DE69430796D1 - Thalidomid zur hemmung der angiogenese - Google Patents

Thalidomid zur hemmung der angiogenese

Info

Publication number
DE69430796D1
DE69430796D1 DE69430796T DE69430796T DE69430796D1 DE 69430796 D1 DE69430796 D1 DE 69430796D1 DE 69430796 T DE69430796 T DE 69430796T DE 69430796 T DE69430796 T DE 69430796T DE 69430796 D1 DE69430796 D1 DE 69430796D1
Authority
DE
Germany
Prior art keywords
disease
sarcoma
thalidomid
inhibiting angiogenesis
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430796T
Other languages
English (en)
Other versions
DE69430796T2 (de
Inventor
Amato Robert D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Original Assignee
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26699202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69430796(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Priority to DE122008000044C priority Critical patent/DE122008000044I2/de
Application granted granted Critical
Publication of DE69430796D1 publication Critical patent/DE69430796D1/de
Publication of DE69430796T2 publication Critical patent/DE69430796T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69430796T 1993-03-01 1994-02-24 Thalidomid zur hemmung der angiogenese Expired - Lifetime DE69430796T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE122008000044C DE122008000044I2 (de) 1993-03-01 1994-02-24

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2504693A 1993-03-01 1993-03-01
US08/168,817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
PCT/US1994/001971 WO1994020085A1 (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
DE69430796D1 true DE69430796D1 (de) 2002-07-18
DE69430796T2 DE69430796T2 (de) 2003-01-30

Family

ID=26699202

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69430796T Expired - Lifetime DE69430796T2 (de) 1993-03-01 1994-02-24 Thalidomid zur hemmung der angiogenese
DE69434490T Expired - Lifetime DE69434490T2 (de) 1993-03-01 1994-02-24 Zusammenstellungen zur Krebsbehandlung
DE122008000044C Active DE122008000044I2 (de) 1993-03-01 1994-02-24

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69434490T Expired - Lifetime DE69434490T2 (de) 1993-03-01 1994-02-24 Zusammenstellungen zur Krebsbehandlung
DE122008000044C Active DE122008000044I2 (de) 1993-03-01 1994-02-24

Country Status (20)

Country Link
US (18) US5629327A (de)
EP (4) EP1245229A3 (de)
JP (4) JPH08507767A (de)
KR (1) KR100506043B1 (de)
AT (2) ATE218865T1 (de)
AU (1) AU676722B2 (de)
BR (1) BR9400764A (de)
CA (3) CA2342974C (de)
CO (1) CO4230017A1 (de)
DE (3) DE69430796T2 (de)
DK (2) DK1264597T3 (de)
ES (2) ES2245711T3 (de)
FR (1) FR08C0036I2 (de)
HK (1) HK1052865A1 (de)
LU (1) LU91471I2 (de)
NL (1) NL300358I2 (de)
NZ (4) NZ535671A (de)
PE (1) PE10095A1 (de)
PT (1) PT688211E (de)
WO (1) WO1994020085A1 (de)

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US8143283B1 (en) * 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US6228879B1 (en) * 1997-10-16 2001-05-08 The Children's Medical Center Methods and compositions for inhibition of angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6805865B1 (en) 1993-05-27 2004-10-19 Entremed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
US20040248799A1 (en) * 1993-05-27 2004-12-09 Holaday John W. Compositions and methods for treating cancer and hyperproliferative disorders
DE4422237A1 (de) 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
US6429221B1 (en) * 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US6358735B1 (en) 1995-06-30 2002-03-19 University Of Kansas Medical Center Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen
US6440729B1 (en) * 1995-06-30 2002-08-27 University Of Kansas Medical Center Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen
US6518281B2 (en) * 1995-08-29 2003-02-11 Celgene Corporation Immunotherapeutic agents
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
JP3263598B2 (ja) * 1995-11-01 2002-03-04 有限会社ドット 経鼻吸収用生理活性ペプチド組成物
US5798368A (en) * 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
UA60308C2 (uk) * 1996-07-24 2003-10-15 Селджін Корпорейшн ЗАМІЩЕНІ 2-(2,6-ДІОКСОПІПЕРИДИН-3-ІЛ)ФТАЛІМІДИ ТА 1-ОКСОІЗОІНДОЛІНИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЗНИЖЕННЯ РІВНЯ ФПН-α
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
EP2177517B1 (de) * 1996-07-24 2011-10-26 Celgene Corporation Amino substituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide zur Verringerung der TNF-Alpha-Stufen
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
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US5955496A (en) * 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
DE69738935D1 (de) * 1996-11-05 2008-10-02 Childrens Medical Center Zusammensetzungen enthaltend Thalidomide und Dexamethason für die Behandlung von Krebs
US5858991A (en) * 1997-01-29 1999-01-12 Vanderbilt University Facilitation of wound healing with CM101/GBS toxin
US5981508A (en) * 1997-01-29 1999-11-09 Vanderbilt University Facilitation of repair of neural injury with CM101/GBS toxin
US6670337B1 (en) 1998-01-29 2003-12-30 Yeda Reaearch And Development Co., Ltd. Facilitation of wound healing with CM101/GBS toxin
US6028060A (en) 1997-01-29 2000-02-22 Vanderbilt University Treatment of chronic inflammatory diseases with CM101/GBS toxin
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LU91471I2 (fr) 2008-11-06
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US6977268B2 (en) 2005-12-20
NZ336527A (en) 2005-01-28
US20050215593A1 (en) 2005-09-29
US20020161024A1 (en) 2002-10-31
US5712291A (en) 1998-01-27
CA2512926C (en) 2010-08-03
US20020052398A1 (en) 2002-05-02
US5629327A (en) 1997-05-13
EP0688211A4 (de) 1997-05-21
NZ262676A (en) 1999-08-30
DK1264597T3 (da) 2006-01-16
US20030176463A1 (en) 2003-09-18
HK1052865A1 (en) 2003-10-03
AU676722B2 (en) 1997-03-20
US20020061923A1 (en) 2002-05-23
JP2004359693A (ja) 2004-12-24
AU6248694A (en) 1994-09-26
KR960701632A (ko) 1996-03-28
CA2157288C (en) 2005-11-08
US6071948A (en) 2000-06-06
EP1245229A3 (de) 2004-05-06
US20070021464A1 (en) 2007-01-25
DK0688211T3 (da) 2002-09-23
FR08C0036I1 (de) 2008-10-17
US20020049231A1 (en) 2002-04-25
FR08C0036I2 (de) 2009-11-20
NL300358I1 (nl) 2008-11-03
PT688211E (pt) 2002-11-29
DE69434490T2 (de) 2006-06-22
US20020119956A1 (en) 2002-08-29
US5593990A (en) 1997-01-14
US6420414B1 (en) 2002-07-16
DE69434490D1 (de) 2005-10-20
US6469045B1 (en) 2002-10-22
CA2512926A1 (en) 1994-09-15
US6235756B1 (en) 2001-05-22
CA2342974C (en) 2005-08-16
JPH08507767A (ja) 1996-08-20
EP1537870A3 (de) 2007-12-12
US8012996B2 (en) 2011-09-06
ES2245711T3 (es) 2006-01-16
US20030187024A1 (en) 2003-10-02
NZ535671A (en) 2006-05-26
AU676722C (en) 1994-09-26
JP2001278789A (ja) 2001-10-10
KR100506043B1 (ko) 2005-11-08
EP1264597B1 (de) 2005-09-14
EP1264597A3 (de) 2003-03-19
NL300358I2 (nl) 2009-06-02
PE10095A1 (es) 1995-04-25

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