DE69530086D1 - Aufnahme von biologisch aktiven molekülen in bioaktives glas - Google Patents
Aufnahme von biologisch aktiven molekülen in bioaktives glasInfo
- Publication number
- DE69530086D1 DE69530086D1 DE69530086T DE69530086T DE69530086D1 DE 69530086 D1 DE69530086 D1 DE 69530086D1 DE 69530086 T DE69530086 T DE 69530086T DE 69530086 T DE69530086 T DE 69530086T DE 69530086 D1 DE69530086 D1 DE 69530086D1
- Authority
- DE
- Germany
- Prior art keywords
- biologically active
- active molecules
- incorporation
- bioactive glass
- carriers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000005313 bioactive glass Substances 0.000 title 1
- 238000010348 incorporation Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28105594A | 1994-07-27 | 1994-07-27 | |
US281055 | 1994-07-27 | ||
US40604795A | 1995-03-17 | 1995-03-17 | |
US406047 | 1995-03-17 | ||
US08/477,585 US5591453A (en) | 1994-07-27 | 1995-06-07 | Incorporation of biologically active molecules into bioactive glasses |
US477585 | 1995-06-07 | ||
PCT/US1995/009401 WO1996003117A1 (en) | 1994-07-27 | 1995-07-26 | Incorporation of biologically active molecules into bioactive glasses |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530086D1 true DE69530086D1 (de) | 2003-04-30 |
DE69530086T2 DE69530086T2 (de) | 2004-03-04 |
Family
ID=27403198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530086T Expired - Fee Related DE69530086T2 (de) | 1994-07-27 | 1995-07-26 | Aufnahme von biologisch aktiven molekülen in bioaktives glas |
Country Status (11)
Country | Link |
---|---|
US (1) | US5591453A (de) |
EP (1) | EP0772436B1 (de) |
JP (1) | JPH10503210A (de) |
AT (1) | ATE235230T1 (de) |
AU (1) | AU3147095A (de) |
CA (1) | CA2195680A1 (de) |
DE (1) | DE69530086T2 (de) |
ES (1) | ES2194919T3 (de) |
IL (1) | IL114770A (de) |
TW (1) | TW448051B (de) |
WO (1) | WO1996003117A1 (de) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7060287B1 (en) * | 1992-02-11 | 2006-06-13 | Bioform Inc. | Tissue augmentation material and method |
US6537574B1 (en) | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
US7968110B2 (en) * | 1992-02-11 | 2011-06-28 | Merz Aesthetics, Inc. | Tissue augmentation material and method |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
DE69332105T2 (de) * | 1992-09-29 | 2003-03-06 | Inhale Therapeutic Systems San | Pulmonale abgabe von aktiven fragmenten des parathormons |
US6022748A (en) * | 1997-08-29 | 2000-02-08 | Sandia Corporation - New Mexico Regents Of The University Of California | Sol-gel matrices for direct colorimetric detection of analytes |
MX9603936A (es) * | 1994-03-07 | 1997-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para el suministro pulmonar de insulina. |
US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
AU696387B2 (en) * | 1994-05-18 | 1998-09-10 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
US5817327A (en) * | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6224913B1 (en) | 1996-05-09 | 2001-05-01 | The Trustees Of The University Of Pennsylvania | Conditioning of bioactive glass surfaces in protein containing solutions |
US6416774B1 (en) * | 1996-05-09 | 2002-07-09 | The Trustees Of The University Of Pennsyvania | Hollow bone mineral-like calcium phosphate particles |
US5830480A (en) * | 1996-05-09 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Stabilization of sol-gel derived silica-based glass |
HU227939B1 (en) * | 1996-05-29 | 2012-06-28 | Delsitech Oy | Dissolvable oxides for biological applications |
US6764690B2 (en) | 1996-05-29 | 2004-07-20 | Delsitech Oy | Dissolvable oxides for biological applications |
US5964807A (en) * | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
US5834008A (en) | 1996-09-19 | 1998-11-10 | U.S. Biomaterials Corp. | Composition and method for acceleration of wound and burn healing |
US6756060B1 (en) | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
US6517860B1 (en) | 1996-12-31 | 2003-02-11 | Quadrant Holdings Cambridge, Ltd. | Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery |
US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US5945360A (en) * | 1997-03-28 | 1999-08-31 | Johns Manville International, Inc. | Biosoluble pot and marble-derived fiberglass |
US5874101A (en) * | 1997-04-14 | 1999-02-23 | Usbiomaterials Corp. | Bioactive-gel compositions and methods |
JP2001524000A (ja) * | 1997-04-22 | 2001-11-27 | ワシントン リサーチ ファンデーション | Trap被覆骨移植片及びプロテーゼ |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
US6077987A (en) | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US5972384A (en) | 1997-10-01 | 1999-10-26 | University Of Maryland, Baltimore | Use of biologically active glass as a drug delivery system |
US6090399A (en) * | 1997-12-11 | 2000-07-18 | Rohm And Haas Company | Controlled release composition incorporating metal oxide glass comprising biologically active compound |
FI980032A0 (fi) * | 1998-01-09 | 1998-01-09 | Heikki Matti Eemeli Rauvala | Ny anvaendning av en heparin bindande, med tillvaext foerknippad molekyl |
US6696258B1 (en) * | 1998-01-20 | 2004-02-24 | Drexel University | Mesoporous materials and methods of making the same |
US6423343B1 (en) | 1998-01-23 | 2002-07-23 | Usbiomaterials Corporation | Bioactive glass treatment of inflammation in skin conditions |
US5958430A (en) * | 1998-02-20 | 1999-09-28 | Battelle Memorial Institute | Thin film composition with biological substance and method of making |
GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
US5968253A (en) * | 1998-07-31 | 1999-10-19 | Norian Corporation | Calcium phosphate cements comprising antimicrobial agents |
EP1123072B1 (de) * | 1998-09-10 | 2014-05-14 | Schott Ag | Anti-inflammatonische und antimikrobielle verwendungen für bioaktive glaszusammensetzungen |
US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
US6663878B1 (en) | 1999-04-29 | 2003-12-16 | Usbiomaterials Corp. | Anti-inflammatory bioactive glass particulates |
DE60029579D1 (de) * | 1999-05-20 | 2006-09-07 | Univ Boston | Polymer verstärkte anatomisch geformte bioaktive prothesen |
DK1196150T3 (da) | 1999-06-14 | 2005-11-21 | Imp College Innovations Ltd | Sölvindeholdende sol-gel-afledte bioglassammensætninger |
US7118921B1 (en) | 1999-06-24 | 2006-10-10 | Mcmaster University | Incorporation and applications of biomolecular interactions within a carrier |
JP2003503423A (ja) * | 1999-06-24 | 2003-01-28 | マクマスター ユニヴァーシティー | キャリア内の生体分子相互作用の取込みおよび適用 |
US6458162B1 (en) * | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
US6303183B1 (en) | 1999-11-08 | 2001-10-16 | Aos Holding Company | Anti-microbial porcelain enamel coating |
US20040009228A1 (en) * | 1999-11-30 | 2004-01-15 | Pertti Tormala | Bioabsorbable drug delivery system for local treatment and prevention of infections |
US6579533B1 (en) * | 1999-11-30 | 2003-06-17 | Bioasborbable Concepts, Ltd. | Bioabsorbable drug delivery system for local treatment and prevention of infections |
AUPQ573300A0 (en) | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
JP4979109B2 (ja) | 2000-04-21 | 2012-07-18 | ゾル−ゲル テクノロジーズ リミテッド | 局所的有効成分の増強された配合安定性および送達を示す組成物 |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US8404217B2 (en) * | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
AU6124601A (en) | 2000-05-10 | 2001-11-20 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
US20020106368A1 (en) * | 2000-07-28 | 2002-08-08 | Adrian Bot | Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same |
EP1372727B1 (de) * | 2001-04-04 | 2010-09-01 | DelSiTech Oy | Biologisch abbaubarer träger und verfahren zu seiner herstellung |
US20030031694A1 (en) * | 2001-04-20 | 2003-02-13 | 3M Innovative Properties Company | Controlled release particles |
US20030129618A1 (en) * | 2001-08-10 | 2003-07-10 | Regents Of The University Of California | Sensitive and rapid detection of pathogenic organisms and toxins using fluorescent polymeric lipids |
BR0214184A (pt) * | 2001-11-08 | 2004-10-13 | Sol Gel Technologies Ltd | Composições que contêm óleos que possuem gravidade especìfica mais alta que a gravidade especìfica da água |
JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
US20030220692A1 (en) * | 2002-02-09 | 2003-11-27 | Shapiro Irving M. | Preparations of nucleus pulposus cells and methods for their generation, identification, and use |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8337893B2 (en) * | 2002-07-10 | 2012-12-25 | Florida Research Foundation, Inc, University Of | Sol-gel derived bioactive glass polymer composite |
US20050008990A1 (en) * | 2003-02-26 | 2005-01-13 | Therics, Inc. | Method and system for repairing endosseous implants, such as with a bone graft implant |
WO2004081222A2 (en) * | 2003-03-14 | 2004-09-23 | Sol-Gel Technologies Ltd. | Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same |
WO2004096140A2 (en) | 2003-04-25 | 2004-11-11 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
EP2263788B1 (de) * | 2003-07-31 | 2018-07-25 | Sol-Gel Technologies Ltd. | Eine verfahren zur herstellung von mikrokapseln die aktive stoff enthalten |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US7189263B2 (en) | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
GB2427611A (en) * | 2004-02-17 | 2007-01-03 | Waters Investments Ltd | Porous hybrid monolith materials with organic groups removed from the surface |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US10149825B2 (en) | 2004-02-27 | 2018-12-11 | Delsitech Oy | Method for preparing adjustably bioresorbable sol-gel derived SiO2 |
US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
GB0420016D0 (en) | 2004-09-09 | 2004-10-13 | Leuven K U Res & Dev | Controlled release oral delivery system |
WO2006082221A1 (en) * | 2005-02-03 | 2006-08-10 | Cinvention Ag | Drug delivery materials made by sol/gel technology |
EP1878044B1 (de) | 2005-04-27 | 2018-03-21 | The Trustees of The University of Pennsylvania | Xerogel-filme zur kontrollierten freigabe pharmazeutisch aktiver moleküle |
US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
JP5164840B2 (ja) * | 2005-08-02 | 2013-03-21 | ソル − ゲル テクノロジーズ リミテッド | 水不溶性成分の金属酸化物被覆 |
US20080254082A1 (en) * | 2005-09-27 | 2008-10-16 | Sol-Gel Technologies Ltd. | Methods for Crop Protection |
US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US20070184087A1 (en) | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
US20070254038A1 (en) * | 2006-04-26 | 2007-11-01 | The Trustees Of The University Of Pennsylvania | Microspheroidal Controlled Release Of Biomolecules |
EP2020987B1 (de) | 2006-06-06 | 2013-10-30 | Universidad Autónoma Metropolitana | Sol-gel-nanostrukturierte titandioxid-reservoirs zur verwendung bei der kontrollierten freisetzung von arzneimitteln im zentralen nervensystem und syntheseverfahren |
US8303967B2 (en) * | 2006-06-29 | 2012-11-06 | Orthovita, Inc. | Bioactive bone graft substitute |
ES2912051T3 (es) | 2007-02-01 | 2022-05-24 | Sol Gel Tech Ltd | Composiciones para aplicación tópica que comprenden un peróxido y retinoide |
MX352876B (es) * | 2007-02-01 | 2017-12-13 | Sol Gel Tech Ltd | Metodo para preparar particulas que comprenden recubrimiento de oxido de metal y particulas con recubrimiento de oxido de metal. |
FI20070174A0 (fi) * | 2007-02-28 | 2007-02-28 | Delsitech Oy | Menetelmä silikakoostumusten valmistamiseksi, silikakoostumukset ja niiden käytöt |
US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
EP2679672B1 (de) | 2007-07-12 | 2016-11-30 | Discgenics | Menschliches Bandscheibengewebe |
US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
US20090324695A1 (en) * | 2008-05-30 | 2009-12-31 | Paul Ducheyne | Biocompatible polymer ceramic composite matrices |
FR2933703B1 (fr) * | 2008-07-11 | 2012-08-17 | Commissariat Energie Atomique | Detecteurs nanoporeux de composes aromatiques monocycliques et autres polluants |
EP2427179A4 (de) * | 2009-05-04 | 2013-09-11 | Psivida Inc | Poröse partikel zur freisetzung von silicium-arzneimitteln |
US9399086B2 (en) | 2009-07-24 | 2016-07-26 | Warsaw Orthopedic, Inc | Implantable medical devices |
EP2629780A4 (de) | 2010-10-20 | 2014-10-01 | 206 Ortho Inc | Implantierbares polymer für knochen- und gefässläsionen |
US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
WO2015095745A1 (en) | 2010-10-20 | 2015-06-25 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
US10525169B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
US11058796B2 (en) | 2010-10-20 | 2021-07-13 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
US9320601B2 (en) | 2011-10-20 | 2016-04-26 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
RU2640918C2 (ru) | 2010-11-01 | 2018-01-12 | Псивида Юэс, Инк. | Биоразлагаемые устройства на основе кремния для доставки терапевтических агентов |
US8551525B2 (en) * | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
KR102237799B1 (ko) | 2012-11-14 | 2021-04-08 | 더블유.알. 그레이스 앤드 캄파니-콘. | 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물 |
US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
CN105025928A (zh) | 2013-03-15 | 2015-11-04 | 普西维达公司 | 用于递送治疗剂的可生物蚀解的硅基组合物 |
US10010609B2 (en) * | 2013-05-23 | 2018-07-03 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
FR3006195B1 (fr) * | 2013-06-03 | 2018-03-02 | Centre National De La Recherche Scientifique | Implant a porosite controlee |
US10195305B2 (en) | 2015-03-24 | 2019-02-05 | Orthovita, Inc. | Bioactive flowable wash-out resistant bone graft material and method for production thereof |
MX2019014437A (es) * | 2017-06-01 | 2022-05-26 | Fundacio Inst De Bioenginyeria De Catalunya Ibec | Particulas de calcio de liberacion de iones controlada, metodo para producirlo y uso de las mismas. |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
CN111246797A (zh) | 2017-10-24 | 2020-06-05 | 德克斯康公司 | 预连接分析物传感器 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE248351C (de) * | ||||
DE222498C (de) * | ||||
DE3134728A1 (de) * | 1981-09-02 | 1983-03-10 | Jürgen Dr.med. 5024 Brauweiler Eitenmüller | Material fuer knochenimplantate, verfahren zu seiner herstellung und seine verwendung |
US4851150A (en) * | 1984-02-27 | 1989-07-25 | University Of Florida | Drying control chemical additives for rapid production of large sol-gel derived silicon, boron and sodium containing monoliths |
DE3423667A1 (de) * | 1984-05-08 | 1985-11-28 | Rüdiger Dipl.-Ing. 5204 Lohmar Scheunemann | Implantat fuer knochen- und zahnwurzelersatz mit spezieller uebergangsstruktur zwischen knochen und implantatkern und knochenseitig ganz oder teilweise resorbierbarer matrix |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
US4849378A (en) * | 1985-02-25 | 1989-07-18 | University Of Florida | Ultraporous gel monoliths having predetermined pore sizes and their production |
US4859525A (en) * | 1985-02-25 | 1989-08-22 | University Of Florida | Method for low temperature processing of lightweight SiC/SiO2 composites and products |
DE3613213A1 (de) * | 1986-04-18 | 1987-10-22 | Merck Patent Gmbh | Tricalciumphosphat fuer implantationsmaterialien |
US5344654A (en) * | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
US5108436A (en) * | 1988-09-29 | 1992-04-28 | Collagen Corporation | Implant fixation |
US5207710A (en) * | 1988-09-29 | 1993-05-04 | Collagen Corporation | Method for improving implant fixation |
US5296026A (en) * | 1988-12-02 | 1994-03-22 | Monroe Eugene A | Phosphate glass cement |
US4976736A (en) * | 1989-04-28 | 1990-12-11 | Interpore International | Coated biomaterials and methods for making same |
FR2651439B1 (fr) * | 1989-09-06 | 1994-09-23 | Fbfc International Sa Nv | Materiau bioreactif pour prothese ou implants composites. |
US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
US5371018A (en) * | 1990-01-23 | 1994-12-06 | Yissum, Research Development Company Of The Hebrew University Of Jerusalem | Qualitative and quantitative processes for reactive chemicals in liquids using doped sol-gel glasses |
IL93134A (en) * | 1990-01-23 | 1997-11-20 | Yissum Res Dev Co | Doped sol-gel glasses for obtaining chemical interactions |
US5074916A (en) * | 1990-05-18 | 1991-12-24 | Geltech, Inc. | Alkali-free bioactive sol-gel compositions |
WO1991017777A2 (en) * | 1990-05-22 | 1991-11-28 | University Of Florida | Injectable bioactive glass compositions and methods for tissue reconstruction |
DE4019617A1 (de) * | 1990-06-20 | 1992-01-02 | Thera Ges Fuer Patente | Implantierbares wirkstoffdepotmaterial |
FR2668367B1 (fr) * | 1990-10-26 | 1994-05-13 | Centre Nal Recherc Scientifique | Medicament implantable a effet prolonge. |
ZA923086B (en) * | 1991-04-29 | 1993-10-28 | South African Medical Research | A delivery system for biologicaly active growth or morphogenetic factors and a method for preparing such delivery system |
JP3051945B2 (ja) * | 1991-07-22 | 2000-06-12 | 大阪瓦斯株式会社 | 無機質均一微小球体、及びその製造方法 |
US5200334A (en) * | 1991-08-13 | 1993-04-06 | The Regents Of The University Of California | Sol-gel encapsulated enzyme |
JPH05253286A (ja) * | 1992-03-12 | 1993-10-05 | Makoto Otsuka | 骨修復材料 |
WO1994004657A1 (en) * | 1992-08-13 | 1994-03-03 | The Trustees Of The University Of Pennsylvania | Bioactive material template for in vitro synthesis of bone tissue |
NO940913L (no) * | 1993-03-26 | 1994-09-27 | Bristol Myers Squibb Co | Preparater for kontrollert frigivelse av biologisk aktiv TGF- |
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1995
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- 1995-07-26 ES ES95927435T patent/ES2194919T3/es not_active Expired - Lifetime
- 1995-07-26 AT AT95927435T patent/ATE235230T1/de not_active IP Right Cessation
- 1995-07-26 DE DE69530086T patent/DE69530086T2/de not_active Expired - Fee Related
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- 1995-07-26 EP EP95927435A patent/EP0772436B1/de not_active Expired - Lifetime
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- 1995-07-26 CA CA002195680A patent/CA2195680A1/en not_active Abandoned
- 1995-07-27 IL IL11477095A patent/IL114770A/en not_active IP Right Cessation
- 1995-07-28 TW TW084107852A patent/TW448051B/zh not_active IP Right Cessation
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ATE235230T1 (de) | 2003-04-15 |
IL114770A0 (en) | 1995-11-27 |
JPH10503210A (ja) | 1998-03-24 |
DE69530086T2 (de) | 2004-03-04 |
EP0772436A4 (de) | 1998-04-15 |
IL114770A (en) | 2002-12-01 |
EP0772436B1 (de) | 2003-03-26 |
US5591453A (en) | 1997-01-07 |
TW448051B (en) | 2001-08-01 |
CA2195680A1 (en) | 1996-02-08 |
WO1996003117A1 (en) | 1996-02-08 |
ES2194919T3 (es) | 2003-12-01 |
AU3147095A (en) | 1996-02-22 |
EP0772436A1 (de) | 1997-05-14 |
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