DE69434651D1 - Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen - Google Patents
Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungenInfo
- Publication number
- DE69434651D1 DE69434651D1 DE69434651T DE69434651T DE69434651D1 DE 69434651 D1 DE69434651 D1 DE 69434651D1 DE 69434651 T DE69434651 T DE 69434651T DE 69434651 T DE69434651 T DE 69434651T DE 69434651 D1 DE69434651 D1 DE 69434651D1
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- sewne
- compositions
- inductive
- inductive compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/386—Ligaments, tendons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16410393A | 1993-12-07 | 1993-12-07 | |
US164103 | 1993-12-07 | ||
US21778094A | 1994-03-25 | 1994-03-25 | |
US217780 | 1994-03-25 | ||
US08/333,576 US6027919A (en) | 1993-12-07 | 1994-11-02 | BMP-12 and BMP-13 proteins and DNA encoding them |
US333576 | 1994-11-02 | ||
PCT/US1994/014030 WO1995016035A2 (en) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69434651D1 true DE69434651D1 (de) | 2006-05-04 |
DE69434651T2 DE69434651T2 (de) | 2007-03-08 |
Family
ID=27388970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434651T Expired - Lifetime DE69434651T2 (de) | 1993-12-07 | 1994-12-06 | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
Country Status (15)
Country | Link |
---|---|
US (5) | US5658882A (de) |
EP (1) | EP0733109B9 (de) |
JP (3) | JP3717930B2 (de) |
KR (1) | KR100353182B1 (de) |
AT (1) | ATE319823T1 (de) |
AU (1) | AU689184B2 (de) |
CA (1) | CA2176942C (de) |
DE (1) | DE69434651T2 (de) |
DK (1) | DK0733109T3 (de) |
ES (1) | ES2255059T3 (de) |
FI (1) | FI119816B (de) |
NO (1) | NO317801B1 (de) |
OA (1) | OA10582A (de) |
PT (1) | PT733109E (de) |
WO (1) | WO1995016035A2 (de) |
Families Citing this family (147)
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US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
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US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
JP3504263B2 (ja) | 1991-11-04 | 2004-03-08 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法 |
DE19525416A1 (de) * | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
US20080233170A1 (en) * | 1992-02-21 | 2008-09-25 | Stryker Corporation | Osteogenic Proteins |
US5986058A (en) * | 1993-07-09 | 1999-11-16 | The Johns Hopkins University School Of Medicine | Polynucleotide encoding growth differentiation factor-7 and protein encoded thereby |
CA2165776A1 (en) * | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-6 |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
JP3717930B2 (ja) * | 1993-12-07 | 2005-11-16 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | Bmp−12、bmp−13およびそれらの腱誘導組成物 |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US5906827A (en) † | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
WO1996014335A1 (en) * | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
US20010011131A1 (en) * | 1997-07-28 | 2001-08-02 | Luyten Frank P. | DNA molecules encoding cartilage-derived morphogenetic proteins |
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NZ305472A (en) * | 1995-04-19 | 1999-09-29 | Hoechst Marion Roussel Ltd For | A protein derived from human mp52 useful in treating cartilage and bone diseases |
DK0831884T3 (da) * | 1995-06-05 | 2003-11-03 | Inst Genetics Llc | Anvendelse af knoglemorfogenetiske proteiner til heling og reparation af bindevævsbinding |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
ZA966489B (en) * | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US7026292B1 (en) | 1995-12-12 | 2006-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
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US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
JPH11335398A (ja) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
EP1074620A1 (de) | 1999-08-06 | 2001-02-07 | HyGene AG | Monomer Protein der TGF-beta Familie |
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DK0831884T3 (da) * | 1995-06-05 | 2003-11-03 | Inst Genetics Llc | Anvendelse af knoglemorfogenetiske proteiner til heling og reparation af bindevævsbinding |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
IT1302534B1 (it) * | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
US6420243B1 (en) * | 2000-12-04 | 2002-07-16 | Motorola, Inc. | Method for producing SOI wafers by delamination |
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1994
- 1994-12-06 JP JP51629395A patent/JP3717930B2/ja not_active Expired - Lifetime
- 1994-12-06 PT PT95904255T patent/PT733109E/pt unknown
- 1994-12-06 CA CA2176942A patent/CA2176942C/en not_active Expired - Lifetime
- 1994-12-06 DK DK95904255T patent/DK0733109T3/da active
- 1994-12-06 ES ES95904255T patent/ES2255059T3/es not_active Expired - Lifetime
- 1994-12-06 EP EP95904255A patent/EP0733109B9/de not_active Expired - Lifetime
- 1994-12-06 DE DE69434651T patent/DE69434651T2/de not_active Expired - Lifetime
- 1994-12-06 AT AT95904255T patent/ATE319823T1/de active
- 1994-12-06 AU AU13013/95A patent/AU689184B2/en not_active Expired
- 1994-12-06 WO PCT/US1994/014030 patent/WO1995016035A2/en active IP Right Grant
- 1994-12-22 US US08/362,670 patent/US5658882A/en not_active Expired - Lifetime
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1996
- 1996-06-04 NO NO19962304A patent/NO317801B1/no not_active IP Right Cessation
- 1996-06-06 FI FI962350A patent/FI119816B/fi not_active IP Right Cessation
- 1996-06-07 OA OA60840A patent/OA10582A/en unknown
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1997
- 1997-02-28 US US08/808,324 patent/US6284872B1/en not_active Expired - Lifetime
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1999
- 1999-05-26 KR KR1019990019060A patent/KR100353182B1/ko not_active IP Right Cessation
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2001
- 2001-08-31 US US09/945,182 patent/US6719968B2/en not_active Expired - Fee Related
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2004
- 2004-02-18 US US10/779,635 patent/US6984623B2/en not_active Expired - Fee Related
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2005
- 2005-06-08 JP JP2005168624A patent/JP3939729B2/ja not_active Expired - Lifetime
- 2005-06-17 US US11/154,826 patent/US7365052B2/en not_active Expired - Fee Related
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2006
- 2006-08-10 JP JP2006218531A patent/JP2007016037A/ja active Pending
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