DE69519378D1 - Mehrfache verkapselung von öllösliche verbindungen - Google Patents

Mehrfache verkapselung von öllösliche verbindungen

Info

Publication number
DE69519378D1
DE69519378D1 DE69519378T DE69519378T DE69519378D1 DE 69519378 D1 DE69519378 D1 DE 69519378D1 DE 69519378 T DE69519378 T DE 69519378T DE 69519378 T DE69519378 T DE 69519378T DE 69519378 D1 DE69519378 D1 DE 69519378D1
Authority
DE
Germany
Prior art keywords
polymer
oleophilic
oil
cross
oleophilic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69519378T
Other languages
English (en)
Other versions
DE69519378T2 (de
Inventor
Stasia Boyle
Kuei-Tu Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69519378D1 publication Critical patent/DE69519378D1/de
Application granted granted Critical
Publication of DE69519378T2 publication Critical patent/DE69519378T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
DE69519378T 1994-07-01 1995-06-24 Mehrfache verkapselung von öllösliche verbindungen Expired - Fee Related DE69519378T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26972094A 1994-07-01 1994-07-01
US08/439,787 US5938990A (en) 1994-07-01 1995-05-24 Encapsulation of oleophilic substances and compositions produced thereby
PCT/EP1995/002468 WO1996001103A1 (en) 1994-07-01 1995-06-24 Multiple encapsulation of oleophilic substances

Publications (2)

Publication Number Publication Date
DE69519378D1 true DE69519378D1 (de) 2000-12-14
DE69519378T2 DE69519378T2 (de) 2001-07-19

Family

ID=26953853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519378T Expired - Fee Related DE69519378T2 (de) 1994-07-01 1995-06-24 Mehrfache verkapselung von öllösliche verbindungen

Country Status (10)

Country Link
US (5) US5938990A (de)
EP (1) EP0768870B1 (de)
JP (1) JPH10502621A (de)
KR (1) KR100392215B1 (de)
CN (1) CN1141935C (de)
AT (1) ATE197397T1 (de)
DE (1) DE69519378T2 (de)
DK (1) DK0768870T3 (de)
ES (1) ES2152409T3 (de)
WO (1) WO1996001103A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
TW367247B (en) * 1998-02-03 1999-08-21 Otsuka Pharma Co Ltd Storage container for Vitamin D solution and transfusion container
US6303167B1 (en) * 1998-11-09 2001-10-16 Archer-Daniels-Midland Company Method of producing vitamin powders
US6770572B1 (en) 1999-01-26 2004-08-03 Alliedsignal Inc. Use of multifunctional si-based oligomer/polymer for the surface modification of nanoporous silica films
US6914073B2 (en) * 1999-03-18 2005-07-05 Bristol Myers Squibb Company Vitamin formulation for cardiovascular health
DE60019239T3 (de) 1999-12-09 2017-03-02 Dsm Ip Assets B.V. Fettlösliche Vitamine enthaltende Zusammensetzungen
EP1106174B9 (de) * 1999-12-09 2017-05-31 DSM IP Assets B.V. Fettlösliche Vitamine enthaltende Zusammensetzungen
JP2001219487A (ja) * 2000-02-10 2001-08-14 Mitsubishi Heavy Ind Ltd 紙製品の製造方法及び製造装置並びに紙接合用糊及び紙接合用糊のマイクロカプセル製造方法
US8178150B2 (en) 2000-02-22 2012-05-15 Suzanne Jaffe Stillman Water containing soluble fiber
US7892586B2 (en) 2001-02-22 2011-02-22 Suzanne Jaffe Stillman Water containing soluble fiber
WO2002026372A2 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
KR100439068B1 (ko) * 2001-09-07 2004-07-05 주식회사 코리아나화장품 레티놀을 3중으로 안정화한 화장료
US7442227B2 (en) * 2001-10-09 2008-10-28 Washington Unniversity Tightly agglomerated non-oxide particles and method for producing the same
DE60238504D1 (de) † 2001-12-20 2011-01-13 Nestle Sa Gelkapseln oder tabletten enthaltendes nahrungsmittel
US6974592B2 (en) † 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
US20040033903A1 (en) * 2002-05-02 2004-02-19 Volker Kuellmer Coated, agglomerated phytochemicals
AU2003254055A1 (en) 2002-07-23 2004-02-09 Wm. Wrigley Jr. Company Encapsulated flavors and chewing gum using same
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US20050214367A1 (en) * 2004-03-22 2005-09-29 Volker Kuellmer Processes for making coated phytochemicals and tocopherols and products formed therefrom
US20050238675A1 (en) * 2004-04-26 2005-10-27 Wenjie Li Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US8075910B2 (en) * 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
DE102004036437A1 (de) * 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
WO2007062274A1 (en) * 2005-11-28 2007-05-31 U.S. Nutraceuticals Llc Dba Valensa International Algal and algal extract dietary supplement composition
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
GB201102557D0 (en) * 2011-02-14 2011-03-30 Univ Nottingham Oil bodies
BR112018011476B1 (pt) * 2015-12-10 2022-04-12 Dsm Ip Assets B.V. Tabletes comprimidos compreendendo pelo menos uma partícula sólida de vitamina e seu uso
CN112641121B (zh) * 2020-10-10 2022-04-19 广州玖洲胶囊生物科技有限公司 一种羟丙甲基纤维素和卡拉胶的填充空心胶囊制备方法
CN112753778A (zh) * 2020-12-31 2021-05-07 大连臻鼎科技有限责任公司 一种高稳定性油脂微粒制品及其制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS507030B1 (de) * 1970-04-02 1975-03-20
US4084012A (en) * 1975-11-03 1978-04-11 The Dow Chemical Company Edible oil emulsions
US4182778A (en) * 1978-05-17 1980-01-08 General Foods Corporation Encapsulation of vitamin and mineral nutrients
JPS574916A (en) * 1980-05-28 1982-01-11 Furointo Sangyo Kk Activation of medical preparation
US4389419A (en) * 1980-11-10 1983-06-21 Damon Corporation Vitamin encapsulation
US4415703A (en) * 1981-01-13 1983-11-15 Daicel Chemical Industries, Ltd. Aqueous dispersion of a cellulose derivative
DE3135329A1 (de) * 1981-09-05 1983-03-24 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von trockenpulvern oxidationsempfindlicher substanzen
US5008254A (en) * 1982-09-03 1991-04-16 Weibel Michael K Sugar beet pectins and their use in comestibles
US4537783A (en) * 1983-04-20 1985-08-27 The Procter & Gamble Company Control of particle size distribution during continuous heat-setting of meat analog
US4670247A (en) * 1983-07-05 1987-06-02 Hoffman-Laroche Inc. Process for preparing fat-soluble vitamin active beadlets
EP0153105B1 (de) * 1984-02-10 1992-09-09 Benzon Pharma A/S Dosierungsform eine Vielzahl mit einer Diffusionshülle überzogener Einheiten enthaltend
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
GB2186485B (en) * 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPS6365945A (ja) * 1986-09-05 1988-03-24 Eisai Co Ltd マイクロカプセルの製造方法
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5051261A (en) * 1987-11-24 1991-09-24 Fmc Corporation Method for preparing a solid sustained release form of a functionally active composition
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
FR2663222A1 (fr) * 1990-06-13 1991-12-20 Medgenix Group Sa Microcapsule de liquide huileux.
DK0497177T3 (da) * 1991-01-28 1995-04-10 Hoffmann La Roche Vitaminholdige formuleringer og fremstilling deraf
US5223268A (en) * 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
EP0595030A3 (de) * 1992-10-01 1995-06-07 Tanabe Seiyaku Co Mehrkern-Mikrosphären mit verzögerter Wirkstoffabgabe und Verfahren zu deren Herstellung.
ES2068762B1 (es) * 1993-07-21 1995-12-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion.
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby

Also Published As

Publication number Publication date
JPH10502621A (ja) 1998-03-10
CN1151694A (zh) 1997-06-11
WO1996001103A1 (en) 1996-01-18
EP0768870A1 (de) 1997-04-23
US5925381A (en) 1999-07-20
US6150086A (en) 2000-11-21
ATE197397T1 (de) 2000-11-11
DK0768870T3 (da) 2001-02-05
US6146825A (en) 2000-11-14
DE69519378T2 (de) 2001-07-19
KR100392215B1 (ko) 2003-11-20
KR970703755A (ko) 1997-08-09
ES2152409T3 (es) 2001-02-01
US6001554A (en) 1999-12-14
CN1141935C (zh) 2004-03-17
US5938990A (en) 1999-08-17
EP0768870B1 (de) 2000-11-08

Similar Documents

Publication Publication Date Title
DE69519378D1 (de) Mehrfache verkapselung von öllösliche verbindungen
DE3382587D1 (de) Injizierbares langwirkendes mikroteilchen-praeparat zur verabreichung entzuendungshemmender mittel.
CA1029607A (en) System and method for generating heat utilizing fluidized beds of different particle size
AU2058988A (en) Polyamide powder consisting of particles having a "gypsum flow" structure - process for obtaining the polyamide powder
NL7612022A (nl) Werkwijze voor het inkapselen van organische polymeren, alsmede de als zodanig verkregen microcapsules.
FR2703065B1 (fr) Matiere fluorescente particulaire de (y1_x, eux) 2o3 et procede pour sa preparation.
IT7826011A0 (it) Rivestimento e prodotto cosi'composizione di rivestimento di ottenuto. organopolisilossano vulcanizzabile per irraggiamento comprendente radicali mercaptoalchili e silaciclopentenili, metodo di
DE69001609T2 (de) Herstellung von niedrigviskosen fotografischen kleinteilchen-dispersionen in gelatine.
PT80386A (de) 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)-pyridin-gluconat und pharmazeutische zubereitungen die diese substanz enthalten
ES2058343T3 (es) Piridinas disubstituidas.
ATE12941T1 (de) Poroese, pulverfoermige polymerteilchen.
HUT36157A (en) Composition suitable for polimerization
JPS523832A (en) Gel fragrant deodorant
NO953897L (no) Fremgangsmåte for innkapsling av substanser i biokapsler
JPS54119585A (en) Production of polymer composition containing physiologically active substance
DE69311367D1 (de) Entfärbung von alkylierten diarylaminen
JPS5235350A (en) Micro-wave heating device
JPS5239573A (en) Process for destroying the texture of the animal fibrous material by s welling and softening
JPS56169124A (en) Synthesizing method for ammonia
JPS51119040A (en) Preparation of heat-resistant coating materials
JPS5267933A (en) Preference control system for multi-processor system
SU715895A1 (ru) Устройство дл управлени отопительным агрегатом
JPS53114629A (en) Data highway system
JPS5214590A (en) Method of eliminating oil-soluble compounds
JPS51138875A (en) Intermittent elmination

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., TE HEERLEN, NL

8339 Ceased/non-payment of the annual fee