DE69621608T2 - Vorrichtung und verfahren für kapillarelektrophorese - Google Patents

Vorrichtung und verfahren für kapillarelektrophorese

Info

Publication number
DE69621608T2
DE69621608T2 DE69621608T DE69621608T DE69621608T2 DE 69621608 T2 DE69621608 T2 DE 69621608T2 DE 69621608 T DE69621608 T DE 69621608T DE 69621608 T DE69621608 T DE 69621608T DE 69621608 T2 DE69621608 T2 DE 69621608T2
Authority
DE
Germany
Prior art keywords
capillary electrophoresis
electrophoresis
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69621608T
Other languages
English (en)
Other versions
DE69621608D1 (de
Inventor
Jonathan Briggs
M Mccormick
W Hoyt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Publication of DE69621608D1 publication Critical patent/DE69621608D1/de
Application granted granted Critical
Publication of DE69621608T2 publication Critical patent/DE69621608T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • B01L9/065—Test-tube stands; Test-tube holders specially adapted for capillary tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
DE69621608T 1995-03-21 1996-03-20 Vorrichtung und verfahren für kapillarelektrophorese Expired - Fee Related DE69621608T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/408,683 US5560811A (en) 1995-03-21 1995-03-21 Capillary electrophoresis apparatus and method
PCT/US1996/003828 WO1996029595A1 (en) 1995-03-21 1996-03-20 Capillary electrophoresis apparatus and method

Publications (2)

Publication Number Publication Date
DE69621608D1 DE69621608D1 (de) 2002-07-11
DE69621608T2 true DE69621608T2 (de) 2003-02-06

Family

ID=23617310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621608T Expired - Fee Related DE69621608T2 (de) 1995-03-21 1996-03-20 Vorrichtung und verfahren für kapillarelektrophorese

Country Status (7)

Country Link
US (1) US5560811A (de)
EP (2) EP1186887A2 (de)
JP (1) JPH11502618A (de)
AU (1) AU715852B2 (de)
CA (1) CA2215974A1 (de)
DE (1) DE69621608T2 (de)
WO (1) WO1996029595A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007005323A1 (de) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Absaugeinrichtung
DE102006058575B4 (de) * 2005-12-12 2009-01-15 Combisep Inc., Ames Multiplex-CE-Fluoreszenzsystem

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
CA2192262C (en) * 1995-12-08 2011-03-15 Yoshihide Hayashizaki Method for purification and transfer to separation/detection systems of dna sequencing samples and plates used therefor
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
AU726987B2 (en) * 1996-06-28 2000-11-30 Caliper Life Sciences, Inc. Electropipettor and compensation means for electrophoretic bias
EP0864860A1 (de) * 1997-03-10 1998-09-16 Japan Science and Technology Corporation Probenplatte und Vielfachkapillarelektrophoresegerät
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
EP0981647B1 (de) * 1997-05-16 2006-08-09 EXACT Sciences Corporation Elektrophoretische analyse von molekülen mit immobilisierten sonden
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US7019827B2 (en) * 1997-06-16 2006-03-28 Diversa Corporation GigaMatrix holding tray having through-hole wells
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
WO1999054711A1 (en) 1998-04-17 1999-10-28 Ljl Biosystems, Inc. Sample-holding devices and systems
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
GB9719673D0 (en) 1997-09-17 1997-11-19 Glaxo Group Ltd Novel apparatus
CA2301557A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
WO1999015888A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
DE69930726T2 (de) 1998-01-12 2007-01-25 Massachusetts Institute Of Technology, Cambridge Verfahren und vorrichtung zur mikrotestdurchführung
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6990221B2 (en) * 1998-02-07 2006-01-24 Biodiscovery, Inc. Automated DNA array image segmentation and analysis
US6349144B1 (en) 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
WO1999041599A1 (fr) * 1998-02-16 1999-08-19 The Institute Of Physical And Chemical Research Cassette capillaire et procede de production correspondant
US6475361B1 (en) 1998-02-20 2002-11-05 Tetragen Sa Capillary electrophoresis apparatus having filling/refilling system and methods for use thereof
US6103083A (en) * 1998-02-20 2000-08-15 Tetragen Capillary electrophoresis apparatus and method
EP0955084B1 (de) * 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
US6350618B1 (en) 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
WO1999066079A1 (en) * 1998-06-19 1999-12-23 Mosaic Technologies Detection of non-viral organisms with srp rna
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
US6551557B1 (en) 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6151969A (en) * 1998-07-14 2000-11-28 Southwest Research Institute Electromechanical and electrochemical impedance spectroscopy for measuring and imaging fatigue damage
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6638716B2 (en) 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP0999443A3 (de) * 1998-11-02 2002-09-18 The Institute of Physical and Chemical Research Kapillarelektroforesesvorrichtung, Probenplatte, und Probeneinspritzverfahren
EP1006355A3 (de) * 1998-11-30 2000-11-08 The Institute of Physical and Chemical Research Kapillarelektrophoresegerät
US6270644B1 (en) 1999-01-27 2001-08-07 Affymetrix, Inc. Capillary array electrophoresis scanner
WO2000046594A1 (en) 1999-02-02 2000-08-10 Caliper Technologies Corp. Methods, devices and systems for characterizing proteins
US6389197B1 (en) 1999-02-10 2002-05-14 California Institute Of Technology Coupling system to a microsphere cavity
EP1224047B1 (de) 1999-02-18 2009-10-28 Corning Incorporated Durch extrusion von siliziumdioxid erhaltene wabenstruktur aus titanhaltigem quarzglas
JP2002537147A (ja) 1999-02-18 2002-11-05 コーニング インコーポレイテッド シリカスートの押出し成形によるシリカガラスハニカム構造体
CA2369002A1 (en) * 1999-02-26 2000-08-31 Mosaic Technologies Methods for purifying dna using immobilized capture probes
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US6027873A (en) * 1999-03-19 2000-02-22 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6306578B1 (en) 1999-03-19 2001-10-23 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6682887B1 (en) 1999-04-30 2004-01-27 Aclara Biosciences, Inc. Detection using degradation of a tagged sequence
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
AU4675800A (en) * 1999-04-30 2000-11-17 Applied Hydrogel Technology Corporation Mixed buffers in gel electrophoresis systems
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
JP4159702B2 (ja) * 1999-05-12 2008-10-01 独立行政法人理化学研究所 キャピラリーカラムへのゲル充填装置
US6533914B1 (en) * 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
JP2003507715A (ja) * 1999-08-13 2003-02-25 カーティージャン テクノロジーズ、 インコーポレイテッド 液体試料取扱い装置
GB2368640B (en) * 1999-08-13 2003-09-17 Cartesian Technologies Inc Apparatus for liquid sample handling
EP1214149A2 (de) * 1999-09-21 2002-06-19 Genome Therapeutics Corp. Vorrichtung zur schnellen bearbeitung von dns-proben mit vollintegrierter flüssigkeitsprobenhandhabung, thermischen zyklen und reinigung
US6572752B1 (en) * 1999-09-29 2003-06-03 Hitachi, Ltd. Capillary electrophoretic instrument and capillary array assembly
US7099502B2 (en) * 1999-10-12 2006-08-29 Biodiscovery, Inc. System and method for automatically processing microarrays
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
CA2400644C (en) * 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
FR2812942B1 (fr) * 2000-08-08 2002-10-31 Commissariat Energie Atomique Dispositif d'imagerie de fluorescence en lumiere polarisee
EP1186886A3 (de) * 2000-09-04 2004-01-07 Fuji Photo Film Co., Ltd. Verfahren zur biochemischen Analyse und dazu geeignetes Gerät
US6821787B2 (en) 2000-11-17 2004-11-23 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
EP1343587A2 (de) * 2000-12-18 2003-09-17 Institut Für Physikalische Hochtechnologie E.V. Vorrichtung zur aufnahme und abgabe von flüssigen substanzen
US7309409B2 (en) * 2001-01-26 2007-12-18 Biocal Technology, Inc. Multi-channel bio-separation cartridge
WO2002059592A2 (en) 2001-01-26 2002-08-01 Biocal Technology, Inc. Optical detection in a multi-channel bio-separation system
WO2002094998A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
WO2002095356A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US20040074931A1 (en) * 2001-05-22 2004-04-22 Coffelt, Jr. Louis Arthur Dual microliter dosage system
US7358052B2 (en) * 2001-05-26 2008-04-15 Monogram Biosciences, Inc. Catalytic amplification of multiplexed assay signals
DE10127045C2 (de) * 2001-06-02 2003-10-30 November Ag Molekulare Medizin Verfahren zum Nachweis einer Substanz und Mikrotiterplatte
US6932940B2 (en) * 2001-06-22 2005-08-23 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation input
US6929779B2 (en) 2001-06-22 2005-08-16 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation output
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
CA2454570C (en) * 2001-07-25 2016-12-20 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US7390463B2 (en) * 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
US20030062833A1 (en) * 2001-10-03 2003-04-03 Wen-Yen Tai Mini-type decorative bulb capable of emitting light through entire circumferential face
US6870165B2 (en) 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US20030104512A1 (en) * 2001-11-30 2003-06-05 Freeman Alex R. Biosensors for single cell and multi cell analysis
US7208072B2 (en) * 2002-01-18 2007-04-24 Biocal Technology, Inc. Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7512496B2 (en) * 2002-09-25 2009-03-31 Soheil Shams Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays
AU2003282885A1 (en) * 2002-09-30 2004-04-23 Nimblegen Systems, Inc. Parallel loading of arrays
US6939450B2 (en) * 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
DE10251669B3 (de) * 2002-11-06 2004-06-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kapillarsubstrat zur Tieftemperaturspeicherung von Suspensionsproben
CA2521999A1 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US6833062B2 (en) * 2003-02-28 2004-12-21 Combisep, Inc. Multiplexed, absorbance-based capillary electrophoresis system and method
US7534335B2 (en) * 2003-02-28 2009-05-19 Combisep, Inc. Multiplexed, absorbance-based capillary electrophoresis system and method
FR2853565A1 (fr) * 2003-04-11 2004-10-15 Commissariat Energie Atomique Microdispositif de transfert collectif d'une pluralite de liquide
US7858387B2 (en) * 2003-04-30 2010-12-28 Perkinelmer Health Sciences, Inc. Method of scanning a sample plate surface mask in an area adjacent to a conductive area using matrix-assisted laser desorption and ionization mass spectrometry
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
JP2007502417A (ja) * 2003-08-11 2007-02-08 モノグラム バイオサイエンシズ，インコーポレーテッド 分子複合体の検出および特徴づけ
US20050072674A1 (en) * 2003-10-03 2005-04-07 Agencourt Bioscience Corporation Method and device for introducing a sample into an electrophoretic apparatus
EP1680666A4 (de) * 2003-10-27 2008-03-26 Monogram Biosciences Inc Nachweisen von menschlichen antitherapeutischen antikörpern
CA2563310A1 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8030092B2 (en) * 2003-11-07 2011-10-04 Princeton Biochemicals, Inc. Controlled electrophoresis method
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
KR100777172B1 (ko) * 2004-06-07 2007-11-28 나노 퓨전 가부시키가이샤 전기 침투류 펌프 시스템 및 전기 침투류 펌프
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
JP4457919B2 (ja) * 2005-02-28 2010-04-28 株式会社島津製作所 電気泳動プレート
JP4507922B2 (ja) * 2005-03-09 2010-07-21 株式会社島津製作所 キャピラリープレートを用いた試料注入方法
US20060201868A1 (en) * 2005-03-11 2006-09-14 Simmons Blake A Methods and devices for high-throughput dielectrophoretic concentration
US20090136362A1 (en) * 2005-03-30 2009-05-28 Nano Fusion Technologies Inc. Electroosmosis Pump and Liquid Feeding Device
JP2006275016A (ja) * 2005-03-30 2006-10-12 Science Solutions International Laboratory Inc 液体輸送装置及び液体輸送システム
JP4987885B2 (ja) * 2006-03-09 2012-07-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 小滴中で反応を行うための装置及びその使用方法
US9892650B2 (en) * 2006-09-11 2018-02-13 Houghton Mifflin Harcourt Publishing Company Recovery of polled data after an online test platform failure
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US9874501B2 (en) 2006-11-24 2018-01-23 Curiox Biosystems Pte Ltd. Use of chemically patterned substrate for liquid handling, chemical and biological reactions
EP2610008A1 (de) * 2007-03-28 2013-07-03 BioNano Genomics, Inc. Verfahren zur makromolekularen Analyse mittels Nanokanalanordnungen
EP2201136B1 (de) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Sequenzierung mittels nanoporen und hybridisierung von sonden zur bildung ternärer komplexe und ausrichtung mit variablem bereich
US7825337B2 (en) * 2007-10-23 2010-11-02 Slam Brands, Inc. Cable management apparatuses and systems
US10725020B2 (en) 2007-11-14 2020-07-28 Curiox Biosystems Pte Ltd. High throughput miniaturized assay system and methods
WO2013114217A1 (en) 2012-02-05 2013-08-08 Curiox Biosystems Pte Ltd. Array plates and methods for making and using same
CN102186989B (zh) 2008-09-03 2021-06-29 纳伯塞斯2.0有限责任公司 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US8455260B2 (en) 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US8784752B2 (en) 2009-04-17 2014-07-22 Curiox Biosystems Pte Ltd Use of chemically patterned substrate for liquid handling, chemical and biological reactions
US8246799B2 (en) 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
AU2010289542A1 (en) 2009-09-01 2012-04-12 Oregon Health & Science University Reversible current gel electrophoresis device for separating biological macromolecules
WO2012011877A2 (en) 2010-07-23 2012-01-26 Curiox Biosystems Pte Ltd Apparatus and method for multiple reactions in small volumes
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
EP2640849B1 (de) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Verfahren zur sequenzierung von biomolekülen durch nachweis der relativen positionen von hybridisierten sonden
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US10294516B2 (en) 2013-01-18 2019-05-21 Nabsys 2.0 Llc Enhanced probe binding
US9557318B2 (en) 2013-07-09 2017-01-31 Curiox Biosystems Pte Ltd. Array plates for washing samples
US20150093757A1 (en) * 2013-09-27 2015-04-02 Protein Simple Methods. apparatus and systems for detection of total protein using capillary electrophoresis
JP5941092B2 (ja) * 2014-04-14 2016-06-29 アークレイ株式会社 分析装置および分析方法
US10545139B2 (en) 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
KR102446247B1 (ko) 2017-04-05 2022-09-21 큐리옥스 바이오시스템즈 피티이 엘티디. 어레이 플레이트 상의 샘플을 세정하기 위한 방법, 디바이스 및 장치
US11099117B2 (en) 2017-12-28 2021-08-24 ChandlerTec Inc. Apparatus and methods for sample acquisition
US10490482B1 (en) * 2018-12-05 2019-11-26 Toyota Motor Engineering & Manufacturing North America, Inc. Cooling devices including jet cooling with an intermediate mesh and methods for using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6113148A (ja) * 1984-06-29 1986-01-21 Hitachi Ltd 連続型核酸断片電気泳動装置
US4925629A (en) * 1988-07-28 1990-05-15 Bioquant, Inc. Diagnostic device
FR2636140B1 (fr) * 1988-09-06 1990-10-12 Bertin & Cie Automate de separation de macromolecules ou de fragments de celles-ci
US5219528A (en) * 1989-07-28 1993-06-15 Pierce Chemical Company Apparatus for rapid immunoassays
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
DE4139211C2 (de) * 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US5338427A (en) * 1993-02-26 1994-08-16 Biometric Imaging Inc. Single use separation cartridge for a capillary electrophoresis instrument
US5356525A (en) * 1993-04-16 1994-10-18 Beckman Instruments, Inc. Sample handling system
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US5332480A (en) * 1993-06-16 1994-07-26 University Of Iowa Research Foundation Capillary bed electrophoresis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006058575B4 (de) * 2005-12-12 2009-01-15 Combisep Inc., Ames Multiplex-CE-Fluoreszenzsystem
DE102007005323A1 (de) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Absaugeinrichtung

Also Published As

Publication number Publication date
JPH11502618A (ja) 1999-03-02
AU5318796A (en) 1996-10-08
AU715852B2 (en) 2000-02-10
DE69621608D1 (de) 2002-07-11
EP1186887A2 (de) 2002-03-13
US5560811A (en) 1996-10-01
EP0815440A1 (de) 1998-01-07
EP0815440B1 (de) 2002-06-05
WO1996029595A1 (en) 1996-09-26
CA2215974A1 (en) 1996-09-26

Similar Documents

Publication Publication Date Title
DE69621608T2 (de) Vorrichtung und verfahren für kapillarelektrophorese
DE69530754D1 (de) Verfahren und vorrichtung zur kapillarentwässerung
DE69627668D1 (de) Verfahren und vorrichtung für den chlamydiennachweis
DE69532091D1 (de) Verfahren und Vorrichtung zur Durchführung von Messungen
DE69633015D1 (de) Vorrichtung für Kapillarelektrophorese
DE69943238D1 (de) Vorrichtung und verfahren zur electrophorese
DE69633771D1 (de) Verfahren und gerät zum kontaktieren
DE69736469D1 (de) Vorrichtung und verfahren für funksender
DE69526257T2 (de) Verfahren zum navigieren und system dafür
DE69600392T2 (de) Vorrichtung und verfahren zum gestalten von bahndefiniertenkurven
DE69521969T2 (de) Verfahren und Vorrichtung zur Lichtbogen unterstützten CVD
DE69804808T2 (de) Verfahren und vorrichtung zur reduzierung von verunreinigungen
DE69609608D1 (de) Vorrichtung und verfahren zur unterbrechungszuweisung
DE69609265T2 (de) Verfahren und Vorrichtung für Gasbehandlung
DE69615566D1 (de) Verfahren und gerät für mehrkanalkopfanordnung
DE69830843D1 (de) Vorrichtung und verfahren für überkritische reaktion
DE69827066D1 (de) Verfahren und Vorrichtung zum Kompensieren von Mehrkanalechos
DE69710022D1 (de) Verfahren und Vorrichtung zum progressiven Biegen von Glasscheibe
DE69532631D1 (de) Einrichtung und verfahren zur datenausgabe
DE69522327D1 (de) Verfahren und vorrichtung zur richtungsbestimmung
DE69818981D1 (de) Vorrichtung und verfahren zur kristallisation
DE700185T1 (de) Verfahren und Vorrichtung für datengesteuertes Verschlüsselungssystem
DE69603694D1 (de) Kuvertiervorrichtung für Dokumente und Verfahren dafür
DE69830975D1 (de) Gerät und Verfahren zur Potential-messung
DE69907445D1 (de) Verfahren und vorrichtung für fahrtregler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee