DE69535944D1 - Verfahren und Vorrichtung zur Erzeugung feiner Partikel - Google Patents

Verfahren und Vorrichtung zur Erzeugung feiner Partikel

Info

Publication number
DE69535944D1
DE69535944D1 DE69535944T DE69535944T DE69535944D1 DE 69535944 D1 DE69535944 D1 DE 69535944D1 DE 69535944 T DE69535944 T DE 69535944T DE 69535944 T DE69535944 T DE 69535944T DE 69535944 D1 DE69535944 D1 DE 69535944D1
Authority
DE
Germany
Prior art keywords
fine particles
producing fine
producing
particles
fine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535944T
Other languages
English (en)
Inventor
Robert E Sievers
Uwe Karst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69535944D1 publication Critical patent/DE69535944D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/09—Mixing systems, i.e. flow charts or diagrams for components having more than two different of undetermined agglomeration states, e.g. supercritical states
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/32—Mixing gases with solids by introducing solids in gas volumes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/39—Mixing systems, i.e. flow charts or diagrams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/28—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector
    • B01F25/281—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector the jet injector being of the explosive rapid expansion of supercritical solutions [RESS] or fluid injection of molecular spray [FIMS] type, i.e. the liquid is jetted in an environment (gas or liquid) by nozzles, in conditions of significant pressure drop, with the possible generation of shock waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/14—Arrangements for controlling delivery; Arrangements for controlling the spray area for supplying a selected one of a plurality of liquids or other fluent materials or several in selected proportions to a spray apparatus, e.g. to a single spray outlet
    • B05B12/1418—Arrangements for controlling delivery; Arrangements for controlling the spray area for supplying a selected one of a plurality of liquids or other fluent materials or several in selected proportions to a spray apparatus, e.g. to a single spray outlet for supplying several liquids or other fluent materials in selected proportions to a single spray outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/26—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device
    • B05B7/28—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid
    • B05B7/32—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid the fed liquid or other fluent material being under pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/025—Processes for applying liquids or other fluent materials performed by spraying using gas close to its critical state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
    • B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE69535944T 1994-04-08 1995-03-29 Verfahren und Vorrichtung zur Erzeugung feiner Partikel Expired - Lifetime DE69535944D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/224,764 US5639441A (en) 1992-03-06 1994-04-08 Methods for fine particle formation

Publications (1)

Publication Number Publication Date
DE69535944D1 true DE69535944D1 (de) 2009-06-10

Family

ID=22842098

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69535944T Expired - Lifetime DE69535944D1 (de) 1994-04-08 1995-03-29 Verfahren und Vorrichtung zur Erzeugung feiner Partikel
DE69525557T Expired - Lifetime DE69525557T2 (de) 1994-04-08 1995-03-29 Verfahren und Apparat zur Erzeugung von feinen Partikeln

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69525557T Expired - Lifetime DE69525557T2 (de) 1994-04-08 1995-03-29 Verfahren und Apparat zur Erzeugung von feinen Partikeln

Country Status (3)

Country Link
US (2) US5639441A (de)
EP (2) EP1160018B1 (de)
DE (2) DE69535944D1 (de)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063910A (en) * 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB9507768D0 (en) 1995-04-13 1995-05-31 Glaxo Group Ltd Method of apparatus
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19616573C2 (de) * 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
AU4978797A (en) * 1997-08-20 1999-03-08 Idaho Research Foundation Inc., The Method for dissociating metals or dissociating metal compounds
US6426136B1 (en) * 1998-02-10 2002-07-30 R & D Technology, Inc. Method of reducing material size
AP1342A (en) * 1998-03-16 2004-12-15 Nektar Therapeutics Aerosolized active agent delivery.
SE9801287D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Incorporation of active substances in carrier matrixes
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
DE19836723B4 (de) * 1998-08-13 2008-04-24 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren zur Homogenisierung von Staubverteilungen
US6184270B1 (en) 1998-09-21 2001-02-06 Eric J. Beckman Production of power formulations
UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
US6454754B1 (en) * 1998-10-29 2002-09-24 Steven R. Frank Respiratory infection treatment device
US6497921B1 (en) * 1998-11-06 2002-12-24 North Carolina State University Method for meniscus coating with liquid carbon dioxide
US6083565A (en) 1998-11-06 2000-07-04 North Carolina State University Method for meniscus coating with liquid carbon dioxide
US6113795A (en) * 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
SE9804000D0 (sv) 1998-11-23 1998-11-23 Astra Ab New composition of matter
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
US6403672B1 (en) * 1998-11-30 2002-06-11 University Technology Corporation Preparation and use of photopolymerized microparticles
US6864301B2 (en) * 1998-11-30 2005-03-08 The Regents Of The University Of Colorado Preparation and use of photopolymerized microparticles
GB9828204D0 (en) * 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
US7081133B2 (en) * 1999-01-19 2006-07-25 Carbomedics Inc. Antibiotic treated implantable medical devices
US6440463B1 (en) * 1999-04-05 2002-08-27 Pharmaceutical Discovery Corporation Methods for fine powder formation
US6256941B1 (en) 1999-06-04 2001-07-10 Haworth, Inc. Pad for panel
JP4874483B2 (ja) * 1999-06-09 2012-02-15 ロバート イー． シーバース 超臨界流体補助ネブライゼーション及びバブル乾燥
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
WO2001003671A2 (de) * 1999-07-13 2001-01-18 Skw Trostberg Aktiengesellschaft Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
AU777338B2 (en) * 1999-12-04 2004-10-14 Research Development Foundation Carbon dioxide enhancement of inhalation therapy
FR2803538B1 (fr) * 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
WO2001045731A1 (en) * 1999-12-21 2001-06-28 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
US6761909B1 (en) * 1999-12-21 2004-07-13 Rxkinetix, Inc. Particulate insulin-containing products and method of manufacture
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
AU5543801A (en) * 2000-05-16 2001-11-26 Ortho Mcneil Pharm Inc Process for coating medical devices using super-critical carbon dioxide
NL1015288C2 (nl) * 2000-05-24 2001-12-14 Peter Ferdinand Elbers Preparaat voor het stabiliseren van de beschermlaag op het epitheel van het hoornvlies of de longblaasjes.
US6451287B1 (en) 2000-05-26 2002-09-17 Smithkline Beecham Corporation Fluorinated copolymer surfactants and use thereof in aerosol compositions
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
ES2170008B1 (es) 2000-08-25 2003-05-01 Soc Es Carburos Metalicos Sa Procedimiento para la precipitacion de particulas solidas finamente divididas.
US6443164B1 (en) 2000-09-22 2002-09-03 Spectrum Products, Inc. Apparatus for automatic application of compositions to the skin
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
DE10059167A1 (de) * 2000-11-29 2002-06-06 Bsh Bosch Siemens Hausgeraete Backofen
GB0102075D0 (en) * 2001-01-26 2001-03-14 Astrazeneca Ab Process
US20030072717A1 (en) * 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
FR2824754B1 (fr) * 2001-05-15 2004-05-28 Separex Sa Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble
CA2448022C (en) * 2001-05-21 2013-11-12 Injet Digital Aerosols Limited Compositions for protein delivery via the pulmonary route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
WO2002094231A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of analgesics through an inhalation route
EP1392258B1 (de) 2001-05-24 2008-11-26 Alexza Pharmaceuticals, Inc. Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US20060167074A1 (en) * 2001-06-19 2006-07-27 Norbert Muller Methods and compositions for the treatment of psychiatric disorders
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
CA2448993A1 (en) * 2001-06-19 2002-12-27 Roche Vitamins Ag Process for the preparation of dispersions
WO2003006223A1 (en) * 2001-07-10 2003-01-23 University Technology Corporation Devices and methods for the production of particles
US7276184B2 (en) * 2001-07-12 2007-10-02 Eastman Kodak Company Surfactant assisted nanomaterial generation process
US6595630B2 (en) * 2001-07-12 2003-07-22 Eastman Kodak Company Method and apparatus for controlling depth of deposition of a solvent free functional material in a receiver
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7033813B2 (en) * 2001-09-05 2006-04-25 Trevor P Castor Inactivated vaccines for aids and other infectious diseases
US6568390B2 (en) * 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
GB0123013D0 (en) * 2001-09-25 2001-11-14 Upperton Ltd Improvements relating to imaging contrast agents
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US20050053678A1 (en) * 2001-10-03 2005-03-10 Gow Robert T. Methods and compositions for betel nut chewing gum
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
NZ532759A (en) * 2001-10-10 2005-10-28 Boehringer Ingelheim Pharma Powder processing with pressurized gaseous fluids
CA2464308A1 (en) 2001-10-22 2003-05-01 Dompe S.P.A. Supercritical fluids processing: preparation of protein microparticles and their stabilisation
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
AU2002363947A1 (en) * 2001-11-21 2003-07-24 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US20030107614A1 (en) * 2001-12-06 2003-06-12 Eastman Kodak Company Method and apparatus for printing
US6866371B2 (en) * 2002-01-17 2005-03-15 Eastman Kodak Company Method and apparatus for printing and coating
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US6832699B2 (en) 2002-02-22 2004-12-21 Terrasimco Inc. Direct pressure apparatus and method for dispensing coatings
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US7128840B2 (en) 2002-03-26 2006-10-31 Idaho Research Foundation, Inc. Ultrasound enhanced process for extracting metal species in supercritical fluids
WO2003086443A1 (en) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration
AU2003234090A1 (en) 2002-04-11 2003-10-27 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
KR20100112206A (ko) * 2002-04-11 2010-10-18 메디뮨 엘엘씨 분무 건조에 의한 생물학적 활성 물질의 보존
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
AU2003222642A1 (en) * 2002-05-10 2003-11-11 Chrysalis Technologies Incorporated Aerosol generator for drug formulation and methods of generating aerosol
WO2003094900A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US7390441B2 (en) * 2002-05-23 2008-06-24 Columbian Chemicals Company Sulfonated conducting polymer-grafted carbon material for fuel cell applications
US7459103B2 (en) 2002-05-23 2008-12-02 Columbian Chemicals Company Conducting polymer-grafted carbon material for fuel cell applications
US7241334B2 (en) * 2002-05-23 2007-07-10 Columbian Chemicals Company Sulfonated carbonaceous materials
US7195834B2 (en) * 2002-05-23 2007-03-27 Columbian Chemicals Company Metallized conducting polymer-grafted carbon material and method for making
US7175930B2 (en) * 2002-05-23 2007-02-13 Columbian Chemicals Company Conducting polymer-grafted carbon material for fuel cell applications
CN100339913C (zh) 2002-05-23 2007-09-26 哥伦比亚化学公司 用于燃料电池的、磺化导电聚合物接枝的碳材料
US6780475B2 (en) * 2002-05-28 2004-08-24 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
US6756084B2 (en) * 2002-05-28 2004-06-29 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
ES2342769T3 (es) * 2002-05-28 2010-07-14 Battelle Memorial Institute Deposicion electrostatica de particulas generadas a partir de la expansion rapida de soluciones liquidas supercriticas.
US6749902B2 (en) * 2002-05-28 2004-06-15 Battelle Memorial Institute Methods for producing films using supercritical fluid
US7185651B2 (en) * 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US6994867B1 (en) 2002-06-21 2006-02-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing L-arginine
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US7011842B1 (en) 2002-06-21 2006-03-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
EP1519898B1 (de) * 2002-06-25 2012-02-29 Aalborg Universitet Verfahren zur herstellung eines produktes mit sub-microner primär-teilchengrösse und apparat zur anwendung des verfahrens
WO2004002395A2 (en) * 2002-06-27 2004-01-08 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
US6966990B2 (en) * 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US20040073186A1 (en) * 2002-10-15 2004-04-15 Cameron Mickey G. Apparatus for automatic application of compositions to the skin
AU2003294470B2 (en) 2002-11-26 2009-09-17 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
US20060002862A1 (en) * 2002-12-17 2006-01-05 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
CA2510019A1 (en) * 2002-12-19 2004-07-08 Baxter International, Inc. Process for preparing combination pharmaceutical formulations using supercritical fluids
MXPA05007154A (es) 2002-12-30 2005-09-21 Nektar Therapeutics Atomizador prepeliculizacion.
US6824079B2 (en) 2003-01-24 2004-11-30 S. C. Johnson & Son, Inc. Aerosol dispenser assembly and method of reducing the particle size of a dispensed product
US20050023368A1 (en) * 2003-01-24 2005-02-03 S.C. Johnson & Son, Inc. Method of designing improved spray dispenser assemblies
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
WO2004071645A2 (en) * 2003-02-07 2004-08-26 Ferro Corporation Method and apparatus for supercritical fluid assisted particle production
US6931888B2 (en) * 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US7449136B2 (en) * 2003-02-21 2008-11-11 Ferro Pfanstiehl Laboratories, Inc. Method and apparatus for producing composite particles using supercritical fluid as plasticizing and extracting agent
US7455797B2 (en) * 2003-02-28 2008-11-25 Ferro Corporation Method and apparatus for producing particles using supercritical fluid
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
US7354601B2 (en) * 2003-05-08 2008-04-08 Walker Stephen E Particulate materials
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
WO2004110603A2 (en) * 2003-06-03 2004-12-23 Ferro Corporation Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
US20040263597A1 (en) * 2003-06-24 2004-12-30 Eastman Kodak Company Apparatus and method of producing multiple spectral deposits from a mixture of a compressed fluid and a marking material
WO2005022603A2 (en) * 2003-09-02 2005-03-10 Integral Technologies, Inc. Low cost conductive containers manufactured from conductive loaded resin-based materials
US20050181059A1 (en) * 2003-09-30 2005-08-18 Spherics, Inc. Nanoparticulate therapeutic biologically active agents
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
US7279184B2 (en) * 2003-10-24 2007-10-09 Herbalscience, Llc Methods and compositions comprising Ilex
EP1706198A2 (de) * 2004-01-22 2006-10-04 SCF Technologies A/S Verfahren und vorrichtung zur herstellung von mikroemulsionen
DE102004006135A1 (de) * 2004-02-07 2005-09-01 Henkel Kgaa Herstellung von mikro-/nanoskaligen Duftstoffpartikeln
US6958308B2 (en) * 2004-03-16 2005-10-25 Columbian Chemicals Company Deposition of dispersed metal particles onto substrates using supercritical fluids
US7220456B2 (en) * 2004-03-31 2007-05-22 Eastman Kodak Company Process for the selective deposition of particulate material
US20050218076A1 (en) * 2004-03-31 2005-10-06 Eastman Kodak Company Process for the formation of particulate material
US7223445B2 (en) * 2004-03-31 2007-05-29 Eastman Kodak Company Process for the deposition of uniform layer of particulate material
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7909263B2 (en) * 2004-07-08 2011-03-22 Cube Technology, Inc. Method of dispersing fine particles in a spray
NO20043150D0 (no) * 2004-07-23 2004-07-23 Ntnu Technology Transfer As "Fremgangsmate og utstyr for varmegjenvining"
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
US20060068987A1 (en) * 2004-09-24 2006-03-30 Srinivas Bollepalli Carbon supported catalyst having reduced water retention
US20060105051A1 (en) * 2004-11-18 2006-05-18 Blair Jackson Manufacture of particles for pulmonary drug delivery by carbon dioxide assisted nebulization
US20060275542A1 (en) * 2005-06-02 2006-12-07 Eastman Kodak Company Deposition of uniform layer of desired material
AU2006259876A1 (en) * 2005-06-13 2006-12-28 Michael H. Gurin Nano-ionic liquids and methods of use
EP1906919A4 (de) * 2005-07-15 2012-12-26 Map Pharmaceuticals Inc Mehrere pharmazeutische wirkstoffe in kombination in diskreten inhalierbaren teilchen und formulierungen davon
WO2007009164A1 (en) * 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
EP1795184A1 (de) * 2005-12-09 2007-06-13 Ludwig-Maximilians-Universität München Verfahren zur Herstelllung von Pulvern mit Kolloidpartikeln
AU2007205861B2 (en) * 2006-01-20 2013-05-09 Oculus Innovative Sciences, Inc. Methods of treating or preventing sinusitis with oxidative reductive potential water solution
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
NL1031224C2 (nl) * 2006-02-23 2007-09-03 Friesland Brands Bv Het bereiden van gedroogde deeltjes met behulp van een superkritisch medium.
US8030376B2 (en) 2006-07-12 2011-10-04 Minusnine Technologies, Inc. Processes for dispersing substances and preparing composite materials
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
US7745566B2 (en) * 2007-01-23 2010-06-29 Ferro Corporation Methods for the purification of polymers
US20080260852A1 (en) * 2007-01-23 2008-10-23 Ferro Pfanstiehl Laboratories, Inc. Supercritical fluid extraction produced by in-line homogenization
KR20090129998A (ko) 2007-02-11 2009-12-17 맵 파마슈티컬스, 인코포레이티드 부작용 프로파일을 최소화하면서 편두통의 빠른 완화를 가능하게 하는 ｄｈｅ의 치료적 투여 방법
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
US9452592B2 (en) * 2007-08-28 2016-09-27 Cryovac, Inc. Multilayer film having an active oxygen barrier layer with radiation enhanced active barrier properties
US8815360B2 (en) * 2007-08-28 2014-08-26 Cryovac, Inc. Multilayer film having passive and active oxygen barrier layers
US8268354B2 (en) 2007-11-07 2012-09-18 Aridis Pharmaceuticals Sonic low pressure spray drying
JP5307382B2 (ja) * 2007-11-14 2013-10-02 日機装株式会社 微粒子化方法
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9010329B2 (en) * 2009-02-10 2015-04-21 Aerophase Electronically-controlled, high pressure flow control valve and method of use
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
US20100291221A1 (en) * 2009-05-15 2010-11-18 Robert Owen Cook Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation
EP2440184B1 (de) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazin-mikropartikel mit definierten spefiischen oberflächenbereichen
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
US9442810B2 (en) 2009-07-31 2016-09-13 Paypal, Inc. Cloud computing: unified management console for services and resources in a data center
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2011245476B2 (en) * 2010-04-26 2016-05-12 VERO Biotech LLC. Delivery of ultra pure nitric oxide (NO)
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
CO6300119A1 (es) * 2010-11-19 2011-07-21 Univ Del Valle Proceso para la preparacion de suspensiones de sales de calcio y metodo para la incorporacion de calcio en bebidas alimenticias nutraceuticas y farmaceuticas
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
CN103565745A (zh) 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
WO2014145443A2 (en) 2013-03-15 2014-09-18 The Board Of Regents Of The University Of Texas System Liquids rich in noble gas and methods of their preparation and use
EP3587404B1 (de) 2013-03-15 2022-07-13 MannKind Corporation Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
CA2977083A1 (en) 2014-02-20 2015-08-27 Kambiz Yadidi Dry powder formulations for inhalation
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US20150367038A1 (en) 2014-06-19 2015-12-24 New York University Fabrication of nanowires and hierarchically porous materials through supercritical co2 assisted nebulization
WO2015200049A1 (en) 2014-06-26 2015-12-30 Island Breeze Systems Ca, Llc Mdi related products and methods of use
GB201414820D0 (en) * 2014-08-20 2014-10-01 Brown Sebastian M Improvements to anaesthetic recycling methods and systems
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP7341061B2 (ja) 2016-11-22 2023-09-08 エレクトロファイ， インコーポレイテッド 治療用又は診断用薬剤を含む粒子並びにその懸濁液及び使用方法
CN108993312A (zh) * 2018-06-13 2018-12-14 河南雅利安新材料有限公司 一种节能环保喷雾造粒塔
AU2020214626A1 (en) 2019-01-31 2021-09-16 Elektrofi, Inc. Particle formation and morphology
AU2020344675A1 (en) 2019-09-13 2022-03-31 Elektrofi, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
US20230181473A1 (en) * 2020-04-17 2023-06-15 Elektrofi, Inc. Methods of forming particles by continuous droplet formation and dehydration

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524590A (en) * 1946-04-22 1950-10-03 Carsten F Boe Emulsion containing a liquefied propellant gas under pressure and method of spraying same
US2908442A (en) * 1959-01-16 1959-10-13 Fincase Ind Tiribi Ltda Method for dispersing natural atmospheric fogs and clouds
US3159535A (en) * 1962-01-31 1964-12-01 Johnson & Son Inc S C Aerosol compositions
US3694546A (en) * 1963-09-20 1972-09-26 Geigy Ag J R Two-phase aerosol spraying system
US4066596A (en) * 1971-08-04 1978-01-03 Martin Paint & Chemical Corporation Aerosol dispensed latex paint and package containing the same
US3869070A (en) * 1973-04-10 1975-03-04 Mdt Chemical Corp Aerosol dispensing container for separately stored fluids
US3856185A (en) * 1973-12-26 1974-12-24 Ciba Geigy Corp Single dose, replaceable supply air pressure operated dispenser
GB1599881A (en) * 1977-02-02 1981-10-07 Millington A R Preparation for diagnostic radiology
US4161458A (en) * 1977-08-29 1979-07-17 Scott's Liquid Gold Incorporated Stable aqueous aerosol system with carbon dioxide propellant
DE2837115A1 (de) * 1978-08-25 1980-03-06 Bayer Ag Neues verfahren zur herstellung von sterilen feststoffen
DE3162767D1 (en) * 1980-05-22 1984-04-26 Jan Schmidt Method and apparatus for treatment and hygienisation of sewage sludge and other organic sludges
FR2501644A1 (fr) * 1981-03-11 1982-09-17 Ramis Jean Poche metallique retournable
EP0081014A1 (de) * 1981-12-04 1983-06-15 Clayton Corporation Druckzerstäubervorrichtung
US4536323A (en) * 1983-06-28 1985-08-20 The Drackett Company Non-flammable aerosol propellant microemulsion system
US4734451A (en) * 1983-09-01 1988-03-29 Battelle Memorial Institute Supercritical fluid molecular spray thin films and fine powders
US4734227A (en) * 1983-09-01 1988-03-29 Battelle Memorial Institute Method of making supercritical fluid molecular spray films, powder and fibers
US4582731A (en) * 1983-09-01 1986-04-15 Battelle Memorial Institute Supercritical fluid molecular spray film deposition and powder formation
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
JPS63500175A (ja) * 1985-05-22 1988-01-21 リポソ−ム　テクノロジ−，インコ−ポレイテツド リポソ−ム吸入法および吸入システム
US4800903A (en) * 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
US4790305A (en) * 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4845056A (en) * 1987-10-09 1989-07-04 Allied-Signal Inc. Continuous process for production of fine particulate ceramics
SU1591990A1 (ru) * 1987-10-14 1990-09-15 Le Nii Radiatsionnoj Gigieny Уctpoйctbo для bbeдehия лekapctbehhыx пopoшkob
US5057342A (en) * 1987-12-21 1991-10-15 Union Carbide Chemicals And Plastics Technology Corporation Methods and apparatus for obtaining a feathered spray when spraying liquids by airless techniques
DE3787533T2 (de) * 1987-12-21 1994-01-20 Union Carbide Corp Verwendung von superkritischen Flüssigkeiten als Verdünner beim Aufsprühen von Überzügen.
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
US5266205A (en) * 1988-02-04 1993-11-30 Battelle Memorial Institute Supercritical fluid reverse micelle separation
US4892232A (en) * 1988-07-25 1990-01-09 Martin James H Unit dose dispenser
SU1577796A1 (ru) * 1988-09-12 1990-07-15 Предприятие П/Я М-5514 Распылитель порошков
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
AU624421B2 (en) * 1988-10-05 1992-06-11 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US4882107A (en) * 1988-11-23 1989-11-21 Union Carbide Chemicals And Plastics Company Inc. Mold release coating process and apparatus using a supercritical fluid
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
FI84698C (fi) * 1989-06-16 1992-01-10 Huhtamaeki Oy Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform.
US5002048A (en) * 1989-12-12 1991-03-26 Makiej Jr Walter J Inhalation device utilizing two or more aerosol containers
US5056511A (en) * 1989-12-14 1991-10-15 Juergen L. Fischer Method and apparatus for compressing, atomizing, and spraying liquid substances
US5044523A (en) * 1990-02-28 1991-09-03 Photofinish Cosmetics Inc. Method and apparatus for dispensing of volatile fluids
US4970093A (en) * 1990-04-12 1990-11-13 University Of Colorado Foundation Chemical deposition methods using supercritical fluid solutions
US5169433A (en) * 1990-07-18 1992-12-08 Formulogics, Inc. Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
US5115803A (en) * 1990-08-31 1992-05-26 Minnesota Mining And Manufacturing Company Aerosol actuator providing increased respirable fraction
US5126126A (en) * 1990-11-20 1992-06-30 Dow Corning Corporation Hair fixatives
CA2093809A1 (en) * 1991-08-15 1993-02-16 Franco Del Bon Inhaler
US5156747A (en) * 1991-10-18 1992-10-20 International Environmental Systems, Inc. Separation of liquids with different boiling points with nebulizing chamber
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
IT1255256B (it) * 1992-07-24 1995-10-20 Alfonso Caruana Dispositivo di chiusura ermatica autoperforabile per flaconi e simili contenitori
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery

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DE69525557D1 (de) 2002-04-04
US5639441A (en) 1997-06-17
EP0677332B1 (de) 2002-02-27
US6095134A (en) 2000-08-01
EP1160018A3 (de) 2002-01-09
EP0677332A2 (de) 1995-10-18
EP1160018B1 (de) 2009-04-29
EP1160018A2 (de) 2001-12-05
EP0677332A3 (de) 1996-10-16
DE69525557T2 (de) 2002-10-31

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