) * 2000-06-17 2009-03-19 Third Wave Technologies, Inc. Nucleic Acid Accessible Hybridization Site Identification Using Mass Spectrometry
AU2001268513A1 (en) * 2000-06-17 2002-01-02 Third Wave Technologies, Inc. Nucleic acid accessible hybridization sites
US20060166227A1 (en) * 2000-06-20 2006-07-27 Stephen Kingsmore Protein expression profiling
AU7172201A (en) 2000-06-30 2002-01-14 Molecular Staging Inc Signal amplification with lollipop probes
US6824981B2 (en) * 2000-08-11 2004-11-30 Agilix Corporation Ultra-sensitive detection systems using alterable peptide tags
WO2002016647A1 (en) * 2000-08-24 2002-02-28 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US6900013B1 (en) 2000-08-25 2005-05-31 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US6849409B2 (en) * 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
US6861222B2 (en) * 2000-11-09 2005-03-01 Yale University Nucleic acid detection using structured probes
US20050009022A1 (en) * 2001-07-06 2005-01-13 Weiner Michael P. Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US20030044798A1 (en) * 2001-08-31 2003-03-06 Lefkowitz Steven M. Methods for generating ligand arrays via deposition of ligands onto olefin displaying substrates, and arrays produced thereby
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
US20030108726A1 (en) * 2001-10-18 2003-06-12 Schembri Carol T. Chemical arrays
US6841663B2 (en) * 2001-10-18 2005-01-11 Agilent Technologies, Inc. Chemical arrays
US7300798B2 (en) * 2001-10-18 2007-11-27 Agilent Technologies, Inc. Chemical arrays
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) * 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
WO2003056298A2 (en) * 2001-11-06 2003-07-10 Agilix Corporation Sensitive coded detection systems
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US20030157586A1 (en) * 2002-02-21 2003-08-21 Martin Bonde Device and method for conducting cellular assays using multiple fluid flow
JP3933058B2 (ja) * 2002-02-25 2007-06-20 日立化成工業株式会社 マイクロ流体システム用支持ユニット及びその製造方法
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US7214492B1 (en) 2002-04-24 2007-05-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US20060234309A1 (en) 2002-05-08 2006-10-19 Northwest Biotherapeutics, Inc Quality assays for antigen presenting cells
US7129046B2 (en) * 2002-10-21 2006-10-31 Agilent Technologies, Inc. Linking to chemical array assemblies with metal layers
TWI245739B (en) * 2002-12-05 2005-12-21 Ibm Method and device for flowing a liquid on a surface
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7541152B2 (en) * 2002-12-24 2009-06-02 Agilent Technologies, Inc. Integrated light source for diagnostic arrays
US6977153B2 (en) * 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
AU2004254552B2 (en) * 2003-01-29 2008-04-24 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US20040191782A1 (en) * 2003-03-31 2004-09-30 Yixin Wang Colorectal cancer prognostics
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20050233390A1 (en) * 2003-04-09 2005-10-20 Allen John W Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
WO2004096984A2 (en) * 2003-04-25 2004-11-11 Janssen Pharmaceutica N.V. Preservation of rna in a biological sample
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005043154A2 (en) * 2003-10-27 2005-05-12 Massachusetts Institute Of Technology High density reaction chambers and methods of use
JP4814103B2 (ja) 2003-11-12 2011-11-16 バイオ−ラッド・ハイファ・リミテッド アレイフォーマットにおいて複数の結合反応を実行するためのシステムおよび方法
ATE448018T1 (de) * 2004-02-18 2009-11-15 Hitachi Chemical Co Ltd Mikrofluidische einheit mit hohlfaser-kanal
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
US20050244984A1 (en) * 2004-04-28 2005-11-03 Parker Russell A Methods and compositions for calibrating chemical array readers
US20050247673A1 (en) * 2004-05-07 2005-11-10 International Business Machines Corporation Confinement of fluids on surfaces
EP2471921A1 (de) 2004-05-28 2012-07-04 Asuragen, Inc. Verfahren und Zusammensetzungen mit microRNA
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
US7378259B2 (en) * 2004-07-15 2008-05-27 Applera Corporation Fluid processing device
EP2302054B1 (de) 2004-11-12 2014-07-16 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
WO2006060653A2 (en) * 2004-11-30 2006-06-08 Veridex Llc Lung cancer prognostics
WO2006059649A1 (ja) * 2004-11-30 2006-06-08 Hitachi Chemical Co., Ltd. 分析前処理用部品
CN102172507A (zh) * 2004-12-09 2011-09-07 日立化成工业株式会社 微流体系统用支持单元及其制造方法
KR20070095452A (ko) * 2005-01-25 2007-09-28 스카이 제네틱스, 인코포레이티드 암 세포의 세포자멸사를 위한 핵산
US20060183893A1 (en) * 2005-01-25 2006-08-17 North Don A Nucleic acids for apoptosis of cancer cells
WO2006084130A2 (en) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Ultra-sensitive detection systems using multidimension signals
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
EP1874960A2 (de) * 2005-04-04 2008-01-09 Veridex, LLC Laser-mikrodissektion und mikroarray-analyse von brusttumoren zeigen mit östrogenrezeptor verbundene gene und wege
EP1888780A4 (de) * 2005-05-06 2009-11-11 Applera Corp Mehrfachkapillarenvorrichtung sowie verfahren zur synthese und abgabe
SG162795A1 (en) 2005-06-15 2010-07-29 Callida Genomics Inc Single molecule arrays for genetic and chemical analysis
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
ES2494843T3 (es) * 2005-09-19 2014-09-16 Janssen Diagnostics, Llc Métodos y materiales para identificar el origen de un carcinoma de origen primario desconocido
US20070202515A1 (en) * 2005-10-12 2007-08-30 Pathologica, Llc. Promac signature application
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
WO2007106523A2 (en) * 2006-03-13 2007-09-20 Veridex, Llc Propagation of primary cells
US20080045471A1 (en) * 2006-03-27 2008-02-21 North Don A Nucleic Acids For Apoptosis Of Cancer Cells
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
US20090002703A1 (en) * 2006-08-16 2009-01-01 Craig Edward Parman Methods and systems for quantifying isobaric labels and peptides
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
DE102006035392A1 (de) 2006-11-02 2008-10-16 Signature Diagnostics Ag Prognostische Marker für die Vorhersage des fünfjährigen progressionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035388A1 (de) * 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung von Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035393A1 (de) 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
EP2162283B1 (de) 2007-06-14 2015-08-12 Massachusetts Institute of Technology Selbstaufbauende filme für protein- und arzneimittelabgabeanwendungen
CA2697106A1 (en) * 2007-08-28 2009-03-12 Donald Bergstrom Expression profiles of biomarker genes in notch mediated cancers
CN101960022A (zh) * 2008-01-22 2011-01-26 维里德克斯有限责任公司 Ⅱ期和ⅲ期结肠癌的分子分期和预后
US7932036B1 (en) 2008-03-12 2011-04-26 Veridex, Llc Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US20110111417A1 (en) 2008-05-14 2011-05-12 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
EP2321042A4 (de) * 2008-07-23 2013-01-16 Ancora Pharmaceuticals Inc Automatisierter oligosaccharidsynthesizer
US9198875B2 (en) 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
JP2012507300A (ja) 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Ｒｎａパターンを評価する方法
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
WO2010125566A2 (en) 2009-04-27 2010-11-04 Technion Research And Development Foundation Ltd. Markers for cancer detection
US9771618B2 (en) * 2009-08-19 2017-09-26 Bioarray Genetics, Inc. Methods for treating breast cancer
EP2507393A4 (de) 2009-11-30 2013-05-01 Caris Life Sciences Luxembourg Holdings Verfahren und systeme zur isolation, speicherung und analyse von vesikeln
CA2787027A1 (en) 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Detection of gastrointestinal disorders
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
EP2388336A1 (de) 2010-05-19 2011-11-23 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
NZ719520A (en) 2010-07-06 2017-07-28 Int Tech Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
ES2629890T3 (es) 2010-11-17 2017-08-16 Interpace Diagnostics, Llc miARN como biomarcadores para distinguir entre neoplasias de tiroides benignas y malignas
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
CH704658A1 (de) * 2011-03-16 2012-09-28 Hugo Dr Ziegler Synthese chemischer Verbindungen an fester Phase.
EP2520661A1 (de) 2011-05-02 2012-11-07 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Genexpressionssignaturen bei Lungenkrebs
EP2527459A1 (de) 2011-05-02 2012-11-28 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Gendetektion von nichtkleinzelligem Lungenkrebs
EP2710147A1 (de) 2011-05-18 2014-03-26 Rheinische Friedrich-Wilhelms-Universität Bonn Molekulare analyse von akuter myeloischer leukämie
EP2524968A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
EP2524967A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
ES2776144T3 (es) 2011-10-28 2020-07-29 Millennium Pharm Inc Biomarcadores de respuesta a inhibidores de NAE
WO2013063382A2 (en) 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
CN104039328B (zh) 2011-11-11 2018-10-09 米伦纽姆医药公司 对蛋白酶体抑制剂的反应的生物标记
CA2855368A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
WO2013075065A1 (en) 2011-11-18 2013-05-23 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
US10265388B2 (en) 2012-02-21 2019-04-23 Cytonics Corporation Systems, compositions, and methods for transplantation
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
EP2870263A1 (de) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnoseportfolio und dessen verwendungen
CA2886783A1 (en) 2012-10-01 2014-04-10 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US20150290669A1 (en) * 2012-10-26 2015-10-15 Massachusetts Institute Of Technology Devices and Methods for Layer-by-Layer Assembly
KR102161331B1 (ko) 2012-11-28 2020-09-29 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 조성물 및 방법
US10597650B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US10597710B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014151551A1 (en) 2013-03-15 2014-09-25 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
EP2970909A4 (de) 2013-03-15 2017-02-15 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
DK2970356T3 (en) 2013-03-15 2018-08-27 Illumina Cambridge Ltd Modified nucleosides or nucleotides
EP2971132B1 (de) 2013-03-15 2020-05-06 Baylor Research Institute Gewebe- und blutbasierte mirna-biomarker zur diagnose, prognose und vorhersage des metastasepotenzials bei kolorektalkrebs
WO2014165814A1 (en) 2013-04-04 2014-10-09 Georgia State University Research Foundation, Inc. Rna microchip detection using nanoparticle-assisted signal amplification
PL3017065T3 (pl) 2013-07-01 2019-03-29 Illumina, Inc. Funkcjonalizacja powierzchni i szczepienie polimeru bez użycia katalizatora
WO2015031654A2 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
BR112016007391A2 (pt) 2013-10-03 2017-08-01 Oklahoma Med Res Found biomarcadores da atividade, da intensidade e da fase aguda da doença lúpus eritematoso sistêmico
EP3084003A4 (de) 2013-12-17 2017-07-19 Merck Sharp & Dohme Corp. Ifn-gamma-gensignaturbiomarker der tumorreaktion auf pd-1 antagonisten
CN114089597A (zh) 2013-12-19 2022-02-25 Illumina公司 包括纳米图案化表面的基底及其制备方法
WO2015109234A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Gene expression panel for prognosis of prostate cancer recurrence
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
US9982250B2 (en) 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
PT3212684T (pt) 2014-10-31 2020-02-03 Illumina Cambridge Ltd Revestimentos de polímeros e de copolímero de dna
EP4242329A3 (de) 2014-12-08 2023-10-25 Berg LLC Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
US11377693B2 (en) 2014-12-09 2022-07-05 Merck Sharp & Dohme Llc System and methods for deriving gene signature biomarkers of response to PD-1 antagonists
EP4029606A1 (de) 2014-12-31 2022-07-20 Visby Medical, Inc. Molekulardiagnostischen analyse
US11326211B2 (en) 2015-04-17 2022-05-10 Merck Sharp & Dohme Corp. Blood-based biomarkers of tumor sensitivity to PD-1 antagonists
US20180207920A1 (en) 2015-07-17 2018-07-26 Illumina, Inc. Polymer sheets for sequencing applications
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
KR102171865B1 (ko) 2016-05-18 2020-10-29 일루미나, 인코포레이티드 패턴화된 소수성 표면을 사용한 자가 조립된 패터닝
JP7042755B2 (ja) 2016-06-05 2022-03-28 バーグ エルエルシー 患者層別化及び潜在的バイオマーカー同定のためのシステム及び方法
WO2018005710A1 (en) 2016-06-29 2018-01-04 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
EP3574114B1 (de) 2017-01-26 2022-06-29 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
EP3615934A1 (de) 2017-04-28 2020-03-04 Merck Sharp & Dohme Corp. Biomarker für krebstherapeutika
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US11497762B2 (en) 2017-11-03 2022-11-15 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
SG11202002931VA (en) 2017-11-09 2020-04-29 Visby Medical Inc Portable molecular diagnostic device and methods for the detection of target viruses
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
WO2020081204A1 (en) 2018-10-18 2020-04-23 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
KR20210151944A (ko) 2019-04-12 2021-12-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 근육량 및 산화 대사를 증가시키기 위한 조성물 및 방법
AU2020265250A1 (en) 2019-04-30 2021-11-18 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
CA3177293A1 (en) 2020-06-22 2021-12-30 Illumina Cambridge Limited Nucleosides and nucleotides with 3' acetal blocking group
US20220033900A1 (en) 2020-07-28 2022-02-03 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
WO2022026909A1 (en) 2020-07-31 2022-02-03 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4320443A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker zur prognose der brustkrebsprogression
WO2022216841A1 (en) 2021-04-06 2022-10-13 Berg Llc Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
CA3214821A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
KR20240004502A (ko) 2021-05-05 2024-01-11 일루미나 케임브리지 리미티드 비스-붕소 융합 헤테로사이클을 함유하는 형광 염료 및 서열분석에서의 용도
EP4341434A1 (de) 2021-05-20 2024-03-27 Illumina, Inc. Zusammensetzungen und verfahren zur sequenzierung durch synthese
CN117677435A (zh) 2021-06-15 2024-03-08 伊鲁米纳公司 用于测序的不含水凝胶的表面官能化
WO2023004357A1 (en) 2021-07-23 2023-01-26 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US20230330659A1 (en) 2022-03-22 2023-10-19 Illumina Cambridge Limited Substrate with orthogonally functional nanodomains
US20230304086A1 (en) 2022-03-28 2023-09-28 Illumina Cambridge Limited Labeled avidin and methods for sequencing
CA3223125A1 (en) 2022-03-29 2023-10-05 Illumina, Inc. Chromenoquinoline dyes and uses in sequencing
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023232829A1 (en) 2022-05-31 2023-12-07 Illumina, Inc Compositions and methods for nucleic acid sequencing
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
US20230416279A1 (en) 2022-06-28 2023-12-28 Illumina Cambridge Limited Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598049A (en) * 1983-08-31 1986-07-01 Systec Inc. General purpose gene synthesizer
DE3565986D1 (en) * 1984-05-02 1988-12-08 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
US4849077A (en) * 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
FR2584498B1 (fr) * 1985-07-02 1987-10-16 Centre Nat Rech Scient Dispositif pour detecter sur une feuille de nitrocellulose la presence de complexes macromoleculaires, tels que antigenes/anticorps et procede de mise en oeuvre.
US4834946A (en) * 1987-02-05 1989-05-30 Levin Andrew E Apparatus for blot screening numerous, small volume, antibody solutions
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5112736A (en) * 1989-06-14 1992-05-12 University Of Utah Dna sequencing using fluorescence background electroblotting membrane
US5039493A (en) * 1990-05-04 1991-08-13 The United States Of America As Represented By The Secretary Of The Navy Positive pressure blotting apparatus with hydropholic filter means
AU1999092A (en) * 1991-05-24 1992-12-30 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
AU675054B2 (en) * 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008021364A1 (de) * 2008-04-29 2009-06-25 Siemens Aktiengesellschaft Verfahren zum Einbringen von Trockenreagenzien in eine Analyseeinheit und Kit
DE102014105437A1 (de) * 2014-04-16 2015-10-22 Amodia Bioservice Gmbh Mikrofluidik-Modul und Kassette für die immunologische und molekulare Diagnostik in einem Analyseautomaten

Also Published As

Publication number Publication date
DE69418595D1 (de) 1999-06-24
EP0675760B1 (de) 1999-05-19
WO1995011748A1 (en) 1995-05-04
EP0675760A1 (de) 1995-10-11
JPH08505407A (ja) 1996-06-11
US5429807A (en) 1995-07-04

Similar Documents

Publication Publication Date Title
DE69418595D1 (de) Verfahren und vorrichtung zur erzeugung von biopolymermatrizen auf einer festphasenträgeroberfläche
DE68927037D1 (de) Verfahren und Vorrichtung zur Erzeugung von Plasma
DE69419813T2 (de) Vorrichtung und Verfahren zur Erzeugung einer annähernden Funktion
DE69705753D1 (de) Vorrichtung und Verfahren zur Bereitstellung einer arretierungs-artigen taktilen Rückkopplung
DE69720581D1 (de) Verfahren zur Engasung von Flüssigkeiten und Gebrauch einer Vorrichtung dafür
DE69425037D1 (de) Verfahren und Vorrichtung zur Generierung von Schriftzeichen
DE69127650D1 (de) Verfahren und Gerät zur Erzeugung von dreidimensionalen graphischen Symbolen
DE69224470T2 (de) Verfahren und Gerät zur Erzeugung von Servomarken
DE69636215D1 (de) Verfahren und vorrichtung zur erzeugung von graviersignalen
DE59300351D1 (de) Verfahren und Vorrichtung zur Erzeugung von Mustern auf Substraten.
DE69324417D1 (de) Vorrichtung und Verfahren zur Koordinateneingabe und Oszillationsgenerator
DE69432507D1 (de) Verfahren und Geräte zur Erzeugung von Zeichnungsdaten
DE69113591D1 (de) Verfahren und gerät zur generierung von pulsen.
DE69303119T2 (de) Verfahren und Vorrichtung zur Herstellung von Klebeelementen zur Dekoration auf einer dreidimensionalen Oberfläche
DE69503094D1 (de) Verfahren und Vorrichtung zur Erzeugung von Stickdaten
DE69327684D1 (de) Verfahren und Vorrichtung zur Schriftzeichenmustererzeugung
DE69820389D1 (de) Verfahren und Vorrichtung zur Erzeugung von Konturlinien
DE68919003T2 (de) Verfahren und Vorrichtung zur Stabilisierung des Oszillations-Frequenz-Unterschiedes einer Anzahl von Lasergeräten.
DE69213480D1 (de) Verfahren und vorrichtung zur vereinfachung einer benutzererzeugung von entscheidungsfunktionen.
DE69426662D1 (de) Vorrichtung und Verfahren zur Herstellung einer Druckplatte
DE69303883D1 (de) Vorrichtung und Verfahren zur Vorbereitung einer Entwicklerlösung
DE4490532D2 (de) Verfahren und Vorrichtung zum Erzeugen einer Bogenfolge
DE59302868D1 (de) Verfahren und Vorrichtung zur Erzeugung einer Abschäl- oder Abreissprobe an einer verschweissten Platine
DE68927339T2 (de) Verfahren und Vorrichtung zur Erzeugung von Halbtonpunkten
DE59611490D1 (de) Vorrichtung und Verfahren zur Erzeugung einer geregelten Spannung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BECKMAN COULTER, INC., BREA, CALIF., US