DE69430130D1 - Polypeptide von der semaphorin-genfamilie - Google Patents
Polypeptide von der semaphorin-genfamilieInfo
- Publication number
- DE69430130D1 DE69430130D1 DE69430130T DE69430130T DE69430130D1 DE 69430130 D1 DE69430130 D1 DE 69430130D1 DE 69430130 T DE69430130 T DE 69430130T DE 69430130 T DE69430130 T DE 69430130T DE 69430130 D1 DE69430130 D1 DE 69430130D1
- Authority
- DE
- Germany
- Prior art keywords
- semaphorin
- semaphorins
- nucleic acids
- cell growth
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0337—Genetically modified Arthropods
- A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/121,713 US5639856A (en) | 1993-09-13 | 1993-09-13 | Semaphorin gene family |
PCT/US1994/010151 WO1995007706A1 (en) | 1993-09-13 | 1994-09-13 | The semaphorin gene family |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430130D1 true DE69430130D1 (de) | 2002-04-18 |
DE69430130T2 DE69430130T2 (de) | 2002-08-22 |
Family
ID=22398364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430130T Expired - Lifetime DE69430130T2 (de) | 1993-09-13 | 1994-09-13 | Polypeptide von der semaphorin-genfamilie |
Country Status (11)
Country | Link |
---|---|
US (8) | US5639856A (de) |
EP (1) | EP0721342B1 (de) |
JP (1) | JP3544378B2 (de) |
AT (1) | ATE214286T1 (de) |
AU (1) | AU683494B2 (de) |
CA (1) | CA2171638C (de) |
DE (1) | DE69430130T2 (de) |
DK (1) | DK0721342T3 (de) |
ES (1) | ES2173922T3 (de) |
PT (1) | PT721342E (de) |
WO (1) | WO1995007706A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5654173A (en) * | 1996-08-23 | 1997-08-05 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1997020928A1 (fr) | 1995-12-06 | 1997-06-12 | Sumitomo Pharmaceuticals Company, Limited | Nouvelle semaphorine z et gene la codant |
US6566094B1 (en) * | 1996-09-11 | 2003-05-20 | Sumitomo Pharmaceuticals Company, Limited | Semaphorin gene: Semaphorin Y |
WO1998013493A2 (en) * | 1996-09-24 | 1998-04-02 | Lxr Biotechnology, Inc. | A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof |
US20070299005A1 (en) * | 1996-09-24 | 2007-12-27 | Tanox, Inc. | Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof |
WO1998015628A1 (fr) * | 1996-10-09 | 1998-04-16 | Sumitomo Pharmaceuticals Company, Limited | Nouveau gene de semaphorine: la semaphorine w |
EP0960888A4 (de) * | 1996-11-15 | 2002-10-16 | Sumitomo Pharma | Neue semaphorin-gene (i) |
EP0892047A3 (de) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Humanes und murines Semaphorin L |
US6428965B1 (en) * | 1997-07-17 | 2002-08-06 | The Johns Hopkins University | Screening assays for the interaction of semaphorins and neuropilins |
US20030170795A1 (en) * | 1997-09-18 | 2003-09-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6562949B1 (en) | 1997-10-28 | 2003-05-13 | Immunex Corporation | Antibodies to viral encoded semaphorin protein receptor polypeptides |
EP1027436A1 (de) * | 1997-10-28 | 2000-08-16 | Immunex Corporation | Rezeptor für viral kodiertes semaphorin protein; polypeptide und dna dafür kodierend |
US7214497B2 (en) | 1997-10-28 | 2007-05-08 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
US6130068A (en) | 1998-10-26 | 2000-10-10 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
US6635421B1 (en) * | 1997-12-09 | 2003-10-21 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
EP1046650A4 (de) | 1997-12-22 | 2001-12-19 | Ono Pharmaceutical Co | Peptide, verfahren zum testen auf humanes pepsinogen ii oder humanes pepsin ii, sowie testsystem |
JPH11187882A (ja) * | 1997-12-26 | 1999-07-13 | Ono Pharmaceut Co Ltd | 新規なポリペプチド、その製造方法、そのポリペプチドをコードするcDNA、そのcDNAからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物 |
EP0933425A1 (de) * | 1998-01-30 | 1999-08-04 | Smithkline Beecham Plc | Der Semaphorinfamilie zugehörige Polypeptide und Polynukleotide |
WO1999038885A2 (en) * | 1998-01-30 | 1999-08-05 | Smithkline Beecham Plc | Sbsemvl polypeptides, being members of the semaphorin protein family, and polynucleotides encoding the same |
US20030166132A1 (en) * | 1998-08-26 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6900288B1 (en) | 1998-11-26 | 2005-05-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Human semaphorin 6A-1 (SEMA6A-A), a gene involved in neuronal development and regeneration mechanisms during apoptosis, and its use as a potential drug target |
EP1210368A2 (de) * | 1999-09-08 | 2002-06-05 | Immunex Corporation | Verwendung von semaphorin zur modulierung des zellausflusses |
US20080213878A1 (en) * | 1999-10-19 | 2008-09-04 | Gregory Donoho | Novel human membrane proteins and polynucleotides encoding the same |
US6750054B2 (en) * | 2000-05-18 | 2004-06-15 | Lexicon Genetics Incorporated | Human semaphorin homologs and polynucleotides encoding the same |
AU1450101A (en) * | 1999-11-02 | 2001-05-14 | Zymogenetics Inc. | Human semaphorin |
WO2001038491A2 (en) * | 1999-11-08 | 2001-05-31 | The General Hospital Corporation | Novel semaphorin domains |
CA2403636A1 (en) * | 2000-03-20 | 2001-09-27 | Lexicon Genetics Incorporated | Human secreted proteins and polynucleotides encoding the same |
WO2001090179A2 (en) * | 2000-05-23 | 2001-11-29 | Lexicon Genetics Incorporated | Novel human thrombospondin-like proteins and polynucleotides encoding the same |
DE60130769T2 (de) * | 2000-07-28 | 2008-07-17 | Dainippon Sumitomo Pharma Co., Ltd. | Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten |
EP1418834A4 (de) * | 2001-07-20 | 2007-04-04 | Sinai School Medicine | Verfahren zur diagnose und behandlung von alzheimer-krankheit und parkinson-krankheit |
EP1429801A1 (de) * | 2001-09-26 | 2004-06-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Neuropilin als neuer therapeutischen zielpunkt zur modulation von immunantworten |
US7781413B2 (en) * | 2001-10-31 | 2010-08-24 | Board Of Regents, The University Of Texas System | SEMA3B inhibits tumor growth and induces apoptosis in cancer cells |
EP1572907A2 (de) * | 2002-02-04 | 2005-09-14 | The Johns Hopkins University | Mit casl(mical)-polynukleotiden, -polypeptiden wechselwirkende moleküle sowie verfahren zu deren verwendung |
EP1442749A1 (de) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verwendung von einem Antikörper gegen CD100 für die Diagnose und die Behandlung von einer entzündlichen Krankheit des Zentralnervensystems |
FR2876913A1 (fr) * | 2004-10-22 | 2006-04-28 | Centre Nat Rech Scient | Modulation de la transmission synaptique par les semaphorines et ses applications |
DE602008004296D1 (de) | 2007-02-14 | 2011-02-17 | Vaccinex Inc | Humanisierte anti-cd100-antikörper |
NZ618067A (en) | 2009-05-08 | 2015-07-31 | Vaccinex Inc | Anti-cd100 antibodies and methods for using the same |
WO2013055922A1 (en) | 2011-10-11 | 2013-04-18 | Vaccinex, Inc. | Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability |
US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
US9975933B2 (en) * | 2013-05-23 | 2018-05-22 | Ajou University Industry-Academic Cooperation Foundation | Tumor tissue-penetrating peptide specific to neuropilin and fusion protein having same peptide fused therein |
CA2916245C (en) | 2013-06-25 | 2023-01-24 | Vaccinex, Inc. | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases |
NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
EP3262064A1 (de) | 2015-02-23 | 2018-01-03 | Seagull Therapeutics SAS | Nichtnatürliche semaphorine 3 und deren medizinische verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA40572C2 (uk) * | 1991-06-24 | 2001-08-15 | Чірон Корпорейшн | Поліпептид, що містить укорочену послідовність вірусу гепатиту с, ізольований епітоп, реагент для імуноаналізу на вірус гепатиту с (варіанти), спосіб виявлення наявності антитіл (варіанти) |
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5416197A (en) * | 1993-10-15 | 1995-05-16 | Trustees Of The University Of Pennsylvania | Antibodies which bind human collapsin |
US5807806A (en) * | 1997-06-12 | 1998-09-15 | Nippon Soda Co., Ltd. | Benzoylpyrazole derivatives having specific substituents and herbicide |
-
1993
- 1993-09-13 US US08/121,713 patent/US5639856A/en not_active Expired - Lifetime
-
1994
- 1994-09-13 AT AT94928057T patent/ATE214286T1/de active
- 1994-09-13 PT PT94928057T patent/PT721342E/pt unknown
- 1994-09-13 ES ES94928057T patent/ES2173922T3/es not_active Expired - Lifetime
- 1994-09-13 AU AU77240/94A patent/AU683494B2/en not_active Ceased
- 1994-09-13 WO PCT/US1994/010151 patent/WO1995007706A1/en active IP Right Grant
- 1994-09-13 CA CA002171638A patent/CA2171638C/en not_active Expired - Fee Related
- 1994-09-13 JP JP50926195A patent/JP3544378B2/ja not_active Expired - Fee Related
- 1994-09-13 EP EP94928057A patent/EP0721342B1/de not_active Expired - Lifetime
- 1994-09-13 DK DK94928057T patent/DK0721342T3/da active
- 1994-09-13 DE DE69430130T patent/DE69430130T2/de not_active Expired - Lifetime
-
1997
- 1997-04-08 US US08/833,391 patent/US6013781A/en not_active Expired - Fee Related
- 1997-04-08 US US08/835,268 patent/US5807826A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 US US09/060,692 patent/US5935865A/en not_active Expired - Lifetime
- 1998-04-15 US US09/060,610 patent/US6344544B1/en not_active Expired - Fee Related
-
2002
- 2002-02-04 US US10/067,632 patent/US7153936B2/en not_active Expired - Fee Related
-
2006
- 2006-10-12 US US11/580,373 patent/US20070033669A1/en not_active Abandoned
-
2007
- 2007-06-14 US US11/763,394 patent/US20080312158A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2171638A1 (en) | 1995-03-23 |
US5639856A (en) | 1997-06-17 |
DK0721342T3 (da) | 2002-07-15 |
US6013781A (en) | 2000-01-11 |
US6344544B1 (en) | 2002-02-05 |
EP0721342A1 (de) | 1996-07-17 |
US5807826A (en) | 1998-09-15 |
ES2173922T3 (es) | 2002-11-01 |
WO1995007706A1 (en) | 1995-03-23 |
EP0721342B1 (de) | 2002-03-13 |
US5935865A (en) | 1999-08-10 |
DE69430130T2 (de) | 2002-08-22 |
AU7724094A (en) | 1995-04-03 |
EP0721342A4 (de) | 1998-07-29 |
AU683494B2 (en) | 1997-11-13 |
PT721342E (pt) | 2002-09-30 |
JP3544378B2 (ja) | 2004-07-21 |
US7153936B2 (en) | 2006-12-26 |
JPH09505725A (ja) | 1997-06-10 |
US20080312158A1 (en) | 2008-12-18 |
ATE214286T1 (de) | 2002-03-15 |
US20030166849A1 (en) | 2003-09-04 |
CA2171638C (en) | 2001-05-29 |
US20070033669A1 (en) | 2007-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |