DE69532642D1 - Antivirale prodrugs - Google Patents

Antivirale prodrugs

Info

Publication number
DE69532642D1
DE69532642D1 DE69532642T DE69532642T DE69532642D1 DE 69532642 D1 DE69532642 D1 DE 69532642D1 DE 69532642 T DE69532642 T DE 69532642T DE 69532642 T DE69532642 T DE 69532642T DE 69532642 D1 DE69532642 D1 DE 69532642D1
Authority
DE
Germany
Prior art keywords
prodrugs
antiviral prodrugs
antiviral
phosphonoacids
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532642T
Other languages
English (en)
Other versions
DE69532642T2 (de
Inventor
Y Hostetler
D Kini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chimerix Corp
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69532642D1 publication Critical patent/DE69532642D1/de
Application granted granted Critical
Publication of DE69532642T2 publication Critical patent/DE69532642T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
DE69532642T 1994-11-15 1995-11-15 Antivirale prodrugs Expired - Lifetime DE69532642T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US340161 1994-11-15
US08/340,161 US5696277A (en) 1994-11-15 1994-11-15 Antiviral prodrugs
PCT/US1995/014940 WO1996015132A1 (en) 1994-11-15 1995-11-15 Improved antiviral prodrugs

Publications (2)

Publication Number Publication Date
DE69532642D1 true DE69532642D1 (de) 2004-04-08
DE69532642T2 DE69532642T2 (de) 2005-06-30

Family

ID=23332146

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532642T Expired - Lifetime DE69532642T2 (de) 1994-11-15 1995-11-15 Antivirale prodrugs

Country Status (11)

Country Link
US (2) US5696277A (de)
EP (1) EP0792275B1 (de)
JP (1) JPH10508858A (de)
AT (1) ATE260926T1 (de)
AU (1) AU700651B2 (de)
CA (1) CA2205136C (de)
DE (1) DE69532642T2 (de)
DK (1) DK0792275T3 (de)
ES (1) ES2217287T3 (de)
PT (1) PT792275E (de)
WO (1) WO1996015132A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
EP1655033A1 (de) 1995-06-07 2006-05-10 Emory University Nucleoside mit anti-hepatitis B virus Wirksamkeit
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
SE9603726D0 (sv) * 1996-10-11 1996-10-11 Astra Ab Novel compounds
SE9604582D0 (sv) * 1996-12-13 1996-12-13 Astra Ab Novel compounds
US6686462B2 (en) 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
US20030229040A1 (en) * 1997-03-21 2003-12-11 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US6126965A (en) * 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
US7262173B2 (en) * 1997-03-21 2007-08-28 Georgetown University Chemosensitizing with liposomes containing oligonucleotides
US6559129B1 (en) * 1997-03-21 2003-05-06 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
ES2276515T3 (es) 1998-02-25 2007-06-16 Emory University 2'-fluoronucleosidos.
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
US6444837B1 (en) * 1998-07-13 2002-09-03 University Of Southern California Synthesis and antiviral activity of a series of pyrophosphate analogs
CN100387237C (zh) 1998-08-10 2008-05-14 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2'-脱氧-核苷
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
DE69923338T2 (de) 1998-11-02 2006-04-06 Gilead Sciences, Inc., Foster City Kombinationstherapie zur behandlung von hepatitis b infektionen
WO2001047511A2 (en) * 1999-12-29 2001-07-05 The Regents Of The University Of California Treatment of drug-resistant human immunodeficiency virus infection
CN1268345C (zh) 2000-03-29 2006-08-09 乔治敦大学 治疗丁型肝炎病毒感染的核苷化合物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CN101099745A (zh) 2000-05-26 2008-01-09 艾登尼科斯（开曼）有限公司 处理黄病毒和瘟病毒的方法和组合物
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
KR20090089922A (ko) 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
WO2002087500A2 (en) * 2001-04-27 2002-11-07 Newbiotics, Inc. Viral enzyme activated prototoxophores and use of same to treat viral infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
RS113904A (en) * 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
PL374831A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
US7186700B2 (en) 2002-09-13 2007-03-06 Idenix Pharmaceuticals, Inc. β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies
US20070207973A1 (en) * 2002-09-24 2007-09-06 Koronis Pharmaceuticals, Incorporated 1,3,5-Triazines for Treatment of Viral Diseases
JP2006507255A (ja) * 2002-09-24 2006-03-02 コローニス ファーマシューティカルズ インコーポレイテッド ウイルス疾患の治療のための１，３，５−トリアジン
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
BR0316868A (pt) * 2002-12-23 2005-10-25 Idenix Cayman Ltd Processo para a produção de pró-medicamentos de nucleosìdeo-3'
KR100883703B1 (ko) 2003-05-30 2009-02-12 파마셋 인코포레이티드 변형 불소화 뉴클레오시드 유사체
JP2007501185A (ja) 2003-07-25 2007-01-25 イデニクス（ケイマン）リミテツド Ｃ型肝炎を含むフラビウイルス関連疾患を治療するためのプリンヌクレオシド類似体
WO2005045310A2 (en) * 2003-10-27 2005-05-19 Wimberly Randal L Dual reflector system
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
MXPA06011219A (es) 2004-03-29 2007-05-08 Univ South Florida Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados.
EP1912643A2 (de) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurinderivate zur behandlung von infektionen mit flaviviridae
SI3109244T1 (sl) 2004-09-14 2019-06-28 Gilead Pharmasset Llc Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
CN102924549A (zh) 2005-09-26 2013-02-13 吉利德制药有限责任公司 作为抗病毒剂的修饰的4'-核苷
CA2634749C (en) 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
US7950880B2 (en) * 2006-10-18 2011-05-31 Kennametal Inc. Spiral flute tap
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
CN101977610B (zh) 2008-01-25 2012-05-16 奇默里克斯公司 治疗病毒感染的方法
EP3042660A3 (de) 2008-04-15 2016-10-26 RFS Pharma, LLC. Nukleosidderivate zur behandlung von caliciviridae-infektionen, einschliesslich norovirus-infektionen
EP2671888A1 (de) 2008-12-23 2013-12-11 Gilead Pharmasset LLC 3',5'-zyklische Nucleosidphosphatanaloga
NZ617066A (en) 2008-12-23 2015-02-27 Gilead Pharmasset Llc Nucleoside analogs
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
PT2534150T (pt) 2010-02-12 2017-05-02 Chimerix Inc Métodos para tratar uma infecção viral
WO2011139709A2 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CA3131037A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
BR112015023705A8 (pt) 2013-03-15 2020-03-17 Univ California compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
EP4005560A1 (de) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Kombinationsformulierung von zwei antiviralen verbindungen
KR20230145550A (ko) 2014-09-15 2023-10-17 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뉴클레오타이드 유사체
EP3875462A1 (de) 2015-09-15 2021-09-08 The Regents of The University of California Nukleotidanaloga
WO2018023054A1 (en) * 2016-07-28 2018-02-01 Kansas State University Research Foundation Protease transition state inhibitor prodrugs
CA3105038A1 (en) * 2018-06-26 2020-01-02 Tsrl, Inc. Metabolically stable prodrugs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7607496L (sv) * 1976-07-01 1978-01-02 Astra Laekemedel Ab Sett for bekempning av virusinfektioner
CA1144937A (en) * 1977-12-22 1983-04-19 Dke J.E. Helgstrand Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections
US5072032A (en) * 1989-06-21 1991-12-10 Mckenna Charles E Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5194654A (en) * 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
WO1994013321A1 (en) * 1992-12-09 1994-06-23 Indiana University Foundation Suppression of myeloid cells
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs

Also Published As

Publication number Publication date
DK0792275T3 (da) 2004-07-05
CA2205136A1 (en) 1996-05-23
ES2217287T3 (es) 2004-11-01
EP0792275B1 (de) 2004-03-03
EP0792275A1 (de) 1997-09-03
US6002029A (en) 1999-12-14
PT792275E (pt) 2004-09-30
ATE260926T1 (de) 2004-03-15
EP0792275A4 (de) 1998-02-25
AU700651B2 (en) 1999-01-14
CA2205136C (en) 2008-01-22
AU4163596A (en) 1996-06-06
DE69532642T2 (de) 2005-06-30
WO1996015132A1 (en) 1996-05-23
JPH10508858A (ja) 1998-09-02
US5696277A (en) 1997-12-09

Similar Documents

Publication Publication Date Title
DE69532642D1 (de) Antivirale prodrugs
DE69129479T2 (de) Verteiltes Rechnersystem
ATE199906T1 (de) Phosphonat-nukleotid ester-derivate
DE69128017D1 (de) Verteiltes rechnersystem
DE69305413D1 (de) Pulverisierungsvorrichtung
KR930702893A (ko) 상보시스템을 저해하거나 또는 면역활성을 억제하는 성분물
FR2591483B1 (fr) Compositions pharmaceutiques antivirales et antitumorales.
DE69327153T2 (de) Anti-hiv-medikament
DE69121446D1 (de) Zerstäubungssystem
DE69328050T2 (de) Rücklaufsperre
FI964619A0 (fi) Epilepsialääkkeiden iholle annostelu
NO840104L (no) Oksalkylerte polyamidoaminer, samt anvendelse av dem
DE69311862T2 (de) Kontinuierliche Dispergiervorrichtung
DE69302723T2 (de) Mehrreihige Wechselrichteranordnung
IT1229295B (it) Differenziale bloccabile
FI925423A0 (fi) Anordning foer att anordna permanenta magneter till en maenniskans kropp
DE9314628U1 (de) Höschenwindel
KR940006900U (ko) 유아용 멜빵
AU1871592A (en) Novel reference influenza viruses and antiviral drug susceptibility methods
KR970000135U (ko) 아기용 멜빵
PT8490T (pt) Cadeira de bebe multiusos
SE9203298D0 (sv) Laekemedel med antidopamineffekt
KR960031081U (ko) 안전거리 지시형 백밀러
MX9203510A (es) Fenilpiperidilaminas y drogas que las contienen.
BR7302524U (pt) Cadeira suspense para crianças

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIMERIX, INC., DEL MAR, CALIF., US

8327 Change in the person/name/address of the patent owner

Owner name: CHIMERIX, INC., LA JOLLA, CALIF., US