DE69624942D1 - Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese - Google Patents
Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophoreseInfo
- Publication number
- DE69624942D1 DE69624942D1 DE69624942T DE69624942T DE69624942D1 DE 69624942 D1 DE69624942 D1 DE 69624942D1 DE 69624942 T DE69624942 T DE 69624942T DE 69624942 T DE69624942 T DE 69624942T DE 69624942 D1 DE69624942 D1 DE 69624942D1
- Authority
- DE
- Germany
- Prior art keywords
- screening
- capillary electrophoresis
- therapeutic compounds
- new therapeutic
- natural samples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000005251 capillar electrophoresis Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
- G01N33/561—Immunoelectrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US850395P | 1995-12-11 | 1995-12-11 | |
US08/662,085 US5783397A (en) | 1995-12-11 | 1996-06-12 | Screening natural samples for new therapeutic compounds using capillary electrophoresis |
PCT/US1996/019779 WO1997022000A1 (en) | 1995-12-11 | 1996-12-10 | Screening natural samples for new therapeutic compounds using capillary electrophoresis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69624942D1 true DE69624942D1 (de) | 2003-01-02 |
DE69624942T2 DE69624942T2 (de) | 2003-09-18 |
Family
ID=26678258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69624942T Expired - Fee Related DE69624942T2 (de) | 1995-12-11 | 1996-12-10 | Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese |
Country Status (8)
Country | Link |
---|---|
US (1) | US5783397A (de) |
EP (1) | EP0876609B1 (de) |
JP (1) | JP3603267B2 (de) |
CA (1) | CA2239418C (de) |
DE (1) | DE69624942T2 (de) |
DK (1) | DK0876609T3 (de) |
ES (1) | ES2187685T3 (de) |
WO (1) | WO1997022000A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
WO1998000231A1 (en) | 1996-06-28 | 1998-01-08 | Caliper Technologies Corporation | High-throughput screening assay systems in microscale fluidic devices |
US6528098B2 (en) * | 1996-10-22 | 2003-03-04 | Advanced Viral Research Corp. | Preparation of a therapeutic composition |
US6455323B1 (en) * | 1997-07-03 | 2002-09-24 | Pharmacia & Upjohn Company | Anti-bacterial methods and materials |
US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
US6299747B1 (en) * | 1997-12-17 | 2001-10-09 | Cetek Corporation | Capillary electrophoretic methods to detect new biologically active compounds in complex biological material |
WO1999034203A1 (en) * | 1997-12-24 | 1999-07-08 | Cetek Corporation | Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities |
US6432651B1 (en) | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
WO2000003240A1 (en) * | 1998-07-10 | 2000-01-20 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US20020010550A1 (en) | 1998-09-14 | 2002-01-24 | George M. Grass | Pharmacokinetic-based drug design tool and method |
WO2000043787A1 (en) * | 1999-01-26 | 2000-07-27 | Du Pont Pharmaceuticals Company | Electrophoretic assays to assess conformational changes of integrins induced by ligand binding |
US6329145B1 (en) * | 1999-02-09 | 2001-12-11 | Gilead Science, Inc. | Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand |
JP3788909B2 (ja) | 1999-02-12 | 2006-06-21 | セテク コーポレイション | 親和力配位子について複合生理学的材料をスクリーニングする高処理量のサイズ排除法 |
US6306628B1 (en) * | 1999-08-25 | 2001-10-23 | Ambergen, Incorporated | Methods for the detection, analysis and isolation of Nascent proteins |
US7217573B1 (en) * | 1999-10-05 | 2007-05-15 | Hitachi, Ltd. | Method of inspecting a DNA chip |
AU2001251370A1 (en) | 2000-04-06 | 2001-10-23 | Pharmacia And Upjohn Company | Antimicrobial methods and materials |
US7252932B1 (en) | 2000-08-23 | 2007-08-07 | Ambergen, Inc. | Methods for the detection, analysis and isolation of nascent proteins |
EP1720011A1 (de) | 2000-12-01 | 2006-11-08 | Cetek Corporation | Kapillares Elektrophoresesystem mit hoher Durchlaufleistung |
US20030132117A1 (en) * | 2002-01-14 | 2003-07-17 | Andras Guttman | Thin film electrophoresis apparatus and method |
US20040266021A9 (en) * | 2001-01-26 | 2004-12-30 | Andras Guttman | Multicapillary fraction collection system and method |
US20030087321A1 (en) * | 2001-09-28 | 2003-05-08 | Tomich Che-Shen C. | Antimicrobial methods and materials |
US20050272089A1 (en) * | 2001-10-19 | 2005-12-08 | Mott John E | Critical genes and polypeptides of haemophilus influenzae and methods of use |
AU2003209054A1 (en) * | 2002-02-07 | 2003-09-02 | Discovery Genomics, Inc. | Factors for angiogenesis, vasculogenesis, cartilage formation, bone formation and methods of use thereof |
CA2501861C (en) * | 2002-10-09 | 2012-03-20 | Waters Investments Limited | Methods and apparatus for identifying compounds in a sample |
US7672786B2 (en) | 2003-07-02 | 2010-03-02 | Sergey Krylov | Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development |
JP4512745B2 (ja) * | 2004-10-29 | 2010-07-28 | 独立行政法人産業技術総合研究所 | 細胞の分離、同定装置及び方法 |
WO2006132623A1 (en) * | 2005-06-03 | 2006-12-14 | Advanced Viral Research Corp. | Methods for providing palliative care with avr118 |
US7959861B2 (en) * | 2007-09-19 | 2011-06-14 | Stc.Unm | Integrated affinity microcolumns and affinity capillary electrophoresis |
EP2243009B1 (de) | 2008-02-12 | 2018-10-10 | Hewlett-Packard Development Company, L.P. | Farbdetektor |
JP2011511946A (ja) | 2008-02-13 | 2011-04-14 | ヒューレット−パッカード デベロップメント カンパニー エル.ピー. | 面積が拡大縮小された光検出器を有する色検出器 |
BRPI0901112A2 (pt) * | 2009-03-12 | 2010-11-16 | Luiz Augusto Pinto | processo de produção de oligonucleotìdeos de alta afinidade e alta especificidade para moléculas orgánicas e inorgánicas |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
CA2814720C (en) | 2010-10-15 | 2016-12-13 | Lockheed Martin Corporation | Micro fluidic optic design |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991006850A1 (en) * | 1989-11-06 | 1991-05-16 | Massachusetts Institute Of Technology | Affinity co-electrophoresis |
US5532124A (en) * | 1991-02-11 | 1996-07-02 | Thomas Jefferson University | Genetically engineered bacteria to identify and produce medically important agents |
ATE147281T1 (de) * | 1991-03-28 | 1997-01-15 | Perseptive Biosystems Inc | Produktinformation in chromatographischem effluenten durch differenzbildung |
US5413686A (en) * | 1992-07-17 | 1995-05-09 | Beckman Instruments, Inc. | Multi-channel automated capillary electrophoresis analyzer |
US5348633A (en) * | 1993-01-22 | 1994-09-20 | Northeastern University | Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis |
WO1994017087A1 (en) * | 1993-01-28 | 1994-08-04 | The Regents Of The University Of California | Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use |
US5324401A (en) * | 1993-02-05 | 1994-06-28 | Iowa State University Research Foundation, Inc. | Multiplexed fluorescence detector system for capillary electrophoresis |
US5567282A (en) * | 1994-01-25 | 1996-10-22 | Wang; Hann-Ping | On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins |
US5536382A (en) * | 1994-05-23 | 1996-07-16 | Advanced Molecular Systems, Inc. | Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample |
US5431793A (en) * | 1994-07-29 | 1995-07-11 | Beckman Instruments, Inc. | Quantitative analysis of glycosylated hemoglobin by immunocappillary electrophoresis |
-
1996
- 1996-06-12 US US08/662,085 patent/US5783397A/en not_active Expired - Lifetime
- 1996-12-10 EP EP96944795A patent/EP0876609B1/de not_active Expired - Lifetime
- 1996-12-10 CA CA002239418A patent/CA2239418C/en not_active Expired - Fee Related
- 1996-12-10 DK DK96944795T patent/DK0876609T3/da active
- 1996-12-10 DE DE69624942T patent/DE69624942T2/de not_active Expired - Fee Related
- 1996-12-10 JP JP52219897A patent/JP3603267B2/ja not_active Expired - Fee Related
- 1996-12-10 ES ES96944795T patent/ES2187685T3/es not_active Expired - Lifetime
- 1996-12-10 WO PCT/US1996/019779 patent/WO1997022000A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2239418A1 (en) | 1997-06-19 |
ES2187685T3 (es) | 2003-06-16 |
US5783397A (en) | 1998-07-21 |
CA2239418C (en) | 2005-09-20 |
WO1997022000A1 (en) | 1997-06-19 |
EP0876609A1 (de) | 1998-11-11 |
JP2000502443A (ja) | 2000-02-29 |
DK0876609T3 (da) | 2003-03-17 |
JP3603267B2 (ja) | 2004-12-22 |
DE69624942T2 (de) | 2003-09-18 |
EP0876609B1 (de) | 2002-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |