DE69429507T2 - Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung - Google Patents

Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung

Info

Publication number
DE69429507T2
DE69429507T2 DE69429507T DE69429507T DE69429507T2 DE 69429507 T2 DE69429507 T2 DE 69429507T2 DE 69429507 T DE69429507 T DE 69429507T DE 69429507 T DE69429507 T DE 69429507T DE 69429507 T2 DE69429507 T2 DE 69429507T2
Authority
DE
Germany
Prior art keywords
biologically active
particles
production
active substances
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429507T
Other languages
English (en)
Other versions
DE69429507D1 (de
Inventor
Viktor Alexeevich Volkonsky
Sergei V Chernyakov
Sergei D Dvuhsherstnov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FeRx Inc
Original Assignee
FeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FeRx Inc filed Critical FeRx Inc
Publication of DE69429507D1 publication Critical patent/DE69429507D1/de
Application granted granted Critical
Publication of DE69429507T2 publication Critical patent/DE69429507T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69429507T 1993-01-29 1994-01-26 Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung Expired - Fee Related DE69429507T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1136393A 1993-01-29 1993-01-29
PCT/US1994/000892 WO1994016683A1 (en) 1993-01-29 1994-01-26 Magnetically responsive composition for carrying biologically active substances and methods of production and use

Publications (2)

Publication Number Publication Date
DE69429507D1 DE69429507D1 (de) 2002-01-31
DE69429507T2 true DE69429507T2 (de) 2002-05-16

Family

ID=21750068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429507T Expired - Fee Related DE69429507T2 (de) 1993-01-29 1994-01-26 Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung

Country Status (12)

Country Link
US (3) US5549915A (de)
EP (1) EP0683665B1 (de)
JP (2) JP3145120B2 (de)
AT (1) ATE210967T1 (de)
AU (1) AU6165394A (de)
CA (1) CA2154913C (de)
DE (1) DE69429507T2 (de)
DK (1) DK0683665T3 (de)
ES (1) ES2165385T3 (de)
HK (1) HK1013256A1 (de)
PT (1) PT683665E (de)
WO (1) WO1994016683A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0683665T3 (da) * 1993-01-29 2002-04-02 Ferx Inc Magnetisk reagerende sammensætning som bærer for biologisk aktive stoffer samt fremgangsmåder til dens fremstilling og anvendelse
US6200547B1 (en) 1994-01-26 2001-03-13 Ferx Incorporated Magnetically responsive compositions for carrying biologically active substances and methods of production and use
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6488615B1 (en) * 2000-03-31 2002-12-03 Ferx Incorporated Permanent magnet keeper-shield assembly
US7090636B2 (en) * 2000-03-31 2006-08-15 Fe Rx Incorporated Permanent magnet keeper-shield assembly
EP1428228A4 (de) * 2001-02-26 2008-04-30 Univ Utah Res Found Magnetaktivierte partikel zur adsorption von gelösten stoffen aus lösung
US6921283B2 (en) * 2001-08-27 2005-07-26 Trompeter Electronics, Inc. BNC connector having visual indication
FR2832598B1 (fr) * 2001-11-26 2006-01-27 Oreal Article de conditionnement et/ou d'application d'un produit
WO2003059325A1 (en) * 2002-01-09 2003-07-24 Ferx Incorporated Magnetic delivery compositions
WO2003066066A1 (en) * 2002-02-01 2003-08-14 Vanderbilt University Targeted drug delivery methods
US8097185B2 (en) * 2002-02-26 2012-01-17 University Of Utah Research Foundation Magnetic activated carbon particles for adsorption of solutes from solution
WO2004066975A1 (en) * 2002-12-18 2004-08-12 Hough Ear Institute Otologic nanotechnology
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
ES2264839B1 (es) * 2003-11-24 2007-10-01 Universidad De Zaragoza (Inst Denanociencia De Ar Agom. Farmacoterapia parenteral focalizada mediante el implante de imanes permanentes en los organos diana.
DE10359252A1 (de) * 2003-12-17 2005-07-28 Siemens Ag Navigierte Wärmebehandlung von Tumoren mit enzymumhüllten Eisenpartikeln
US20070100457A1 (en) * 2004-03-04 2007-05-03 Hyde Edward R Jr Paramagnetic liquid interface
CN1976681A (zh) * 2004-03-26 2007-06-06 弗尔克斯破产财产公司 可磁性靶向丝裂霉素c组合物及其使用方法
US20060024378A1 (en) * 2004-08-02 2006-02-02 Mehta Rakesh H Magnetically responsive carbon nano-structures for transporting biologically active substances, and methods relating thereto
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
US8568286B2 (en) * 2006-06-14 2013-10-29 Cardiac Pacemakers, Inc. Methods to position therapeutic agents using a magnetic field
CN103705947A (zh) 2006-06-28 2014-04-09 株式会社Ihi 药物、药物引导装置、磁性检测装置和药物设计方法
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
JP5433155B2 (ja) * 2008-02-20 2014-03-05 株式会社Ihi 磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置
JP2009274962A (ja) * 2008-05-12 2009-11-26 Yoshihiro Ishikawa 鉄サレン錯体、磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置
EP2357166B1 (de) 2008-11-20 2020-01-15 IHI Corporation Automagnetische metall-salen-komplexverbindung
US9314602B2 (en) 2009-12-25 2016-04-19 Ihi Corporation Magnetic body and drug delivery control device using magnetic body
EP2578643B1 (de) 2010-06-01 2019-07-10 IHI Corporation Fluoreszierendes farbstoffmaterial und verwendung davon
US9744235B2 (en) 2010-10-19 2017-08-29 The Board Of Regents Of The University Of Oklahoma Treatment of cardiovascular disorders with targeted nanoparticles
US8740872B2 (en) 2010-10-19 2014-06-03 The Board Of Regents Of The University Of Oklahoma Magnetically-targeted treatment for cardiac disorders
US10398668B2 (en) 2010-10-19 2019-09-03 The Board Of Regents Of The University Of Oklahoma Glutamate treatment of cardiovascular disorders
JP2012131737A (ja) * 2010-12-21 2012-07-12 Ihi Corp 金属サレン錯体化合物及びその製造方法
WO2012086683A1 (ja) 2010-12-21 2012-06-28 株式会社Ihi 金属サレン錯体化合物及びその製造方法
JP2012176905A (ja) * 2011-02-25 2012-09-13 Ihi Corp 金属サレン錯体化合物
JP2012167067A (ja) 2011-02-15 2012-09-06 Ihi Corp 自己磁性金属サレン錯体化合物
JP5873656B2 (ja) 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
JP6017766B2 (ja) 2011-07-26 2016-11-02 株式会社Ihi 新規な金属サレン錯体化合物の抗がん剤
US9468621B2 (en) 2011-10-04 2016-10-18 Ihi Corporation Metal-salen complex compound responsive drug and intra-corporeal behavior control system for metal-salen complex compound
WO2013051363A1 (ja) * 2011-10-06 2013-04-11 株式会社Ihi 磁性組成物及びその製造方法
WO2016046989A1 (ja) 2014-09-26 2016-03-31 株式会社Ihi 抗がん剤、がん細胞殺傷方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3718594A (en) * 1970-11-30 1973-02-27 Eastman Kodak Co Method of preparing magnetically responsive carrier particles
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
US4345588A (en) * 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4501726A (en) * 1981-11-12 1985-02-26 Schroeder Ulf Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
JPS59122429A (ja) * 1982-12-28 1984-07-14 Japan Synthetic Rubber Co Ltd 生物学的物質の担体用磁性粒子
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
US4849209A (en) * 1985-06-07 1989-07-18 Cadema Medical Products, Inc. Treatment of arthritis, including rheumatoid arthritis with 166 Holmium radionuclide
US4818614A (en) * 1985-07-29 1989-04-04 Shiseido Company Ltd. Modified powder
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US4871716A (en) * 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
JPH01122037U (de) * 1988-02-12 1989-08-18
SU1722256A3 (ru) * 1989-11-02 1992-03-23 Viktor A Volkonskij Cпocoб пoлучehия maгhиtoупpabляemoй диcпepcии
DK0683665T3 (da) * 1993-01-29 2002-04-02 Ferx Inc Magnetisk reagerende sammensætning som bærer for biologisk aktive stoffer samt fremgangsmåder til dens fremstilling og anvendelse

Also Published As

Publication number Publication date
US5705195A (en) 1998-01-06
DK0683665T3 (da) 2002-04-02
DE69429507D1 (de) 2002-01-31
US5651989A (en) 1997-07-29
JP3176600B2 (ja) 2001-06-18
AU6165394A (en) 1994-08-15
JP3145120B2 (ja) 2001-03-12
ATE210967T1 (de) 2002-01-15
ES2165385T3 (es) 2002-03-16
PT683665E (pt) 2002-05-31
EP0683665B1 (de) 2001-12-19
EP0683665A4 (de) 1996-04-17
HK1013256A1 (en) 1999-08-20
JP2001010978A (ja) 2001-01-16
WO1994016683A1 (en) 1994-08-04
CA2154913A1 (en) 1994-08-04
EP0683665A1 (de) 1995-11-29
US5549915A (en) 1996-08-27
CA2154913C (en) 1999-10-19
JPH08506111A (ja) 1996-07-02

Similar Documents

Publication Publication Date Title
DE69429507D1 (de) Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung
CA2317019A1 (en) Magnetically responsive composition
DE69220641T2 (de) Thermoplastisch überzogene Eisenpulvermaterialien und Verfahren zu deren Herstellung
ATE179185T1 (de) Verbundmaterial mit kleinem durchmesser, welches ein wasserlösliches carboxylpolysaccharid und magnetisches eisenoxid enthaltet
DE69724589D1 (de) Phosphatbeschichtetes eisenpulver und verfahren zu dessen herstellung
GR3024898T3 (en) Monocrystalline particles of iron-oxide for application in medical diagnosis and therapy
EP0284549A3 (en) Magnetic fluid compositions
ATE192686T1 (de) Verfahren zum herstellen von pulver-vorformlingen und davon hergestellte schleifartikel
GB2035798A (en) Magnetic polymer particles
DE3171973D1 (en) Covalently bonded liposome-protein-compositions and method of producing them
HUT56878A (en) Process for producing new group of modified, high affinity antibodies suitable for treating cancer
EP0316159A3 (en) Porous composite materials and methods for preparing them
ATE216596T1 (de) Kolloidale radiomarkierte zusammensetzungen, deren anwendung und verfahren zu deren herstellung
EP0642507A4 (en) Catalytic antibodies against cocaine and methods of using and producing same.
HU9302312D0 (en) Process for producing bicycloaza-macrocyclo-phosphonic acids, conjugates and contrast materials containing them
DE236246T1 (de) Mischstoff innerhalb einer rohrfoermigen umhuellung enthaltend einen verdichteten stoff zur behandlung fluessiger metalle und verfahren zu seiner herstellung.
DE68927649D1 (de) Verfahren zur Herstellung von 3',4'-Anhydrovinblastin
ATE126461T1 (de) Eisen-basispulver, mischung daraus und herstellung dieser mischung.
HU900222D0 (en) Process for giving 5b-10, 45rh-103 isotops to ferrofluidic ferric oxide, advantageous stopping vital functions of cancerous cells
GB8330465D0 (en) Fr-900452 substance
UA18443A (uk) Спосіб обробки рідиhою твердих частиhок, переважhо граhул
MD614G2 (ro) Procedeu de obţinere a biomasei de spirulină
Ostrovka et al. Tertiary treatment of biologically purified aniline-dye industry sewage by pulverized active anthracite.
Yefimova et al. The Carburization of the Caterpillar-Track Link Bushings of Industrial Tractors in a Fluidized Bed
Yang Granular Bainite Discrimination by X-Ray Diffraction Method

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee