DE69502733D1 - Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes - Google Patents

Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes

Info

Publication number
DE69502733D1
DE69502733D1 DE69502733T DE69502733T DE69502733D1 DE 69502733 D1 DE69502733 D1 DE 69502733D1 DE 69502733 T DE69502733 T DE 69502733T DE 69502733 T DE69502733 T DE 69502733T DE 69502733 D1 DE69502733 D1 DE 69502733D1
Authority
DE
Germany
Prior art keywords
preselected
blood vessel
cells
molecules
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69502733T
Other languages
English (en)
Other versions
DE69502733T2 (de
Inventor
Gunter Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of DE69502733D1 publication Critical patent/DE69502733D1/de
Publication of DE69502733T2 publication Critical patent/DE69502733T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
DE69502733T 1994-10-25 1995-06-27 Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes Expired - Lifetime DE69502733T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/328,895 US6132419A (en) 1992-05-22 1994-10-25 Electroporetic gene and drug therapy
PCT/US1995/008138 WO1996012520A1 (en) 1994-10-25 1995-06-27 Electroporetic gene and drug therapy by induced electric fields

Publications (2)

Publication Number Publication Date
DE69502733D1 true DE69502733D1 (de) 1998-07-02
DE69502733T2 DE69502733T2 (de) 1998-09-24

Family

ID=23282925

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69502733T Expired - Lifetime DE69502733T2 (de) 1994-10-25 1995-06-27 Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes

Country Status (8)

Country Link
US (1) US6132419A (de)
EP (1) EP0788392B1 (de)
AT (1) ATE166585T1 (de)
AU (1) AU2951595A (de)
DE (1) DE69502733T2 (de)
DK (1) DK0788392T3 (de)
ES (1) ES2117871T3 (de)
WO (1) WO1996012520A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585763B1 (en) * 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
US6775574B1 (en) * 1997-11-07 2004-08-10 Medtronic, Inc. Method and system for myocardial infarction repair
CA2320377C (en) 1998-02-24 2008-07-08 Boston Scientific Limited High flow rate dialysis catheters and related methods
EP1079890A4 (de) * 1998-05-08 2008-12-03 Genetronics Inc Elektrisch induzierte gefässdilation
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US20060127466A1 (en) * 2000-02-25 2006-06-15 Arindam Sen Method for transdermal or intradermal delivery of molecules
WO2001065911A2 (en) * 2000-03-03 2001-09-13 Valentis, Inc. Improved poloxamer and poloxamine compositions for nucleic acid delivery
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6994706B2 (en) * 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
AU2002348417B9 (en) 2001-10-26 2010-02-04 Baylor College Of Medicine A composition and method to alter lean body mass and bone properties in a subject
US6733518B2 (en) 2001-10-31 2004-05-11 Seacoast Technologies, Inc. Method and apparatus for thermal therapy
US7211083B2 (en) * 2003-03-17 2007-05-01 Minnesota Medical Physics, Llc Apparatus and method for hair removal by electroporation
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7361642B2 (en) 2003-08-04 2008-04-22 Vgx Pharmaceuticals, Inc. Canine specific growth hormone releasing hormone
US20050171574A1 (en) 2003-12-24 2005-08-04 The Regents Of The University Of California Electroporation to interrupt blood flow
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
WO2005065722A2 (en) 2003-12-31 2005-07-21 Advisys, Inc. Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation
US7517863B2 (en) 2004-01-20 2009-04-14 Vgx Pharmaceuticals, Inc. Enhanced secretion/retention of growth hormone releasing hormone (GHRH) from muscle cells by species-specific signal peptide
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
SG123643A1 (en) * 2004-12-28 2006-07-26 Nanyan Polytechnic Programmable apparatus and method for optimizing and real time monitoring of gene transfection basedon user configured arbitrary waveform pulsing tra in
LT2816118T (lt) 2005-05-31 2018-12-10 The Regents Of The University Of Colorado, A Body Corporate Genų pristatymo būdai
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
WO2007104756A1 (en) * 2006-03-13 2007-09-20 Novo Nordisk A/S Medical system comprising dual purpose communication means
US9173992B2 (en) 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
US8058253B2 (en) 2006-07-06 2011-11-15 Vgx Pharmaceuticals, Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
JP2010506657A (ja) 2006-10-16 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 組織の不可逆的エレクトロポレーションに使用される、所定の導電率を有するゲル
WO2009121009A2 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Irreversible electroporation device for use in attenuating neointimal
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8849395B2 (en) * 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
US9173704B2 (en) 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
WO2010008834A2 (en) 2008-06-23 2010-01-21 Angiodynamics, Inc. Treatment devices and methods
WO2010085765A2 (en) 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
US8231603B2 (en) 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
US20100249488A1 (en) * 2009-03-30 2010-09-30 MagneGene, Inc. Method of contactless magnetic electroporation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
WO2010137021A2 (en) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
RU2539991C2 (ru) 2009-12-16 2015-01-27 Кронтек Фарма Аб Впрыскивающие игла и устройство
EP3578205A1 (de) 2010-08-06 2019-12-11 ModernaTX, Inc. Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
CA2813466A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids that disrupt major groove binding partner interactions
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
WO2012106281A2 (en) 2011-01-31 2012-08-09 The General Hospital Corporation Multimodal trail molecules and uses in cellular therapies
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
WO2012172424A1 (en) 2011-06-15 2012-12-20 Crontech Pharma Ab Injection needle and device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
CN110511939A (zh) 2011-10-03 2019-11-29 现代泰克斯公司 修饰的核苷、核苷酸和核酸及其用途
EP2791160B1 (de) 2011-12-16 2022-03-02 ModernaTX, Inc. Modifizierte mrna zusammensetzungen
DE102012000354A1 (de) * 2012-01-11 2013-07-11 Udo Tartler Vorrichtung für eine Angussöffnung einer Gussform
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP2833923A4 (de) 2012-04-02 2016-02-24 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von proteinen
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014145042A1 (en) 2013-03-15 2014-09-18 Loma Linda University Treatment of autoimmune diseases
CA2913155A1 (en) 2013-05-21 2014-11-27 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
WO2016168601A1 (en) 2015-04-17 2016-10-20 Khalid Shah Agents, systems and methods for treating cancer
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
WO2018089690A1 (en) * 2016-11-09 2018-05-17 Sigma Genetics, Inc. Systems, devices, and methods for elecroporation induced by magnetic fields
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
CA3176902A1 (en) 2020-03-27 2021-09-30 Svenska Vaccinfabriken Produktion Ab Compositions and methods for treating and preventing coronaviruses
US20230295244A1 (en) 2021-09-29 2023-09-21 Svenska Vaccinfabriken Produktion Ab Compositions and methods for treating and preventing coronaviruses

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320462A (en) * 1940-09-27 1943-06-01 Nawells Frank Clock operated switch
US3978864A (en) * 1965-10-11 1976-09-07 L. B. Smith Estates, Inc. Electrotherapeutic treatment head
US4374669A (en) * 1975-05-09 1983-02-22 Mac Gregor David C Cardiovascular prosthetic devices and implants with porous systems
SU624640A1 (ru) * 1977-03-28 1978-09-25 Каунасский Медицинский Институт Способ электрофореза
DE3166638D1 (en) * 1980-12-23 1984-11-15 Kontron Ag Implantable electrode
US4501265A (en) * 1982-12-23 1985-02-26 Electro-Biology, Inc. Applicator head for electromagnetic treatment of an afflicted body region
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4842598A (en) * 1984-12-06 1989-06-27 Controlled Release Technologies, Inc. Therapeutic agent delivery system and method
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US4906576A (en) * 1986-05-09 1990-03-06 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4801459A (en) * 1986-08-05 1989-01-31 Liburdy Robert P Technique for drug and chemical delivery
US4818697A (en) * 1986-10-27 1989-04-04 Life Resonances, Inc. Techniques for enhancing the permeability of ions through membranes
US5290409A (en) * 1986-10-27 1994-03-01 Life Resonances, Inc. Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation
US5098843A (en) * 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
JP2798459B2 (ja) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー エレクトロポレーションを利用した診断装置及び分子の組織内移動装置
WO1989010690A1 (en) * 1988-05-02 1989-11-16 University Of South Florida Method for electrofusing biological particles to tissues
US5224922A (en) * 1988-05-19 1993-07-06 Kurtz Warren H Quasistatic biological cell and tissue modifier
US5183456A (en) * 1989-11-15 1993-02-02 Life Resonances, Inc. Method and apparatus for the treatment of cancer
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
DE69110467T2 (de) * 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5419763B1 (en) * 1994-01-04 1997-07-15 Cor Trak Medical Inc Prostatic drug-delivery catheter

Also Published As

Publication number Publication date
US6132419A (en) 2000-10-17
DE69502733T2 (de) 1998-09-24
EP0788392B1 (de) 1998-05-27
EP0788392A1 (de) 1997-08-13
WO1996012520A1 (en) 1996-05-02
AU2951595A (en) 1996-05-15
ATE166585T1 (de) 1998-06-15
ES2117871T3 (es) 1998-08-16
DK0788392T3 (da) 1999-03-01

Similar Documents

Publication Publication Date Title
DE69502733T2 (de) Elektrophoretische gen- und medikamenttherapie mittels eines induzierten elektrischen feldes
RU2141853C1 (ru) Система для клинического применения электропорации с обратной связью, управляющей напряжением
Jaroszeski et al. In vivo antitumor effects of electrochemotherapy in a hepatoma model
US6564093B1 (en) Transdermal active drug delivery system and method
EP0625360B1 (de) Gerät und einheit zur dosierung von medikamenten und zur sammlung von körperflüssigkeiten
US4953565A (en) Endermic application kits for external medicines
US6366808B1 (en) Implantable device and method for the electrical treatment of cancer
CN1980610B (zh) 电磁治疗装置
US20070026514A1 (en) Electromagnetic treatment apparatus for enhancing pharmacological, chemical, and topical agent effectiveness and method for using same
FI59203B (fi) Elektromedicinsk apparat foer terapeutisk behandling av celler och/eller levande vaevnad
US20050052630A1 (en) Constant current electroporation device and methods of use
DE69332033T2 (de) Magnetotherapeutische vorrichtung
US20130218235A9 (en) Excessive fibrous capsule formation and capsular contracture apparatus and method for using same
DE69511422D1 (de) Durchflussvorrichtung und verfahren zur elektroporation
EP1945295A2 (de) Elektromagnetische felder für systemische wirkung in der therapie
Gehl Electroporation for drug and gene delivery in the clinic: doctors go electric
ATE236681T1 (de) Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen
EP1131131A1 (de) System und verfahren zum aktiven transdermalen verabreichen einer arznei
EP3612270B1 (de) Elektromagnetisches modulares system für zellregeneration
CA2112131C (en) Device for causing protons to migrate out of electrolytical internal body fluids
JPH0623060A (ja) 電子薬物投与器
WO2008051521A2 (en) Excessive fibrous capsule formation and capsular contracture apparatus and method for using same
MX2008004415A (en) Electromagnetic fields for systemic effect in therapy
KR20070015908A (ko) 전자기적 치료 장치 및 방법
EP2077789A2 (de) Übermässige faserkapsel-bildung und kapselkontraktionsgerät und verfahren zu seiner anwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition