DE69535895D1 - Resorbierbare synthetische proteine zur verwendung in implantaten - Google Patents

Resorbierbare synthetische proteine zur verwendung in implantaten

Info

Publication number
DE69535895D1
DE69535895D1 DE69535895T DE69535895T DE69535895D1 DE 69535895 D1 DE69535895 D1 DE 69535895D1 DE 69535895 T DE69535895 T DE 69535895T DE 69535895 T DE69535895 T DE 69535895T DE 69535895 D1 DE69535895 D1 DE 69535895D1
Authority
DE
Germany
Prior art keywords
repeating units
compositions
active substance
biologically active
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535895T
Other languages
English (en)
Inventor
Joseph Cappello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protein Polymer Technologies Inc
Original Assignee
Protein Polymer Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Polymer Technologies Inc filed Critical Protein Polymer Technologies Inc
Application granted granted Critical
Publication of DE69535895D1 publication Critical patent/DE69535895D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • DTEXTILES; PAPER
    • D01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01FCHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/047Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18Manufacture of films or sheets
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/61Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00Characterised by the use of proteins; Derivatives thereof
DE69535895T 1994-03-11 1995-03-10 Resorbierbare synthetische proteine zur verwendung in implantaten Expired - Lifetime DE69535895D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/212,237 US5606019A (en) 1987-10-29 1994-03-11 Synthetic protein as implantables
PCT/US1995/002772 WO1995024478A1 (en) 1994-03-11 1995-03-10 Synthetic proteins as implantables

Publications (1)

Publication Number Publication Date
DE69535895D1 true DE69535895D1 (de) 2009-01-22

Family

ID=22790163

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535895T Expired - Lifetime DE69535895D1 (de) 1994-03-11 1995-03-10 Resorbierbare synthetische proteine zur verwendung in implantaten

Country Status (7)

Country Link
US (3) US5606019A (de)
EP (1) EP0804595B1 (de)
JP (1) JP3378254B2 (de)
AT (1) ATE417111T1 (de)
CA (1) CA2183644A1 (de)
DE (1) DE69535895D1 (de)
WO (1) WO1995024478A1 (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
CA2262446A1 (en) * 1996-08-07 1998-02-12 Protein Specialties, Ltd. Self-aligning peptides derived from elastin and other fibrous proteins
US6489446B1 (en) 1996-08-07 2002-12-03 Hsc Research And Development Limited Partnership Self-aligning peptides modeled on human elastin and other fibrous proteins
US6127166A (en) * 1997-11-03 2000-10-03 Bayley; Hagan Molluscan ligament polypeptides and genes encoding them
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
WO1999030632A1 (en) * 1997-12-18 1999-06-24 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like
WO2000056774A1 (en) * 1999-03-19 2000-09-28 Duke University Methods of using bioelastomers
IT1309453B1 (it) * 1999-10-01 2002-01-23 Consorzio Per Gli Studi Uni Substrato bioartificiale per la realizzazione di tessuti e organianimali, in particolare umani.
CA2422884C (en) * 2000-10-24 2009-05-19 Cryolife, Inc. In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
AU2001297782B2 (en) * 2000-11-07 2006-03-02 Cryolife, Inc. Expandable foam-like biomaterials and methods
US6629988B2 (en) * 2001-08-28 2003-10-07 Ethicon, Inc. Composite staple for completing an anastomosis
US20050090641A1 (en) * 2001-10-02 2005-04-28 Regina Valluzzi Self-assembling polymers, and materials fabricated therefrom
EP1448089A4 (de) * 2001-11-01 2008-06-04 Spine Wave Inc Vorrichtungen und vefahren zur wiederinstandsetzung einer rückgratscheibe
US7799833B2 (en) 2001-11-01 2010-09-21 Spine Wave, Inc. System and method for the pretreatment of the endplates of an intervertebral disc
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US20110009960A1 (en) * 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
EP1558444B1 (de) * 2002-06-24 2016-09-21 Tufts University Seidebiomaterial und verwendungsverfahren davon
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
US7297678B2 (en) * 2003-03-12 2007-11-20 Genencor International, Inc. Use of repeat sequence protein polymers in personal care compositions
US20050142094A1 (en) * 2003-03-12 2005-06-30 Manoj Kumar Use of repeat sequence protein polymers in personal care compositions
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
WO2005068495A1 (ja) * 2004-01-13 2005-07-28 Toray Industries, Inc. クモ糸タンパク質を含む絹糸および該絹糸を産生するカイコ
EP2138195A3 (de) 2004-06-16 2010-07-21 Affinergy Inc. Grenzflächenbiomaterialien zur Förderung der Anhaftung von Zielanalyten
US7722579B2 (en) * 2004-06-29 2010-05-25 Spine Wave, Inc. Devices for injecting a curable biomaterial into a intervertebral space
US7825083B2 (en) * 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
US20070098702A1 (en) * 2005-02-17 2007-05-03 University Of Maryland, Baltimore Recombinant protein polymer vectors for systemic gene delivery
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20060253068A1 (en) * 2005-04-20 2006-11-09 Van Bilsen Paul Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
US8333830B2 (en) * 2005-08-22 2012-12-18 Danisco Us Inc. Composites of repeat sequence proteins and their preparation
US20070102010A1 (en) * 2005-10-07 2007-05-10 Lemperle Stefan M Naso-pharyngeal tissue engineering
US8841255B2 (en) * 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) * 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CA2634034A1 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8178495B2 (en) * 2008-06-27 2012-05-15 Duke University Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US20070179618A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
CN101553262A (zh) * 2006-11-13 2009-10-07 悉尼大学 原弹性蛋白用于组织修复或恢复的用途
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) * 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US9102916B2 (en) * 2007-02-27 2015-08-11 Trustees Of Tufts College Tissue-engineered silk organs
EP2155233A2 (de) 2007-05-10 2010-02-24 Elastin Specialties, Inc. Synthetisches peptidmaterial zur gelenkrekonstruktion, -reparatur und -polsterung
CN101772348B (zh) 2007-05-29 2014-07-16 塔夫茨大学信托人 利用超声处理使丝纤蛋白凝胶化的方法
JP2011511668A (ja) * 2008-02-07 2011-04-14 トラスティーズ オブ タフツ カレッジ 3次元絹ハイドロキシアパタイト組成物
JP5777510B2 (ja) 2008-05-09 2015-09-09 エボニック コーポレイションEvonik Corporation 生物適合性及び生分解性のエラストマー性ポリマー
US9040073B2 (en) * 2008-05-15 2015-05-26 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
MX2011003618A (es) 2008-10-09 2011-06-16 Tufts College Peliculas de seda modificadas que contienen glicerol.
US9326840B2 (en) 2008-12-15 2016-05-03 Allergan, Inc. Prosthetic device and method of manufacturing the same
US9204953B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Biocompatible surgical scaffold with varying stretch
US9204954B2 (en) * 2008-12-15 2015-12-08 Allergan, Inc. Knitted scaffold with diagonal yarn
US9308070B2 (en) * 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
RU2015108720A (ru) 2008-12-15 2015-08-10 Аллерган, Инк. Вязаная хирургическая имплантируемая сетка
EP2453931A4 (de) 2009-07-14 2014-04-30 Tufts College Wundheilungssysteme mit einem elektrogesponnenen seidenmaterial
HUE032703T2 (en) * 2009-08-14 2017-10-30 Phasebio Pharmaceuticals Inc Modified vasoactive intestinal peptides
EP2475330A1 (de) * 2009-09-11 2012-07-18 Allergan, Inc. Prothesenvorrichtung und herstellungsverfahren dafür
CA2775706A1 (en) 2009-09-28 2011-03-31 Trustees Of Tufts College Drawn silk egel fibers and methods of making same
CA2774643A1 (en) 2009-09-29 2011-04-07 Trustees Of Tufts College Silk nanospheres and microspheres and methods of making same
US9132207B2 (en) * 2009-10-27 2015-09-15 Spine Wave, Inc. Radiopaque injectable nucleus hydrogel compositions
US9603971B2 (en) 2010-03-05 2017-03-28 Trustees Of Tufts College Silk-based ionomeric compositions
JP6081358B2 (ja) 2010-09-01 2017-02-15 トラスティーズ・オブ・タフツ・カレッジTrustees Of Tufts College 絹フィブロインおよびポリエチレングリコールをベースとする生体材料
EP2629836B1 (de) 2010-10-19 2018-09-12 Trustees Of Tufts College Mikronadeln auf seidenfibroinbasis und verfahren zu ihrer herstellung
WO2012074966A2 (en) * 2010-11-29 2012-06-07 Bioo Scientific Corporation Improved production of anti-peptide antibodies
WO2012111438A1 (ja) * 2011-02-18 2012-08-23 国立大学法人京都大学 組織再生用材料、これを含むタンパク質水溶液及びこれをゲル化させる方法
US9700425B1 (en) 2011-03-20 2017-07-11 Nuvasive, Inc. Vertebral body replacement and insertion methods
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
JP6077316B2 (ja) * 2012-02-02 2017-02-08 三洋化成工業株式会社 組織再生用材料及び組織再生用タンパク質溶液
EP2811987B1 (de) 2012-02-06 2021-01-20 Children's Medical Center Corporation Mehrschichtiges biomaterial zur geweberegenerierung und wundheilung
EP2668962B1 (de) * 2012-05-29 2016-10-26 Albert-Ludwigs-Universität Freiburg Proteinassembler
US9492448B2 (en) 2012-06-20 2016-11-15 University Of Virginia Patent Foundation Compositions and methods for regulating glucose homeostasis and insulin action
JP6058367B2 (ja) * 2012-11-28 2017-01-11 三洋化成工業株式会社 インプラント用コーティング剤、インプラント及びインプラントの製造方法
US20140194370A1 (en) 2013-01-08 2014-07-10 University Of Utah Research Foundation Silk-elastin like protein polymers for embolization and chemoembolization to treat cancer
JP6326326B2 (ja) * 2013-08-30 2018-05-16 三洋化成工業株式会社 創傷治癒剤
WO2015172046A1 (en) 2014-05-08 2015-11-12 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
KR101844481B1 (ko) * 2016-03-04 2018-04-02 주식회사 브레인온 기억력 향상 효과를 가지는 펩타이드
CN110279845B (zh) * 2015-12-21 2021-08-20 保脑稳有限公司 记忆力、学习力、认知力提高用组合物
KR101706296B1 (ko) 2015-12-21 2017-02-13 주식회사 브레인온 기억력, 학습력, 인지력 향상용 조성물
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
US11896591B2 (en) 2017-05-22 2024-02-13 University Of Virginia Patent Foundation Compositions and methods for preparing and using mitochondrial uncouplers
US10849914B2 (en) 2017-06-12 2020-12-01 University Of Utah Research Foundation Methods for producing chemoembolic agents for the delivery of anti-cancer agents
KR101844480B1 (ko) * 2017-07-24 2018-04-02 주식회사 브레인온 기억력 향상 효과를 가지는 펩타이드
CA3097751A1 (en) 2018-04-20 2019-10-24 Virginia Tech Intellectual Properties, Inc. Oxadiazolopyrazines and oxadiazolopyridines useful as mitochondrial uncouplers
US20220409779A1 (en) * 2019-12-02 2022-12-29 Kyoto University Bronchial embolization material

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215200A (en) * 1978-10-02 1980-07-29 Cornell Research Foundation, Inc. Chemically and enzymatically modified collagen hemostatic agent
US4589882A (en) * 1983-09-19 1986-05-20 Urry Dan W Enzymatically crosslinked bioelastomers
US4783523A (en) * 1986-08-27 1988-11-08 Urry Dan W Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides
US5243038A (en) * 1986-11-04 1993-09-07 Protein Polymer Technologies, Inc. Construction of synthetic DNA and its use in large polypeptide synthesis
AU612340B2 (en) * 1986-11-04 1991-07-11 Protein Polymers Technologies, Inc. Construction of synthetic dna and its use in large polypeptide synthesis
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
EP0406357B1 (de) * 1988-11-09 1998-01-07 Protein Polymer Technologies, Inc. Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer
US5171505A (en) * 1990-11-28 1992-12-15 E. I. Du Pont De Nemours And Company Process for spinning polypeptide fibers
US5235041A (en) * 1990-12-28 1993-08-10 Protein Polymer Technologies, Inc. Purification of structurally ordered recombinant protein polymers
US5523291A (en) * 1993-09-07 1996-06-04 Datascope Investment Corp. Injectable compositions for soft tissue augmentation
US5773577A (en) * 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking

Also Published As

Publication number Publication date
US6380154B1 (en) 2002-04-30
JP2001508754A (ja) 2001-07-03
EP0804595B1 (de) 2008-12-10
US5606019A (en) 1997-02-25
EP0804595A1 (de) 1997-11-05
US20020045567A1 (en) 2002-04-18
CA2183644A1 (en) 1995-09-14
ATE417111T1 (de) 2008-12-15
US20030176355A1 (en) 2003-09-18
WO1995024478A1 (en) 1995-09-14
JP3378254B2 (ja) 2003-02-17
EP0804595A4 (de) 1997-11-05

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