DE69518333D1 - Polysaccharide mit hohem anteil an iduronsäure - Google Patents

Polysaccharide mit hohem anteil an iduronsäure

Info

Publication number
DE69518333D1
DE69518333D1 DE69518333T DE69518333T DE69518333D1 DE 69518333 D1 DE69518333 D1 DE 69518333D1 DE 69518333 T DE69518333 T DE 69518333T DE 69518333 T DE69518333 T DE 69518333T DE 69518333 D1 DE69518333 D1 DE 69518333D1
Authority
DE
Germany
Prior art keywords
pct
polysaccharide
iduronsäure
sulfation
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69518333T
Other languages
English (en)
Other versions
DE69518333T2 (de
Inventor
Giorgio Zoppetti
Pasqua Oreste
Giovanni Cipolletti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inalco SpA
Original Assignee
Inalco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11369805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69518333(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inalco SpA filed Critical Inalco SpA
Application granted granted Critical
Publication of DE69518333D1 publication Critical patent/DE69518333D1/de
Publication of DE69518333T2 publication Critical patent/DE69518333T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
DE69518333T 1994-11-04 1995-10-30 Polysaccharide mit hohem anteil an iduronsäure Expired - Fee Related DE69518333T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942240A IT1271057B (it) 1994-11-04 1994-11-04 Polisaccaridi aventi un elevato contenuto di acido iduronico
PCT/EP1995/004241 WO1996014425A1 (en) 1994-11-04 1995-10-30 Polysaccharides having a high iduronic acid content

Publications (2)

Publication Number Publication Date
DE69518333D1 true DE69518333D1 (en) 2000-09-14
DE69518333T2 DE69518333T2 (de) 2001-02-22

Family

ID=11369805

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69518333T Expired - Fee Related DE69518333T2 (de) 1994-11-04 1995-10-30 Polysaccharide mit hohem anteil an iduronsäure

Country Status (13)

Country Link
US (1) US5958899A (de)
EP (1) EP0789777B1 (de)
JP (1) JP3640259B2 (de)
CN (1) CN1094977C (de)
AT (1) ATE195348T1 (de)
AU (1) AU3926195A (de)
CA (1) CA2204366A1 (de)
DE (1) DE69518333T2 (de)
DK (1) DK0789777T3 (de)
ES (1) ES2150589T3 (de)
IT (1) IT1271057B (de)
PT (1) PT789777E (de)
WO (1) WO1996014425A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
SE9701454D0 (sv) * 1997-04-18 1997-04-18 Ulf Lindahl new DNA sequences and a process for enzyme manufacture
US8088604B2 (en) * 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US7307159B2 (en) * 2001-05-08 2007-12-11 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase from P. multocida and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
CN1098354C (zh) * 1998-11-12 2003-01-08 武汉大学 双酶催化法合成1－β－D－呋喃核糖苷－1，2，4－三氮唑－3－甲酰胺
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
DK1379639T3 (da) 2000-12-08 2005-11-28 Biotie Therapies Corp Muse-glucuronyl-C5-epimerase, DNA der koder for samme, og anvendelser deraf
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US8580290B2 (en) 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
EP1518120A4 (de) 2002-03-11 2008-08-13 Momenta Pharmaceuticals Inc Analyse sulfatierter polysaccharide
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
PL375088A1 (en) * 2002-06-18 2005-11-14 Glycores 2000 S.R.L. Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
FI20065035A (fi) * 2006-01-19 2007-07-20 Polysackaridforskning I Uppsal Olennaisesti puhdas entsyymi
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2009014715A2 (en) * 2007-07-23 2009-01-29 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
CN101591401A (zh) * 2009-02-27 2009-12-02 江南大学 一种制备高活性低分子量肝素的方法
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
EP2655421B1 (de) 2010-12-23 2022-02-09 The University of North Carolina At Chapel Hill Chemoenzymatische synthese von strukturell homogenen heparinen mit ultra-niedrigem molekulargewicht
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
BR112014024291B1 (pt) 2012-03-30 2022-07-05 The Board Of Regents Of The University Of Oklahoma Método para a produção de forma recombinante de um polímero de heparosan com alto peso molecular, uso do referido polímero para aumento de tecido, polinucleotídeo isolado e composição de material biológico compreendendo o referido polímero
US9951149B2 (en) 2013-06-17 2018-04-24 The University Of North Carolina At Chapel Hill Reversible heparin molecules and methods of making and using the same
US10259889B2 (en) * 2015-03-31 2019-04-16 Seikagaku Corporation Method for sulfating glycosaminoglycan
CN110446511B (zh) 2017-03-10 2024-04-02 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
WO2019090203A1 (en) 2017-11-03 2019-05-09 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
CN108486187A (zh) * 2018-02-02 2018-09-04 南京微构医药科技有限公司 一种艾杜糖醛酸的制备工艺
EP3810152A4 (de) 2018-06-20 2022-04-27 The University of North Carolina at Chapel Hill Zellschutzverfahren und zusammensetzungen
CN110577559B (zh) * 2019-08-19 2023-02-17 江西科技师范大学 α-L-艾杜糖醛酸酶测定用荧光糖苷酶底物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2254083A (en) * 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide

Also Published As

Publication number Publication date
DE69518333T2 (de) 2001-02-22
ATE195348T1 (de) 2000-08-15
WO1996014425A1 (en) 1996-05-17
DK0789777T3 (da) 2000-11-06
ITMI942240A0 (it) 1994-11-04
ITMI942240A1 (it) 1996-05-04
IT1271057B (it) 1997-05-26
CN1094977C (zh) 2002-11-27
JPH10508204A (ja) 1998-08-18
EP0789777B1 (de) 2000-08-09
PT789777E (pt) 2001-01-31
AU3926195A (en) 1996-05-31
US5958899A (en) 1999-09-28
EP0789777A1 (de) 1997-08-20
CA2204366A1 (en) 1996-05-17
CN1162339A (zh) 1997-10-15
JP3640259B2 (ja) 2005-04-20
ES2150589T3 (es) 2000-12-01

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8339 Ceased/non-payment of the annual fee