DE69629114D1 - Ionisches molekularkonjugat von n-acylierten poly(2-amino-2deoxy-d-glucose) und polypeptide-derivaten - Google Patents

Ionisches molekularkonjugat von n-acylierten poly(2-amino-2deoxy-d-glucose) und polypeptide-derivaten

Info

Publication number
DE69629114D1
DE69629114D1 DE69629114T DE69629114T DE69629114D1 DE 69629114 D1 DE69629114 D1 DE 69629114D1 DE 69629114 T DE69629114 T DE 69629114T DE 69629114 T DE69629114 T DE 69629114T DE 69629114 D1 DE69629114 D1 DE 69629114D1
Authority
DE
Germany
Prior art keywords
2deoxy
glucose
amino
polypeptide derivatives
molecular conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69629114T
Other languages
English (en)
Other versions
DE69629114T2 (de
Inventor
Shalaby W Shalaby
Steven A Jackson
Francis Ignatious
Jeaques-Pierre Moreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Manufacturing Ireland Ltd
Original Assignee
Kinerton Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinerton Ltd filed Critical Kinerton Ltd
Publication of DE69629114D1 publication Critical patent/DE69629114D1/de
Application granted granted Critical
Publication of DE69629114T2 publication Critical patent/DE69629114T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69629114T 1995-06-06 1996-05-24 Ionisches molekularkonjugat von n-acylierten poly(2-amino-2deoxy-d-glucose) und polypeptide-derivaten Expired - Fee Related DE69629114T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/468,947 US5665702A (en) 1995-06-06 1995-06-06 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US468947 1995-06-06
PCT/US1996/007756 WO1996039160A1 (en) 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Publications (2)

Publication Number Publication Date
DE69629114D1 true DE69629114D1 (de) 2003-08-21
DE69629114T2 DE69629114T2 (de) 2004-04-22

Family

ID=23861854

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69629114T Expired - Fee Related DE69629114T2 (de) 1995-06-06 1996-05-24 Ionisches molekularkonjugat von n-acylierten poly(2-amino-2deoxy-d-glucose) und polypeptide-derivaten

Country Status (21)

Country Link
US (2) US5665702A (de)
EP (1) EP0830137B1 (de)
JP (1) JPH11508289A (de)
KR (1) KR19990022399A (de)
CN (1) CN1192152A (de)
AT (1) ATE245031T1 (de)
AU (1) AU717188B2 (de)
BR (1) BR9609031A (de)
CA (1) CA2222995C (de)
CZ (1) CZ391697A3 (de)
DE (1) DE69629114T2 (de)
DK (1) DK0830137T3 (de)
ES (1) ES2201188T3 (de)
HU (1) HUP9901627A3 (de)
NZ (1) NZ308909A (de)
PL (1) PL323735A1 (de)
PT (1) PT830137E (de)
RU (1) RU2172323C2 (de)
SI (1) SI9620090A (de)
SK (1) SK168397A3 (de)
WO (1) WO1996039160A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6479457B2 (en) * 1995-06-06 2002-11-12 Kinerton Limited Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
PL193111B1 (pl) * 1998-01-29 2007-01-31 Poly Med Inc Związana mikrocząstka, otoczona mikrocząstka zawierająca co najmniej jedną związaną mikrocząstkę, kompozycja farmaceutyczna zawierająca związaną mikrocząstkę lub otoczoną mikrocząstkę oraz sposób wytwarzania otoczonej mikrocząstki
DE69907870T2 (de) 1998-01-29 2004-03-04 Kinerton Ltd., Blanchardstown Verfahren zur herstellung von absorbierbaren mikropartikeln
CZ303120B6 (cs) 1998-12-07 2012-04-11 Societe De Conseils De Recherches Et Dapplications Scientifiques S. A. Sloucenina a farmaceutický prostredek
JP4532618B2 (ja) * 1999-02-25 2010-08-25 株式会社グライコメディクス 新規糖鎖プライマー
US7037889B2 (en) 2000-09-13 2006-05-02 Praecis Pharmaceuticals Inc. Pharmaceutical compositions for sustained drug delivery
US7122622B2 (en) * 2002-04-16 2006-10-17 Biosynthema Inc. Peptide compounds having improved binding affinity to somatostatin receptors
US7244445B2 (en) 2002-07-29 2007-07-17 Poly Med, Inc Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
CA2504345A1 (en) * 2002-10-31 2004-05-13 Pfizer Products Inc. Liquid conjugates of solid pharmaceuticals
US9221867B2 (en) 2003-01-06 2015-12-29 Angiochem Inc. Method for transporting a compound across the blood-brain barrier
ES2393335T3 (es) 2003-12-16 2012-12-20 Ipsen Pharma Análogos de GLP-1
EP1915167A4 (de) 2005-07-08 2010-04-07 Ipsen Pharma Melanocortinrezeptorliganden
EP2471555A3 (de) 2005-07-15 2012-10-17 Angiochem Inc. Verwendung von Aprotininpolypeptiden als Träger in pharmazeutischen Konjugaten
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2650006A1 (de) 2007-09-07 2013-10-16 Ipsen Pharma S.A.S. Analoga von Exendin-4 und Exendin-3
AU2008325194B2 (en) 2007-11-05 2012-04-19 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Use melanocortins to treat insulin sensitivity
US8841440B2 (en) * 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
RU2509809C2 (ru) 2008-07-04 2014-03-20 Транслэшионал Кэнсэр Драгз Фарма, С.Л. Способы лечения и диагностики рака
AU2009280012B2 (en) 2008-08-07 2012-12-06 Ipsen Pharma S.A.S. Truncated analogues of glucose-dependent insulinotropic polypeptide
WO2010016940A2 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
CA2733006A1 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal
US8828925B2 (en) 2008-10-15 2014-09-09 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
EP2346906A4 (de) 2008-10-15 2013-04-24 Angiochem Inc Konjugate aus glp-1-agonisten und ihre verwendung
JP5759379B2 (ja) 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド ニューロテンシンまたはニューロテンシンアナログおよびその使用
BRPI0922611A2 (pt) 2008-12-17 2018-11-06 Angiochem Inc inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos
US20110293562A1 (en) 2009-02-12 2011-12-01 Proyecto De Biomedicina Cima, S.L. Use of cardiotrophin-1 for the treatment of metabolic diseases
EP2448965A4 (de) 2009-07-02 2015-02-11 Angiochem Inc Multimerpeptid-konjugate und deren verwendungen
US8759299B2 (en) 2009-07-22 2014-06-24 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59
US9415012B2 (en) * 2011-06-14 2016-08-16 Ipsen Pharma S.A.S. Sustained-release composition containing peptides as active ingredient
US9962401B2 (en) * 2011-09-27 2018-05-08 Purdue Research Foundation Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles
EP3307326B9 (de) 2015-06-15 2021-02-24 Angiochem Inc. Verfahren zur behandlung von leptomeningealer karzinomatose

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS63258579A (ja) * 1987-04-15 1988-10-26 Fuji Boseki Kk 生理活性物質固定化用担体の製造法
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
EP0544000B1 (de) * 1990-08-17 1997-05-02 Drug Delivery System Institute, Ltd. N-acetylcarboxymethylchitosanderivat und verfahren zur herstellung
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release

Also Published As

Publication number Publication date
CA2222995C (en) 2005-05-10
CZ391697A3 (cs) 1998-05-13
SI9620090A (sl) 1998-08-31
HUP9901627A1 (hu) 1999-09-28
EP0830137A1 (de) 1998-03-25
BR9609031A (pt) 1999-12-14
CA2222995A1 (en) 1996-12-12
EP0830137B1 (de) 2003-07-16
EP0830137A4 (de) 2002-06-26
ATE245031T1 (de) 2003-08-15
JPH11508289A (ja) 1999-07-21
WO1996039160A1 (en) 1996-12-12
ES2201188T3 (es) 2004-03-16
AU717188B2 (en) 2000-03-23
PT830137E (pt) 2003-10-31
DE69629114T2 (de) 2004-04-22
PL323735A1 (en) 1998-04-14
US5665702A (en) 1997-09-09
NZ308909A (en) 1999-06-29
CN1192152A (zh) 1998-09-02
DK0830137T3 (da) 2003-11-03
RU2172323C2 (ru) 2001-08-20
KR19990022399A (ko) 1999-03-25
HUP9901627A3 (en) 1999-11-29
AU5878996A (en) 1996-12-24
SK168397A3 (en) 1998-04-08
US5821221A (en) 1998-10-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: IPSEN MANUFACTURING IRELAND LTD., BLANCHARDSTOWN,

8339 Ceased/non-payment of the annual fee