DE69430573T2 - Test und reagentien zur identifizierung von antiproliferierenden stoffen - Google Patents

Test und reagentien zur identifizierung von antiproliferierenden stoffen

Info

Publication number
DE69430573T2
DE69430573T2 DE69430573T DE69430573T DE69430573T2 DE 69430573 T2 DE69430573 T2 DE 69430573T2 DE 69430573 T DE69430573 T DE 69430573T DE 69430573 T DE69430573 T DE 69430573T DE 69430573 T2 DE69430573 T2 DE 69430573T2
Authority
DE
Germany
Prior art keywords
cell
cycle
reagents
agent
identifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430573T
Other languages
English (en)
Other versions
DE69430573D1 (de
Inventor
Giulio Draetta
Guillaume Cottarel
Veronique Damagnez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GPC BIOTECH INC. (N.D.GES.D. STAATES DELAWARE), CA
Original Assignee
MITOTIX Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MITOTIX Inc filed Critical MITOTIX Inc
Application granted granted Critical
Publication of DE69430573D1 publication Critical patent/DE69430573D1/de
Publication of DE69430573T2 publication Critical patent/DE69430573T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
DE69430573T 1993-06-04 1994-06-06 Test und reagentien zur identifizierung von antiproliferierenden stoffen Expired - Fee Related DE69430573T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/073,383 US5443962A (en) 1993-06-04 1993-06-04 Methods of identifying inhibitors of cdc25 phosphatase
PCT/US1994/006365 WO1994028914A1 (en) 1993-06-04 1994-06-06 Assay and reagents for identifying anti-proliferative agents

Publications (2)

Publication Number Publication Date
DE69430573D1 DE69430573D1 (de) 2002-06-13
DE69430573T2 true DE69430573T2 (de) 2002-11-07

Family

ID=22113378

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430573T Expired - Fee Related DE69430573T2 (de) 1993-06-04 1994-06-06 Test und reagentien zur identifizierung von antiproliferierenden stoffen

Country Status (8)

Country Link
US (2) US5443962A (de)
EP (1) EP0708653B1 (de)
JP (1) JPH08510650A (de)
AT (1) ATE217190T1 (de)
AU (1) AU702174B2 (de)
CA (1) CA2163524C (de)
DE (1) DE69430573T2 (de)
WO (1) WO1994028914A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
AUPM516994A0 (en) * 1994-04-20 1994-05-12 Gene Shears Pty. Limited An in vivo gene expression system
US6037136A (en) * 1994-10-24 2000-03-14 Cold Spring Harbor Laboratory Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
US5801015A (en) * 1995-06-05 1998-09-01 Mitotix, Inc. Nucleic acid encoding a Candida cell cycle regulatory protein, TYP1 polypeptide
NO953680D0 (no) * 1995-09-18 1995-09-18 Hans Prydz Cellesyklusenzymer
US5972697A (en) * 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins
US7125677B2 (en) * 1995-11-13 2006-10-24 The Salk Institute For Biological Studies NIMA interacting proteins
US5861249A (en) * 1996-04-23 1999-01-19 Cold Spring Harbor Laboratory Assays and reagents for identifying modulators of cdc25-mediated mitotic activation
US6048693A (en) * 1996-10-16 2000-04-11 Bittech, Inc. Phenotypic assays of cyclin/cyclin-dependent kinase function
AU4858597A (en) * 1996-10-30 1998-05-22 National Research Council Of Canada (candida albicans) proteins associated with virulence and hyphal formation and uses thereof
DE69825066T2 (de) 1997-02-07 2005-08-25 Princeton University Gentechnisch hergestellte Proteinkinasen, welche modifizierte Nukleotidtriphosphatsubstrate verwenden können
US6227658B1 (en) * 1997-06-23 2001-05-08 Kabushiki Kaisha Toshiba Apparatus and method for forming thin film using ink-jet mechanism
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
CA2216559A1 (en) * 1997-09-25 1999-03-25 Michel Roberge G2 checkpoint inhibitors and assay
GB9722320D0 (en) * 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
ES2267873T3 (es) 1997-10-27 2007-03-16 Agouron Pharmaceuticals, Inc. Derivados de 4-aminotiazol, su preparacion y uso como inhibidores de kinasas dependientes de ciclina.
EP1049475A4 (de) 1998-01-08 2003-06-04 Univ California Aus meeresschwämmen -i(adocia) gewonnene kinesinmotor-modulatoren
JP2002507427A (ja) 1998-03-27 2002-03-12 ザ スクリップス リサーチ インスティテュート キナーゼＷｅｅｌ融合タンパク組成物、ヌクレオチド配列、発現系およびその利用法
DE19860834C1 (de) * 1998-12-30 2000-08-24 Albrecht E Sippel Methode zur zellulären High-Throughput-Detektion von nukleären Rezeptor-Liganden-Interaktionen
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (de) 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6610483B1 (en) * 1999-07-23 2003-08-26 Princeton University Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof
AU6394500A (en) * 1999-07-30 2001-02-19 Basf Bioresearch Corporation Native cdc25 substrates, compositions and uses related thereto
EP1259640A2 (de) * 1999-09-13 2002-11-27 Basf Aktiengesellschaft Methoden und zusammensetzungen zur durchmusterung von zellzyklusmodulatoren
DK1218494T3 (da) * 1999-09-22 2005-08-08 Canbas Co Ltd Præparater og fremgangsmåder til inhibering af C2-cellecyklusstandsning og sensibilisering af celler til DNA-beskadigende midler
FR2815347A1 (fr) * 1999-12-14 2002-04-19 Sod Conseils Rech Applic METHODE D'OBTENTION DE LA PHOSPHATASE Cdc25C HUMAINE ET METHODE D'IDENTIFICATION DE MODULATEURS DE LA PHOSPHATASE Cdc25C HUMAINE
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
KR100560701B1 (ko) 2003-11-03 2006-03-16 씨제이 주식회사 Ｃｄｃ25Ｂ 포스파타제 과발현 유도가능한 세포주를사용한 ｃｄｃ25Ｂ 억제제 스크리닝 방법
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
WO2007127002A2 (en) * 2006-03-31 2007-11-08 Cell Signaling Technology, Inc. Protein markers of responsiveness to type iii receptor tyrosine kinase inhibitors
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
KR100887246B1 (ko) 2007-11-22 2009-03-06 건국대학교 산학협력단 예쁜꼬마선충을 이용한 세포주기 조절인자 억제제 스크리닝방법
CN114958609B (zh) * 2022-05-11 2023-10-20 西南民族大学 调控dna复制或修复的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06507787A (ja) * 1991-05-16 1994-09-08 コールド スプリング ハーバー ラボラトリー Ｄ−型サイクリン並びにそれに関連する使用方法
ATE273386T1 (de) * 1991-09-20 2004-08-15 Hutchinson Fred Cancer Res Menschliches cyclin e
US5262409A (en) * 1991-10-11 1993-11-16 Fred Hutchinson Cancer Research Center Binary tumor therapy
US5294538A (en) * 1991-11-18 1994-03-15 Cold Spring Harbor Labs. Method of screening for antimitotic compounds using the CDC25 tyrosine phosphatase
US5441880A (en) * 1991-11-18 1995-08-15 Cold Spring Harbor Laboratory Human cdc25 genes, encoded products and uses thereof
EP0633933A1 (de) * 1992-03-23 1995-01-18 Imperial Cancer Research Technology Limited Leucin-zipper
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase

Also Published As

Publication number Publication date
US5443962A (en) 1995-08-22
JPH08510650A (ja) 1996-11-12
AU7055194A (en) 1995-01-03
EP0708653B1 (de) 2002-05-08
EP0708653A4 (de) 1998-11-18
ATE217190T1 (de) 2002-05-15
EP0708653A1 (de) 1996-05-01
WO1994028914A1 (en) 1994-12-22
CA2163524A1 (en) 1994-12-22
US6251585B1 (en) 2001-06-26
DE69430573D1 (de) 2002-06-13
CA2163524C (en) 2003-04-08
AU702174B2 (en) 1999-02-18

Similar Documents

Publication Publication Date Title
DE69430573D1 (de) Test und reagentien zur identifizierung von antiproliferierenden stoffen
ES2157220T3 (es) Aparato de ensayo analitico con control negativo y positivo incorporado.
DE69522831D1 (de) Assays und vorrichtungen zum nachweis von extrahepatischer biliäreratresie
ES2054617T3 (es) Nuevo metodo para la deteccion y/o determinacion cuantitativa de agentes ligantes especificos y sus correspondientes sustancias ligables.
CY1111229T1 (el) Μεθοδος προσδιορισμου ρευματοειδους αρθριτιδας με μετρηση αντι-ccp και ιντερλευκλινης 6
ATE241139T1 (de) Vorrichtung zur durchführung eines oder mehrerer kompetitiver immunoassays
ATE403153T1 (de) Test zum direkten nachweisen einer rs virus bezogenen biologischen zelle in einer körperflüssigkeitsprobe
DE69838090D1 (de) Mehrgefässplatten mit kleiner störstrahlung für fluoreszenzmessungen von biologischen und biochemischen proben
PL1721162T3 (pl) Sposób oceny reumatoidalnego zapalenia stawów przez pomiar anty-CCP oraz amyloidu A w surowicy
ES2109802T3 (es) Dispositivo de ensayo y su fabricacion.
DE60013320D1 (de) Analytassay-vorrichtung mit vorabsorbieren-zone
DE60029413D1 (de) Enzymatische messung von mycophenolsäure
ATE243758T1 (de) Testverfahren und testsatz zur diagnose von autoimmunerkrankungen
ES2161011T3 (es) Reactivos para ensayo de ion diazonio y metodos para su utilizacion.
DE69132144D1 (de) Menschliche phospholipase aktivierender proteinteil
Draetta et al. Methods of identifying inhibitors of cdc25 phosphatase
AU2836299A (en) Use of 14-3-3 proteins as sensitive biological markers for detecting pollution caused, inter alia, by polychlorinated biphenyl (pcb) and (xeno)oestrogen and method for quick determination of 14-3-3 proteins
ES2121756T3 (es) Analisis enzimatico y equipo de analisis para medir la activacion celular.
DE59910326D1 (de) Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
BR0215452A (pt) Teste de proteìna tirosina-fosfatase (ptpase) altamente sensitivo com o emprego de 6,8-diflúor-4-metil-umbeliferilfosfato

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GPC BIOTECH INC. (N.D.GES.D. STAATES DELAWARE), CA

8339 Ceased/non-payment of the annual fee