DE69430573T2 - Test und reagentien zur identifizierung von antiproliferierenden stoffen - Google Patents
Test und reagentien zur identifizierung von antiproliferierenden stoffenInfo
- Publication number
- DE69430573T2 DE69430573T2 DE69430573T DE69430573T DE69430573T2 DE 69430573 T2 DE69430573 T2 DE 69430573T2 DE 69430573 T DE69430573 T DE 69430573T DE 69430573 T DE69430573 T DE 69430573T DE 69430573 T2 DE69430573 T2 DE 69430573T2
- Authority
- DE
- Germany
- Prior art keywords
- cell
- cycle
- reagents
- agent
- identifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/073,383 US5443962A (en) | 1993-06-04 | 1993-06-04 | Methods of identifying inhibitors of cdc25 phosphatase |
PCT/US1994/006365 WO1994028914A1 (en) | 1993-06-04 | 1994-06-06 | Assay and reagents for identifying anti-proliferative agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430573D1 DE69430573D1 (de) | 2002-06-13 |
DE69430573T2 true DE69430573T2 (de) | 2002-11-07 |
Family
ID=22113378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430573T Expired - Fee Related DE69430573T2 (de) | 1993-06-04 | 1994-06-06 | Test und reagentien zur identifizierung von antiproliferierenden stoffen |
Country Status (8)
Country | Link |
---|---|
US (2) | US5443962A (de) |
EP (1) | EP0708653B1 (de) |
JP (1) | JPH08510650A (de) |
AT (1) | ATE217190T1 (de) |
AU (1) | AU702174B2 (de) |
CA (1) | CA2163524C (de) |
DE (1) | DE69430573T2 (de) |
WO (1) | WO1994028914A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443962A (en) * | 1993-06-04 | 1995-08-22 | Mitotix, Inc. | Methods of identifying inhibitors of cdc25 phosphatase |
AUPM516994A0 (en) * | 1994-04-20 | 1994-05-12 | Gene Shears Pty. Limited | An in vivo gene expression system |
US6037136A (en) * | 1994-10-24 | 2000-03-14 | Cold Spring Harbor Laboratory | Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto |
US5801015A (en) * | 1995-06-05 | 1998-09-01 | Mitotix, Inc. | Nucleic acid encoding a Candida cell cycle regulatory protein, TYP1 polypeptide |
NO953680D0 (no) * | 1995-09-18 | 1995-09-18 | Hans Prydz | Cellesyklusenzymer |
US5972697A (en) * | 1995-11-13 | 1999-10-26 | The Salk Institute For Biological Studies | NIMA interacting proteins |
US7125677B2 (en) * | 1995-11-13 | 2006-10-24 | The Salk Institute For Biological Studies | NIMA interacting proteins |
US5861249A (en) * | 1996-04-23 | 1999-01-19 | Cold Spring Harbor Laboratory | Assays and reagents for identifying modulators of cdc25-mediated mitotic activation |
US6048693A (en) * | 1996-10-16 | 2000-04-11 | Bittech, Inc. | Phenotypic assays of cyclin/cyclin-dependent kinase function |
WO1998018927A1 (en) * | 1996-10-30 | 1998-05-07 | National Research Council Of Canada | Candida albicans proteins associated with virulence and hyphal formation and uses thereof |
WO1998035048A2 (en) | 1997-02-07 | 1998-08-13 | Princeton University | Engineered protein kinases which can utilize modified nucleotide triphosphate substrates |
US6227658B1 (en) * | 1997-06-23 | 2001-05-08 | Kabushiki Kaisha Toshiba | Apparatus and method for forming thin film using ink-jet mechanism |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
CA2216559A1 (en) * | 1997-09-25 | 1999-03-25 | Michel Roberge | G2 checkpoint inhibitors and assay |
GB9722320D0 (en) * | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
TR200001081T2 (tr) * | 1997-10-27 | 2000-10-23 | Agouron Pharmaceuticals, Inc. | CDKS inhibitörleri olarak ikame edilmiş 4-amino tiyazol-2-il bileşikleri |
EP1049475A4 (de) | 1998-01-08 | 2003-06-04 | Univ California | Aus meeresschwämmen -i(adocia) gewonnene kinesinmotor-modulatoren |
ES2286882T3 (es) * | 1998-03-27 | 2007-12-01 | The Scripps Research Institute | Composiciones de proteina de fusion de quinasa wee1, secuencias de nucleotidos, sistemas de expresion y procedimientos de uso. |
DE19860834C1 (de) | 1998-12-30 | 2000-08-24 | Albrecht E Sippel | Methode zur zellulären High-Throughput-Detektion von nukleären Rezeptor-Liganden-Interaktionen |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
US6624171B1 (en) * | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
JP2002541264A (ja) | 1999-04-08 | 2002-12-03 | ユーエイビー・リサーチ・ファウンデーション | 冨gオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法 |
US20080318890A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US7960540B2 (en) * | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US8114850B2 (en) * | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20080318889A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US6610483B1 (en) * | 1999-07-23 | 2003-08-26 | Princeton University | Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof |
WO2001009373A2 (en) * | 1999-07-30 | 2001-02-08 | Basf Bioresearch Corporation | Native cdc25 substrates, compositions and uses related thereto |
CA2384445A1 (en) * | 1999-09-13 | 2001-03-22 | Basf Aktiengesellschaft | Methods and compositions for the screening of cell cycle modulators |
DE60019318T2 (de) * | 1999-09-22 | 2006-03-09 | Canbas Co., Ltd., Numazu | Zusammensetzungen und verfahren zur inhibierung vom zellulären g2-übergang und sensitisierung von zellen gegen dna-schädigenden wirkstoffe |
FR2815347A1 (fr) * | 1999-12-14 | 2002-04-19 | Sod Conseils Rech Applic | METHODE D'OBTENTION DE LA PHOSPHATASE Cdc25C HUMAINE ET METHODE D'IDENTIFICATION DE MODULATEURS DE LA PHOSPHATASE Cdc25C HUMAINE |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
AR047938A1 (es) * | 2003-08-25 | 2006-03-15 | Combinatorx Inc | Formulaciones, conjugados y combinaciones de farmacos para el tratamiento de neoplasmas |
KR100560701B1 (ko) | 2003-11-03 | 2006-03-16 | 씨제이 주식회사 | Cdc25B 포스파타제 과발현 유도가능한 세포주를사용한 cdc25B 억제제 스크리닝 방법 |
US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
WO2007127002A2 (en) * | 2006-03-31 | 2007-11-08 | Cell Signaling Technology, Inc. | Protein markers of responsiveness to type iii receptor tyrosine kinase inhibitors |
US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
KR100887246B1 (ko) | 2007-11-22 | 2009-03-06 | 건국대학교 산학협력단 | 예쁜꼬마선충을 이용한 세포주기 조절인자 억제제 스크리닝방법 |
CN114958609B (zh) * | 2022-05-11 | 2023-10-20 | 西南民族大学 | 调控dna复制或修复的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0584264A1 (de) * | 1991-05-16 | 1994-03-02 | Cold Spring Harbor Laboratory | D-typ cyclin und darauf bezogene anwendungen |
CA2119443C (en) * | 1991-09-20 | 1999-11-02 | James M. Roberts | Human cyclin e |
US5262409A (en) * | 1991-10-11 | 1993-11-16 | Fred Hutchinson Cancer Research Center | Binary tumor therapy |
US5441880A (en) * | 1991-11-18 | 1995-08-15 | Cold Spring Harbor Laboratory | Human cdc25 genes, encoded products and uses thereof |
US5294538A (en) * | 1991-11-18 | 1994-03-15 | Cold Spring Harbor Labs. | Method of screening for antimitotic compounds using the CDC25 tyrosine phosphatase |
EP0633933A1 (de) * | 1992-03-23 | 1995-01-18 | Imperial Cancer Research Technology Limited | Leucin-zipper |
US5443962A (en) * | 1993-06-04 | 1995-08-22 | Mitotix, Inc. | Methods of identifying inhibitors of cdc25 phosphatase |
-
1993
- 1993-06-04 US US08/073,383 patent/US5443962A/en not_active Expired - Fee Related
-
1994
- 1994-06-06 DE DE69430573T patent/DE69430573T2/de not_active Expired - Fee Related
- 1994-06-06 AT AT94919387T patent/ATE217190T1/de active
- 1994-06-06 EP EP94919387A patent/EP0708653B1/de not_active Expired - Lifetime
- 1994-06-06 JP JP7502026A patent/JPH08510650A/ja active Pending
- 1994-06-06 CA CA002163524A patent/CA2163524C/en not_active Expired - Fee Related
- 1994-06-06 WO PCT/US1994/006365 patent/WO1994028914A1/en active IP Right Grant
- 1994-06-06 AU AU70551/94A patent/AU702174B2/en not_active Ceased
-
1995
- 1995-04-24 US US08/428,762 patent/US6251585B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0708653B1 (de) | 2002-05-08 |
EP0708653A1 (de) | 1996-05-01 |
US5443962A (en) | 1995-08-22 |
EP0708653A4 (de) | 1998-11-18 |
ATE217190T1 (de) | 2002-05-15 |
DE69430573D1 (de) | 2002-06-13 |
CA2163524C (en) | 2003-04-08 |
AU702174B2 (en) | 1999-02-18 |
JPH08510650A (ja) | 1996-11-12 |
CA2163524A1 (en) | 1994-12-22 |
AU7055194A (en) | 1995-01-03 |
WO1994028914A1 (en) | 1994-12-22 |
US6251585B1 (en) | 2001-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: GPC BIOTECH INC. (N.D.GES.D. STAATES DELAWARE), CA |
|
8339 | Ceased/non-payment of the annual fee |