DE69514371T2 - Einspritzbares polyethylenoxidgel-implantat und ein verfahren zu seiner herstellung - Google Patents

Einspritzbares polyethylenoxidgel-implantat und ein verfahren zu seiner herstellung

Info

Publication number
DE69514371T2
DE69514371T2 DE69514371T DE69514371T DE69514371T2 DE 69514371 T2 DE69514371 T2 DE 69514371T2 DE 69514371 T DE69514371 T DE 69514371T DE 69514371 T DE69514371 T DE 69514371T DE 69514371 T2 DE69514371 T2 DE 69514371T2
Authority
DE
Germany
Prior art keywords
polyethylene oxide
producing
same
implant
oxide gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69514371T
Other languages
English (en)
Other versions
DE69514371D1 (de
Inventor
L Villain
A Parel
G Lee
Gabriel Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of DE69514371D1 publication Critical patent/DE69514371D1/de
Application granted granted Critical
Publication of DE69514371T2 publication Critical patent/DE69514371T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059—Cosmetic or alloplastic implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
    • A61F9/0133—Knives or scalpels specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320044—Blunt dissectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/12—Mammary prostheses and implants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
    • C08J2371/02—Polyalkylene oxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/905—Eye
    • Y10S623/906—Corneal
DE69514371T 1994-09-01 1995-08-30 Einspritzbares polyethylenoxidgel-implantat und ein verfahren zu seiner herstellung Expired - Fee Related DE69514371T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/299,583 US5634943A (en) 1990-07-12 1994-09-01 Injectable polyethylene oxide gel implant and method for production
PCT/US1995/010733 WO1996006883A1 (en) 1994-09-01 1995-08-30 Injectable polyethylene oxide gel implant and method for production

Publications (2)

Publication Number Publication Date
DE69514371D1 DE69514371D1 (de) 2000-02-10
DE69514371T2 true DE69514371T2 (de) 2000-08-10

Family

ID=23155423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69514371T Expired - Fee Related DE69514371T2 (de) 1994-09-01 1995-08-30 Einspritzbares polyethylenoxidgel-implantat und ein verfahren zu seiner herstellung

Country Status (15)

Country Link
US (3) US5634943A (de)
EP (1) EP0778858B1 (de)
JP (1) JP3681393B2 (de)
KR (1) KR100369961B1 (de)
AT (1) ATE188499T1 (de)
AU (1) AU690327B2 (de)
BR (1) BR9508696A (de)
CA (1) CA2198906A1 (de)
CO (1) CO4440603A1 (de)
DE (1) DE69514371T2 (de)
ES (1) ES2145293T3 (de)
MX (1) MX9701582A (de)
TW (1) TW421600B (de)
WO (1) WO1996006883A1 (de)
ZA (1) ZA957331B (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US6566406B1 (en) 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
FR2786400B1 (fr) * 1998-11-30 2002-05-10 Imedex Biomateriaux Procede de preparation d'un materiau collagenique a vitesse de biodegradation in vivo controlee et materiaux obtenus
US6361560B1 (en) * 1998-12-23 2002-03-26 Anamed, Inc. Corneal implant and method of manufacture
US7635388B1 (en) 2000-05-04 2009-12-22 Tyler Thomas D Device and method for incremental correction of sight disorders and occular diseases
WO2002021965A1 (en) 2000-09-12 2002-03-21 Anamed, Inc. System for packaging and handling an implant and method of use
US8668735B2 (en) 2000-09-12 2014-03-11 Revision Optics, Inc. Corneal implant storage and delivery devices
US6296607B1 (en) * 2000-10-20 2001-10-02 Praxis, Llc. In situ bulking device
DE10106546A1 (de) * 2001-02-13 2002-08-22 Ethicon Gmbh Verfahren zum Herstellen eines medizinischen Implantats
US6537569B2 (en) * 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
US6482870B1 (en) * 2001-07-19 2002-11-19 Shahriar Hojjati Emami Crosslink polyethylene oxide in the melt by means of 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane
KR100798058B1 (ko) * 2001-12-01 2008-01-28 가부시키가이샤 아이 메딕 뼈 고정용 임플란트
US7579442B2 (en) * 2002-04-16 2009-08-25 Ocugenics, LLC Method for stromal corneal repair and refractive alteration
US20030232287A1 (en) * 2002-06-14 2003-12-18 Bango Joseph J. Method for stromal corneal repair and refractive alteration using photolithography
US20110098790A1 (en) * 2009-10-26 2011-04-28 Albert Daxer Methods for treating corneal disease
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
GB2406854A (en) * 2003-09-03 2005-04-13 Frederick Pearson Method and apparatus for sterilising a material or treating carbonaceous material
EP1696831B1 (de) * 2003-12-05 2014-01-15 Innolene LLC Verfahren zum herstellen einer refraktiven okularlinse
EP1689333B1 (de) * 2003-12-05 2014-02-12 Innfocus, Inc. Verbesserte glaukom-implantationsvorrichtung
US20050186240A1 (en) * 2004-02-23 2005-08-25 Ringeisen Timothy A. Gel suitable for implantation and delivery system
US20050220882A1 (en) * 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US8057541B2 (en) 2006-02-24 2011-11-15 Revision Optics, Inc. Method of using small diameter intracorneal inlays to treat visual impairment
US10835371B2 (en) 2004-04-30 2020-11-17 Rvo 2.0, Inc. Small diameter corneal inlay methods
US7776086B2 (en) 2004-04-30 2010-08-17 Revision Optics, Inc. Aspherical corneal implant
EP1799754B1 (de) * 2004-08-25 2008-03-19 Union Carbide Chemicals & Plastics Technology Corporation Polymerfolie
US7919112B2 (en) * 2004-08-26 2011-04-05 Pathak Holdings, Llc Implantable tissue compositions and method
US20060074182A1 (en) * 2004-09-30 2006-04-06 Depuy Products, Inc. Hydrogel composition and methods for making the same
WO2006102676A1 (en) * 2005-03-23 2006-09-28 Tissue Engineering Refraction, Inc. Injectable polyethylene oxide dermal fillers and related devices
EP1933751A4 (de) * 2005-10-13 2009-12-02 Shui T Lai Intrastromale refraktive chirurgie durch induktion von formveränderungen in der hornhaut
US10555805B2 (en) 2006-02-24 2020-02-11 Rvo 2.0, Inc. Anterior corneal shapes and methods of providing the shapes
AU2007253255A1 (en) 2006-05-23 2007-11-29 Albert Daxer Corneal implant and method for correction of impaired vision in the human eye
EP2021094A4 (de) * 2006-05-25 2010-02-10 Gen Hospital Corp Antivernetzungsmittel und verfahren zur hemmung der vernetzung injizierbarer hydrogelformulierungen
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US9549848B2 (en) 2007-03-28 2017-01-24 Revision Optics, Inc. Corneal implant inserters and methods of use
US9271828B2 (en) 2007-03-28 2016-03-01 Revision Optics, Inc. Corneal implant retaining devices and methods of use
US8162953B2 (en) 2007-03-28 2012-04-24 Revision Optics, Inc. Insertion system for corneal implants
CN201075472Y (zh) * 2007-05-28 2008-06-18 富士康(昆山)电脑接插件有限公司 电连接器
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US20090220578A1 (en) * 2008-02-28 2009-09-03 Depuy Products, Inc. Hydrogel composition and method for making the same
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
US8745133B2 (en) * 2008-03-28 2014-06-03 Yahoo! Inc. System and method for optimizing the storage of data
AU2009231636B2 (en) 2008-04-04 2014-07-24 Revision Optics, Inc. Corneal inlay design and methods of correcting vision
US9539143B2 (en) 2008-04-04 2017-01-10 Revision Optics, Inc. Methods of correcting vision
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PT2442835E (pt) 2009-06-16 2015-03-23 Baxter Healthcare Sa Esponja hemostática
ES2636741T3 (es) 2009-07-31 2017-10-09 Sanofi-Aventis Deutschland Gmbh Composición de insulina de acción prolongada
WO2011012718A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Prodrugs comprising an insulin linker conjugate
KR101756493B1 (ko) 2009-10-29 2017-07-10 아센디스 파마 에이에스 생분해성 하이드로겔의 살균
JP2013514093A (ja) 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
CN103037845B (zh) 2010-06-01 2015-11-25 巴克斯特国际公司 用于制备干燥、稳定的止血组合物的方法
US9084728B2 (en) 2010-06-01 2015-07-21 Baxter International Inc. Process for making dry and stable hemostatic compositions
JP6289096B2 (ja) 2010-06-01 2018-03-07 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血組成物を作製するためのプロセス
US8469948B2 (en) 2010-08-23 2013-06-25 Revision Optics, Inc. Methods and devices for forming corneal channels
EP2438930A1 (de) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrug mit einem exendinbindenden Konjugat
KR101272484B1 (ko) * 2011-01-19 2013-06-10 세원셀론텍(주) 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법
US20130090291A1 (en) 2011-10-11 2013-04-11 Baxter Healthcare S.A. Hemostatic compositions
AU2012318257B2 (en) 2011-10-11 2015-10-01 Baxter Healthcare S.A. Hemostatic compositions
RU2619654C2 (ru) 2011-10-21 2017-05-17 Ревижн Оптикс, Инк. Устройства для хранения и подачи имплантатов роговицы
US20130108671A1 (en) 2011-10-27 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
WO2016144404A1 (en) 2015-03-12 2016-09-15 Revision Optics, Inc. Methods of correcting vision
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CN105169469B (zh) * 2015-08-29 2018-05-25 北京诺康达医药科技有限公司 一种组织密封剂及其制备方法和应用
JP7395113B2 (ja) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス 止血組成物を調製する方法
US11864990B2 (en) * 2019-02-26 2024-01-09 Avedro, Inc. Bioresorbable corneal implants
CN112679726B (zh) * 2020-12-23 2023-03-17 鸡西市唯大新材料科技有限公司 用聚氧化乙烯制备具有亲油及亲水性透明有机凝胶的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB117032A (en) * 1917-12-31 1918-07-04 Albert Edgar Alexander Cleaning Shop for Cleansing Work by Means of a Sand Jet.
US3264202A (en) * 1961-06-13 1966-08-02 Union Carbide Corp Ionizing radiation of water solution of polyalkylene oxide and product thereof
FR1441586A (fr) * 1965-04-21 1966-06-10 Centre Nat Rech Scient Gel de polyoxyéthylèneglycol et procédé de préparation
US3419006A (en) * 1966-08-08 1968-12-31 Union Carbide Corp Novel dressing and use thereof
US4381320A (en) * 1981-06-03 1983-04-26 Johnson & Johnson Non-ionic absorbent polymers
DE3343674A1 (de) * 1983-12-02 1985-09-05 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von (alpha) -substituierten acrylsaeureamiden
US4790919A (en) * 1984-06-28 1988-12-13 E. I. Du Pont De Nemours And Company Process for preparation of electrophoresis gel material
US4911691A (en) * 1984-09-21 1990-03-27 Menlo Care, Inc. Assembly for adminstering IV solution
US4883699A (en) * 1984-09-21 1989-11-28 Menlo Care, Inc. Polymeric article having high tensile energy to break when hydrated
US4616644A (en) * 1985-06-14 1986-10-14 Johnson & Johnson Products, Inc. Hemostatic adhesive bandage
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
GB8615701D0 (en) * 1986-06-27 1986-08-06 Delta Biotechnology Ltd Stable gene integration vector
US4706680A (en) * 1986-06-30 1987-11-17 Nepera Inc. Conductive adhesive medical electrode assemblies
US4684558A (en) * 1986-06-30 1987-08-04 Nepera Inc. Adhesive polyethylene oxide hydrogel sheet and its production
GB8717799D0 (en) * 1987-07-28 1987-09-03 Atomic Energy Authority Uk Polymer electrolytes
US5143071A (en) * 1989-03-30 1992-09-01 Nepera, Inc. Non-stringy adhesive hydrophilic gels
WO1993022987A2 (en) * 1992-05-20 1993-11-25 Cytrx Corporation Gel composition for implant and method
WO1994017851A1 (en) * 1993-02-08 1994-08-18 Massachusetts Institute Of Technology Bilayer composite hydrogels for corneal prostheses
FR2707499B1 (fr) * 1993-04-30 1995-12-01 Patrice Navatel Procédé de formation de gels par action de rayons ionisants, et produits obtenus.

Also Published As

Publication number Publication date
US5681869A (en) 1997-10-28
DE69514371D1 (de) 2000-02-10
TW421600B (en) 2001-02-11
ZA957331B (en) 1996-04-15
KR970705600A (ko) 1997-10-09
CO4440603A1 (es) 1997-05-07
BR9508696A (pt) 1997-09-09
US5634943A (en) 1997-06-03
AU3413695A (en) 1996-03-22
ES2145293T3 (es) 2000-07-01
ATE188499T1 (de) 2000-01-15
WO1996006883A1 (en) 1996-03-07
AU690327B2 (en) 1998-04-23
EP0778858A1 (de) 1997-06-18
EP0778858B1 (de) 2000-01-05
JP3681393B2 (ja) 2005-08-10
CA2198906A1 (en) 1996-03-07
KR100369961B1 (ko) 2003-03-15
JPH10505115A (ja) 1998-05-19
MX9701582A (es) 1998-03-31
US5645583A (en) 1997-07-08

Similar Documents

Publication Publication Date Title
DE69514371T2 (de) Einspritzbares polyethylenoxidgel-implantat und ein verfahren zu seiner herstellung
CA2083165C (en) Device and method for treating facial lines
Froum et al. Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio-Oss) for sinus augmentation: histomorphometry at 26 to 32 weeks after grafting.
Scantlebury et al. The development of guided regeneration: making the impossible possible and the unpredictable predictable
Del Corso et al. The use of leukocyte-and platelet-rich fibrin during immediate postextractive implantation and loading for the esthetic replacement of a fractured maxillary central incisor
CN108355171B (zh) 脱细胞真皮基质引导组织再生膜材料及其制备方法和应用
CA1295259C (en) Process for augmenting soft tissue with cross-linked polyvinyl pyrrolidone
JPH0622571B2 (ja) コラーゲン／鉱質混合物の水分含量調整法
Ezoddini-Ardakani et al. Histologic evaluation of chitosan as an accelerator of bone regeneration in microdrilled rat tibias
RU2399387C2 (ru) Материал для имплантации и пластики пародонта и способ его приготовления
Cakir et al. Experimental Evaluation of the Effects of Ankaferd Blood Stopperand Collagenated Heterologous Bone Graft on Bone Healing in Sinus Floor Augmentation.
CH643732A5 (en) Aid for covering and/or filling bone defects and process for the production thereof
US20030078394A1 (en) Method of producing low molecular weight chitin/chitosan and method of producing an osteoconduction substance
Kohavi et al. Short-Tern Effect of Guided Bone Regeneration and Electrical Stimulation on Bone Growth in A Surgically Modelled Resorbed Dog Mandibular Ridge
RU2297250C2 (ru) Трансплантационная смесь
CN110267689A (zh) 准备移植物方法
Kumar et al. Awareness of guided tissue regeneration membranes in implant dentistry among dental students.
Zhu et al. The Influence of Storage in Saline or Irradiation by Ultraviolet on Implant Hydrophilicity and Osseointegration: An Experimental Study in Rabbits
CA1310918C (en) Gamma irradiation of collagen/mineral mixtures
Alamoudi Promoting of fibroblast cells attachment on barrier bone membranes using ultraviolet light and non-thermal plasma
WO2023201195A2 (en) Systems, methods, and devices of exosome delivery for bone healing
CN105013002B (zh) 可吸收生物活性骨诱导材料及其制备方法
RU93048621A (ru) Способ устранения дефекта костной ткани
RU2136297C1 (ru) Способ получения трансплантата "био-матрикс имплант" для стоматологии
RU2300343C1 (ru) Способ остеогингивопластики при пародонтите тяжелой степени

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee