DE69433160D1 - Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region - Google Patents
Konserviertes Motiv der Hepatitis C Virus E2/NS1 RegionInfo
- Publication number
- DE69433160D1 DE69433160D1 DE69433160T DE69433160T DE69433160D1 DE 69433160 D1 DE69433160 D1 DE 69433160D1 DE 69433160 T DE69433160 T DE 69433160T DE 69433160 T DE69433160 T DE 69433160T DE 69433160 D1 DE69433160 D1 DE 69433160D1
- Authority
- DE
- Germany
- Prior art keywords
- motif
- region
- virus
- hcv
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6169993A | 1993-05-12 | 1993-05-12 | |
US61699 | 1993-05-12 | ||
PCT/US1994/004853 WO1994026306A1 (en) | 1993-05-12 | 1994-05-03 | Conserved motif of hepatitis c virus e2/ns1 region |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433160D1 true DE69433160D1 (de) | 2003-10-30 |
DE69433160T2 DE69433160T2 (de) | 2004-07-08 |
Family
ID=22037528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433160T Revoked DE69433160T2 (de) | 1993-05-12 | 1994-05-03 | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
Country Status (7)
Country | Link |
---|---|
US (6) | US7098303B1 (de) |
EP (2) | EP0697888B1 (de) |
JP (3) | JPH08510240A (de) |
AT (1) | ATE249838T1 (de) |
CA (1) | CA2162557C (de) |
DE (1) | DE69433160T2 (de) |
WO (1) | WO1994026306A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69433160T2 (de) * | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
DE19504302A1 (de) * | 1995-02-09 | 1996-08-14 | Boehringer Mannheim Gmbh | Methode zur serologischen Typisierung mittels typspezifischer Antigene |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
KR970065713A (ko) * | 1996-03-19 | 1997-10-13 | 성재갑 | C형 간염 바이러스(일본형)의 분비형 외피 단백질 1 및 2 |
GB9810756D0 (en) | 1998-05-19 | 1998-07-15 | Angeletti P Ist Richerche Bio | Mimotopes of hypervariable region 1 of the e2 glycoprotein of hcv and uses thereof |
WO2001021807A1 (en) * | 1999-09-23 | 2001-03-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health Services | Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof |
AU772617B2 (en) * | 1999-11-19 | 2004-05-06 | Csl Limited | Vaccine compositions |
ATE555794T1 (de) * | 2000-02-14 | 2012-05-15 | Mitsubishi Tanabe Pharma Corp | Heilmittel gegen hepatitis |
WO2009021063A2 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Composition and method of use for hcv immunization |
US8314371B2 (en) | 2008-11-06 | 2012-11-20 | Applied Materials, Inc. | Rapid thermal processing chamber with micro-positioning system |
US20100322943A1 (en) | 2009-06-17 | 2010-12-23 | Thomas Cantor | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
GB201415714D0 (en) * | 2014-09-05 | 2014-10-22 | Medical Res Council | Antibodies and antigen binding fragments thereof |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6146633A (en) | 1973-05-07 | 2000-11-14 | The Ohio State University | Method for treatment of antigenically modified polypeptides |
US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
ZA814386B (en) * | 1980-07-01 | 1982-07-28 | Nat Res Dev | Production of viral antigens |
DE3167442D1 (en) | 1980-07-07 | 1985-01-10 | Nat Res Dev | Improvements in or relating to cell lines |
US4341761A (en) | 1980-07-25 | 1982-07-27 | E. I. Du Pont De Nemours And Company | Antibodies to immunogenic peptides and their use to purify human fibroblast interferon |
US4466917A (en) | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
US4493890A (en) | 1981-03-23 | 1985-01-15 | Miles Laboratories, Inc. | Activated apoglucose oxidase and its use in specific binding assays |
US4399121A (en) | 1981-11-04 | 1983-08-16 | Miles Laboratories, Inc. | Iodothyronine immunogens and antibodies |
US4427783A (en) | 1981-12-14 | 1984-01-24 | Hoffmann-La Roche Inc. | Immunoassay of thymosin α1 |
EP0116201B1 (de) | 1983-01-12 | 1992-04-22 | Chiron Corporation | Sekretorische Expression in Eukaryoten |
CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
ATE102250T1 (de) | 1984-05-11 | 1994-03-15 | Chiron Corp | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4629783A (en) | 1985-04-29 | 1986-12-16 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
BR8807310A (pt) | 1987-11-18 | 1990-03-13 | Chiron Corp | Polinucleotidio,polinucleotidio recombinante,vetor recombinante,celula hospedeira,sistema de expressao recombinante,celula transformada,polipeptidio,hcv,preparacao de polipeptidio,polipeptidio de hcv,polipeptidio purificado,polipeptidio recombinante,polipeptidio de fusao,anticorpo monoclonal,preparacao purificada de anticorpos policlonais,particula,sonda de polinucleotidio,kit anticorpo para epetopo de hcv,metodo para producao de polipeptidio,metodo para deteccao de acidos nucleicos de hcv,imunoensaio para detectar antigeno de hcv,imunoensaio para detectar anticorpos dirigidos contra antigeno de hcv,vacina para tratamento de infeccao de hcv,celula,celula infectada com hcv,metodo para producao de anticorpos para hcv e metodo para isolar cdna derivado do genoma de um agente infeccioso nao identificado |
US5252459A (en) | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
JP2656995B2 (ja) * | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
AU638719B2 (en) | 1989-05-18 | 1993-07-08 | Novartis Vaccines And Diagnostics, Inc. | Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus |
HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
US5308750A (en) | 1989-12-22 | 1994-05-03 | Abbott Laboratories | Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same |
US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
CA2047792C (en) | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
SK285623B6 (sk) * | 1990-11-08 | 2007-05-03 | Chiron Corporation | Spôsob produkcie asialoglykoproteínu hepatitis C vírusu |
US6274148B1 (en) | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
US5574132A (en) | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
RU2148587C1 (ru) | 1991-06-24 | 2000-05-10 | Чирон Корпорейшн | Полипептид и способ его получения, реагент для иммуноанализа, способ определения присутствия антител и способ индукции иммунного ответа |
RU2212899C2 (ru) | 1991-09-13 | 2003-09-27 | Чирон Корпорейшн | Hcv иммунореактивные полипептидные композиции |
JP3177983B2 (ja) | 1992-02-05 | 2001-06-18 | ダイキン工業株式会社 | ポリテトラフルオロエチレン成形用粉末 |
KR20030096423A (ko) | 1992-03-06 | 2003-12-31 | 엔. 브이. 이노제네틱스 소시에떼아노님 | 면역학적으로 중요한 에피토프에 상응하는 펩티드의 측정방법 및 면역학적으로 중요한 에피토프에 상응하는 항체또는 비오티닐화된 펩티드의 측정 방법에 상기 펩티드를사용하는 방법, 상기 펩티드의 제조방법 및 상기 펩티드를함유하는 조성물 |
DE69433160T2 (de) * | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
EP0992581B2 (de) | 1993-11-04 | 2011-05-25 | Innogenetics N.V. | Immunodominante menschliche T-Zell Epitope des Hepatitis C Virus |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
PT1354204E (pt) * | 2000-06-15 | 2007-03-30 | Novartis Vaccines & Diagnostic | Ensaio de combinação dum antigénio/anticorpo para o hcv |
-
1994
- 1994-05-03 DE DE69433160T patent/DE69433160T2/de not_active Revoked
- 1994-05-03 EP EP94915985A patent/EP0697888B1/de not_active Revoked
- 1994-05-03 EP EP03077917A patent/EP1421951A3/de not_active Withdrawn
- 1994-05-03 CA CA002162557A patent/CA2162557C/en not_active Expired - Fee Related
- 1994-05-03 JP JP6525508A patent/JPH08510240A/ja active Pending
- 1994-05-03 AT AT94915985T patent/ATE249838T1/de not_active IP Right Cessation
- 1994-05-03 WO PCT/US1994/004853 patent/WO1994026306A1/en active IP Right Grant
-
1995
- 1995-05-09 US US08/437,952 patent/US7098303B1/en not_active Expired - Lifetime
- 1995-05-09 US US08/437,943 patent/US6692907B1/en not_active Expired - Lifetime
- 1995-05-09 US US08/438,183 patent/US7135185B1/en not_active Expired - Lifetime
- 1995-05-09 US US08/438,182 patent/US20030017156A1/en not_active Abandoned
-
1997
- 1997-03-25 US US08/823,980 patent/US7252827B1/en not_active Expired - Fee Related
-
2004
- 2004-11-30 JP JP2004347900A patent/JP2005097319A/ja not_active Withdrawn
-
2005
- 2005-05-25 JP JP2005152406A patent/JP2005325126A/ja not_active Withdrawn
-
2006
- 2006-09-18 US US11/522,614 patent/US7371386B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20070014813A1 (en) | 2007-01-18 |
EP1421951A3 (de) | 2005-10-05 |
CA2162557A1 (en) | 1994-11-24 |
EP0697888B1 (de) | 2003-09-17 |
JPH08510240A (ja) | 1996-10-29 |
US6692907B1 (en) | 2004-02-17 |
US7252827B1 (en) | 2007-08-07 |
US20030017156A1 (en) | 2003-01-23 |
US7371386B2 (en) | 2008-05-13 |
US7135185B1 (en) | 2006-11-14 |
US7098303B1 (en) | 2006-08-29 |
JP2005097319A (ja) | 2005-04-14 |
JP2005325126A (ja) | 2005-11-24 |
EP0697888A1 (de) | 1996-02-28 |
ATE249838T1 (de) | 2003-10-15 |
EP1421951A2 (de) | 2004-05-26 |
WO1994026306A1 (en) | 1994-11-24 |
DE69433160T2 (de) | 2004-07-08 |
CA2162557C (en) | 2004-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |