DE69535242D1 - Somatostatin bindende peptide-metallchelat konjugate - Google Patents

Somatostatin bindende peptide-metallchelat konjugate

Info

Publication number
DE69535242D1
DE69535242D1 DE69535242T DE69535242T DE69535242D1 DE 69535242 D1 DE69535242 D1 DE 69535242D1 DE 69535242 T DE69535242 T DE 69535242T DE 69535242 T DE69535242 T DE 69535242T DE 69535242 D1 DE69535242 D1 DE 69535242D1
Authority
DE
Germany
Prior art keywords
agents
reagents
methods
imaging
binding peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535242T
Other languages
English (en)
Other versions
DE69535242T2 (de
Inventor
Richard Dean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Publication of DE69535242D1 publication Critical patent/DE69535242D1/de
Application granted granted Critical
Publication of DE69535242T2 publication Critical patent/DE69535242T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69535242T 1994-05-12 1995-05-12 Somatostatin bindende peptide-metallchelat konjugate Expired - Fee Related DE69535242T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US241625 1994-05-12
US08/241,625 US5783170A (en) 1991-11-27 1994-05-12 Peptide-metal chelate conjugates
PCT/US1995/006034 WO1995031221A1 (en) 1994-05-12 1995-05-12 Somatostatin binding peptide-metal chelate conjugates

Publications (2)

Publication Number Publication Date
DE69535242D1 true DE69535242D1 (de) 2006-11-09
DE69535242T2 DE69535242T2 (de) 2007-05-16

Family

ID=22911488

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535242T Expired - Fee Related DE69535242T2 (de) 1994-05-12 1995-05-12 Somatostatin bindende peptide-metallchelat konjugate

Country Status (12)

Country Link
US (5) US5783170A (de)
EP (1) EP0759786B1 (de)
JP (1) JP3918157B2 (de)
CN (1) CN1078480C (de)
AT (1) ATE340594T1 (de)
AU (1) AU708797B2 (de)
DE (1) DE69535242T2 (de)
DK (1) DK0759786T3 (de)
ES (1) ES2274517T3 (de)
PT (1) PT759786E (de)
WO (1) WO1995031221A1 (de)
ZA (1) ZA953878B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6713605B1 (en) * 1996-04-10 2004-03-30 Kansas State University Research Foundation Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes
US6685913B1 (en) * 1999-03-09 2004-02-03 Thomas Jefferson University Lipid soluble radioactive metal chelates for tumor therapy
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
US20020187099A1 (en) * 2001-05-16 2002-12-12 Rajesh Manchanda Stabilization of radionuclide-containing compositions
AU2003259172A1 (en) * 2002-07-24 2004-02-09 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
CN1771335A (zh) * 2003-02-13 2006-05-10 加州大学评议会 使用集光多生色团检测和分析多核苷酸－结合蛋白相互作用的方法和组合物
WO2004081031A2 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
WO2004106939A2 (en) * 2003-06-03 2004-12-09 Paul Scherrer Institut Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides
US8540968B2 (en) * 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
CA2557698A1 (en) 2004-03-02 2005-09-15 Cellectar, Llc Phospholipid analogs as diapeutic* agents and methods therefor
EP1717247A1 (de) * 2005-04-28 2006-11-02 Schering AG Zyklische Peptide, die sich am Somatostatinrezeptor binden
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
US7842280B2 (en) * 2006-09-06 2010-11-30 Case Western Reserve University Flexibly labeling peptides
WO2008143958A1 (en) * 2007-05-18 2008-11-27 The Brigham And Women's Hospital, Inc. Use of somatostatin analogs in myocardial perfusion imaging
WO2009032181A2 (en) * 2007-09-04 2009-03-12 Ipsen Pharma S.A.S. Methods and intermediates for chemical synthesis of polypeptides and proteins
CA2725811A1 (en) 2008-06-06 2009-12-10 Providence Medical Technology, Inc. Facet joint implants and delivery tools
US8361152B2 (en) 2008-06-06 2013-01-29 Providence Medical Technology, Inc. Facet joint implants and delivery tools
US20100316567A1 (en) 2009-06-12 2010-12-16 Weichert Jamey P Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer stem cells
WO2011031919A2 (en) * 2009-09-11 2011-03-17 Cellectar, Inc. Non-radioactive phospholipid compounds, compositions, and methods of use
US20120065092A1 (en) * 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
MX2014002690A (es) * 2011-09-07 2014-04-14 Dow Global Technologies Llc Fluido de servicio de pozo que tiene polimeros modificados hidrofobicamente.
US20160040212A1 (en) * 2013-03-15 2016-02-11 The Broad Institute, Inc. Methods for the Detection of DNA-RNA Proximity in Vivo
CN110256310A (zh) * 2019-07-01 2019-09-20 吉尔生化（上海）有限公司 一种n-芴甲氧羰基-s-(4-甲氧基三苯甲基)-l-高半胱氨酸的制备方法

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
EP0169232B1 (de) * 1984-01-23 1990-04-25 For Energiteknikk Institutt Zusammensetzung zur Technetium-99m-Markierung von proteinhaltigem Material
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
CA1336076C (en) * 1985-01-14 1995-06-27 Alan R. Fritzberg Metal radionuclide labeled proteins for diagnosis and therapy
US4611054A (en) * 1985-04-29 1986-09-09 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
JPS62155994A (ja) * 1985-12-27 1987-07-10 Mitsubishi Monsanto Chem Co 活性汚泥のバルキング防止剤及びそのバルキング防止方法
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
EP0284071B1 (de) * 1987-03-26 1994-06-08 Neorx Corporation Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
DE3850497T2 (de) * 1987-04-02 1995-02-23 Centocor Inc Methode zur markierung von antikörpern mit einem metallion.
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
ATE124269T1 (de) * 1988-02-09 1995-07-15 Mallinckrodt Inc Verfahren zur herstellung eines mit metall- radionuklid-markierten proteins.
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
EP0413766A4 (en) * 1988-05-02 1991-11-21 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
WO1990006323A2 (en) * 1988-11-29 1990-06-14 Centocor, Inc. Chimeric proteins incorporating a metal binding protein
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
CA2012115C (en) * 1989-03-15 2001-07-03 Biomeasure, Inc. Iodinated somatostatins
US5196515A (en) * 1989-03-17 1993-03-23 The Johns Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
KR0173119B1 (ko) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 선형 소마토스타틴 유사체
DE69023394T2 (de) * 1989-06-16 1996-07-04 Merck Frosst Canada Inc Chelat-Derivate von atrialnatriurethischem Faktor (ANF).
US5248764A (en) * 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
HU219336B (en) * 1989-07-20 2001-03-28 Novartis Ag Process for producing peptide derivatives and pharmaceutical compositions comprising such compounds and diagnostic unit containing such compounds
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US5112953A (en) * 1989-12-29 1992-05-12 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
US5175257A (en) * 1989-12-29 1992-12-29 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
EP0450480B1 (de) * 1990-04-06 1995-06-21 The Administrators of The Tulane Educational Fund Somatostatinanaloge
US5178025A (en) * 1990-08-31 1993-01-12 Innovative Medical Engineering, Inc. Tiltable lift seat devices
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
EP0542934B1 (de) * 1991-02-08 1999-06-16 Biomeasure, Inc. Verwendung von somatostatinanalogen zur behandlung von melanomen
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
AU657770B2 (en) * 1991-06-03 1995-03-23 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
EP0629133B1 (de) * 1992-01-03 2000-11-29 Rhomed, Incorporated Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
AU3606793A (en) * 1992-02-05 1993-09-03 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
ATE337338T1 (de) * 1993-06-23 2006-09-15 Diatide Inc Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung
CA2189420A1 (en) * 1994-05-02 1995-11-09 Richard T. Dean Technetium-99m labeled imaging agents
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications

Also Published As

Publication number Publication date
US5981477A (en) 1999-11-09
US5965108A (en) 1999-10-12
CN1155248A (zh) 1997-07-23
EP0759786A1 (de) 1997-03-05
DE69535242T2 (de) 2007-05-16
US5783170A (en) 1998-07-21
DK0759786T3 (da) 2007-01-29
WO1995031221A1 (en) 1995-11-23
US5972308A (en) 1999-10-26
CN1078480C (zh) 2002-01-30
AU2550095A (en) 1995-12-05
ZA953878B (en) 1996-01-18
ATE340594T1 (de) 2006-10-15
PT759786E (pt) 2007-01-31
ES2274517T3 (es) 2007-05-16
JP3918157B2 (ja) 2007-05-23
JPH10500411A (ja) 1998-01-13
US5985241A (en) 1999-11-16
AU708797B2 (en) 1999-08-12
EP0759786B1 (de) 2006-09-27

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8327 Change in the person/name/address of the patent owner

Owner name: CIS BIO INTERNATIONAL, GIF SUR YVETTE, FR

8328 Change in the person/name/address of the agent

Representative=s name: DOERRIES FRANK-MOLNIA & POHLMAN, 80538 MUENCHEN

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: DF-MP, 80333 MUENCHEN

8339 Ceased/non-payment of the annual fee