DE69522702T2 - Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält - Google Patents

Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält

Info

Publication number
DE69522702T2
DE69522702T2 DE69522702T DE69522702T DE69522702T2 DE 69522702 T2 DE69522702 T2 DE 69522702T2 DE 69522702 T DE69522702 T DE 69522702T DE 69522702 T DE69522702 T DE 69522702T DE 69522702 T2 DE69522702 T2 DE 69522702T2
Authority
DE
Germany
Prior art keywords
pct
thrombin inhibitor
solution containing
stable aqueous
infusion solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69522702T
Other languages
English (en)
Other versions
DE69522702D1 (de
Inventor
Ulla Stjernfelt
Mats Sundgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69522702D1 publication Critical patent/DE69522702D1/de
Application granted granted Critical
Publication of DE69522702T2 publication Critical patent/DE69522702T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
DE69522702T 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält Expired - Fee Related DE69522702T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer
PCT/SE1995/001228 WO1996014084A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor

Publications (2)

Publication Number Publication Date
DE69522702D1 DE69522702D1 (de) 2001-10-18
DE69522702T2 true DE69522702T2 (de) 2002-07-11

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69522702T Expired - Fee Related DE69522702T2 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält

Country Status (31)

Country Link
US (1) US5830865A (de)
EP (1) EP0789585B1 (de)
JP (1) JPH10508598A (de)
KR (1) KR100416677B1 (de)
CN (1) CN1090508C (de)
AT (1) ATE205399T1 (de)
AU (1) AU695719B2 (de)
BR (1) BR9509634A (de)
CA (1) CA2203396A1 (de)
CZ (1) CZ287256B6 (de)
DE (1) DE69522702T2 (de)
DK (1) DK0789585T3 (de)
EE (1) EE9700218A (de)
ES (1) ES2163528T3 (de)
FI (1) FI971949A (de)
HU (1) HU217073B (de)
IL (1) IL115879A (de)
IS (1) IS4468A (de)
MX (1) MX9703339A (de)
MY (1) MY112593A (de)
NO (1) NO322048B1 (de)
NZ (1) NZ295492A (de)
PL (1) PL320342A1 (de)
PT (1) PT789585E (de)
RU (1) RU2164803C2 (de)
SE (1) SE504185C2 (de)
SK (1) SK53597A3 (de)
TR (1) TR199501391A2 (de)
TW (1) TW407057B (de)
WO (1) WO1996014084A1 (de)
ZA (1) ZA959377B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
SI1569912T1 (sl) 2002-12-03 2015-09-30 Pharmacyclics Llc Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038068A1 (en) 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
HUT77560A (hu) 1998-06-29
MY112593A (en) 2001-07-31
DE69522702D1 (de) 2001-10-18
HU217073B (hu) 1999-11-29
IL115879A (en) 2001-08-08
MX9703339A (es) 1997-07-31
CZ129497A3 (cs) 1998-02-18
BR9509634A (pt) 1998-01-06
NO322048B1 (no) 2006-08-07
PL320342A1 (en) 1997-09-29
NO972065L (no) 1997-05-05
SE9403831D0 (sv) 1994-11-08
RU2164803C2 (ru) 2001-04-10
EE9700218A (et) 1998-02-16
KR970706844A (ko) 1997-12-01
IL115879A0 (en) 1996-01-31
CZ287256B6 (en) 2000-10-11
DK0789585T3 (da) 2001-11-12
NZ295492A (en) 1998-06-26
TR199501391A2 (tr) 1996-06-21
ES2163528T3 (es) 2002-02-01
KR100416677B1 (ko) 2004-06-16
SK53597A3 (en) 1998-07-08
CA2203396A1 (en) 1996-05-17
FI971949A0 (fi) 1997-05-07
US5830865A (en) 1998-11-03
EP0789585B1 (de) 2001-09-12
CN1162921A (zh) 1997-10-22
JPH10508598A (ja) 1998-08-25
TW407057B (en) 2000-10-01
ATE205399T1 (de) 2001-09-15
ZA959377B (en) 1996-05-08
NO972065D0 (no) 1997-05-05
AU3884695A (en) 1996-05-31
EP0789585A1 (de) 1997-08-20
WO1996014084A1 (en) 1996-05-17
FI971949A (fi) 1997-05-07
IS4468A (is) 1997-04-21
AU695719B2 (en) 1998-08-20
CN1090508C (zh) 2002-09-11
SE504185C2 (sv) 1996-12-02
PT789585E (pt) 2002-01-30
SE9403831L (sv) 1996-05-09

Similar Documents

Publication Publication Date Title
ATE177421T1 (de) Wasserlösliches nimesulid-salz, sowie dessen verwendung zur behandlung von entzündungen
DE59409832D1 (de) Pflaster zur behandlung von nagelmykosen
NO972538D0 (no) Nye sulfonamider
DE68919358D1 (de) Zusammensetzung zur behandlung der schizophrenie.
SE9401406D0 (sv) Pharmaceutical products for curing tumourous diseases and process for preparing same
NO972128L (no) 2,2-dikloralkankarboksylsyrer, fremgangsmåte for fremstilling av disse, legemiddel inneholdende disse og anvendelse derav for behandling av insulinresistens
DE69116380T2 (de) Pharmazeutische zubereitung zur behandlung verlängerter gerinnungszeit
DE69522702D1 (de) Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
ATE84716T1 (de) 4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelialgewebekrankheiten.
DE69230790D1 (de) Arzneimittel zur Behandlung von durch Babesia verursachten Protozoeninfektionen
ATE194076T1 (de) Verwendung von n,s-diacetylcystein-ethylester (dacee) zur herstellung eines medikaments zur behandlung viraler erkrankungen
DE69623641T2 (de) Topisch anzuwendendes abschäumendes arzneimittel zur behandlung von durch pityrosporum ovale verursachten hauterkrankungen
ATE207353T1 (de) Verwendung von benzydamin zur behandlung von krankheitszuständen, die durch tnf verursacht werden
DE69626276D1 (de) Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen
TH25616A (th) สารละลายในน้ำสำหรับฉีดที่มีความเสถียรในการเก็บซึ่งประกอบด้วยสารยับยั้งธรอมบิน
TH25616B (th) สารละลายในน้ำสำหรับฉีดที่มีความเสถียรในการเก็บซึ่งประกอบด้วยสารยับยั้งธรอมบิน
TH19245A (th) วิธีป้องกันการสลายของโปรตีนซี
ATE167055T1 (de) 4-guanidinobutyramid zur verbesserung des blutkreislaufs
RU93055681A (ru) Ингибиторы вич-протеазы, способ их получения, их использование в фармкомпозициях

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee