DE69433146D1 - Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen - Google Patents
Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische ZusammenstellungenInfo
- Publication number
- DE69433146D1 DE69433146D1 DE69433146T DE69433146T DE69433146D1 DE 69433146 D1 DE69433146 D1 DE 69433146D1 DE 69433146 T DE69433146 T DE 69433146T DE 69433146 T DE69433146 T DE 69433146T DE 69433146 D1 DE69433146 D1 DE 69433146D1
- Authority
- DE
- Germany
- Prior art keywords
- substd
- opt
- nhcoocme3
- substits
- succinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7633793A | 1993-06-11 | 1993-06-11 | |
US76337 | 1993-06-11 | ||
US12297493A | 1993-09-17 | 1993-09-17 | |
US122974 | 1993-09-17 | ||
WOPCT/US93/11827 | 1993-12-13 | ||
PCT/US1993/011827 WO1994013655A1 (en) | 1992-12-15 | 1993-12-13 | 7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433146D1 true DE69433146D1 (de) | 2003-10-16 |
DE69433146T2 DE69433146T2 (de) | 2004-06-09 |
Family
ID=26757982
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433715T Expired - Fee Related DE69433715T2 (de) | 1993-06-11 | 1994-06-03 | Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen |
DE69433146T Expired - Fee Related DE69433146T2 (de) | 1993-06-11 | 1994-06-03 | Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen |
DE69424166T Expired - Fee Related DE69424166T2 (de) | 1993-06-11 | 1994-06-03 | Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433715T Expired - Fee Related DE69433715T2 (de) | 1993-06-11 | 1994-06-03 | Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69424166T Expired - Fee Related DE69424166T2 (de) | 1993-06-11 | 1994-06-03 | Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
Country Status (18)
Country | Link |
---|---|
US (2) | US5965739A (de) |
EP (3) | EP0982302B1 (de) |
JP (1) | JPH09511212A (de) |
AT (3) | ATE264316T1 (de) |
AU (1) | AU7138894A (de) |
CA (1) | CA2161328A1 (de) |
DE (3) | DE69433715T2 (de) |
DK (3) | DK0982302T3 (de) |
ES (3) | ES2219968T3 (de) |
GR (1) | GR3033836T3 (de) |
IL (1) | IL109957A (de) |
LV (2) | LV12692B (de) |
NZ (2) | NZ268475A (de) |
PT (3) | PT703909E (de) |
SI (2) | SI0703909T1 (de) |
TW (1) | TW401407B (de) |
WO (1) | WO1994029288A1 (de) |
ZA (1) | ZA944034B (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998656A (en) * | 1991-09-23 | 1999-12-07 | Florida State University | C10 tricyclic taxanes |
FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2697522B1 (fr) * | 1992-10-30 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
US5380751A (en) * | 1992-12-04 | 1995-01-10 | Bristol-Myers Squibb Company | 6,7-modified paclitaxels |
CA2109861C (en) * | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
FR2721026B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2721025B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
IT1275936B1 (it) * | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
CA2170661A1 (en) | 1995-03-22 | 1996-09-23 | John K. Thottathil | Novel methods for the preparation of taxanes using oaxzolidine intermediates |
US5780653A (en) * | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
SI0912504T1 (en) * | 1996-05-08 | 2003-02-28 | Pharmacia & Upjohn Company | Oxazolidine ester |
NZ332475A (en) * | 1996-05-08 | 2000-05-26 | Upjohn Co | silylated baccatin derivatives, 3-(substituted amino)-3-phenyl-(2R,3S)-isoserinate derivatives, the oxazolidine ester thereof and other immediates used to prepare baccatin derivatives |
AU737078C (en) | 1996-05-24 | 2002-05-02 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing diseases of body passageways |
US5977386A (en) * | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
US5912264A (en) * | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
US7112338B2 (en) * | 1997-03-12 | 2006-09-26 | The Regents Of The University Of California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
US6017935A (en) * | 1997-04-24 | 2000-01-25 | Bristol-Myers Squibb Company | 7-sulfur substituted paclitaxels |
US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
US6235776B1 (en) | 1998-11-12 | 2001-05-22 | Cell Pathways, Inc. | Method for treating a patient with neoplasia by treatment with a paclitaxel derivative |
US6235782B1 (en) | 1998-11-12 | 2001-05-22 | Rifat Pamukcu | Method for treating a patient with neoplasia by treatment with a platinum coordination complex |
MXPA02002579A (es) * | 1999-09-09 | 2003-10-14 | Univ California | Entrega de liposomas cationicas de taxanos a vasos sanguineos angiogenicos. |
WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
US6414015B1 (en) * | 2000-01-28 | 2002-07-02 | Utah State University | Laulimalide microtubule stabilizing agents |
AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
AU783422B2 (en) * | 2000-02-02 | 2005-10-27 | Florida State University Research Foundation, Inc. | C10 carbamoyloxy substituted taxanes as antitumor agents |
EP1165068B1 (de) * | 2000-02-02 | 2007-12-19 | Florida State University Research Foundation, Inc. | Heterosubstituierte taxan-c10-acetate als antitumormittel |
HUP0200756A3 (en) * | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them |
GEP20043239B (en) | 2000-02-02 | 2004-05-25 | Florida State Univ Research Foundation Us | C10 Carbonate Substituted Taxanes as Antitumor Agents |
US6362217B2 (en) | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
DE60131537T2 (de) | 2000-06-22 | 2008-10-23 | Nitromed, Inc., Lexington | Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung |
WO2002024179A2 (en) | 2000-09-22 | 2002-03-28 | Bristol-Myers Squibb Company | Method for reducing toxicity of combined chemotherapies |
PT2314293T (pt) | 2001-01-16 | 2017-04-11 | Vascular Therapies Llc | Dispositivo implantável que contém material de matriz reabsorvível e rapamicina para prevenir ou tratar doenças vasuloproliferativas |
CN100432064C (zh) * | 2001-03-23 | 2008-11-12 | 台湾神隆股份有限公司 | 紫杉烷衍生物的制备方法 |
CA2354478A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes |
DE60327651D1 (de) * | 2002-10-09 | 2009-06-25 | Chatham Biotec Ltd | Thio-analoga von paclitaxel und deren vorprodukte |
US7064980B2 (en) * | 2003-09-17 | 2006-06-20 | Sandisk Corporation | Non-volatile memory and method with bit line coupled compensation |
HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
EP1737444A4 (de) | 2004-03-05 | 2008-05-21 | Univ Florida State Res Found | C7-lactyloxa-substituierte taxane |
CA2597682A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
JP2009521463A (ja) * | 2005-12-21 | 2009-06-04 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサン誘導体のための方法およびそれに有用な中間体 |
ITMI20062479A1 (it) * | 2006-12-21 | 2008-06-22 | Indena Spa | Processo per la preparazione di secotassani |
EP2080764B1 (de) | 2008-01-18 | 2012-08-22 | INDENA S.p.A. | Feste Formen von Ortataxel |
WO2009145981A1 (en) * | 2008-03-31 | 2009-12-03 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes |
WO2011134067A1 (en) * | 2010-04-29 | 2011-11-03 | 6570763 Canada Inc. | Novel amino acid molecule and uses thereof |
CN101863862B (zh) * | 2010-06-18 | 2012-01-11 | 云南汉德生物技术有限公司 | 一种工业半合成紫杉醇的方法 |
CN103980232A (zh) * | 2014-06-05 | 2014-08-13 | 北京诺普德医药科技有限公司 | 10-乙酰基多西紫杉醇及其用途 |
CN111138386A (zh) * | 2019-12-30 | 2020-05-12 | 重庆市碚圣医药科技股份有限公司 | 一种多西他赛的半合成方法 |
CN115260130A (zh) * | 2022-07-07 | 2022-11-01 | 上海卓鼎生物技术有限公司 | 一种10-脱乙酰基紫杉醇的制备方法 |
CN116462643A (zh) * | 2023-03-29 | 2023-07-21 | 无锡贝塔医药科技有限公司 | 一种氘或氚标记的多西他赛的合成方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
US5157049A (en) * | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
EP0366841A1 (de) * | 1988-11-03 | 1990-05-09 | Dresser-Rand Company | Kreuzkopf und Kreuzkopfzapfenbefestigung |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
IL95436A (en) * | 1989-08-23 | 1996-07-23 | Centre Nat Rech Scient | Process for preparing the history of phenylisosarine |
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
FR2658513B1 (fr) * | 1990-02-21 | 1994-02-04 | Rhone Poulenc Sante | Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r). |
FR2658510B1 (fr) * | 1990-02-21 | 1992-04-30 | Rhone Poulenc Sante | Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi. |
FR2662441B1 (fr) * | 1990-05-22 | 1992-10-23 | Rhone Poulenc Sante | Procede de preparation enantioselective de derives de la phenylisoserine. |
FR2662440B1 (fr) * | 1990-05-22 | 1992-07-31 | Rhone Poulenc Sante | Procede de preparation stereoselective de derives de la phenylisoserine. |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
FR2687151B1 (fr) * | 1992-02-07 | 1994-03-25 | Rhone Poulenc Rorer Sa | Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent. |
US5248796A (en) * | 1992-06-18 | 1993-09-28 | Bristol-Myers Squibb Company | Taxol derivatives |
ATE136460T1 (de) * | 1992-07-01 | 1996-04-15 | Bristol Myers Squibb Co | Fluor-taxole mit antitumor-wirkung |
US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
FR2696458B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696459B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696464B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III. |
FR2697522B1 (fr) * | 1992-10-30 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
US5380751A (en) * | 1992-12-04 | 1995-01-10 | Bristol-Myers Squibb Company | 6,7-modified paclitaxels |
CA2109861C (en) * | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
FR2698871B1 (fr) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
-
1994
- 1994-06-03 CA CA002161328A patent/CA2161328A1/en not_active Abandoned
- 1994-06-03 AT AT99118034T patent/ATE264316T1/de not_active IP Right Cessation
- 1994-06-03 DK DK99118034T patent/DK0982302T3/da active
- 1994-06-03 AU AU71388/94A patent/AU7138894A/en not_active Abandoned
- 1994-06-03 PT PT94920688T patent/PT703909E/pt unknown
- 1994-06-03 NZ NZ268475A patent/NZ268475A/en unknown
- 1994-06-03 DK DK99118033T patent/DK0982301T3/da active
- 1994-06-03 DE DE69433715T patent/DE69433715T2/de not_active Expired - Fee Related
- 1994-06-03 JP JP7501878A patent/JPH09511212A/ja not_active Ceased
- 1994-06-03 EP EP99118034A patent/EP0982302B1/de not_active Expired - Lifetime
- 1994-06-03 EP EP99118033A patent/EP0982301B1/de not_active Expired - Lifetime
- 1994-06-03 SI SI9430317T patent/SI0703909T1/xx unknown
- 1994-06-03 DE DE69433146T patent/DE69433146T2/de not_active Expired - Fee Related
- 1994-06-03 PT PT99118034T patent/PT982302E/pt unknown
- 1994-06-03 DE DE69424166T patent/DE69424166T2/de not_active Expired - Fee Related
- 1994-06-03 SI SI9430464T patent/SI0982302T1/xx unknown
- 1994-06-03 AT AT94920688T patent/ATE192147T1/de not_active IP Right Cessation
- 1994-06-03 ES ES99118034T patent/ES2219968T3/es not_active Expired - Lifetime
- 1994-06-03 DK DK94920688T patent/DK0703909T3/da active
- 1994-06-03 AT AT99118033T patent/ATE249448T1/de not_active IP Right Cessation
- 1994-06-03 US US08/557,034 patent/US5965739A/en not_active Expired - Fee Related
- 1994-06-03 ES ES94920688T patent/ES2145829T3/es not_active Expired - Lifetime
- 1994-06-03 WO PCT/US1994/006035 patent/WO1994029288A1/en active IP Right Grant
- 1994-06-03 PT PT99118033T patent/PT982301E/pt unknown
- 1994-06-03 ES ES99118033T patent/ES2205663T3/es not_active Expired - Lifetime
- 1994-06-03 EP EP94920688A patent/EP0703909B1/de not_active Expired - Lifetime
- 1994-06-03 NZ NZ330671A patent/NZ330671A/xx unknown
- 1994-06-08 ZA ZA944034A patent/ZA944034B/xx unknown
- 1994-06-09 IL IL10995794A patent/IL109957A/en not_active IP Right Cessation
- 1994-06-09 TW TW083105245A patent/TW401407B/zh not_active IP Right Cessation
- 1994-06-10 US US08/258,019 patent/US5556878A/en not_active Expired - Fee Related
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2000
- 2000-06-30 GR GR20000401537T patent/GR3033836T3/el not_active IP Right Cessation
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2001
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2005
- 2005-04-14 LV LVP-05-45A patent/LV13319B/en unknown
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