DE69628783D1 - Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung - Google Patents

Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung

Info

Publication number
DE69628783D1
DE69628783D1 DE69628783T DE69628783T DE69628783D1 DE 69628783 D1 DE69628783 D1 DE 69628783D1 DE 69628783 T DE69628783 T DE 69628783T DE 69628783 T DE69628783 T DE 69628783T DE 69628783 D1 DE69628783 D1 DE 69628783D1
Authority
DE
Germany
Prior art keywords
polyester copolymers
self
forming
hydrogel
solvating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69628783T
Other languages
English (en)
Other versions
DE69628783T2 (de
Inventor
Shalaby W Shalaby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poly Med Inc
Original Assignee
Poly Med Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poly Med Inc filed Critical Poly Med Inc
Publication of DE69628783D1 publication Critical patent/DE69628783D1/de
Application granted granted Critical
Publication of DE69628783T2 publication Critical patent/DE69628783T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
    • C08G63/664Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
DE69628783T 1995-04-13 1996-04-12 Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung Expired - Lifetime DE69628783T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/421,222 US5612052A (en) 1995-04-13 1995-04-13 Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US421222 1995-04-13

Publications (2)

Publication Number Publication Date
DE69628783D1 true DE69628783D1 (de) 2003-07-31
DE69628783T2 DE69628783T2 (de) 2004-04-29

Family

ID=23669666

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69628783T Expired - Lifetime DE69628783T2 (de) 1995-04-13 1996-04-12 Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung
DE0737703T Pending DE737703T1 (de) 1995-04-13 1996-04-12 Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE0737703T Pending DE737703T1 (de) 1995-04-13 1996-04-12 Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung

Country Status (7)

Country Link
US (2) US5612052A (de)
EP (1) EP0737703B1 (de)
JP (1) JP3107514B2 (de)
AT (1) ATE243720T1 (de)
AU (1) AU685357B2 (de)
CA (1) CA2174072C (de)
DE (2) DE69628783T2 (de)

Families Citing this family (202)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217911B1 (en) * 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US8226683B2 (en) * 1994-03-11 2012-07-24 Poly-Med, Inc. High strength nitrogenous caprolactone copolymers and biomedical constructs therefrom
US5773563A (en) * 1994-03-11 1998-06-30 Poly-Med, Inc. Absorbable ε-caprolactone polymers
GB9406094D0 (en) * 1994-03-28 1994-05-18 Univ Nottingham And University Polymer microspheres and a method of production thereof
US5618850A (en) 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6551610B2 (en) * 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
FR2741628B1 (fr) * 1995-11-29 1998-02-06 Centre Nat Rech Scient Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
WO1997022371A1 (en) * 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
AU737078C (en) * 1996-05-24 2002-05-02 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
US6696499B1 (en) 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5989399A (en) * 1996-09-04 1999-11-23 The Research Foundation Of State University Of New York Effective surface treatment for a new separation medium in electrophoresis
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US6495579B1 (en) * 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6515016B2 (en) * 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
WO1998029506A1 (en) 1996-12-31 1998-07-09 Kimberly-Clark Worldwide, Inc. Water-responsive polymer compositions and method of making the same
US6251419B1 (en) * 1997-04-22 2001-06-26 Hans Georg Graber Membrane system for controlled tissue regeneration in cases of diseases of the periodontium
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
AU8588898A (en) 1997-07-28 1999-02-16 Mary L. Redmond Composition and process for the treatment of epidermal traumas such as decubitusulcers
US5945480A (en) * 1997-07-31 1999-08-31 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method for making the fibers
US5952433A (en) * 1997-07-31 1999-09-14 Kimberly-Clark Worldwide, Inc. Modified polyactide compositions and a reactive-extrusion process to make the same
US6552162B1 (en) 1997-07-31 2003-04-22 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same
US6316522B1 (en) * 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
PT1034207E (pt) * 1997-10-03 2005-07-29 Macromed Inc Copolimeros tribloco de poli(lactido-co-glicolido) e polietilenoglicol, de baixo peso molecular, biodegradaveis, com propriedades de gelificacao termica inversa
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
WO1999038535A1 (en) 1998-01-29 1999-08-05 Kinerton Limited Process for making absorbable microparticles
JP3842042B2 (ja) * 1998-01-29 2006-11-08 ポリ−メド・インコーポレーテッド 吸収可能なマイクロ粒子
DE69925775T2 (de) 1998-04-06 2006-04-27 Ethicon, Inc. Thermisch verformbare biokompatible absorbierbare polymere Zwei-Phasen-Matrix für den Einsatz bei medizinischen Vorrichtungen
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
CA2332978A1 (en) 1998-05-23 1999-12-02 Stephen J. Herman Method of treatment for premature rupture of membranes in pregnancy (prom)
US6350518B1 (en) 1998-06-01 2002-02-26 Kimberly-Clark Worldwide, Inc. Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer
AU2763099A (en) 1998-06-22 2000-01-10 Charles E. Worden Enriched platelet wound healant
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US20040043068A1 (en) * 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6255408B1 (en) 1998-11-06 2001-07-03 Poly-Med, Inc. Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof
US6299631B1 (en) 1998-11-12 2001-10-09 Poly-Med, Inc. Polyester/cyanoacrylate tissue adhesive formulations
US7351426B2 (en) * 1998-11-12 2008-04-01 Poly-Med, Inc. Polyester/cyanoacrylate tissue adhesive compositions
US7083634B2 (en) * 1998-11-12 2006-08-01 Poly Med Inc Stabilized polyester/cyanoacrylate tissue adhesive formulation
US6113922A (en) * 1998-11-13 2000-09-05 Swenson; Russell H. Compositions expressing a pressure of carbon dioxide for improved healing of wounds
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
JP2002537415A (ja) * 1999-02-19 2002-11-05 バイオサルフ アーゲー マイクロカプセルの製造のための生物分解性複合材料
ES2243232T3 (es) * 1999-02-23 2005-12-01 Angiotech International Ag Composiciones y metodos para mejorar la integridad de cavidades y vias corporales comprometidas.
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6423818B1 (en) * 1999-07-30 2002-07-23 Takehisa Matsuda Coumarin endcapped absorbable polymers
US6462169B1 (en) 1999-11-30 2002-10-08 Poly-Med, Inc. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
KR100416242B1 (ko) 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US6740100B2 (en) * 1999-12-23 2004-05-25 Omeros Corporation Tendon repair using adhesive
ES2280270T3 (es) 1999-12-28 2007-09-16 Kimberly-Clark Worldwide, Inc. Sistema indicador dependiente de la utilizacion para articulos absorbentes.
IL149752A0 (en) 1999-12-28 2002-11-10 Kimberly Clark Co Controlled release anti-microbial wipe for hard surfaces
US6514306B1 (en) * 2000-01-27 2003-02-04 Honeywell International Inc. Anti-microbial fibrous media
WO2001056533A2 (en) 2000-02-07 2001-08-09 Omeros Corporation Soft tissue repair system
US6309810B1 (en) 2000-06-13 2001-10-30 Eastman Kodak Company Photochemical delivery article and method of use
US6361225B1 (en) 2000-06-13 2002-03-26 Eastman Kodak Company Apparatus for providing a photochemical reaction
US6296993B1 (en) 2000-06-13 2001-10-02 Eastman Kodak Company Method of providing digitized photographic image
US6794485B2 (en) 2000-10-27 2004-09-21 Poly-Med, Inc. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US20020161168A1 (en) 2000-10-27 2002-10-31 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US8299205B2 (en) 2000-10-27 2012-10-30 Poly-Med, Inc. Acetone-soluble, absorbable, crystalline polyaxial copolymers and applications thereof
US7416559B2 (en) 2000-10-27 2008-08-26 Poly-Med, Inc. Micromantled drug-eluting stent
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US6685956B2 (en) 2001-05-16 2004-02-03 The Research Foundation At State University Of New York Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications
US20030124149A1 (en) * 2001-07-06 2003-07-03 Shalaby Shalaby W. Bioactive absorbable microparticles as therapeutic vaccines
JP2005504813A (ja) * 2001-09-24 2005-02-17 メドトロニック・エイヴイイー・インコーポレーテッド 合理的薬剤療法デバイス及び方法
US6699940B2 (en) 2001-12-04 2004-03-02 Poly Med, Inc. Cyanoacrylate-capped heterochain polymers and tissue adhesives and sealants therefrom
US20030199917A1 (en) * 2002-04-22 2003-10-23 Knudson Mark B. Thrombus treatment with emboli management
WO2003090807A1 (en) * 2002-04-24 2003-11-06 Poly-Med, Inc. Multifaceted endovascular stent coating for preventing restenosis
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US6945448B2 (en) * 2002-06-18 2005-09-20 Zimmer Technology, Inc. Method for attaching a porous metal layer to a metal substrate
US7918382B2 (en) 2002-06-18 2011-04-05 Zimmer Technology, Inc. Method for attaching a porous metal layer to a metal substrate
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
ATE416795T1 (de) * 2002-09-26 2008-12-15 Angiotech Int Ag Perivaskuläre hüllen
AU2003274419A1 (en) * 2002-10-31 2004-05-25 Pfizer Products Inc. Liquid conjugates of solid pharmaceuticals
US20040236415A1 (en) * 2003-01-02 2004-11-25 Richard Thomas Medical devices having drug releasing polymer reservoirs
US20040166088A1 (en) * 2003-01-15 2004-08-26 Shalaby Shalaby W. Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
BR122018074353B8 (pt) 2003-01-28 2021-07-27 Ironwood Pharmaceuticals Inc composição farmacêutica, polipeptídeo e métodos para a produção dos mesmos
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20040151691A1 (en) 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US20040243224A1 (en) * 2003-04-03 2004-12-02 Medtronic Vascular, Inc. Methods and compositions for inhibiting narrowing in mammalian vascular pathways
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US20050090905A1 (en) * 2003-10-23 2005-04-28 Hawkins Michael E. Porous implant with a dried, lubricious when wet, in vivo absorbable coating
ATE551339T1 (de) 2003-11-05 2012-04-15 Sarcode Bioscience Inc Modulatoren der zellulären adhäsion
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US20050149174A1 (en) * 2003-12-18 2005-07-07 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050154455A1 (en) * 2003-12-18 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050154451A1 (en) * 2003-12-18 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050137683A1 (en) * 2003-12-19 2005-06-23 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050154452A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050152940A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050152943A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050152942A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050159809A1 (en) * 2004-01-21 2005-07-21 Medtronic Vascular, Inc. Implantable medical devices for treating or preventing restenosis
US20050272153A1 (en) * 2004-01-27 2005-12-08 Zou Xuenong Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
US20050197691A1 (en) * 2004-02-18 2005-09-08 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US7220800B2 (en) * 2004-04-02 2007-05-22 Adherent Laboratories, Inc. Water soluble contact lens blocking composition with absorbent disintegrant
US7138459B2 (en) * 2004-04-02 2006-11-21 Adherent Laboratories, Inc. Water soluble contact lens blocking composition
US20050228490A1 (en) * 2004-04-09 2005-10-13 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
KR100974733B1 (ko) * 2004-04-28 2010-08-06 안지오디바이스 인터내셔널 게엠베하 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및이와 관련된 제조 및 사용 방법
US20050261762A1 (en) * 2004-05-21 2005-11-24 Medtronic Vascular, Inc. Medical devices to prevent or inhibit restenosis
WO2006026325A2 (en) * 2004-08-26 2006-03-09 Pathak Chandrashekhar P Implantable tissue compositions and method
US8303973B2 (en) 2004-09-17 2012-11-06 Angiotech Pharmaceuticals (Us), Inc. Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
US20060062822A1 (en) * 2004-09-21 2006-03-23 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20060088571A1 (en) * 2004-10-21 2006-04-27 Medtronic Vascular, Inc. Biocompatible and hemocompatible polymer compositions
EP1679065A1 (de) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Zubereitung mit kontrollierter Freisetzung von Interferon auf PEGT/PBT-Block-Copolymer-Basis
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US7790216B2 (en) * 2005-04-19 2010-09-07 Zimmer Technology, Inc. Method for producing a zirconia-layered orthopedic implant component
SI1881823T1 (sl) 2005-05-17 2015-04-30 Sarcode Bioscience Inc. Sestavki in postopki za zdravljenje bolezni oäśesa
US8927001B2 (en) * 2005-06-15 2015-01-06 Poly-Med, Inc. Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof
US8784861B2 (en) * 2005-06-15 2014-07-22 Poly-Med, Inc. Swellable fiber- and microfiber-forming polyether-esters and applications thereof
US20070027530A1 (en) * 2005-07-26 2007-02-01 Medtronic Vascular, Inc. Intraluminal device, catheter assembly, and method of use thereof
US20070067020A1 (en) * 2005-09-22 2007-03-22 Medtronic Vasular, Inc. Intraluminal stent, delivery system, and a method of treating a vascular condition
US20070073328A1 (en) * 2005-09-26 2007-03-29 Wilson-Cook Medical Inc., Incrementally expandable balloon
EP3566742A1 (de) 2005-10-13 2019-11-13 Synthes GmbH Wirkstoffimprägnierte hülle
US8288477B2 (en) 2005-12-06 2012-10-16 Tyco Healthcare Group Lp Bioabsorbable compounds and compositions containing them
FR2896057A1 (fr) * 2006-01-12 2007-07-13 St Microelectronics Sa Procede et dispositif de generation d'un nombre aleatoire dans un peripherique usb
EP1976459A4 (de) * 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Poröses knochenimplantat
US20070231361A1 (en) * 2006-03-28 2007-10-04 Medtronic Vascular, Inc. Use of Fatty Acids to Inhibit the Growth of Aneurysms
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
JP2008069324A (ja) * 2006-09-15 2008-03-27 Mitsui Chemicals Inc 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体
JP5019851B2 (ja) * 2006-11-09 2012-09-05 学校法人 関西大学 温度応答性ゾル−ゲル転移を示す生分解性ポリマー及びその製造方法
US20090081312A1 (en) * 2007-03-26 2009-03-26 Block James C Prevention and treatment of alveolar osteitis
US20080241795A1 (en) * 2007-03-26 2008-10-02 Block James C Prevention and treatment of alveolar osteitis
US20080241270A1 (en) * 2007-03-30 2008-10-02 Neal Robert A Fluid composition for inhibiting surgical adhesion formation and related method of production
CN201075472Y (zh) * 2007-05-28 2008-06-18 富士康(昆山)电脑接插件有限公司 电连接器
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (zh) 2007-06-04 2013-11-13 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8790345B2 (en) * 2007-08-21 2014-07-29 Zimmer, Inc. Titanium alloy with oxidized zirconium for a prosthetic implant
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
CA3105972A1 (en) * 2007-10-19 2009-04-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
US7862538B2 (en) * 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
EP2095832A1 (de) 2008-02-28 2009-09-02 Bayer MaterialScience AG Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile.
US8952075B2 (en) * 2008-05-22 2015-02-10 Poly-Med, Inc. Bioactive polymeric liquid formulations of absorbable, segmented aliphatic polyurethane compositions
US8745133B2 (en) * 2008-03-28 2014-06-03 Yahoo! Inc. System and method for optimizing the storage of data
CN102065893A (zh) * 2008-04-15 2011-05-18 萨可德公司 Lfa-1拮抗剂向胃肠系统的递送
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9492593B2 (en) 2008-09-24 2016-11-15 Poly-Med, Inc. Absorbable, permeability-modulated barrier composites and applications thereof
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) * 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
CA2750242C (en) 2009-02-12 2018-05-22 Incept, Llc Drug delivery through hydrogel plugs
US8383140B2 (en) * 2009-04-03 2013-02-26 Poly-Med, Inc. Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions
CA2977830C (en) * 2009-05-04 2019-09-17 Incept, Llc Biomaterials for track and puncture closure
WO2011050175A1 (en) * 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
CN103635446B (zh) 2011-05-04 2016-02-03 巴兰斯医疗公司 戊四唑衍生物
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8936784B2 (en) 2011-10-17 2015-01-20 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
KR20190090048A (ko) 2011-12-05 2019-07-31 인셉트, 엘엘씨 의료용 유기젤 방법 및 조성물
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
EP2612846A1 (de) 2012-01-09 2013-07-10 Bayer MaterialScience AG Beta-Aminosäureester und deren Verwendung
EP2634179A1 (de) * 2012-02-28 2013-09-04 Sanofi Funktionale PLA-PEG-Copolymere, Nanopartikel, Herstellung und Verwendung zur gezielten Arzneimittelabgabe und Abbildung
CN104185480B (zh) 2012-03-28 2016-04-20 东丽株式会社 生物降解性材料以及生物降解性材料的制造方法
WO2013146999A1 (ja) 2012-03-28 2013-10-03 東レ株式会社 生分解性材料及び生分解性材料の製造方法
EP2877465A4 (de) 2012-07-25 2016-05-11 Sarcode Bioscience Inc Lfa-1-hemmer und polymorph davon
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
JP2016519130A (ja) 2013-05-02 2016-06-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 治療ペプチド
CN105555328B (zh) 2013-06-21 2019-01-11 德普伊新特斯产品公司 膜及制造方法
CA2926691A1 (en) 2013-10-10 2015-04-16 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
US10653401B2 (en) * 2014-08-11 2020-05-19 Smith & Nephew, Inc. Medical device for repairing soft tissue and method of using same
WO2016094594A1 (en) 2014-12-09 2016-06-16 Sweetwater Energy, Inc. Rapid pretreatment
US10155063B2 (en) 2015-11-12 2018-12-18 University Of Virginia Patent Foundation Methods for vas-occlusive contraception and reversal thereof
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
EP3402804A1 (de) 2016-01-11 2018-11-21 Synergy Pharmaceuticals Inc. Formulierungen und verfahren zur behandlung von colitis ulcerosa
KR102126984B1 (ko) * 2016-07-25 2020-06-26 주식회사 삼양바이오팜 생분해성 고분자의 정제 방법
US20180028715A1 (en) 2016-07-27 2018-02-01 Contraline, Inc. Carbon-based compositions useful for occlusive medical devices and methods of making and using them
US10751124B2 (en) 2017-01-05 2020-08-25 Contraline, Inc. Methods for implanting and reversing stimuli-responsive implants
EP3583223A4 (de) 2017-02-16 2020-12-23 Sweetwater Energy, Inc. Hochdruckzonenbildung zur vorbehandlung
EP3375452A1 (de) 2017-03-16 2018-09-19 Evangelos Andreakos Verwendung von lambda-interferonen bei der behandlung von störungen und verwandten erkrankungen
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
US20200268893A1 (en) * 2017-06-30 2020-08-27 Poly-Med, Inc. In-situ gel-forming delivery systems, methods and compositions
WO2020102234A1 (en) 2018-11-13 2020-05-22 Contraline, Inc. Systems and methods for delivering biomaterials
EP4077490A1 (de) 2019-12-22 2022-10-26 Sweetwater Energy, Inc. Verfahren zum herstellen spezialisierter lignin- und ligninprodukte aus biomasse
CN117511851B (zh) * 2024-01-03 2024-03-26 中国肉类食品综合研究中心 水凝胶支架在细胞培育肉制备中的应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2991766A (en) * 1960-03-04 1961-07-11 Gen Motors Corp Air injection system for an internal combustion engine
US3991766A (en) * 1973-05-31 1976-11-16 American Cyanamid Company Controlled release of medicaments using polymers from glycolic acid
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4209607A (en) * 1978-05-12 1980-06-24 Ethicon, Inc. Polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
US4226243A (en) * 1979-07-27 1980-10-07 Ethicon, Inc. Surgical devices of polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
US4369229A (en) * 1981-01-29 1983-01-18 The Kendall Company Composite hydrogel-forming article and method of making same
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
EP0092918B1 (de) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US5385738A (en) * 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
JPH0778017B2 (ja) * 1985-12-28 1995-08-23 住友製薬株式会社 パルス的かつ持続放出性製剤
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5135752A (en) * 1988-10-14 1992-08-04 Zetachron, Inc. Buccal dosage form
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
EP0374531B1 (de) * 1988-12-22 1994-05-04 American Cyanamid Company Verfahren zur Behandlung von Periodontitis durch protrahierte Wirkstoffabgabe von Arzneimitteln in der Zahnhöhle, Zusammensetzung davon und Vorrichtung zur Verabreichung
US5171148A (en) * 1989-06-30 1992-12-15 Ethicon, Inc. Dental inserts for treatment of periodontal disease
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US4994277A (en) * 1989-10-31 1991-02-19 Pfizer Hospital Products Group, Inc. Use of xanthan gum for preventing adhesions
US5093319A (en) * 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5366756A (en) * 1992-06-15 1994-11-22 United States Surgical Corporation Method for treating bioabsorbable implant material
GB2280850B (en) * 1993-07-28 1997-07-30 Johnson & Johnson Medical Absorbable composite materials for use in the treatment of periodontal disease
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
GB9412273D0 (en) * 1994-06-18 1994-08-10 Univ Nottingham Administration means
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof

Also Published As

Publication number Publication date
CA2174072C (en) 2003-05-27
JP3107514B2 (ja) 2000-11-13
CA2174072A1 (en) 1996-10-14
AU5056196A (en) 1996-10-31
EP0737703B1 (de) 2003-06-25
US5612052A (en) 1997-03-18
DE737703T1 (de) 1997-05-15
EP0737703A3 (de) 1998-10-28
JPH09100343A (ja) 1997-04-15
EP0737703A2 (de) 1996-10-16
AU685357B2 (en) 1998-01-15
ATE243720T1 (de) 2003-07-15
US5714159A (en) 1998-02-03
DE69628783T2 (de) 2004-04-29

Similar Documents

Publication Publication Date Title
DE69628783D1 (de) Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung
DE69929278D1 (de) Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung
CA2235919A1 (en) Non-polymeric sustained release delivery system
DK0790823T3 (da) Lægemiddelafgivende kirurgisk implantat eller forbindingsmateriale
SE9804183D0 (sv) Biocompatible glue
IE812025L (en) Composition for treating osteitis
DK1125577T3 (da) Væskeformige medikamentindföringspræparater
AR020055A1 (es) Una composicion farmaceutica o cosmetica que contiene una sustancia de esmalte activa, usos de dicha composicion y un metodo para preparar la misma.
ES2166783T3 (es) Factor viii activado utilizado como agente terapeutico y metodo para el tratamiento de la deficiencia de factor viii.
BR0008787A (pt) Sistema à base de colágeno injetável para aplicação de células ou agentes terapêuticos
ATE316779T1 (de) Implantate zur gesteuerten freisetzung von pharmazeutischen wirkstoffen und verfahren zur herstellung
NO20004282D0 (no) Matriksproteinpreparater for sÕrheling
BR9406059A (pt) Composição farmacéutica e método para tratamento de uma infecção helmintica em um animal
DE69426530D1 (de) Pharmazeutische zusammensetzung zur förderung der gewebeheilung und -regenerierung und darreichungssatz
PT841939E (pt) Agentes terapeuticos e doencas auto-imunes
Jean et al. Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses
DK0821969T3 (da) Medicinsk sammensætning omfattende TCF-II
HK1036593A1 (en) Use of oxazolidinones in the manufacture of a medicament for treating non-topical infections.
RU2339399C2 (ru) Способ лечения ран мягких тканей
Herman et al. Congenital aplasia cutis: nonsurgical treatment with a synthetic skin substitute
UA30310A (uk) Спосіб лікування механічної жовтяниці у експериментальних тварин
UA39244A (uk) Спосіб апендектомії
UA29707A (uk) Спосіб відновлення кісткових тканин при переломах
IT1275987B1 (it) Composizione farmaceutica attiva nella cura di affezioni dermatologiche

Legal Events

Date Code Title Description
8364 No opposition during term of opposition