DE69506393T2 - Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen - Google Patents
Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzenInfo
- Publication number
- DE69506393T2 DE69506393T2 DE69506393T DE69506393T DE69506393T2 DE 69506393 T2 DE69506393 T2 DE 69506393T2 DE 69506393 T DE69506393 T DE 69506393T DE 69506393 T DE69506393 T DE 69506393T DE 69506393 T2 DE69506393 T2 DE 69506393T2
- Authority
- DE
- Germany
- Prior art keywords
- ligitation
- hybridisation
- dna sequences
- specific dna
- detecting specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22261394A | 1994-04-04 | 1994-04-04 | |
PCT/IB1995/000226 WO1995027078A1 (en) | 1994-04-04 | 1995-04-03 | Hibridization-ligation assays for the detection of specific nucleic acid sequences |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69506393D1 DE69506393D1 (de) | 1999-01-14 |
DE69506393T2 true DE69506393T2 (de) | 1999-07-01 |
Family
ID=22832958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69506393T Expired - Lifetime DE69506393T2 (de) | 1994-04-04 | 1995-04-03 | Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5800994A (de) |
EP (1) | EP0754241B1 (de) |
JP (1) | JP3738910B2 (de) |
AT (1) | ATE174066T1 (de) |
BR (1) | BR9507343A (de) |
CA (1) | CA2186465A1 (de) |
DE (1) | DE69506393T2 (de) |
PL (1) | PL316611A1 (de) |
WO (1) | WO1995027078A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
GB9507238D0 (en) * | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
US6297006B1 (en) * | 1997-01-16 | 2001-10-02 | Hyseq, Inc. | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments |
US6309824B1 (en) * | 1997-01-16 | 2001-10-30 | Hyseq, Inc. | Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes |
JP4294740B2 (ja) * | 1997-05-23 | 2009-07-15 | ソレクサ・インコーポレイテッド | 分析物の系列的プロセシングのためのシステムおよび装置 |
CA2300940A1 (en) * | 1997-08-15 | 1999-02-25 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
WO1999029890A2 (en) * | 1997-12-12 | 1999-06-17 | Digene Corporation | Assessment of human papilloma virus-related disease |
JP3662850B2 (ja) | 1998-06-24 | 2005-06-22 | イルミナ インコーポレイテッド | 微小球を有するアレイセンサーのデコード |
US5998175A (en) * | 1998-07-24 | 1999-12-07 | Lumigen, Inc. | Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers |
US6232067B1 (en) * | 1998-08-17 | 2001-05-15 | The Perkin-Elmer Corporation | Adapter directed expression analysis |
US6180408B1 (en) * | 1998-08-21 | 2001-01-30 | Washington University | Fluorescence polarization in nucleic acid analysis |
EP0990903B1 (de) | 1998-09-18 | 2003-03-12 | Massachusetts Institute Of Technology | Biologische Verwendungen von halbleitenden Nanokristallen |
AU7569600A (en) | 1999-05-20 | 2000-12-28 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
JP2003527087A (ja) * | 1999-08-13 | 2003-09-16 | イェール・ユニバーシティ | バイナリーコード化配列タグ |
WO2001025481A1 (fr) * | 1999-10-04 | 2001-04-12 | Olympus Optical Co., Ltd. | Procede de detection d'acide nucleique |
US6569685B1 (en) | 1999-10-05 | 2003-05-27 | The Molecular Sciences Institute, Inc. | Protein fingerprint system and related methods |
US6136549A (en) * | 1999-10-15 | 2000-10-24 | Feistel; Christopher C. | systems and methods for performing magnetic chromatography assays |
US7390675B2 (en) * | 1999-10-15 | 2008-06-24 | Christopher Feistel | Multi-functional and configurable assay |
US7371584B2 (en) * | 1999-10-15 | 2008-05-13 | Wavesence, Inc. | Multi-functional and configurable assay |
US6368801B1 (en) | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
AU2001265121A1 (en) * | 2000-05-30 | 2001-12-11 | Applera Corporation | Methods for detecting target nucleic acids using coupled ligation and amplification |
US7439016B1 (en) * | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
US7601497B2 (en) * | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
US6562575B1 (en) | 2000-06-26 | 2003-05-13 | Epicentre Technologies Corporation | Analyte-specific assays based on formation of a replicase substrate |
JP4755755B2 (ja) * | 2000-12-15 | 2011-08-24 | 独立行政法人産業技術総合研究所 | 複数検査多重化用懸濁液およびその懸濁液を用いた複数検査多重化方法 |
US20040266021A9 (en) * | 2001-01-26 | 2004-12-30 | Andras Guttman | Multicapillary fraction collection system and method |
US20020168667A1 (en) * | 2001-03-23 | 2002-11-14 | Fuji Photo Film Co., Ltd. | Antigen detecting agent and antigen detecting kit, antigen detecting apparatus and antigen detecting method using the same |
US7018795B2 (en) * | 2001-03-23 | 2006-03-28 | Fuji Photo Film Co., Ltd. | Hybridization probe and target nucleic acid detecting kit, target nucleic acid detecting apparatus and target nucleic acid detecting method using the same |
US20020168756A1 (en) * | 2001-03-23 | 2002-11-14 | Fuji Photo Film Co., Ltd. | Particle size variable reactor |
US7077982B2 (en) * | 2001-03-23 | 2006-07-18 | Fuji Photo Film Co., Ltd. | Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit |
US20030003476A1 (en) * | 2001-03-23 | 2003-01-02 | Fuji Photo Film Co., Ltd. | Waste water inspecting agent and waste water inspecting apparatus using the same |
AU2002362013B2 (en) * | 2001-11-21 | 2008-04-24 | Applied Biosystems, Llc. | Digital assay |
JP4274948B2 (ja) * | 2002-03-13 | 2009-06-10 | シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト | 核酸検出方法 |
US20030179381A1 (en) * | 2002-03-18 | 2003-09-25 | Fuji Photo Film Co., Ltd. | Sensor, color sensor and apparatus for inspection using the same |
CA2497297A1 (en) * | 2002-08-30 | 2004-03-11 | Bayer Healthcare Llc | Solid phase based nucleic acid assays combining high affinity and high specificity |
US8394944B2 (en) * | 2002-09-20 | 2013-03-12 | Siemens Healthcare Diagnostics Inc. | Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation |
US20040235005A1 (en) * | 2002-10-23 | 2004-11-25 | Ernest Friedlander | Methods and composition for detecting targets |
JP4294946B2 (ja) * | 2002-12-13 | 2009-07-15 | 富士フイルム株式会社 | 標的検出装置及び標的検出方法並びに標的検出用基材 |
US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
US7076127B2 (en) * | 2003-01-14 | 2006-07-11 | Fuji Photo Film Co., Ltd. | Optical switch and safety apparatus using the same |
US8043834B2 (en) | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
WO2005001129A2 (en) * | 2003-06-06 | 2005-01-06 | Applera Corporation | Mobility cassettes |
US20060008823A1 (en) * | 2004-05-12 | 2006-01-12 | Kemp Jennifer T | DNA profiling and SNP detection utilizing microarrays |
EP1863908B1 (de) | 2005-04-01 | 2010-11-17 | Qiagen GmbH | Reverse transkription und amplifikation von rna bei simultaner degradierung von dna |
US20070020699A1 (en) * | 2005-07-19 | 2007-01-25 | Idexx Laboratories, Inc. | Lateral flow assay and device using magnetic particles |
EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
WO2010062546A1 (en) * | 2008-10-27 | 2010-06-03 | Qiagen Gaithersburg Inc. | Fast results hybrid capture assay on an automated platform |
WO2010088292A1 (en) * | 2009-01-28 | 2010-08-05 | Qiagen Gaithersburg, Inc. | Sequence-specific large volume sample preparation method and assay |
US9797000B2 (en) | 2009-05-01 | 2017-10-24 | Qiagen Gaithersburg Inc. | Non-target amplification method for detection of RNA splice-forms in a sample |
EP2478087B1 (de) | 2009-09-14 | 2017-01-18 | QIAGEN Gaithersburg, Inc. | Zusammensetzungen und verfahren zur rückgewinnung von nukleinsäuren oder proteinen aus in zytologischen medien fixierten gewebeproben |
US9605303B2 (en) | 2010-01-29 | 2017-03-28 | Qiagen Gaithersburg, Inc. | Method of determining and confirming the presence of an HPV in a sample |
US9689047B2 (en) * | 2010-01-29 | 2017-06-27 | Qiagen Gaithersburg Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
AU2011255638B2 (en) | 2010-05-19 | 2016-08-25 | Qiagen Gaithersburg, Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
WO2012116220A2 (en) | 2011-02-24 | 2012-08-30 | Qiagen Gaithersburg, Inc. | Materials and methods for detection of hpv nucleic acid |
US9447458B2 (en) | 2011-11-16 | 2016-09-20 | Canon U.S. Life Sciences, Inc. | Detection of neighboring variants |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US5242794A (en) * | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4925785A (en) * | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
US5312910A (en) * | 1987-05-26 | 1994-05-17 | Monsanto Company | Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase |
US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
CA1341584C (en) * | 1988-04-06 | 2008-11-18 | Bruce Wallace | Method of amplifying and detecting nucleic acid sequences |
WO1989009835A1 (en) * | 1988-04-08 | 1989-10-19 | The Salk Institute For Biological Studies | Ligase-based amplification method |
US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
EP1507000B1 (de) * | 1990-05-03 | 2010-03-03 | Cornell Research Foundation, Inc. | Hitzestabiles Ligase enthaltendes DNS-Amplifikationssystem zur Bestimmung von genetischen Krankheiten |
CA2049879A1 (en) * | 1990-08-30 | 1992-03-01 | Keith C. Backman | Controlled initial target-dependent production of templates for ligase chain reaction |
CA2046713A1 (en) * | 1990-10-16 | 1992-04-17 | Richard M. Martinelli | Amplification of midivariant dna templates |
NZ245242A (en) * | 1992-01-17 | 1994-12-22 | Pioneer Hi Bred Int | Identifying variations between organisms by detecting polymorphisms in single sequence repeats |
ATE173767T1 (de) * | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
WO1994008047A1 (en) * | 1992-09-25 | 1994-04-14 | Abbott Laboratories | Ligase chain reaction method for detecting small mutations |
-
1995
- 1995-04-03 EP EP95912383A patent/EP0754241B1/de not_active Expired - Lifetime
- 1995-04-03 CA CA002186465A patent/CA2186465A1/en not_active Abandoned
- 1995-04-03 BR BR9507343A patent/BR9507343A/pt not_active IP Right Cessation
- 1995-04-03 DE DE69506393T patent/DE69506393T2/de not_active Expired - Lifetime
- 1995-04-03 WO PCT/IB1995/000226 patent/WO1995027078A1/en active IP Right Grant
- 1995-04-03 PL PL95316611A patent/PL316611A1/xx unknown
- 1995-04-03 JP JP52554895A patent/JP3738910B2/ja not_active Expired - Fee Related
- 1995-04-03 AT AT95912383T patent/ATE174066T1/de not_active IP Right Cessation
-
1996
- 1996-07-24 US US08/685,793 patent/US5800994A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3738910B2 (ja) | 2006-01-25 |
ATE174066T1 (de) | 1998-12-15 |
JPH09510878A (ja) | 1997-11-04 |
CA2186465A1 (en) | 1995-10-12 |
US5800994A (en) | 1998-09-01 |
EP0754241A1 (de) | 1997-01-22 |
PL316611A1 (en) | 1997-01-20 |
AU684915B2 (en) | 1998-01-08 |
EP0754241B1 (de) | 1998-12-02 |
AU1958595A (en) | 1995-10-23 |
BR9507343A (pt) | 1997-09-16 |
WO1995027078A1 (en) | 1995-10-12 |
DE69506393D1 (de) | 1999-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |