DE69430130T2 - Polypeptide von der semaphorin-genfamilie - Google Patents
Polypeptide von der semaphorin-genfamilieInfo
- Publication number
- DE69430130T2 DE69430130T2 DE69430130T DE69430130T DE69430130T2 DE 69430130 T2 DE69430130 T2 DE 69430130T2 DE 69430130 T DE69430130 T DE 69430130T DE 69430130 T DE69430130 T DE 69430130T DE 69430130 T2 DE69430130 T2 DE 69430130T2
- Authority
- DE
- Germany
- Prior art keywords
- semaphorin
- semaphorins
- nucleic acids
- cell growth
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0337—Genetically modified Arthropods
- A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/121,713 US5639856A (en) | 1993-09-13 | 1993-09-13 | Semaphorin gene family |
PCT/US1994/010151 WO1995007706A1 (en) | 1993-09-13 | 1994-09-13 | The semaphorin gene family |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430130D1 DE69430130D1 (de) | 2002-04-18 |
DE69430130T2 true DE69430130T2 (de) | 2002-08-22 |
Family
ID=22398364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430130T Expired - Lifetime DE69430130T2 (de) | 1993-09-13 | 1994-09-13 | Polypeptide von der semaphorin-genfamilie |
Country Status (11)
Country | Link |
---|---|
US (8) | US5639856A (de) |
EP (1) | EP0721342B1 (de) |
JP (1) | JP3544378B2 (de) |
AT (1) | ATE214286T1 (de) |
AU (1) | AU683494B2 (de) |
CA (1) | CA2171638C (de) |
DE (1) | DE69430130T2 (de) |
DK (1) | DK0721342T3 (de) |
ES (1) | ES2173922T3 (de) |
PT (1) | PT721342E (de) |
WO (1) | WO1995007706A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5654173A (en) * | 1996-08-23 | 1997-08-05 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
DE69637846D1 (de) | 1995-12-06 | 2009-04-09 | Dainippon Sumitomo Pharma Co | Neues semaphorin z und dafür kodierendes gen |
WO1998011216A1 (fr) * | 1996-09-11 | 1998-03-19 | Sumitomo Pharmaceuticals Company, Limited | Nouveau gene de semaphorine: semaphorine y |
PT932678E (pt) * | 1996-09-24 | 2006-07-31 | Tanox Inc | Familia de genes que codificam peptidos relacionados com apoptose, peptidos por eles codificados e metodos para sua utilizacao |
US20070299005A1 (en) * | 1996-09-24 | 2007-12-27 | Tanox, Inc. | Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof |
WO1998015628A1 (fr) | 1996-10-09 | 1998-04-16 | Sumitomo Pharmaceuticals Company, Limited | Nouveau gene de semaphorine: la semaphorine w |
US6436669B1 (en) * | 1996-11-15 | 2002-08-20 | Sumitomo Pharmaceuticals Company, Limited | Semaphorin genes (I) |
EP0892047A3 (de) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Humanes und murines Semaphorin L |
US6428965B1 (en) * | 1997-07-17 | 2002-08-06 | The Johns Hopkins University | Screening assays for the interaction of semaphorins and neuropilins |
US20030166108A1 (en) * | 1997-09-18 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6130068A (en) | 1998-10-26 | 2000-10-10 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
EP1027436A1 (de) * | 1997-10-28 | 2000-08-16 | Immunex Corporation | Rezeptor für viral kodiertes semaphorin protein; polypeptide und dna dafür kodierend |
US7214497B2 (en) | 1997-10-28 | 2007-05-08 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
US6562949B1 (en) | 1997-10-28 | 2003-05-13 | Immunex Corporation | Antibodies to viral encoded semaphorin protein receptor polypeptides |
US6635421B1 (en) * | 1997-12-09 | 2003-10-21 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
EP1046650A4 (de) | 1997-12-22 | 2001-12-19 | Ono Pharmaceutical Co | Peptide, verfahren zum testen auf humanes pepsinogen ii oder humanes pepsin ii, sowie testsystem |
JPH11187882A (ja) * | 1997-12-26 | 1999-07-13 | Ono Pharmaceut Co Ltd | 新規なポリペプチド、その製造方法、そのポリペプチドをコードするcDNA、そのcDNAからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物 |
EP0933425A1 (de) * | 1998-01-30 | 1999-08-04 | Smithkline Beecham Plc | Der Semaphorinfamilie zugehörige Polypeptide und Polynukleotide |
EP1066317A2 (de) * | 1998-01-30 | 2001-01-10 | Smithkline Beecham Plc | Sbsemvl polypeptide, die der semaphorin protein familie angehören, und die dafür kodierenden polynukleotide |
US7339033B2 (en) * | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
EP1135488A1 (de) | 1998-11-26 | 2001-09-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Menschliches semaphorin 6a-1 (sema6a-1), ein gen das beteiligt ist an die neuronal-entwicklung und regenerationsmechanismen während apoptosis, und dessen anwendung als potentielles arzneimittel-ziel |
CA2384104A1 (en) * | 1999-09-08 | 2001-03-15 | Melanie K. Spriggs | Use of semaphorin for modulation of cellular efflux |
US20080213878A1 (en) * | 1999-10-19 | 2008-09-04 | Gregory Donoho | Novel human membrane proteins and polynucleotides encoding the same |
AU1450101A (en) * | 1999-11-02 | 2001-05-14 | Zymogenetics Inc. | Human semaphorin |
WO2001038491A2 (en) * | 1999-11-08 | 2001-05-31 | The General Hospital Corporation | Novel semaphorin domains |
EP1268538A2 (de) * | 2000-03-20 | 2003-01-02 | Lexicon Genetics Incorporated | Menschliche sekretierte proteine und deren kodierende poloynukleinsäuren |
WO2001088133A2 (en) * | 2000-05-18 | 2001-11-22 | Lexicon Genetics Incorporated | Human semaphorin homologs and polynucleotides encoding the same |
WO2001090179A2 (en) * | 2000-05-23 | 2001-11-29 | Lexicon Genetics Incorporated | Novel human thrombospondin-like proteins and polynucleotides encoding the same |
DE60130769T2 (de) * | 2000-07-28 | 2008-07-17 | Dainippon Sumitomo Pharma Co., Ltd. | Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten |
EP1418834A4 (de) * | 2001-07-20 | 2007-04-04 | Sinai School Medicine | Verfahren zur diagnose und behandlung von alzheimer-krankheit und parkinson-krankheit |
WO2003035100A1 (en) * | 2001-09-26 | 2003-05-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Neuropilin as a novel therapeutic target for modulation of immune reponses |
US7781413B2 (en) * | 2001-10-31 | 2010-08-24 | Board Of Regents, The University Of Texas System | SEMA3B inhibits tumor growth and induces apoptosis in cancer cells |
US20030232419A1 (en) * | 2002-02-04 | 2003-12-18 | Kolodkin Alex L. | Molecules interacting with CASL (MICAL) polynucleotides, polypeptides, and methods of using the same |
EP1442749A1 (de) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verwendung von einem Antikörper gegen CD100 für die Diagnose und die Behandlung von einer entzündlichen Krankheit des Zentralnervensystems |
FR2876913A1 (fr) * | 2004-10-22 | 2006-04-28 | Centre Nat Rech Scient | Modulation de la transmission synaptique par les semaphorines et ses applications |
WO2008100995A1 (en) | 2007-02-14 | 2008-08-21 | Vaccinex, Inc. | Humanized anti-cd100 antibodies |
KR20170080705A (ko) | 2009-05-08 | 2017-07-10 | 백시넥스 인코포레이티드 | 항-cd100 항체 및 이의 사용 방법 |
JP6395606B2 (ja) | 2011-10-11 | 2018-09-26 | バクシネックス インコーポレーティッド | 血液脳関門透過性の調節のためのセマフォリン−4d結合分子の使用 |
US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
JP6391676B2 (ja) * | 2013-05-23 | 2018-09-19 | アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションAjou University Industry−Academic Cooperation Foundation | ニューロピリンに特異的な腫瘍浸透性ペプチド及びこのペプチドが融合された融合タンパク質 |
PT3013350T (pt) | 2013-06-25 | 2020-04-08 | Vaccinex Inc | Utilização de moléculas inibitórias de semaforina-4d em combinação com uma terapia de imunomodulação para inibir o crescimento e metástase de um tumor |
NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
EP3262064A1 (de) | 2015-02-23 | 2018-01-03 | Seagull Therapeutics SAS | Nichtnatürliche semaphorine 3 und deren medizinische verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2148587C1 (ru) * | 1991-06-24 | 2000-05-10 | Чирон Корпорейшн | Полипептид и способ его получения, реагент для иммуноанализа, способ определения присутствия антител и способ индукции иммунного ответа |
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5416197A (en) * | 1993-10-15 | 1995-05-16 | Trustees Of The University Of Pennsylvania | Antibodies which bind human collapsin |
US5807806A (en) * | 1997-06-12 | 1998-09-15 | Nippon Soda Co., Ltd. | Benzoylpyrazole derivatives having specific substituents and herbicide |
-
1993
- 1993-09-13 US US08/121,713 patent/US5639856A/en not_active Expired - Lifetime
-
1994
- 1994-09-13 WO PCT/US1994/010151 patent/WO1995007706A1/en active IP Right Grant
- 1994-09-13 AT AT94928057T patent/ATE214286T1/de active
- 1994-09-13 CA CA002171638A patent/CA2171638C/en not_active Expired - Fee Related
- 1994-09-13 EP EP94928057A patent/EP0721342B1/de not_active Expired - Lifetime
- 1994-09-13 AU AU77240/94A patent/AU683494B2/en not_active Ceased
- 1994-09-13 DE DE69430130T patent/DE69430130T2/de not_active Expired - Lifetime
- 1994-09-13 DK DK94928057T patent/DK0721342T3/da active
- 1994-09-13 JP JP50926195A patent/JP3544378B2/ja not_active Expired - Fee Related
- 1994-09-13 PT PT94928057T patent/PT721342E/pt unknown
- 1994-09-13 ES ES94928057T patent/ES2173922T3/es not_active Expired - Lifetime
-
1997
- 1997-04-08 US US08/833,391 patent/US6013781A/en not_active Expired - Fee Related
- 1997-04-08 US US08/835,268 patent/US5807826A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 US US09/060,610 patent/US6344544B1/en not_active Expired - Fee Related
- 1998-04-15 US US09/060,692 patent/US5935865A/en not_active Expired - Lifetime
-
2002
- 2002-02-04 US US10/067,632 patent/US7153936B2/en not_active Expired - Fee Related
-
2006
- 2006-10-12 US US11/580,373 patent/US20070033669A1/en not_active Abandoned
-
2007
- 2007-06-14 US US11/763,394 patent/US20080312158A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080312158A1 (en) | 2008-12-18 |
AU7724094A (en) | 1995-04-03 |
US6344544B1 (en) | 2002-02-05 |
US6013781A (en) | 2000-01-11 |
EP0721342A4 (de) | 1998-07-29 |
AU683494B2 (en) | 1997-11-13 |
US5807826A (en) | 1998-09-15 |
DK0721342T3 (da) | 2002-07-15 |
US20070033669A1 (en) | 2007-02-08 |
CA2171638A1 (en) | 1995-03-23 |
ES2173922T3 (es) | 2002-11-01 |
EP0721342A1 (de) | 1996-07-17 |
CA2171638C (en) | 2001-05-29 |
DE69430130D1 (de) | 2002-04-18 |
US5935865A (en) | 1999-08-10 |
US20030166849A1 (en) | 2003-09-04 |
EP0721342B1 (de) | 2002-03-13 |
JP3544378B2 (ja) | 2004-07-21 |
JPH09505725A (ja) | 1997-06-10 |
WO1995007706A1 (en) | 1995-03-23 |
US5639856A (en) | 1997-06-17 |
PT721342E (pt) | 2002-09-30 |
ATE214286T1 (de) | 2002-03-15 |
US7153936B2 (en) | 2006-12-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |