DE69433160D1 - Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region - Google Patents
Konserviertes Motiv der Hepatitis C Virus E2/NS1 RegionInfo
- Publication number
- DE69433160D1 DE69433160D1 DE69433160T DE69433160T DE69433160D1 DE 69433160 D1 DE69433160 D1 DE 69433160D1 DE 69433160 T DE69433160 T DE 69433160T DE 69433160 T DE69433160 T DE 69433160T DE 69433160 D1 DE69433160 D1 DE 69433160D1
- Authority
- DE
- Germany
- Prior art keywords
- motif
- region
- virus
- hcv
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6169993A | 1993-05-12 | 1993-05-12 | |
US61699 | 1993-05-12 | ||
PCT/US1994/004853 WO1994026306A1 (en) | 1993-05-12 | 1994-05-03 | Conserved motif of hepatitis c virus e2/ns1 region |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433160D1 true DE69433160D1 (de) | 2003-10-30 |
DE69433160T2 DE69433160T2 (de) | 2004-07-08 |
Family
ID=22037528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433160T Revoked DE69433160T2 (de) | 1993-05-12 | 1994-05-03 | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
Country Status (7)
Country | Link |
---|---|
US (6) | US20030017156A1 (de) |
EP (2) | EP1421951A3 (de) |
JP (3) | JPH08510240A (de) |
AT (1) | ATE249838T1 (de) |
CA (1) | CA2162557C (de) |
DE (1) | DE69433160T2 (de) |
WO (1) | WO1994026306A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE249838T1 (de) * | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
DE19504302A1 (de) * | 1995-02-09 | 1996-08-14 | Boehringer Mannheim Gmbh | Methode zur serologischen Typisierung mittels typspezifischer Antigene |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
KR970065713A (ko) * | 1996-03-19 | 1997-10-13 | 성재갑 | C형 간염 바이러스(일본형)의 분비형 외피 단백질 1 및 2 |
GB9810756D0 (en) | 1998-05-19 | 1998-07-15 | Angeletti P Ist Richerche Bio | Mimotopes of hypervariable region 1 of the e2 glycoprotein of hcv and uses thereof |
WO2001021807A1 (en) * | 1999-09-23 | 2001-03-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health Services | Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof |
WO2001037869A1 (en) * | 1999-11-19 | 2001-05-31 | Csl Limited | Vaccine compositions |
CN100391469C (zh) * | 2000-02-14 | 2008-06-04 | 三菱制药株式会社 | 丙型肝炎治疗药 |
WO2009021063A2 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Composition and method of use for hcv immunization |
US8314371B2 (en) | 2008-11-06 | 2012-11-20 | Applied Materials, Inc. | Rapid thermal processing chamber with micro-positioning system |
WO2010148117A1 (en) | 2009-06-17 | 2010-12-23 | Scantibodies Laboratory, Inc. | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
GB201415714D0 (en) * | 2014-09-05 | 2014-10-22 | Medical Res Council | Antibodies and antigen binding fragments thereof |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6039948A (en) * | 1973-05-07 | 2000-03-21 | The Ohio State University | Method for treatment of antigenically modified polypeptides |
US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
CA1188985A (en) * | 1980-07-01 | 1985-06-18 | Edward J. Stott | Production of viral antigens |
EP0043718B1 (de) | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Zellinien |
US4341761A (en) | 1980-07-25 | 1982-07-27 | E. I. Du Pont De Nemours And Company | Antibodies to immunogenic peptides and their use to purify human fibroblast interferon |
US4466917A (en) | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
US4493890A (en) | 1981-03-23 | 1985-01-15 | Miles Laboratories, Inc. | Activated apoglucose oxidase and its use in specific binding assays |
US4399121A (en) | 1981-11-04 | 1983-08-16 | Miles Laboratories, Inc. | Iodothyronine immunogens and antibodies |
US4427783A (en) | 1981-12-14 | 1984-01-24 | Hoffmann-La Roche Inc. | Immunoassay of thymosin α1 |
EP0116201B1 (de) | 1983-01-12 | 1992-04-22 | Chiron Corporation | Sekretorische Expression in Eukaryoten |
CA1341116C (en) | 1983-02-22 | 2000-10-17 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
EP0164556B1 (de) | 1984-05-11 | 1994-03-02 | Chiron Corporation | Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion |
US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4629783A (en) | 1985-04-29 | 1986-12-16 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
DE318216T1 (de) | 1987-11-18 | 1990-06-13 | Chiron Corp., Emeryville, Calif., Us | Nanbv-diagnostika und vakzine. |
US5252459A (en) | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
HUT54896A (en) | 1989-03-17 | 1991-04-29 | Chiron Corp | Process for producing aquous diagnosticum and vaccine of nanbv |
MC2188A1 (fr) | 1989-05-18 | 1992-09-16 | Chiron Corp | Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US5308750A (en) | 1989-12-22 | 1994-05-03 | Abbott Laboratories | Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same |
US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
CA2047792C (en) | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
SK286106B6 (sk) * | 1990-11-08 | 2008-03-05 | Novartis Vaccines & Diagnostics, Inc. | Spôsob vykonávania imunodiagnostickej skúšky na detekciu protilátky proti vírusu hepatitídy C |
US6274148B1 (en) | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
HU227547B1 (en) | 1991-06-24 | 2011-08-29 | Novartis Vaccines & Diagnostic | Hepatitis c virus (hcv) polypeptides |
WO1993006126A1 (en) | 1991-09-13 | 1993-04-01 | Chiron Corporation | Immunoreactive hepatitis c virus polypeptide compositions |
DE69326979T2 (de) | 1992-02-05 | 2000-04-20 | Daikin Ind Ltd | Polytetrafluoräthylenformpulver |
ATE364621T1 (de) | 1992-03-06 | 2007-07-15 | Innogenetics Nv | Hiv-peptide |
ATE249838T1 (de) * | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
EP0979867A3 (de) | 1993-11-04 | 2007-06-13 | Innogenetics N.V. | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
CN100463922C (zh) * | 2000-06-15 | 2009-02-25 | 诺华疫苗和诊断公司 | 抗hcv抗体的免疫测定 |
-
1994
- 1994-05-03 AT AT94915985T patent/ATE249838T1/de not_active IP Right Cessation
- 1994-05-03 WO PCT/US1994/004853 patent/WO1994026306A1/en active IP Right Grant
- 1994-05-03 EP EP03077917A patent/EP1421951A3/de not_active Withdrawn
- 1994-05-03 JP JP6525508A patent/JPH08510240A/ja active Pending
- 1994-05-03 DE DE69433160T patent/DE69433160T2/de not_active Revoked
- 1994-05-03 EP EP94915985A patent/EP0697888B1/de not_active Revoked
- 1994-05-03 CA CA002162557A patent/CA2162557C/en not_active Expired - Fee Related
-
1995
- 1995-05-09 US US08/438,182 patent/US20030017156A1/en not_active Abandoned
- 1995-05-09 US US08/438,183 patent/US7135185B1/en not_active Expired - Lifetime
- 1995-05-09 US US08/437,943 patent/US6692907B1/en not_active Expired - Lifetime
- 1995-05-09 US US08/437,952 patent/US7098303B1/en not_active Expired - Lifetime
-
1997
- 1997-03-25 US US08/823,980 patent/US7252827B1/en not_active Expired - Fee Related
-
2004
- 2004-11-30 JP JP2004347900A patent/JP2005097319A/ja not_active Withdrawn
-
2005
- 2005-05-25 JP JP2005152406A patent/JP2005325126A/ja not_active Withdrawn
-
2006
- 2006-09-18 US US11/522,614 patent/US7371386B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6692907B1 (en) | 2004-02-17 |
DE69433160T2 (de) | 2004-07-08 |
JPH08510240A (ja) | 1996-10-29 |
EP0697888A1 (de) | 1996-02-28 |
US20070014813A1 (en) | 2007-01-18 |
US7098303B1 (en) | 2006-08-29 |
US7135185B1 (en) | 2006-11-14 |
EP1421951A2 (de) | 2004-05-26 |
US7371386B2 (en) | 2008-05-13 |
WO1994026306A1 (en) | 1994-11-24 |
EP0697888B1 (de) | 2003-09-17 |
CA2162557A1 (en) | 1994-11-24 |
EP1421951A3 (de) | 2005-10-05 |
JP2005097319A (ja) | 2005-04-14 |
ATE249838T1 (de) | 2003-10-15 |
US20030017156A1 (en) | 2003-01-23 |
US7252827B1 (en) | 2007-08-07 |
JP2005325126A (ja) | 2005-11-24 |
CA2162557C (en) | 2004-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |