DE69627768D1 - Reihenanalyse-Verfahren der Genexpression - Google Patents

Reihenanalyse-Verfahren der Genexpression

Info

Publication number
DE69627768D1
DE69627768D1 DE69627768T DE69627768T DE69627768D1 DE 69627768 D1 DE69627768 D1 DE 69627768D1 DE 69627768 T DE69627768 T DE 69627768T DE 69627768 T DE69627768 T DE 69627768T DE 69627768 D1 DE69627768 D1 DE 69627768D1
Authority
DE
Germany
Prior art keywords
gene expression
analysis method
sage
series analysis
transcripts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69627768T
Other languages
English (en)
Other versions
DE69627768T2 (de
Inventor
Kenneth W Kinzler
Victor E Velculescu
Bert Vogelstein
Lin Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
School of Medicine of Johns Hopkins University
Original Assignee
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/527,154 external-priority patent/US5695937A/en
Application filed by Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69627768D1 publication Critical patent/DE69627768D1/de
Publication of DE69627768T2 publication Critical patent/DE69627768T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
DE69627768T 1995-09-12 1996-09-12 Reihenanalyse-Verfahren der Genexpression Expired - Lifetime DE69627768T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US527154 1995-09-12
US08/527,154 US5695937A (en) 1995-09-12 1995-09-12 Method for serial analysis of gene expression
US08/544,861 US5866330A (en) 1995-09-12 1995-10-18 Method for serial analysis of gene expression
US544861 1995-10-18

Publications (2)

Publication Number Publication Date
DE69627768D1 true DE69627768D1 (de) 2003-06-05
DE69627768T2 DE69627768T2 (de) 2004-04-08

Family

ID=27062344

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0761822T Pending DE761822T1 (de) 1995-09-12 1996-09-12 Reihenanalyse-Verfahren der Genexpression
DE69627768T Expired - Lifetime DE69627768T2 (de) 1995-09-12 1996-09-12 Reihenanalyse-Verfahren der Genexpression

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0761822T Pending DE761822T1 (de) 1995-09-12 1996-09-12 Reihenanalyse-Verfahren der Genexpression

Country Status (12)

Country Link
US (3) US5866330A (de)
EP (2) EP0761822B1 (de)
JP (3) JP3334806B2 (de)
AT (1) ATE239093T1 (de)
AU (2) AU707846B2 (de)
CA (1) CA2185379A1 (de)
DE (2) DE761822T1 (de)
DK (1) DK0761822T3 (de)
ES (1) ES2194957T3 (de)
GB (1) GB2305241B (de)
IE (1) IE80465B1 (de)
WO (1) WO1997010363A1 (de)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5866330A (en) * 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5871697A (en) * 1995-10-24 1999-02-16 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US6418382B2 (en) 1995-10-24 2002-07-09 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US5972693A (en) * 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
GB9618544D0 (en) * 1996-09-05 1996-10-16 Brax Genomics Ltd Characterising DNA
US5981190A (en) * 1997-01-08 1999-11-09 Ontogeny, Inc. Analysis of gene expression, methods and reagents therefor
US5968784A (en) * 1997-01-15 1999-10-19 Chugai Pharmaceutical Co., Ltd. Method for analyzing quantitative expression of genes
US6461814B1 (en) * 1997-01-15 2002-10-08 Dominic G. Spinella Method of identifying gene transcription patterns
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
EP0981535A4 (de) * 1997-05-12 2000-11-29 Life Technologies Inc Verfahren zur herstellung und reinigung von nukleinsäuremolekülen
AU7499198A (en) 1997-05-21 1998-12-11 Johns Hopkins University, The Gene expression profiles in normal and cancer cells
US6432640B1 (en) 1997-09-17 2002-08-13 The Johns Hopkins University P53-induced apoptosis
US6399334B1 (en) 1997-09-24 2002-06-04 Invitrogen Corporation Normalized nucleic acid libraries and methods of production thereof
US6297010B1 (en) * 1998-01-30 2001-10-02 Genzyme Corporation Method for detecting and identifying mutations
US6136537A (en) * 1998-02-23 2000-10-24 Macevicz; Stephen C. Gene expression analysis
US6054276A (en) 1998-02-23 2000-04-25 Macevicz; Stephen C. DNA restriction site mapping
DE19822287C2 (de) * 1998-05-18 2003-04-24 Switch Biotech Ag Klonierungsvektor, seine Herstellung und Verwendung zur Analyse von mRNA Expressionsmuster
AU4825699A (en) * 1998-06-19 2000-01-05 Genzyme Corporation Identification and use of differentially expressed genes and polynucleotide sequences
WO2000029621A2 (en) * 1998-11-16 2000-05-25 Genelabs Technologies, Inc. Method for measuring target polynucleotides and novel asthma biomolecules
DE69913092T2 (de) * 1999-01-27 2004-09-09 Commissariat à l'Energie Atomique Microassay zur Serienanalyse der Genexpression und Anwendungen davon
JP3924976B2 (ja) * 1999-02-17 2007-06-06 味の素株式会社 遺伝子の発現頻度の解析方法
WO2000050889A1 (en) * 1999-02-23 2000-08-31 Warner-Lambert Company System and method for managing and presenting information derived from gene expression profiling
US7008768B1 (en) * 1999-02-26 2006-03-07 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting radiation exposure
EP2360270B1 (de) 1999-05-20 2016-11-09 Illumina, Inc. Kombinatorische Entschlüsselung von Zufallsnukleinsäurearrays
US20060115826A1 (en) * 1999-06-28 2006-06-01 Michael Bevilacqua Gene expression profiling for identification monitoring and treatment of multiple sclerosis
US20040225449A1 (en) * 1999-06-28 2004-11-11 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using selected gene expression profiles
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US20080183395A1 (en) * 1999-06-28 2008-07-31 Michael Bevilacqua Gene expression profiling for identification, monitoring and treatment of multiple sclerosis
US20050060101A1 (en) * 1999-06-28 2005-03-17 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
AU6387000A (en) * 1999-07-29 2001-02-19 Genzyme Corporation Serial analysis of genetic alterations
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
US6376177B1 (en) 1999-10-06 2002-04-23 Virtual Pro, Inc. Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips
US6221600B1 (en) 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
GB9923790D0 (en) * 1999-10-08 1999-12-08 Isis Innovation Immunoregulatory compositions
AU2743001A (en) * 1999-12-29 2001-07-09 Arch Development Corporation Method for generation of longer cdna fragments from sage tags for gene identification
EP1257664A4 (de) 2000-01-28 2006-04-05 Althea Technologies Inc Verfahren zur analyse der genexpression
US6566130B1 (en) 2000-01-28 2003-05-20 Henry M. Jackson Foundation For The Advancement Of Military Medicine Androgen-regulated gene expressed in prostate tissue
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
WO2001057257A2 (en) * 2000-02-04 2001-08-09 Genzyme Corporation Isolation and identification of mrnas correlating to secreted proteins
WO2001070948A2 (en) * 2000-03-20 2001-09-27 Newlink Genetics Methods and compositions for elucidating protein expression profiles in cells
US6897020B2 (en) 2000-03-20 2005-05-24 Newlink Genetics Inc. Methods and compositions for elucidating relative protein expression levels in cells
US6468749B1 (en) 2000-03-30 2002-10-22 Quark Biotech, Inc. Sequence-dependent gene sorting techniques
AU2001262152A1 (en) * 2000-03-31 2001-10-08 Memorec Stoffel Gmbh Method for extracting nucleic acids
DK2278030T3 (en) 2000-04-10 2017-07-24 Taxon Biosciences Inc METHODS OF RESEARCH AND GENETIC ANALYSIS OF POPULATIONS
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
AU2001255870B2 (en) * 2000-04-28 2006-07-13 Sangamo Biosciences, Inc. Databases of regulatory sequences; methods of making and using same
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
US6610489B2 (en) * 2000-04-28 2003-08-26 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
US7374879B2 (en) * 2000-05-01 2008-05-20 Eiken Kagaku Kabushiki Kaisya Method for detecting product of nucleic acid synthesizing reaction
DE10027218A1 (de) * 2000-05-31 2001-12-06 Hubert Bernauer Artifizielle genetische Markierung mit synthetischer DNA
EP1356096A2 (de) * 2000-06-30 2003-10-29 Syngenta Participations AG Methode zur identifizierung, auftrennung und quantitativen bestimmung von nukleinsäurefragmenten
US7300751B2 (en) * 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
AU2001280875A1 (en) * 2000-07-28 2002-02-13 The Johns Hopkins University Serial analysis of transcript expression using long tags
US7257562B2 (en) * 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
DE10100121A1 (de) * 2001-01-03 2002-08-01 Henkel Kgaa Verfahren zur Bestimmung des Hautstreß oder der Hautalterung in vitro
DE10100127A1 (de) * 2001-01-03 2002-10-02 Henkel Kgaa Verfahren zur Bestimmung der Homeostase der Haut
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
WO2002059359A2 (en) 2001-01-24 2002-08-01 Syngenta Participations Ag Method for non-redundant library construction
EP1423529B1 (de) * 2001-01-24 2013-11-20 Genomic Expression APS Verfahren zur analyse der genexpression
US20030165865A1 (en) * 2001-01-29 2003-09-04 Hinkel Christopher A. Methods of analysis of nucleic acids
FR2821087B1 (fr) * 2001-02-16 2004-01-02 Centre Nat Rech Scient Procede d'analyse qualitative et quantitative d'une population d'acides nucleiques contenus dans un echantillon
GB0104993D0 (en) * 2001-02-28 2001-04-18 Isis Innovations Ltd Methods for analysis of RNA
US6850930B2 (en) 2001-03-13 2005-02-01 Honeywell International Inc. Method for transforming words to unique numerical representation
US20040142337A1 (en) * 2001-03-15 2004-07-22 Mikio Yamamoto Method of constructing cdna tag for identifying expressed gene and method of analyzing gene expression
CA2444467A1 (en) * 2001-04-18 2002-10-24 Ulrich J. Krull Gradient resolved hybridisation platform
AU2002305391A1 (en) * 2001-05-04 2002-11-18 Health Research, Inc. A high throughput assay for identification of gene expression modifiers
US20030082584A1 (en) * 2001-06-29 2003-05-01 Liang Shi Enzymatic ligation-based identification of transcript expression
US20030170695A1 (en) * 2001-06-29 2003-09-11 Liang Shi Enzymatic ligation-based identification of nucleotide sequences
US7026123B1 (en) * 2001-08-29 2006-04-11 Pioneer Hi-Bred International, Inc. UTR tag assay for gene function discovery
KR20040064275A (ko) 2001-11-09 2004-07-16 소스 프리시전 메디슨, 인코포레이티드 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인
US20040234995A1 (en) * 2001-11-09 2004-11-25 Musick Eleanor M. System and method for storage and analysis of gene expression data
US20030190618A1 (en) * 2002-03-06 2003-10-09 Babru Samal Method for generating five prime biased tandem tag libraries of cDNAs
CA2482425A1 (en) * 2002-04-26 2003-11-06 Lynx Therapeutics, Inc. Constant length signatures for parallel sequencing of polynucleotides
US7115370B2 (en) 2002-06-05 2006-10-03 Capital Genomix, Inc. Combinatorial oligonucleotide PCR
EP1523554A2 (de) * 2002-06-12 2005-04-20 Riken Verfahren zur nutzung von 5' enden transkribierter nukleinsäureregionen für die klonierung oder zur analyse
JP2004097158A (ja) * 2002-09-12 2004-04-02 Kureha Chem Ind Co Ltd 発現遺伝子同定用cDNAタグの作成方法、及び該cDNAタグを用いる遺伝子発現解析方法
AU2003295692A1 (en) * 2002-11-15 2004-06-15 Sangamo Biosciences, Inc. Methods and compositions for analysis of regulatory sequences
GB0228289D0 (en) * 2002-12-04 2003-01-08 Genome Inst Of Singapore Nat U Method
DE10260931B4 (de) * 2002-12-20 2006-06-01 Henkel Kgaa Verfahren zur Bestimmung der Homeostase behaarter Haut
DE10260928A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Verfahren zur Bestimmung von Markern humaner Gesichtshaut
EP1587914A4 (de) * 2003-01-16 2007-06-27 Health Research Inc Verfahren zur umfassenden identifizierung zellabstammungslinien-spezifischer gene
AU2004239760A1 (en) * 2003-05-09 2004-11-25 Health Research Inc. Improved methods for protein interaction determination
US20100216649A1 (en) * 2003-05-09 2010-08-26 Pruitt Steven C Methods for protein interaction determination
US8222005B2 (en) * 2003-09-17 2012-07-17 Agency For Science, Technology And Research Method for gene identification signature (GIS) analysis
US20060024681A1 (en) * 2003-10-31 2006-02-02 Agencourt Bioscience Corporation Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof
JP3845416B2 (ja) * 2003-12-01 2006-11-15 株式会社ポストゲノム研究所 遺伝子タグの取得方法
WO2005071112A2 (en) * 2004-01-26 2005-08-04 Isis Innovation Ltd Molecular analysis
US20050266447A1 (en) * 2004-04-19 2005-12-01 Pioneer Hi-Bred International, Inc. Method for identifying activators of gene transcription
US20070003924A1 (en) * 2004-06-18 2007-01-04 The Ohio State University Research Foundation Serial analysis of ribosomal and other microbial sequence tags
US8005621B2 (en) * 2004-09-13 2011-08-23 Agency For Science Technology And Research Transcript mapping method
PL2298815T3 (pl) 2005-07-25 2015-08-31 Emergent Product Dev Seattle Zmniejszenie ilości komórek B przy użyciu cząsteczek wiążących specyficznych dla CD20 i CD37
DE602007009634D1 (de) * 2006-01-04 2010-11-18 Si Lok Verfahren zur zuordnung von nukleinsäuren und zur identifikation fein strukturierter variationen in nukleinsäuren sowie hilfsmittel dafür
US8071296B2 (en) * 2006-03-13 2011-12-06 Agency For Science, Technology And Research Nucleic acid interaction analysis
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US20080124707A1 (en) * 2006-06-09 2008-05-29 Agency For Science, Technology And Research Nucleic acid concatenation
EP2041178A2 (de) * 2006-06-12 2009-04-01 Trubion Pharmaceuticals, Inc. Multivalente einzelkettenbindungsproteine mit effektorfunktion
JP2010532764A (ja) * 2007-07-06 2010-10-14 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド C末端に配置された特異的結合性ドメインを有する結合性ペプチド
JP2011509095A (ja) 2008-01-09 2011-03-24 ライフ テクノロジーズ コーポレーション 核酸配列決定のための対をなすタグのライブラリーを製造する方法
WO2012044847A1 (en) 2010-10-01 2012-04-05 Life Technologies Corporation Nucleic acid adaptors and uses thereof
US8263367B2 (en) * 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
US8309317B2 (en) * 2008-04-05 2012-11-13 Single Cell Technology, Inc. Method of screening single cells for the production of biologically active agents
NZ621443A (en) * 2008-04-11 2015-09-25 Emergent Product Dev Seattle Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
US8362318B2 (en) 2008-12-18 2013-01-29 Board Of Trustees Of Michigan State University Enzyme directed oil biosynthesis in microalgae
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2910650A1 (de) 2009-08-24 2015-08-26 National University Corporation Kanazawa University Nachweis von Kolorektalkrebs durch Genexpressionsprofilierung
WO2011082253A2 (en) 2009-12-30 2011-07-07 Board Of Trustees Of Michigan State University A method to produce acetyldiacylglycerols (ac-tags) by expression ofan acetyltransferase gene isolated from euonymus alatus (burning bush)
WO2011137368A2 (en) 2010-04-30 2011-11-03 Life Technologies Corporation Systems and methods for analyzing nucleic acid sequences
AU2011268263B2 (en) 2010-06-16 2015-04-09 Taxon Biosciences, Inc. Methods of creating synthetic consortia of microorganisms
US9268903B2 (en) 2010-07-06 2016-02-23 Life Technologies Corporation Systems and methods for sequence data alignment quality assessment
CN110016499B (zh) 2011-04-15 2023-11-14 约翰·霍普金斯大学 安全测序系统
US9758829B2 (en) 2012-06-22 2017-09-12 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
EP2694669B1 (de) 2012-06-28 2017-05-17 Taxon Biosciences, Inc. Verfahren zur herstellung oder schaffung eines synthetischen mikrobiellen konsortiums, identifiziert durch computeranalyse von amplicon-sequenzen
AU2013338393B2 (en) 2012-10-29 2017-05-11 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US10392629B2 (en) 2014-01-17 2019-08-27 Board Of Trustees Of Michigan State University Increased caloric and nutritional content of plant biomass
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
CA2997929A1 (en) 2015-09-08 2017-03-16 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
UA126278C2 (uk) 2015-09-21 2022-09-14 Аптево Рісьорч Енд Девелопмент Ллс Поліпептиди, які зв'язують cd3
US11384399B2 (en) 2015-09-29 2022-07-12 Htg Molecular Diagnostics, Inc. Methods for subtyping diffuse large B-cell lymphoma (DLBCL)
CN109023536A (zh) * 2018-06-28 2018-12-18 河南师范大学 一种植物降解组文库构建方法
WO2024052948A1 (ja) 2022-09-05 2024-03-14 株式会社キュービクス 膵臓癌に特異的な遺伝子発現パターンの検出及びca19-9の測定の併用による膵臓癌の検出

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036946C (en) * 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
WO1993000353A1 (en) * 1991-06-20 1993-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
AU3665893A (en) * 1992-02-12 1993-09-03 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Sequences characteristic of human gene transcription product
US5665544A (en) * 1992-05-27 1997-09-09 Amersham International Plc RNA fingerprinting to determine RNA population differences
US5840484A (en) * 1992-07-17 1998-11-24 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US6114114A (en) * 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US5652128A (en) * 1993-01-05 1997-07-29 Jarvik; Jonathan Wallace Method for producing tagged genes, transcripts, and proteins
EP0679716A4 (de) * 1993-11-12 1999-06-09 Kenichi Matsubara Genetische Signaturen.
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
EP1813684A3 (de) * 1994-02-14 2009-11-18 Smithkline Beecham Corporation Unterschiedlich exprimierte Gene in gesunden und kranken Individuen
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5866330A (en) * 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5658736A (en) * 1996-01-16 1997-08-19 Genetics Institute, Inc. Oligonucleotide population preparation

Also Published As

Publication number Publication date
EP0761822A3 (de) 1998-08-05
GB2305241A (en) 1997-04-02
US5866330A (en) 1999-02-02
AU7018896A (en) 1997-04-01
EP1231284A3 (de) 2003-02-26
US6746845B2 (en) 2004-06-08
AU6561496A (en) 1997-03-20
GB2305241B (en) 1999-11-10
GB9619024D0 (en) 1996-10-23
ATE239093T1 (de) 2003-05-15
JP2001145495A (ja) 2001-05-29
DK0761822T3 (da) 2003-08-18
EP0761822A2 (de) 1997-03-12
DE69627768T2 (de) 2004-04-08
EP1231284A2 (de) 2002-08-14
JPH10511002A (ja) 1998-10-27
WO1997010363A1 (en) 1997-03-20
DE761822T1 (de) 2001-01-11
EP0761822B1 (de) 2003-05-02
US20030049653A1 (en) 2003-03-13
US6383743B1 (en) 2002-05-07
CA2185379A1 (en) 1997-03-13
JP2001155035A (ja) 2001-06-08
AU707846B2 (en) 1999-07-22
ES2194957T3 (es) 2003-12-01
JP3334806B2 (ja) 2002-10-15
IE80465B1 (en) 1998-08-12

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