DE69506157T2 - Transdermales Matrixsystem auf Basis eines Styrol-Isopren-Styrol Copolymers zur Verabreichung eines Östrogens und/oder Gestagens - Google Patents

Transdermales Matrixsystem auf Basis eines Styrol-Isopren-Styrol Copolymers zur Verabreichung eines Östrogens und/oder Gestagens

Info

Publication number
DE69506157T2
DE69506157T2 DE69506157T DE69506157T DE69506157T2 DE 69506157 T2 DE69506157 T2 DE 69506157T2 DE 69506157 T DE69506157 T DE 69506157T DE 69506157 T DE69506157 T DE 69506157T DE 69506157 T2 DE69506157 T2 DE 69506157T2
Authority
DE
Germany
Prior art keywords
styrene
pts
isoprene
gestagen
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69506157T
Other languages
English (en)
Other versions
DE69506157D1 (de
Inventor
Claude Mikler
Laurent Liorzou
Daniel Dhuique-Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires dHygiene et de Dietetique SA
Original Assignee
Laboratoires dHygiene et de Dietetique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires dHygiene et de Dietetique SA filed Critical Laboratoires dHygiene et de Dietetique SA
Publication of DE69506157D1 publication Critical patent/DE69506157D1/de
Application granted granted Critical
Publication of DE69506157T2 publication Critical patent/DE69506157T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
DE69506157T 1994-03-28 1995-03-15 Transdermales Matrixsystem auf Basis eines Styrol-Isopren-Styrol Copolymers zur Verabreichung eines Östrogens und/oder Gestagens Expired - Fee Related DE69506157T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9403599A FR2717689B1 (fr) 1994-03-28 1994-03-28 Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.

Publications (2)

Publication Number Publication Date
DE69506157D1 DE69506157D1 (de) 1999-01-07
DE69506157T2 true DE69506157T2 (de) 1999-07-01

Family

ID=9461479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69506157T Expired - Fee Related DE69506157T2 (de) 1994-03-28 1995-03-15 Transdermales Matrixsystem auf Basis eines Styrol-Isopren-Styrol Copolymers zur Verabreichung eines Östrogens und/oder Gestagens

Country Status (23)

Country Link
US (1) US5580572A (de)
EP (1) EP0674901B1 (de)
JP (1) JPH07330609A (de)
KR (1) KR950031057A (de)
CN (1) CN1114903A (de)
AT (1) ATE173618T1 (de)
AU (1) AU691558B2 (de)
CA (1) CA2145584A1 (de)
CZ (1) CZ76795A3 (de)
DE (1) DE69506157T2 (de)
DK (1) DK0674901T3 (de)
ES (1) ES2128673T3 (de)
FI (1) FI951424A (de)
FR (1) FR2717689B1 (de)
GR (1) GR3029401T3 (de)
HU (1) HU219465B (de)
LV (1) LV10929B (de)
NO (1) NO951126L (de)
NZ (1) NZ270811A (de)
PL (1) PL178896B1 (de)
RU (1) RU2110282C1 (de)
SK (1) SK39095A3 (de)
ZA (1) ZA952469B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004028284A1 (de) * 2004-06-11 2006-01-05 Hexal Ag Matrixkontrolliertes transdermales therapeutisches System auf Basis eines Schmelzklebstoffs zur Anwendung von Norelgestromin

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WO1990004397A1 (de) * 1988-10-27 1990-05-03 Schering Aktiengesellschaft Berlin Und Bergkamen Mittel zur transdermalen applikation enthaltend gestoden
US6148830A (en) 1994-04-19 2000-11-21 Applied Elastomerics, Inc. Tear resistant, multiblock copolymer gels and articles
US7134236B2 (en) * 1994-04-19 2006-11-14 Applied Elastomerics, Inc. Gelatinous elastomer compositions and articles for use as fishing bait
US7234560B2 (en) * 1994-04-19 2007-06-26 Applied Elastomerics, Inc. Inflatable restraint cushions and other uses
US5820878A (en) * 1994-11-18 1998-10-13 Hisamitsu Pharmaceutical Co., Inc. Percutaneously absorbable patch
FR2739031B1 (fr) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base de copolymere styrene-isoprene-styrene, procede de preparation et utilisation en therapeutique
JP3857348B2 (ja) * 1996-02-20 2006-12-13 ソニー株式会社 テープカートリッジ
DE19700913C2 (de) * 1997-01-14 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Hormonen
KR20010112479A (ko) * 1999-07-01 2001-12-20 나까도미 히로다카 경피흡수 첩부제
JP4648518B2 (ja) * 2000-06-01 2011-03-09 帝國製薬株式会社 ４−ビフェニル酢酸含有貼付剤
DE10236319A1 (de) * 2002-08-08 2004-02-19 Beiersdorf Ag Hautfreundliche Wirkstoffpflaster auf der Basis von SBC mit mindestens einem pharmazeutischen Wirkstoff mit einem Gehalt von mindestens 34 Gew.-% und dessen Herstellung
US20050191339A1 (en) * 2002-08-08 2005-09-01 Beiersdorf Ag Skin friendly active ingredient plaster based on SBC, containing at least 34 WT.% of a pharmaceutical active ingredient and production thereof
JP2004224741A (ja) * 2003-01-23 2004-08-12 Hisamitsu Pharmaceut Co Inc ツロブテロール経皮吸収型製剤
JP4422430B2 (ja) * 2003-05-14 2010-02-24 帝國製薬株式会社 エストロゲン及び／又はプロゲストゲン含有外用貼付剤
JP4311728B2 (ja) * 2003-12-10 2009-08-12 ニチバン株式会社 経皮吸収型貼付剤
US20070062884A1 (en) 2005-08-11 2007-03-22 Board Of Regents, The University Of Texas System N-halamines compounds as multifunctional additives
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2013078422A2 (en) 2011-11-23 2013-05-30 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10206932B2 (en) 2014-05-22 2019-02-19 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299501A (en) * 1979-08-10 1981-11-10 Ortho Pharmaceutical Corporation Continuous process for the preparation of semisolid dispersions
JPS60188315A (ja) * 1984-03-07 1985-09-25 Yamanouchi Pharmaceut Co Ltd グリチルレチン酸配合鎮痒プラスター
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5032402A (en) * 1988-10-27 1991-07-16 The University Of Kentucky Research Foundation 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer
AU633733B2 (en) * 1990-05-17 1993-02-04 Hisamitsu Pharmaceutical Co., Inc. Percutaneous preparation containing estradiol
US5232702A (en) * 1991-07-22 1993-08-03 Dow Corning Corporation Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices
JPH05331064A (ja) * 1992-05-26 1993-12-14 Sekisui Chem Co Ltd 消炎鎮痛貼付剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004028284A1 (de) * 2004-06-11 2006-01-05 Hexal Ag Matrixkontrolliertes transdermales therapeutisches System auf Basis eines Schmelzklebstoffs zur Anwendung von Norelgestromin

Also Published As

Publication number Publication date
EP0674901A1 (de) 1995-10-04
GR3029401T3 (en) 1999-05-28
CZ76795A3 (en) 1995-10-18
ES2128673T3 (es) 1999-05-16
CA2145584A1 (en) 1995-09-29
ZA952469B (en) 1995-12-19
RU2110282C1 (ru) 1998-05-10
HUT75238A (en) 1997-05-28
EP0674901B1 (de) 1998-11-25
AU1497895A (en) 1995-10-05
FR2717689B1 (fr) 1996-07-05
LV10929A (lv) 1995-12-20
US5580572A (en) 1996-12-03
AU691558B2 (en) 1998-05-21
NO951126L (no) 1995-09-29
FI951424A0 (fi) 1995-03-24
FR2717689A1 (fr) 1995-09-29
KR950031057A (ko) 1995-12-18
DK0674901T3 (da) 1999-08-09
NZ270811A (en) 1995-12-21
DE69506157D1 (de) 1999-01-07
PL178896B1 (pl) 2000-06-30
PL307891A1 (en) 1995-10-02
FI951424A (fi) 1995-09-29
ATE173618T1 (de) 1998-12-15
LV10929B (en) 1996-08-20
CN1114903A (zh) 1996-01-17
HU9500880D0 (en) 1995-05-29
NO951126D0 (no) 1995-03-24
HU219465B (hu) 2001-04-28
JPH07330609A (ja) 1995-12-19
SK39095A3 (en) 1995-10-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee