DE69430130D1 - Polypeptide von der semaphorin-genfamilie - Google Patents

Polypeptide von der semaphorin-genfamilie

Info

Publication number
DE69430130D1
DE69430130D1 DE69430130T DE69430130T DE69430130D1 DE 69430130 D1 DE69430130 D1 DE 69430130D1 DE 69430130 T DE69430130 T DE 69430130T DE 69430130 T DE69430130 T DE 69430130T DE 69430130 D1 DE69430130 D1 DE 69430130D1
Authority
DE
Germany
Prior art keywords
semaphorin
semaphorins
nucleic acids
cell growth
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430130T
Other languages
English (en)
Other versions
DE69430130T2 (de
Inventor
Corey S Goodman
Alex L Kolodkin
David Matthes
David R Bentley
Timothy O'connor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69430130D1 publication Critical patent/DE69430130D1/de
Application granted granted Critical
Publication of DE69430130T2 publication Critical patent/DE69430130T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0337—Genetically modified Arthropods
    • A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
DE69430130T 1993-09-13 1994-09-13 Polypeptide von der semaphorin-genfamilie Expired - Lifetime DE69430130T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/121,713 US5639856A (en) 1993-09-13 1993-09-13 Semaphorin gene family
PCT/US1994/010151 WO1995007706A1 (en) 1993-09-13 1994-09-13 The semaphorin gene family

Publications (2)

Publication Number Publication Date
DE69430130D1 true DE69430130D1 (de) 2002-04-18
DE69430130T2 DE69430130T2 (de) 2002-08-22

Family

ID=22398364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430130T Expired - Lifetime DE69430130T2 (de) 1993-09-13 1994-09-13 Polypeptide von der semaphorin-genfamilie

Country Status (11)

Country Link
US (8) US5639856A (de)
EP (1) EP0721342B1 (de)
JP (1) JP3544378B2 (de)
AT (1) ATE214286T1 (de)
AU (1) AU683494B2 (de)
CA (1) CA2171638C (de)
DE (1) DE69430130T2 (de)
DK (1) DK0721342T3 (de)
ES (1) ES2173922T3 (de)
PT (1) PT721342E (de)
WO (1) WO1995007706A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5654173A (en) * 1996-08-23 1997-08-05 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
JP4129992B2 (ja) 1995-12-06 2008-08-06 大日本住友製薬株式会社 新規セマフォリンｚおよびそれをコードする遺伝子
US6566094B1 (en) * 1996-09-11 2003-05-20 Sumitomo Pharmaceuticals Company, Limited Semaphorin gene: Semaphorin Y
PT932678E (pt) * 1996-09-24 2006-07-31 Tanox Inc Familia de genes que codificam peptidos relacionados com apoptose, peptidos por eles codificados e metodos para sua utilizacao
US20070299005A1 (en) * 1996-09-24 2007-12-27 Tanox, Inc. Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
US6902730B1 (en) 1996-10-09 2005-06-07 Sumitomo Pharmaceuticals Company, Limited Semaphorin gene: Semaphorin W
US6436669B1 (en) * 1996-11-15 2002-08-20 Sumitomo Pharmaceuticals Company, Limited Semaphorin genes (I)
EP0892047A3 (de) * 1997-07-09 2000-03-08 Hoechst Marion Roussel Deutschland GmbH Humanes und murines Semaphorin L
US6428965B1 (en) * 1997-07-17 2002-08-06 The Johns Hopkins University Screening assays for the interaction of semaphorins and neuropilins
US20030170794A1 (en) * 1997-09-18 2003-09-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6130068A (en) 1998-10-26 2000-10-10 Immunex Corporation Viral encoded semaphorin protein receptor DNA and polypeptides
EP1027436A1 (de) * 1997-10-28 2000-08-16 Immunex Corporation Rezeptor für viral kodiertes semaphorin protein; polypeptide und dna dafür kodierend
US7214497B2 (en) 1997-10-28 2007-05-08 Immunex Corporation Viral encoded semaphorin protein receptor DNA and polypeptides
US6562949B1 (en) 1997-10-28 2003-05-13 Immunex Corporation Antibodies to viral encoded semaphorin protein receptor polypeptides
US6635421B1 (en) * 1997-12-09 2003-10-21 Children's Medical Center Corporation Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
KR20010033385A (ko) 1997-12-22 2001-04-25 오노 야꾸힝 고교 가부시키가이샤 펩티드, 사람 펩시노겐 ⅱ 또는 사람 펩신 ⅱ의 측정 방법및 측정용 키트
JPH11187882A (ja) * 1997-12-26 1999-07-13 Ono Pharmaceut Co Ltd 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｃＤＮＡ、そのｃＤＮＡからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物
EP1066317A2 (de) * 1998-01-30 2001-01-10 Smithkline Beecham Plc Sbsemvl polypeptide, die der semaphorin protein familie angehören, und die dafür kodierenden polynukleotide
EP0933425A1 (de) * 1998-01-30 1999-08-04 Smithkline Beecham Plc Der Semaphorinfamilie zugehörige Polypeptide und Polynukleotide
US20030166132A1 (en) * 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1135488A1 (de) 1998-11-26 2001-09-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Menschliches semaphorin 6a-1 (sema6a-1), ein gen das beteiligt ist an die neuronal-entwicklung und regenerationsmechanismen während apoptosis, und dessen anwendung als potentielles arzneimittel-ziel
US20020049312A1 (en) * 2000-05-23 2002-04-25 Turner C. Alexander Noel human thrombospondin-like proteins and polynucleotides encoding the same
CA2384104A1 (en) * 1999-09-08 2001-03-15 Melanie K. Spriggs Use of semaphorin for modulation of cellular efflux
US6750054B2 (en) 2000-05-18 2004-06-15 Lexicon Genetics Incorporated Human semaphorin homologs and polynucleotides encoding the same
US20080213878A1 (en) * 1999-10-19 2008-09-04 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
WO2001032707A1 (en) * 1999-11-02 2001-05-10 Zymogenetics, Inc. Human semaphorin
WO2001038491A2 (en) * 1999-11-08 2001-05-31 The General Hospital Corporation Novel semaphorin domains
WO2001070806A2 (en) * 2000-03-20 2001-09-27 Lexicon Genetics Incorporated Human secreted proteins and polynucleotides encoding the same
AU2001276694A1 (en) * 2000-07-28 2002-02-13 Sumitomo Pharmaceuticals Company, Limited Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
WO2003007803A2 (en) * 2001-07-20 2003-01-30 Mount Sinai School Of Medicine Of New York University Methods for diagnosing and treating alzheimer's disease and parkinson's disease
EP1429801A1 (de) * 2001-09-26 2004-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Neuropilin als neuer therapeutischen zielpunkt zur modulation von immunantworten
US7781413B2 (en) * 2001-10-31 2010-08-24 Board Of Regents, The University Of Texas System SEMA3B inhibits tumor growth and induces apoptosis in cancer cells
WO2003066821A2 (en) * 2002-02-04 2003-08-14 The Johns Hopkins University Molecules interacting with casl (mical) polynucleotides, polypeptides, and methods of using the same
EP1442749A1 (de) 2003-01-31 2004-08-04 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verwendung von einem Antikörper gegen CD100 für die Diagnose und die Behandlung von einer entzündlichen Krankheit des Zentralnervensystems
FR2876913A1 (fr) * 2004-10-22 2006-04-28 Centre Nat Rech Scient Modulation de la transmission synaptique par les semaphorines et ses applications
EP2069404B1 (de) 2007-02-14 2011-01-05 Vaccinex, Inc. Humanisierte anti-cd100-antikörper
KR101754433B1 (ko) 2009-05-08 2017-07-05 백시넥스 인코포레이티드 항-ｃｄ100 항체 및 이의 사용 방법
DK2766093T3 (en) 2011-10-11 2018-06-06 Vaccinex Inc USE OF SEMAPHORIN-4D BINDING MOLECULES FOR MODULATING THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
KR101551299B1 (ko) * 2013-05-23 2015-09-10 아주대학교산학협력단 뉴로필린에 특이적인 종양 침투성 펩타이드 및 이 펩타이드가 융합된 융합 단백질
DK3013350T3 (da) 2013-06-25 2020-04-14 Vaccinex Inc Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
US10906948B2 (en) 2015-02-23 2021-02-02 Seagull Therapeutics Sas Non-natural Semaphorins 3 and their medical use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2148587C1 (ru) * 1991-06-24 2000-05-10 Чирон Корпорейшн Полипептид и способ его получения, реагент для иммуноанализа, способ определения присутствия антител и способ индукции иммунного ответа
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5416197A (en) * 1993-10-15 1995-05-16 Trustees Of The University Of Pennsylvania Antibodies which bind human collapsin
US5807806A (en) * 1997-06-12 1998-09-15 Nippon Soda Co., Ltd. Benzoylpyrazole derivatives having specific substituents and herbicide

Also Published As

Publication number Publication date
ES2173922T3 (es) 2002-11-01
JP3544378B2 (ja) 2004-07-21
AU7724094A (en) 1995-04-03
ATE214286T1 (de) 2002-03-15
US6013781A (en) 2000-01-11
US20070033669A1 (en) 2007-02-08
EP0721342B1 (de) 2002-03-13
WO1995007706A1 (en) 1995-03-23
EP0721342A4 (de) 1998-07-29
US6344544B1 (en) 2002-02-05
US5935865A (en) 1999-08-10
US5807826A (en) 1998-09-15
EP0721342A1 (de) 1996-07-17
CA2171638C (en) 2001-05-29
US5639856A (en) 1997-06-17
US20030166849A1 (en) 2003-09-04
CA2171638A1 (en) 1995-03-23
US7153936B2 (en) 2006-12-26
JPH09505725A (ja) 1997-06-10
DK0721342T3 (da) 2002-07-15
AU683494B2 (en) 1997-11-13
DE69430130T2 (de) 2002-08-22
PT721342E (pt) 2002-09-30
US20080312158A1 (en) 2008-12-18

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