DE69621015T2 - Gasemulsionen, die durch fluorierte ether mit niedrigen ostwaldkoeffizienten stabilisiert sind - Google Patents
Gasemulsionen, die durch fluorierte ether mit niedrigen ostwaldkoeffizienten stabilisiert sindInfo
- Publication number
- DE69621015T2 DE69621015T2 DE69621015T DE69621015T DE69621015T2 DE 69621015 T2 DE69621015 T2 DE 69621015T2 DE 69621015 T DE69621015 T DE 69621015T DE 69621015 T DE69621015 T DE 69621015T DE 69621015 T2 DE69621015 T2 DE 69621015T2
- Authority
- DE
- Germany
- Prior art keywords
- gas emulsions
- ocf2
- emulsions stabilized
- 2ocf3
- fluorine ethers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000839 emulsion Substances 0.000 title abstract 3
- -1 FLUORINE ETHERS Chemical class 0.000 title 1
- 229910052731 fluorine Inorganic materials 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- XZKOELJOFVHXRS-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-(1,1,2,2,3,3,3-heptafluoropropoxy)propane Chemical compound FC(F)(F)C(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)F XZKOELJOFVHXRS-UHFFFAOYSA-N 0.000 abstract 1
- JTPMOHUDFCBCEC-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-1,2-bis(trifluoromethoxy)ethane Chemical compound FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F JTPMOHUDFCBCEC-UHFFFAOYSA-N 0.000 abstract 1
- YSGKVOMJRCQYMT-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-1-[1,1,2,2-tetrafluoro-2-(trifluoromethoxy)ethoxy]-2-(trifluoromethoxy)ethane Chemical compound FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F YSGKVOMJRCQYMT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/479,621 US5804162A (en) | 1995-06-07 | 1995-06-07 | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| PCT/US1996/009068 WO1996040281A2 (en) | 1995-06-07 | 1996-06-05 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69621015D1 DE69621015D1 (de) | 2002-06-06 |
| DE69621015T2 true DE69621015T2 (de) | 2002-12-19 |
Family
ID=23904745
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69636486T Expired - Fee Related DE69636486T2 (de) | 1995-06-07 | 1996-06-05 | Gasemulsionen, die durch fluorierte Ether mit niedrigen Ostwaldkoeffizienten stabilisiert sind |
| DE69621015T Expired - Fee Related DE69621015T2 (de) | 1995-06-07 | 1996-06-05 | Gasemulsionen, die durch fluorierte ether mit niedrigen ostwaldkoeffizienten stabilisiert sind |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69636486T Expired - Fee Related DE69636486T2 (de) | 1995-06-07 | 1996-06-05 | Gasemulsionen, die durch fluorierte Ether mit niedrigen Ostwaldkoeffizienten stabilisiert sind |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5804162A (de) |
| EP (2) | EP1174153B1 (de) |
| JP (1) | JP4067116B2 (de) |
| KR (1) | KR100401429B1 (de) |
| CN (1) | CN1087954C (de) |
| AT (2) | ATE337018T1 (de) |
| AU (1) | AU712946B2 (de) |
| CA (1) | CA2222186A1 (de) |
| CZ (1) | CZ391397A3 (de) |
| DE (2) | DE69636486T2 (de) |
| DK (1) | DK0833669T3 (de) |
| ES (2) | ES2176462T3 (de) |
| HU (1) | HUP9900848A3 (de) |
| IL (1) | IL122217A (de) |
| NO (1) | NO975317L (de) |
| PL (1) | PL185883B1 (de) |
| PT (1) | PT833669E (de) |
| WO (1) | WO1996040281A2 (de) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| AU694135B2 (en) * | 1993-07-30 | 1998-07-16 | Imcor Pharmaceutical Company | Stabilized microbubble compositions for ultrasound |
| US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| ATE345682T1 (de) | 1996-05-01 | 2006-12-15 | Imarx Pharmaceutical Corp | In vitro verfahren zum einbringen von nukleinsäuren in eine zelle |
| HUP0001608A3 (en) * | 1996-08-05 | 2001-01-29 | Schering Ag | Process for producing contrasting agents for magnetic resonance tomography |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| ES2289188T3 (es) | 1996-09-11 | 2008-02-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador. |
| NZ335265A (en) * | 1996-10-21 | 2000-07-28 | Nycomed Imaging As | Gas containing contrast agents that may be co-administered with vasodilator drugs to enhance differences in return signal intensity from normal and hypoperfused myocardial tissue contrast agents |
| EP1001816A4 (de) * | 1996-11-25 | 2002-07-17 | Imarx Pharmaceutical Corp | Perfluoriete ethern zusammensetzungen wie kontrastmittel |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6548047B1 (en) * | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| AU3072799A (en) | 1998-03-19 | 1999-10-11 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| EP1161451A4 (de) | 1999-02-26 | 2006-05-17 | Human Genome Sciences Inc | Menschliches alpha-endokin und verfahren zu seiner verwendung |
| US6270460B1 (en) * | 1999-06-24 | 2001-08-07 | Acuson Corporation | Apparatus and method to limit the life span of a diagnostic medical ultrasound probe |
| CA2747325A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| CA2413160A1 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| US6849194B2 (en) | 2000-11-17 | 2005-02-01 | Pcbu Services, Inc. | Methods for preparing ethers, ether compositions, fluoroether fire extinguishing systems, mixtures and methods |
| EP1683865A3 (de) | 2001-02-02 | 2006-10-25 | Eli Lilly & Company | Säugerproteine und insbesondere CD200 |
| CN1564826A (zh) | 2001-02-09 | 2005-01-12 | 人类基因组科学公司 | 人类g蛋白趋化因子受体(ccr5)hdgnr10 |
| JP2004536579A (ja) | 2001-04-13 | 2004-12-09 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 血管内皮増殖因子２ |
| DE10119522A1 (de) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel |
| EP1463751B1 (de) | 2001-12-21 | 2013-05-22 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
| ATE427363T1 (de) | 2002-01-08 | 2009-04-15 | Novartis Vaccines & Diagnostic | In kanzerísen mammazellen differentiell exprimierte genprodukte und ihre verwendungsverfahren |
| US7300743B2 (en) * | 2003-03-06 | 2007-11-27 | E. I. Du Pont De Nemours And Company | Radiation durable organic compounds with high transparency in the vacuum ultraviolet, and method for preparing |
| EP2266628A3 (de) | 2003-05-13 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Methode zur Bestimmung der Anfälligkeit für Knochenmetastasen über die Expression von EPhA2 |
| US20050074406A1 (en) * | 2003-10-03 | 2005-04-07 | Scimed Life Systems, Inc. | Ultrasound coating for enhancing visualization of medical device in ultrasound images |
| PL1729795T3 (pl) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Białka fuzyjne albuminy |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| HUE042197T2 (hu) | 2005-07-19 | 2019-06-28 | Stemgen S P A | Tumor õssejtek tumorképzõ potenciáljának gátlása LIF segítségével |
| US7943134B2 (en) | 2005-08-31 | 2011-05-17 | Academia Sinica | Compositions and methods for identifying response targets and treating flavivirus infection responses |
| EP3037544A1 (de) | 2005-10-13 | 2016-06-29 | Human Genome Sciences, Inc. | Verfahren und zusammensetzung zur verwendung bei der behandlung von systemisch lupus erythematosus patienten mit autoantikörper-positiven leiden |
| CA2628238A1 (en) | 2005-11-07 | 2007-05-18 | The Scripps Research Institute | Compositions and methods for controlling tissue factor signaling specificity |
| US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
| US20110020368A1 (en) | 2008-03-25 | 2011-01-27 | Nancy Hynes | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
| US20110110863A1 (en) * | 2008-05-02 | 2011-05-12 | Celsense, Inc. | Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications |
| GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| US20100160576A1 (en) * | 2008-11-21 | 2010-06-24 | University Of Tennessee Research Foundation | Perfluorinated poly(oxymethylene) compounds |
| EP2241323A1 (de) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W und Hirnkrebs |
| EP2292266A1 (de) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Behandlung von Krebs durch Modulation von Copine III |
| WO2011036118A1 (en) | 2009-09-22 | 2011-03-31 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
| WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
| US20120213801A1 (en) | 2009-10-30 | 2012-08-23 | Ekaterina Gresko | Phosphorylated Twist1 and cancer |
| EP2542578A1 (de) | 2010-03-05 | 2013-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Smoc1, tenascin-c und hirnkrebs |
| US20130034543A1 (en) | 2010-04-19 | 2013-02-07 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear | Modulating xrn1 |
| EP2580239A1 (de) | 2010-06-10 | 2013-04-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Behandlung von krebs mittels modulation von mammalian-ste20-like-kinase 3 |
| EP2614080A1 (de) | 2010-09-10 | 2013-07-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Phosphoryliertes twist1 und metastasen |
| WO2012168259A1 (en) | 2011-06-06 | 2012-12-13 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
| US20140314787A1 (en) | 2011-11-08 | 2014-10-23 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute | Treatment for neurodegenerative diseases |
| EP2776838A1 (de) | 2011-11-08 | 2014-09-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Frühe diagnose neurodegenerativer erkrankungen |
| US20140363448A1 (en) | 2012-01-02 | 2014-12-11 | Novartis Ag | Cdcp1 and breast cancer |
| JP2013180956A (ja) * | 2012-02-29 | 2013-09-12 | Sunstar Engineering Inc | 殺菌剤組成物 |
| US20150266961A1 (en) | 2012-03-29 | 2015-09-24 | Novartis Forschungsstiftung, Zweigniederlassung, Fridrich Miescher Institute | Inhibition of interleukin-8 and/or its receptor cxcr1 in the treatment of her2/her3-overexpressing breast cancer |
| EP2866831A1 (de) | 2012-06-29 | 2015-05-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Behandlung von krankheiten durch modulation einer spezifischen isoform von mkl1 |
| EP2870242A1 (de) | 2012-07-05 | 2015-05-13 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Neue behandlung für neurodegenerative erkrankungen |
| WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
| ES2761587T3 (es) | 2013-08-07 | 2020-05-20 | Friedrich Miescher Institute For Biomedical Res | Nuevo método de cribado para el tratamiento de la ataxia de Friedreich |
| WO2015189816A1 (en) | 2014-06-13 | 2015-12-17 | Friedrich Miescher Institute For Biomedical Research | New treatment against influenza virus |
| WO2015198202A1 (en) | 2014-06-23 | 2015-12-30 | Friedrich Miescher Institute For Biomedical Research | Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas |
| EP3164129A1 (de) | 2014-07-01 | 2017-05-10 | Friedrich Miescher Institute for Biomedical Research | Kombination eines brafv600e-hemmers und mertk-hemmers zur melanombehandlung |
| EP3197557A1 (de) | 2014-09-24 | 2017-08-02 | Friedrich Miescher Institute for Biomedical Research | Lats und brustrkrebs |
| CN104353088A (zh) * | 2014-09-30 | 2015-02-18 | 东南大学 | 一种脂质气泡的制备方法 |
| US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
| NZ733010A (en) | 2014-12-31 | 2023-01-27 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods |
| WO2017072669A1 (en) | 2015-10-28 | 2017-05-04 | Friedrich Miescher Institute For Biomedical Research | Tenascin-w and biliary tract cancers |
| EP3176206A1 (de) * | 2015-12-01 | 2017-06-07 | Evonik Degussa GmbH | Verfahren zur herstellung feinzelliger schaumstoffe unter verwendung eines zellalterungshemmers |
| CN109641068B (zh) | 2016-05-04 | 2022-09-30 | 蓝瑟斯医学影像公司 | 用于制备超声波造影剂的方法及装置 |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| US11225689B2 (en) | 2016-08-17 | 2022-01-18 | The Broad Institute, Inc. | Method for determination and identification of cell signatures and cell markers |
| US20200016202A1 (en) | 2016-10-07 | 2020-01-16 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| US11913075B2 (en) | 2017-04-01 | 2024-02-27 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
| WO2019079362A1 (en) | 2017-10-16 | 2019-04-25 | Massachusetts Institute Of Technology | HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS |
| WO2019094983A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| WO2019213660A2 (en) | 2018-05-04 | 2019-11-07 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses |
| WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
| WO2020077236A1 (en) | 2018-10-12 | 2020-04-16 | The Broad Institute, Inc. | Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues |
| WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| WO2020172343A2 (en) | 2019-02-19 | 2020-08-27 | Massachusetts Institute Of Technology | Methods for treating injuries |
| US20220154282A1 (en) | 2019-03-12 | 2022-05-19 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| US20220143148A1 (en) | 2019-03-14 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
| WO2020191069A1 (en) | 2019-03-18 | 2020-09-24 | The Broad Institute, Inc. | Modulation of type 2 immunity by targeting clec-2 signaling |
| EP3942023A1 (de) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Zusammensetzungen und verfahren zur modulation metabolischer regulatoren der t-zell-pathogenität |
| WO2020243371A1 (en) | 2019-05-28 | 2020-12-03 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
| US20220243178A1 (en) | 2019-05-31 | 2022-08-04 | The Broad Institute, Inc. | Methods for treating metabolic disorders by targeting adcy5 |
| US20220282333A1 (en) | 2019-08-13 | 2022-09-08 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
| US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
| US11865168B2 (en) | 2019-12-30 | 2024-01-09 | Massachusetts Institute Of Technology | Compositions and methods for treating bacterial infections |
| WO2024016003A2 (en) | 2022-07-14 | 2024-01-18 | The Broad Institute, Inc. | Aav capsids that enable cns-wide gene delivery through interactions with the transferrin receptor |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
| CA1170569A (en) * | 1980-11-17 | 1984-07-10 | Julia S. Rasor | Microbubble precursors and methods for their production and use |
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
| DE3313947A1 (de) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
| DE3324754A1 (de) * | 1983-07-06 | 1985-01-17 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ultraschallkontrastmittel sowie dessen herstellung |
| GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
| US5186922A (en) * | 1985-03-15 | 1993-02-16 | See/Shell Biotechnology, Inc. | Use of biodegradable microspheres labeled with imaging energy constrast materials |
| US4613326A (en) * | 1985-07-12 | 1986-09-23 | Becton, Dickinson And Company | Two-component medication syringe assembly |
| DE3529195A1 (de) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung |
| US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| EP0247156B1 (de) * | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung) |
| US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
| GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
| EP0231091B1 (de) * | 1986-01-24 | 1993-03-31 | Children's Hospital Medical Center | Stabile Emulsionen von stark fluorierten, organischen Verbindungen |
| US4925678A (en) * | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
| US4781676A (en) * | 1987-02-20 | 1988-11-01 | Air Products And Chemicals, Inc. | Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells |
| US5108759A (en) * | 1987-04-01 | 1992-04-28 | Ranney David F | Endothelial envelopment drug carriers |
| DE3741199A1 (de) * | 1987-12-02 | 1989-08-17 | Schering Ag | Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie |
| DE3741201A1 (de) * | 1987-12-02 | 1989-06-15 | Schering Ag | Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung |
| US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
| IE66912B1 (en) * | 1988-02-05 | 1996-02-07 | Schering Ag | Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents |
| US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
| US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
| US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5305757A (en) * | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US6088613A (en) * | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5209720A (en) * | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
| US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
| US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| IN172208B (de) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| GB9009423D0 (en) * | 1990-04-26 | 1990-06-20 | Williams Alun R | Assessment of vascular perfusion by the display of harmonic echoes from ultrasonically excited gas bubbles |
| US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5315997A (en) * | 1990-06-19 | 1994-05-31 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging using diamagnetic contrast |
| JP2599492B2 (ja) * | 1990-08-21 | 1997-04-09 | 第一製薬株式会社 | リポソーム製剤の製造法 |
| ES2074725T3 (es) * | 1990-10-05 | 1995-09-16 | Bracco Int Bv | Metodo para la preparacion de suspensiones estables de microesferas huecas llenas de gas adecuadas para ecografia ultrasonica. |
| DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
| US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| DE69215722T3 (de) * | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen |
| US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| US5558857A (en) * | 1991-06-03 | 1996-09-24 | Nycomed Imaging As | Contrast agents |
| DK0593624T3 (da) * | 1991-07-05 | 1997-05-20 | Nycomed Imaging As | Forbedringer af eller i relation til kontrastmidler |
| GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
| WO1993003671A1 (en) * | 1991-08-13 | 1993-03-04 | Molecular Biosystem, Inc. | Method of mri imaging using diamagnetic contrast agents |
| KR100191303B1 (ko) * | 1991-09-17 | 1999-06-15 | 씨. 큐웨이 스티븐 | 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법 |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
| WO1993006869A1 (en) * | 1991-10-04 | 1993-04-15 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
| US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
| US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
| GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
| DE4219723A1 (de) * | 1992-06-13 | 1993-12-16 | Schering Ag | Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik |
| AU4563093A (en) * | 1992-07-03 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echographic contrast agent composition |
| EP0835664A3 (de) * | 1992-09-16 | 1998-08-12 | Nycomed As | Verbesserungen in oder an Kontrastmitteln |
| US5314644A (en) * | 1992-10-19 | 1994-05-24 | Virginia Polytechnic Institute And State University | Microbubble generator |
| AU5457394A (en) * | 1992-11-02 | 1994-05-24 | Drexel University | Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same |
| US5393527A (en) * | 1993-01-04 | 1995-02-28 | Becton, Dickinson And Company | Stabilized microspheres and methods of preparation |
| NZ262237A (en) * | 1993-01-25 | 1997-06-24 | Sonus Pharma Inc | Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in |
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| CN1245156C (zh) * | 1993-02-22 | 2006-03-15 | 美国生物科学有限公司 | 用于体内传送生物制品的方法及用于该方法的组合物 |
| GB9305349D0 (en) * | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5333613A (en) * | 1993-03-23 | 1994-08-02 | Delineate | Microparticles as ultrasonic contrast media |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| PT682530E (pt) * | 1993-12-15 | 2003-06-30 | Bracco Research Sa | Misturas de gases uteis como meios de contraste para ultrassons |
| DE4406474A1 (de) * | 1994-02-23 | 1995-08-24 | Schering Ag | Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel |
| US5502094A (en) * | 1994-05-20 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use |
| US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| GB9808582D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9808599D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
-
1995
- 1995-06-07 US US08/479,621 patent/US5804162A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 CN CN96195879A patent/CN1087954C/zh not_active Expired - Fee Related
- 1996-06-05 CZ CZ973913A patent/CZ391397A3/cs unknown
- 1996-06-05 AT AT01119824T patent/ATE337018T1/de not_active IP Right Cessation
- 1996-06-05 DK DK96918164T patent/DK0833669T3/da active
- 1996-06-05 KR KR1019970709075A patent/KR100401429B1/ko not_active IP Right Cessation
- 1996-06-05 EP EP01119824A patent/EP1174153B1/de not_active Expired - Lifetime
- 1996-06-05 US US08/973,281 patent/US6193952B1/en not_active Expired - Fee Related
- 1996-06-05 PL PL96323868A patent/PL185883B1/pl unknown
- 1996-06-05 ES ES96918164T patent/ES2176462T3/es not_active Expired - Lifetime
- 1996-06-05 JP JP50147797A patent/JP4067116B2/ja not_active Expired - Fee Related
- 1996-06-05 DE DE69636486T patent/DE69636486T2/de not_active Expired - Fee Related
- 1996-06-05 HU HU9900848A patent/HUP9900848A3/hu unknown
- 1996-06-05 IL IL12221796A patent/IL122217A/en not_active IP Right Cessation
- 1996-06-05 CA CA002222186A patent/CA2222186A1/en not_active Abandoned
- 1996-06-05 ES ES01119824T patent/ES2269262T3/es not_active Expired - Lifetime
- 1996-06-05 AU AU60487/96A patent/AU712946B2/en not_active Ceased
- 1996-06-05 DE DE69621015T patent/DE69621015T2/de not_active Expired - Fee Related
- 1996-06-05 WO PCT/US1996/009068 patent/WO1996040281A2/en not_active Application Discontinuation
- 1996-06-05 AT AT96918164T patent/ATE216894T1/de not_active IP Right Cessation
- 1996-06-05 EP EP96918164A patent/EP0833669B1/de not_active Expired - Lifetime
- 1996-06-05 PT PT96918164T patent/PT833669E/pt unknown
-
1997
- 1997-11-19 NO NO975317A patent/NO975317L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69621015D1 (de) | Gasemulsionen, die durch fluorierte ether mit niedrigen ostwaldkoeffizienten stabilisiert sind | |
| US6075559A (en) | Vehicle moving image processing method and system | |
| EP1617674A2 (de) | Verlustfreie Codierung eines interessierenden Gebiets | |
| DE69924587D1 (de) | Verfahren zur Bildrekonstruktion für Tomographie | |
| WO1992018165A3 (en) | Improved fluorocarbon contrast media for use with MRI and radiographic imaging | |
| DE69033118T2 (de) | Liposome als kontrastmittel für ultraschallabbildung | |
| EP1175060A3 (de) | Middleware-schicht zwischen Sprachanwendungen und Sprachtreiber | |
| NL950010I1 (nl) | R¦ntgencontrastmiddelen. | |
| DE69403094D1 (de) | Lösungsmittelgemisch sowie Reinigungsverfahren die es verwenden | |
| EP0751670A3 (de) | Optischer Weg für ein Abtastsystem | |
| DE3855807D1 (de) | Einen Tetra-Polyol enthaltendes Impfstoff-Adjuvans | |
| ATE333721T1 (de) | Sende-empfänger-eingangsschaltung | |
| EP1143427A3 (de) | Optisches Aufzeichnungsverfahren, optisches Aufzeichnungsgerät und optisches Aufzeichnungsmedium | |
| CA2110045A1 (en) | Hydroxy containing fluorovinyl compounds and polymers thereof | |
| DE69027433D1 (de) | Niedrig viskose entschäumer/antischaum mittel | |
| WO2003010199A3 (en) | Identification of specific tumour antigens by means of the selection of cdna libraries with sera and the use of said antigens in diagnostic imaging techniques | |
| DE50210291D1 (de) | Spiegel, optisches abbildungssystem und deren verwendung | |
| CA2110925A1 (en) | Polyetheresterols, Their Preparation, and Their Use in Polyurethanes | |
| WO2002077712A3 (en) | Photoresist composition | |
| Woods et al. | Motion compensated multiresolution transmission of HDTV | |
| DE3785121D1 (de) | Halogenhaltige ether. | |
| Imhof | A simple proof of Pitman's 2M–X theorem | |
| Shreeve | Phenomena, comment and notes. | |
| JPH0392969A (ja) | 画像表示装置 | |
| JPH0235883A (ja) | 画像データ通信装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |