DE69624942D1 - Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese - Google Patents

Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese

Info

Publication number
DE69624942D1
DE69624942D1 DE69624942T DE69624942T DE69624942D1 DE 69624942 D1 DE69624942 D1 DE 69624942D1 DE 69624942 T DE69624942 T DE 69624942T DE 69624942 T DE69624942 T DE 69624942T DE 69624942 D1 DE69624942 D1 DE 69624942D1
Authority
DE
Germany
Prior art keywords
screening
capillary electrophoresis
therapeutic compounds
new therapeutic
natural samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624942T
Other languages
English (en)
Other versions
DE69624942T2 (de
Inventor
Dallas E Hughes
L Karger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Application granted granted Critical
Publication of DE69624942D1 publication Critical patent/DE69624942D1/de
Publication of DE69624942T2 publication Critical patent/DE69624942T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
DE69624942T 1995-12-11 1996-12-10 Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese Expired - Fee Related DE69624942T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US850395P 1995-12-11 1995-12-11
US08/662,085 US5783397A (en) 1995-12-11 1996-06-12 Screening natural samples for new therapeutic compounds using capillary electrophoresis
PCT/US1996/019779 WO1997022000A1 (en) 1995-12-11 1996-12-10 Screening natural samples for new therapeutic compounds using capillary electrophoresis

Publications (2)

Publication Number Publication Date
DE69624942D1 true DE69624942D1 (de) 2003-01-02
DE69624942T2 DE69624942T2 (de) 2003-09-18

Family

ID=26678258

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624942T Expired - Fee Related DE69624942T2 (de) 1995-12-11 1996-12-10 Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese

Country Status (8)

Country Link
US (1) US5783397A (de)
EP (1) EP0876609B1 (de)
JP (1) JP3603267B2 (de)
CA (1) CA2239418C (de)
DE (1) DE69624942T2 (de)
DK (1) DK0876609T3 (de)
ES (1) ES2187685T3 (de)
WO (1) WO1997022000A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
BR9710054A (pt) 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
US6528098B2 (en) * 1996-10-22 2003-03-04 Advanced Viral Research Corp. Preparation of a therapeutic composition
US6455323B1 (en) * 1997-07-03 2002-09-24 Pharmacia & Upjohn Company Anti-bacterial methods and materials
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6299747B1 (en) * 1997-12-17 2001-10-09 Cetek Corporation Capillary electrophoretic methods to detect new biologically active compounds in complex biological material
US6524866B1 (en) * 1997-12-24 2003-02-25 Cetek Corporation Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
WO2000003240A1 (en) * 1998-07-10 2000-01-20 Cetek Corporation Method to detect and analyze tight-binding ligands in complex biological samples
US6432651B1 (en) 1998-07-10 2002-08-13 Cetek Corporation Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US20020010550A1 (en) 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
AU3349900A (en) * 1999-01-26 2000-08-07 Du Pont Pharmaceuticals Company Electrophoretic assays to assess conformational changes of integrins induced by ligand binding
US6329145B1 (en) * 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
WO2000047999A1 (en) 1999-02-12 2000-08-17 Cetek Corporation High throughput size-exclusive method of screening complex biological materials for affinity ligands
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
US7217573B1 (en) * 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
US6764823B2 (en) 2000-04-06 2004-07-20 Pharmacia & Upjohn Company Antimicrobial methods and materials
US7252932B1 (en) 2000-08-23 2007-08-07 Ambergen, Inc. Methods for the detection, analysis and isolation of nascent proteins
EP1720011A1 (de) 2000-12-01 2006-11-08 Cetek Corporation Kapillares Elektrophoresesystem mit hoher Durchlaufleistung
US20030132117A1 (en) * 2002-01-14 2003-07-17 Andras Guttman Thin film electrophoresis apparatus and method
US20040266021A9 (en) * 2001-01-26 2004-12-30 Andras Guttman Multicapillary fraction collection system and method
US20030087321A1 (en) * 2001-09-28 2003-05-08 Tomich Che-Shen C. Antimicrobial methods and materials
US20050272089A1 (en) * 2001-10-19 2005-12-08 Mott John E Critical genes and polypeptides of haemophilus influenzae and methods of use
US20030220249A1 (en) * 2002-02-07 2003-11-27 Hackett Perry B. Factors for angiogenesis, vasculogenesis, cartilage formation, bone formation, and methods of use thereof
CA2501861C (en) * 2002-10-09 2012-03-20 Waters Investments Limited Methods and apparatus for identifying compounds in a sample
US7672786B2 (en) 2003-07-02 2010-03-02 Sergey Krylov Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development
JP4512745B2 (ja) * 2004-10-29 2010-07-28 独立行政法人産業技術総合研究所 細胞の分離、同定装置及び方法
WO2006132623A1 (en) * 2005-06-03 2006-12-14 Advanced Viral Research Corp. Methods for providing palliative care with avr118
US7959861B2 (en) * 2007-09-19 2011-06-14 Stc.Unm Integrated affinity microcolumns and affinity capillary electrophoresis
KR101388539B1 (ko) 2008-02-12 2014-04-23 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 색 검출기
WO2009102328A1 (en) 2008-02-13 2009-08-20 Hewlett-Packard Development Company, L.P. Color detector having area scaled photodetectors
BRPI0901112A2 (pt) * 2009-03-12 2010-11-16 Luiz Augusto Pinto processo de produção de oligonucleotìdeos de alta afinidade e alta especificidade para moléculas orgánicas e inorgánicas
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
US8961764B2 (en) 2010-10-15 2015-02-24 Lockheed Martin Corporation Micro fluidic optic design
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006850A1 (en) * 1989-11-06 1991-05-16 Massachusetts Institute Of Technology Affinity co-electrophoresis
WO1992013972A1 (en) * 1991-02-11 1992-08-20 Thomas Jefferson University Genetically engineered bacteria to identify and produce medically important agents
EP0533909B1 (de) * 1991-03-28 1997-01-08 Perseptive Biosystems, Inc. Produktinformation in chromatographischem effluenten durch differenzbildung
US5413686A (en) * 1992-07-17 1995-05-09 Beckman Instruments, Inc. Multi-channel automated capillary electrophoresis analyzer
US5348633A (en) * 1993-01-22 1994-09-20 Northeastern University Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis
AU682340B2 (en) * 1993-01-28 1997-10-02 Regents Of The University Of California, The TATA-binding protein associated factors, nucleic acids encoding TAFs, and methods of use
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US5567282A (en) * 1994-01-25 1996-10-22 Wang; Hann-Ping On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins
US5536382A (en) * 1994-05-23 1996-07-16 Advanced Molecular Systems, Inc. Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample
US5431793A (en) * 1994-07-29 1995-07-11 Beckman Instruments, Inc. Quantitative analysis of glycosylated hemoglobin by immunocappillary electrophoresis

Also Published As

Publication number Publication date
ES2187685T3 (es) 2003-06-16
EP0876609A1 (de) 1998-11-11
DK0876609T3 (da) 2003-03-17
JP3603267B2 (ja) 2004-12-22
DE69624942T2 (de) 2003-09-18
CA2239418C (en) 2005-09-20
CA2239418A1 (en) 1997-06-19
US5783397A (en) 1998-07-21
EP0876609B1 (de) 2002-11-20
JP2000502443A (ja) 2000-02-29
WO1997022000A1 (en) 1997-06-19

Similar Documents

Publication Publication Date Title
DE69624942D1 (de) Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese
DK0746398T3 (da) Antistofrensning
DE69609922T2 (de) Verfahren zur Trocknung von Gasen mittels Glycol mit anschliessender Raffinierung von gasförmigen Abflüssen
DE69918549D1 (de) Gerät zur feststellung von zahnbelag mittels fluoreszenzmessung
KR950700779A (ko) 단백질의 정제방법(Protein purification)
DE68926428D1 (de) Personalisierung von Benutzerschnittstellen für Anwendungsprogramme
DE19681286T1 (de) Neue Kristallform von Olanzapin
ATE332368T1 (de) Selektion von proteinen mittels rns-protein fusionen
DE69632447D1 (de) Analysator zur Analyse von Urinbestandteilen
DE69638019D1 (de) Multiplexvorrichtung für Kapillarelektrophorese
DE69822934D1 (de) Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese
BR9609148A (pt) Método para aumentar o fluxo por eletrotransporte de polipeptídeos
DE69420750D1 (de) Verfahren zur Probenanalyse mittels Kapillarelektroforese
DE69622978D1 (de) Analysator zur Analyse von Urinbestandteilen
DE69817749D1 (de) Verwendung von mittels leitenten Mischmembranen hergestelltem Synthesegas
DE69505840T2 (de) Hydrogenierung von halogenierten verbindungen
JPS5716492A (en) Self control type bridge for stringed instrument
DE69505105T2 (de) Neue Klasse von stabilisierenden Verbindungen für Phosphorschirme
ATA80784A (de) Verfahren zur verlaengerung von resthaar mittels ergaenzungshaaren
DK0401657T3 (da) Fremgangsmåde til C-terminal modificering af proteiner
DE69506384T2 (de) Neue Klasse von stabilisierenden Verbindungen für Phosphorschirme
DE29512292U1 (de) Halterung zur reproduzierbaren Lagerung von Patienten
NO952921D0 (no) Innvendig stöttekonstruksjon for strengeinstrument
DE69602173T2 (de) Anwendung der gegenstrom-chromatographie zur entfaltung chemischer banken
DE29707343U1 (de) Stangenförmiger Abstandhalter für Bewehrung von Betonbauteilen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee