DE69601720T2 - Verfahren und vorrichtung zur dna-sequensbestimmung und zum mutationsnachweis - Google Patents

Verfahren und vorrichtung zur dna-sequensbestimmung und zum mutationsnachweis

Info

Publication number
DE69601720T2
DE69601720T2 DE69601720T DE69601720T DE69601720T2 DE 69601720 T2 DE69601720 T2 DE 69601720T2 DE 69601720 T DE69601720 T DE 69601720T DE 69601720 T DE69601720 T DE 69601720T DE 69601720 T2 DE69601720 T2 DE 69601720T2
Authority
DE
Germany
Prior art keywords
dna sequence
detecting mutations
determining dna
determining
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69601720T
Other languages
English (en)
Other versions
DE69601720D1 (de
Inventor
Ronald J Green
Vrijmoed Chi
Rodney D Gilchrist
Gregory Dee
John K Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Visible Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visible Genetics Inc filed Critical Visible Genetics Inc
Application granted granted Critical
Publication of DE69601720D1 publication Critical patent/DE69601720D1/de
Publication of DE69601720T2 publication Critical patent/DE69601720T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
DE69601720T 1995-06-30 1996-06-28 Verfahren und vorrichtung zur dna-sequensbestimmung und zum mutationsnachweis Expired - Lifetime DE69601720T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/497,202 US5853979A (en) 1995-06-30 1995-06-30 Method and system for DNA sequence determination and mutation detection with reference to a standard
PCT/US1996/011130 WO1997002488A1 (en) 1995-06-30 1996-06-28 Method and system for dna sequence determination and mutation detection

Publications (2)

Publication Number Publication Date
DE69601720D1 DE69601720D1 (de) 1999-04-15
DE69601720T2 true DE69601720T2 (de) 1999-07-22

Family

ID=23975872

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69601720T Expired - Lifetime DE69601720T2 (de) 1995-06-30 1996-06-28 Verfahren und vorrichtung zur dna-sequensbestimmung und zum mutationsnachweis

Country Status (7)

Country Link
US (2) US5853979A (de)
EP (1) EP0835442B1 (de)
JP (1) JPH11509622A (de)
AU (1) AU700410B2 (de)
CA (1) CA2225385A1 (de)
DE (1) DE69601720T2 (de)
WO (1) WO1997002488A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6466923B1 (en) 1997-05-12 2002-10-15 Chroma Graphics, Inc. Method and apparatus for biomathematical pattern recognition
SE9702008D0 (sv) 1997-05-28 1997-05-28 Pharmacia Biotech Ab A method and a system for nucleic acid seouence analysis
US6349144B1 (en) 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
US6990221B2 (en) * 1998-02-07 2006-01-24 Biodiscovery, Inc. Automated DNA array image segmentation and analysis
JP3091176B2 (ja) * 1998-02-18 2000-09-25 株式会社ヘレナ研究所 分離分析検査データ処理装置
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6404907B1 (en) 1998-06-26 2002-06-11 Visible Genetics Inc. Method for sequencing nucleic acids with reduced errors
US6821402B1 (en) 1998-09-16 2004-11-23 Applera Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6334099B1 (en) * 1999-05-25 2001-12-25 Digital Gene Technologies, Inc. Methods for normalization of experimental data
AU5156200A (en) * 1999-05-25 2000-12-12 Digital Gene Technologies, Inc. Methods and system for amplitude normalization and selection of data peaks
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6406854B1 (en) * 1999-09-16 2002-06-18 Mj Research Method and compositions for evaluating resolution of nucleic acid separation systems
US7099502B2 (en) * 1999-10-12 2006-08-29 Biodiscovery, Inc. System and method for automatically processing microarrays
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US7917301B1 (en) * 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US6760668B1 (en) 2000-03-24 2004-07-06 Bayer Healthcare Llc Method for alignment of DNA sequences with enhanced accuracy and read length
JP3628232B2 (ja) * 2000-03-31 2005-03-09 三洋電機株式会社 微生物識別方法、微生物識別装置、微生物識別用データベースの作成方法および微生物識別プログラムを記録した記録媒体
US6436641B1 (en) * 2000-04-17 2002-08-20 Visible Genetics Inc. Method and apparatus for DNA sequencing
US20020116135A1 (en) * 2000-07-21 2002-08-22 Pasika Hugh J. Methods, systems, and articles of manufacture for evaluating biological data
CA2419126A1 (en) * 2000-08-14 2002-02-21 Incyte Genomics, Inc. Basecalling system and protocol
US6681186B1 (en) 2000-09-08 2004-01-20 Paracel, Inc. System and method for improving the accuracy of DNA sequencing and error probability estimation through application of a mathematical model to the analysis of electropherograms
US7222059B2 (en) * 2001-11-15 2007-05-22 Siemens Medical Solutions Diagnostics Electrophoretic trace simulator
EP1501863A4 (de) * 2002-05-03 2007-01-24 Sequenom Inc Kinaseankerproteinmuteine, peptide davon und damit im zusammenhang stehende verfahren
CA2494787A1 (en) 2002-08-07 2004-03-25 Ishihara Sangyo Kaisha, Ltd. Titanium dioxide pigments,method for production thereof and resin composition comprising the same
US7512496B2 (en) * 2002-09-25 2009-03-31 Soheil Shams Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays
US20040142347A1 (en) * 2002-09-26 2004-07-22 Stockwell Timothy B. Mitochondrial DNA autoscoring system
WO2004050839A2 (en) 2002-11-27 2004-06-17 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
US20040215401A1 (en) * 2003-04-25 2004-10-28 Krane Dan Edward Computerized analysis of forensic DNA evidence
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP2248911A1 (de) 2004-02-19 2010-11-10 Helicos Biosciences Corporation Verfahren und Zusammensetzungen zur Analyse von Polynukleotidsequenzen
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005230936B2 (en) 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7617054B2 (en) * 2004-07-20 2009-11-10 Conexio 4 Pty Ltd Method and apparatus for analysing nucleic acid sequence
US8484000B2 (en) 2004-09-02 2013-07-09 Vialogy Llc Detecting events of interest using quantum resonance interferometry
US20070099227A1 (en) * 2004-10-12 2007-05-03 Curry Bo U Significance analysis using data smoothing with shaped response functions
US20060160102A1 (en) 2005-01-18 2006-07-20 Hossein Fakhrai-Rad Identification of rare alleles by enzymatic enrichment of mismatched heteroduplexes
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US9388462B1 (en) * 2006-05-12 2016-07-12 The Board Of Trustees Of The Leland Stanford Junior University DNA sequencing and approaches therefor
US8126235B2 (en) * 2008-04-04 2012-02-28 Massachusetts Institute Of Technology Methods and apparatus for automated base-calling on multiple DNA strands
US11124827B2 (en) 2016-06-23 2021-09-21 Roche Sequencing Solutions, Inc. Period-to-period analysis of AC signals from nanopore sequencing
EP3475447B1 (de) 2016-06-23 2021-04-21 F. Hoffmann-La Roche AG Bildung und kalibrierung von nanoporensequenzierungszellen
WO2019129555A1 (en) 2017-12-28 2019-07-04 F. Hoffmann-La Roche Ag Measuring and removing noise in stochastic signals from a nanopore dna sequencing system driven by an alternating signal
US11435283B2 (en) 2018-04-17 2022-09-06 Sharif University Of Technology Optically detecting mutations in a sequence of DNA

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2056998A1 (de) * 1970-11-20 1972-05-25 Bodenseewerk Perkin Elmer Co Peakintegrator
EP0199327B1 (de) * 1985-04-19 1992-03-04 Fuji Photo Film Co., Ltd. Signalverarbeitungsverfahren um die Reihenfolge der Basen von Nukleinsäure festzustellen
US4941092A (en) * 1985-05-23 1990-07-10 Fuji Photo Film Co., Ltd. Signal processing method for determining base sequence of nucleic acid
EP0240729A3 (de) * 1986-03-05 1988-08-24 Fuji Photo Film Co., Ltd. Verfahren zur autoradiographischen Untersuchung des Grundaufbaus von Nukleinsäuren
US4811218A (en) * 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5246866A (en) * 1987-12-23 1993-09-21 Hitachi Software Engineering Co., Ltd. Method for transcription of a DNA sequence
GB8826816D0 (en) * 1988-11-16 1988-12-21 Atomic Energy Authority Uk Method for spectrum matching
US4960999A (en) * 1989-02-13 1990-10-02 Kms Fusion, Inc. Scanning and storage of electrophoretic records
US5108179A (en) * 1989-08-09 1992-04-28 Myers Stephen A System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands
US5119316A (en) * 1990-06-29 1992-06-02 E. I. Du Pont De Nemours And Company Method for determining dna sequences
JP2814409B2 (ja) * 1990-11-30 1998-10-22 日立ソフトウェアエンジニアリング 株式会社 多色泳動パターン読み取り装置
JP2873884B2 (ja) * 1991-03-22 1999-03-24 日立ソフトウェアエンジニアリング 株式会社 多色泳動パターン読み取り装置
US5419825A (en) * 1991-07-29 1995-05-30 Shimadzu Corporation Base sequencing apparatus
US5502773A (en) * 1991-09-20 1996-03-26 Vanderbilt University Method and apparatus for automated processing of DNA sequence data
US5365455A (en) * 1991-09-20 1994-11-15 Vanderbilt University Method and apparatus for automatic nucleic acid sequence determination
US5308751A (en) 1992-03-23 1994-05-03 General Atomics Method for sequencing double-stranded DNA
DE592060T1 (de) * 1992-10-09 1994-12-08 Univ Nebraska Digitale DNS-Typisierung.
US5273632A (en) * 1992-11-19 1993-12-28 University Of Utah Research Foundation Methods and apparatus for analysis of chromatographic migration patterns
DE4405251C2 (de) * 1993-02-19 1996-09-26 Olympus Optical Co Verfahren zur Verarbeitung von Elektrophoresedaten
US6017434A (en) * 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5916747A (en) 1995-06-30 1999-06-29 Visible Genetics Inc. Method and apparatus for alignment of signals for use in DNA based-calling
EP0896632B1 (de) 1996-05-01 2001-12-12 Visible Genetics Inc. Verfahren zum nachweis und zur identifizierung von mikroorganismen
EP0944739A4 (de) 1996-09-16 2000-01-05 Univ Utah Res Found Verfahren und apparat zur analyse von chromatografischen auftrennungsmustern

Also Published As

Publication number Publication date
JPH11509622A (ja) 1999-08-24
EP0835442B1 (de) 1999-03-10
US6303303B1 (en) 2001-10-16
EP0835442A1 (de) 1998-04-15
US5853979A (en) 1998-12-29
AU6403996A (en) 1997-02-05
CA2225385A1 (en) 1997-01-23
AU700410B2 (en) 1999-01-07
WO1997002488A1 (en) 1997-01-23
DE69601720D1 (de) 1999-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER HEALTHCARE LLC (N.D.GES.D. STAATES DELAWARE)

8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN