DE69523566T2 - Dichte-gradientmedien zur trennung von zellen - Google Patents

Dichte-gradientmedien zur trennung von zellen

Info

Publication number
DE69523566T2
DE69523566T2 DE69523566T DE69523566T DE69523566T2 DE 69523566 T2 DE69523566 T2 DE 69523566T2 DE 69523566 T DE69523566 T DE 69523566T DE 69523566 T DE69523566 T DE 69523566T DE 69523566 T2 DE69523566 T2 DE 69523566T2
Authority
DE
Germany
Prior art keywords
density gradient
cell separation
gradient media
gradient medium
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69523566T
Other languages
English (en)
Other versions
DE69523566D1 (de
Inventor
M Saunders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Imaging Corp
Original Assignee
Applied Imaging Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Imaging Corp filed Critical Applied Imaging Corp
Publication of DE69523566D1 publication Critical patent/DE69523566D1/de
Application granted granted Critical
Publication of DE69523566T2 publication Critical patent/DE69523566T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE69523566T 1994-01-31 1995-01-23 Dichte-gradientmedien zur trennung von zellen Expired - Fee Related DE69523566T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/189,509 US5489386A (en) 1994-01-31 1994-01-31 Density gradient medium for the separation of cells
PCT/US1995/000956 WO1995020429A1 (en) 1994-01-31 1995-01-23 Density gradient medium for separating cells

Publications (2)

Publication Number Publication Date
DE69523566D1 DE69523566D1 (de) 2001-12-06
DE69523566T2 true DE69523566T2 (de) 2002-09-05

Family

ID=22697630

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523566T Expired - Fee Related DE69523566T2 (de) 1994-01-31 1995-01-23 Dichte-gradientmedien zur trennung von zellen

Country Status (9)

Country Link
US (1) US5489386A (de)
EP (1) EP0739229B1 (de)
JP (1) JP3017291B2 (de)
AT (1) ATE207777T1 (de)
AU (1) AU680738B2 (de)
CA (1) CA2182367C (de)
DE (1) DE69523566T2 (de)
DK (1) DK0739229T3 (de)
WO (1) WO1995020429A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI940823A0 (fi) * 1994-02-22 1994-02-22 Orion Yhtymae Oy Analysatorkyvett foer turbidimetriska och nefelometriska bestaemningar av helblodsprov
WO1996027420A1 (en) * 1995-03-08 1996-09-12 Bioseparations, Inc. Method for enriching rare cell population
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
AUPN883396A0 (en) * 1996-03-21 1996-04-18 Australian Red Cross Society (Western Australian Division) Centrifugation support
US6210889B1 (en) 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
US6535393B2 (en) * 1998-12-04 2003-03-18 Micron Technology, Inc. Electrical device allowing for increased device densities
IT1311989B1 (it) * 1999-03-30 2002-03-22 Giammaria Sitar Procedimento per isolare cellule fetali presenti nel sangue perifericomaterno.
US7135335B2 (en) * 1999-05-28 2006-11-14 Stemcell Technologies Inc. Method for separating cells using immunorosettes
US7947236B2 (en) 1999-12-03 2011-05-24 Becton, Dickinson And Company Device for separating components of a fluid sample
CA2439748A1 (en) 2001-03-07 2002-09-19 The Texas A & M University System Density gradient solutions of metal ion chelate complexes
US7316932B2 (en) * 2001-10-01 2008-01-08 Stemcell Technologies Inc. Method for separating cells
US7653260B2 (en) * 2004-06-17 2010-01-26 Carl Zeis MicroImaging GmbH System and method of registering field of view
US8582924B2 (en) * 2004-06-30 2013-11-12 Carl Zeiss Microimaging Gmbh Data structure of an image storage and retrieval system
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
US7673758B2 (en) * 2005-08-10 2010-03-09 The Regents Of The University Of California Collection tubes apparatus, systems, and methods
US7971730B2 (en) 2005-08-10 2011-07-05 The Regents Of The University Of California Collection tubes apparatus, systems and methods
US9248447B2 (en) * 2005-08-10 2016-02-02 The Regents Of The University Of California Polymers for use in centrifugal separation of liquids
US7674388B2 (en) * 2005-08-10 2010-03-09 The Regents Of The University Of California Photopolymer serum separator
US20070238088A1 (en) * 2006-03-29 2007-10-11 General Electric Company Hydrophilic functionalized colloidal silica compositions, methods of making, and uses therefor
ES2374686T3 (es) 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
JP5593221B2 (ja) * 2007-06-15 2014-09-17 ヒストロックス，インコーポレイテッド． 顕微鏡機器を標準化するための方法およびシステム
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) * 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7978258B2 (en) * 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
ES2548183T3 (es) 2008-07-21 2015-10-14 Becton Dickinson And Company Dispositivo de separación de fases de densidad
JP5607621B2 (ja) 2008-07-21 2014-10-15 ベクトン・ディキンソン・アンド・カンパニー 密度相分離デバイス
CA2731155C (en) 2008-07-21 2013-09-24 Becton, Dickinson And Company Density phase separation device
WO2010012002A1 (en) * 2008-07-25 2010-01-28 Saryna Medical Corporation Methods and systems for genetic analysis of fetal nucleated red blood cells
CA2737116C (en) * 2008-09-16 2019-01-15 Historx, Inc. Reproducible quantification of biomarker expression
PL2429708T3 (pl) 2009-05-15 2021-06-14 Becton, Dickinson And Company Urządzenie do rozdzielania faz gęstości
EP2435108B1 (de) 2009-05-29 2016-12-07 EndoCellutions, Inc. Vorrichtung und verfahren zur absaugung und trennung von komponenten verschiedener dichte aus einem physiologischen fluid mit zellen
AU2011208382B2 (en) 2010-01-21 2015-02-26 Biocep Ltd. Magnetic separation of rare cells
NL1037672C2 (nl) * 2010-02-01 2011-08-03 Eurotrol B V Werkwijze voor het bepalen van de betrouwbaarheid van een inrichting voor het meten van de concentratie van een stof in volledig bloed, werkwijze voor het behandelen van volledig bloed, houder en kit.
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
WO2012023298A1 (ja) * 2010-08-20 2012-02-23 国立大学法人北陸先端科学技術大学院大学 血球の密度変化を利用した密度勾配遠心による有核赤血球の回収法
JP6208473B2 (ja) 2012-06-20 2017-10-04 アークレイ株式会社 血液成分を含む試料の処理方法
US9669405B2 (en) 2012-10-22 2017-06-06 The Regents Of The University Of California Sterilizable photopolymer serum separator
US9217697B2 (en) 2012-11-30 2015-12-22 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US10603665B2 (en) 2013-01-29 2020-03-31 Endocellutions, Inc. Cell concentration devices and methods that include an insert defining a lumen and a cannula assembly
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
JP6989609B2 (ja) * 2017-01-25 2022-01-05 ヤンタイ・アウスビオ・ラボラトリーズ・カンパニー・リミテッド 診断目的の自動サンプル処理のための装置および方法
USD898184S1 (en) 2019-01-29 2020-10-06 Handi-Craft Company Breast pump valve
KR200492521Y1 (ko) * 2019-02-11 2020-10-30 주식회사 이리농수산자재 농산물 랩핑용 결속부재
US11738288B2 (en) 2020-06-29 2023-08-29 Jacques Chammas Automated system and method to isolate specific cells from blood or bone marrow

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049692A (en) * 1974-12-16 1977-09-20 Corning Glass Works Stabilized blood separating composition
US4101422A (en) * 1977-05-11 1978-07-18 Emery Industries, Inc. Copolyesters useful in blood separation assemblies
US4386003A (en) * 1981-09-17 1983-05-31 Sherwood Medical Industries Inc. Blood separating composition
US4416778A (en) * 1981-10-20 1983-11-22 Neocyte, Inc. Means for preparing neocyte enriched blood
US4797475A (en) * 1983-05-20 1989-01-10 The Regents Of The University Of California Method and composition for isolating white cell elements
US4818418A (en) * 1984-09-24 1989-04-04 Becton Dickinson And Company Blood partitioning method
US4751001A (en) * 1984-09-24 1988-06-14 Becton Dickinson And Company Blood partitioning apparatus
US4917801A (en) * 1984-12-04 1990-04-17 Becton Dickinson And Company Lymphocyte collection tube
US5053134A (en) * 1984-12-04 1991-10-01 Becton Dickinson And Company Lymphocyte collection tube
US5260186A (en) * 1986-03-10 1993-11-09 Boris Cercek Provision of density specific blood cells for the structuredness of the cytoplasmic matrix (SCM) test
US4927750A (en) * 1986-04-09 1990-05-22 Jeanette Simpson Cell separation process
US4835097A (en) * 1986-10-15 1989-05-30 Saunders Alexander M Method for ascertaining the history of a condition of the body from a single blood sample
EP0353587A3 (de) * 1988-07-26 1992-07-29 Nippon Paint Co., Ltd. Abdichtungsmittel für Serumabtrennung und dafür gebrauchte feine Harzteilchen
ATE162631T1 (de) * 1989-11-13 1998-02-15 Childrens Medical Center Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna
CA2081203A1 (en) * 1990-04-23 1991-10-24 Ronald J. Berenson Method for enriching fetal cells from maternal blood
DE4222573C1 (de) * 1992-05-16 1993-08-12 Dorothee Dr. 4400 Muenster De Ahlert
US5275933A (en) * 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood

Also Published As

Publication number Publication date
ATE207777T1 (de) 2001-11-15
JPH09508971A (ja) 1997-09-09
AU680738B2 (en) 1997-08-07
DE69523566D1 (de) 2001-12-06
JP3017291B2 (ja) 2000-03-06
AU1833795A (en) 1995-08-15
WO1995020429A1 (en) 1995-08-03
EP0739229A1 (de) 1996-10-30
EP0739229B1 (de) 2001-10-31
CA2182367A1 (en) 1995-08-03
EP0739229A4 (de) 1997-12-03
CA2182367C (en) 2002-07-09
US5489386A (en) 1996-02-06
DK0739229T3 (da) 2002-02-25

Similar Documents

Publication Publication Date Title
DE69523566T2 (de) Dichte-gradientmedien zur trennung von zellen
IL110364A0 (en) Enriching and identifying fetal nucleated erythrocytes in maternal blood for in situ hybridization
RU99110373A (ru) Использование антител против эмбрионального гемоглобина для идентификации плодных клеток
US4725406A (en) Apparatus and method for diagnostic analysis of biological fluids
CA2469878A1 (en) Blood cell separating system
DE69430365T2 (de) Isolierung fötaler erythrozyten
BR9306867A (pt) Enriquecimento e identificação de células fetais do sangue materno para a hibridização in situ
EP0257759A3 (de) Teilchen zum Kalibrieren von Durchflusszytometriegeräten und anderen Analysevorrichtungen
FI932150A0 (fi) Analyssystem foer glykerande blodproteiner
DE69513188D1 (de) Vorrichtung und verfahren zur trennung von zellen
GB9518156D0 (en) Method of isolating cells
BR8100378A (pt) Aparelho e processo para ensaios de separacao,classificacao e compatibilidade de celulas vermelhas do sangue
Müller et al. Species-specific aggregation factor in sponges: VI. Aggregation receptor from the cell surface
Biava et al. Fine structure of normal human juxtaglomerular cells. II. Specific and nonspecific cytoplasmic granules.
DE69501326T2 (de) Differentielle expansion von fötalen stamzellen im mütterlichen kreislauf zur verwendung in der pränatalen genetischen analyse
DK0974056T3 (da) Prænatale in vitro-diagnostiske fremgangsmåder
ATE49659T1 (de) Probe zur identifizierung von hla d.
Foraker et al. Glycogen in invasive squamous carcinoma of the uterine cervix
Miller et al. Comparison of acid phosphatase ACP1 variants by isoelectric focusing and conventional electrophoresis: identification of three new alleles, ACP1* N, ACP1* P and ACP1* S
ATE228026T1 (de) Methode zur erreicherung von populationen seltener zellen
WO1997030354A3 (en) Foetal cell analysis
Saunders et al. Method for separating rare cells from a population of cells
IT8783430A0 (it) Dispositivo atto ad effettuare in modo automatico il prelievo e la distribuzione standardizzata di campioni analitici in piastre contenenti terreni di coltura.
Clavert et al. Comparative electrophoretic study between rabbit and human seminal fluid
Law et al. Interactions Between Complement Proteins and Cell Membranes: The Chemical Nature of the Bond Formed Between C3b and Cell Surface Macromolecules

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee