DE69631014D1 - Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix-metallproteinase - Google Patents

Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix-metallproteinase

Info

Publication number
DE69631014D1
DE69631014D1 DE69631014T DE69631014T DE69631014D1 DE 69631014 D1 DE69631014 D1 DE 69631014D1 DE 69631014 T DE69631014 T DE 69631014T DE 69631014 T DE69631014 T DE 69631014T DE 69631014 D1 DE69631014 D1 DE 69631014D1
Authority
DE
Germany
Prior art keywords
fibrinolytic
fibrin
matrix metal
fibrinogen degradation
metal proteinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69631014T
Other languages
English (en)
Other versions
DE69631014T2 (de
Inventor
Alessandra Bini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center Inc
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Publication of DE69631014D1 publication Critical patent/DE69631014D1/de
Application granted granted Critical
Publication of DE69631014T2 publication Critical patent/DE69631014T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69631014T 1995-05-17 1996-05-17 Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix-metallproteinase Expired - Fee Related DE69631014T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US446887 1995-05-17
US08/446,887 US5830468A (en) 1995-05-17 1995-05-17 Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
PCT/US1996/007188 WO1996036227A1 (en) 1995-05-17 1996-05-17 Fibrin(ogen) degradation and clot lysis by fibrinolytic matrix metalloproteinase

Publications (2)

Publication Number Publication Date
DE69631014D1 true DE69631014D1 (de) 2004-01-22
DE69631014T2 DE69631014T2 (de) 2004-09-16

Family

ID=23774197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631014T Expired - Fee Related DE69631014T2 (de) 1995-05-17 1996-05-17 Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix-metallproteinase

Country Status (9)

Country Link
US (2) US5830468A (de)
EP (1) EP0771146B1 (de)
JP (1) JPH10506925A (de)
AT (1) ATE255904T1 (de)
AU (1) AU6145396A (de)
CA (1) CA2194692A1 (de)
DE (1) DE69631014T2 (de)
ES (1) ES2212802T3 (de)
WO (1) WO1996036227A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817768A (en) * 1995-06-07 1998-10-06 The New York Blood Center, Inc. Monospecific antibodies against a subunit of fibrinogen
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
AU4344800A (en) * 1999-04-16 2000-11-02 New York Blood Center, Inc., The Monoclonal antibodies reactive with fibrin(ogen) degradation products generated by matrix metalloproteinases
US7063838B1 (en) 1999-09-24 2006-06-20 Proteon Therapeutics Llc Methods for treating an artery or vein in a human subject
US7632494B2 (en) * 1999-09-24 2009-12-15 Proteon Therapeutics, Inc. Methods for enlarging the diameter of a biological conduit in a human subject
DK1923068T3 (da) * 1999-09-24 2011-06-27 Proteon Therapeutics Inc Systemer og fremgangsmåder til åbning af blokerede biologiske kanaler
US6440414B1 (en) * 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) * 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
EA007654B1 (ru) * 1999-12-17 2006-12-29 Эмджен Инк. Способ лечения закупорки стационарного катетера с использованием фибринолитических металлопротеиназ
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
EP1425390B1 (de) * 2001-08-13 2012-02-01 University of Florida Research Foundation, Inc. Material und verfahren zur förderung der reparatur von nervengewebe
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
ES2335167B1 (es) * 2007-02-26 2011-01-24 Proyecto De Biomedicina Cima, S.L. Uso de la metaloproteinasa de matriz-10 (mmp10) para tratamientos tromboliticos.
ES2313841B1 (es) * 2007-06-26 2010-01-12 Proyecto De Biomedicina Cima, S.L. Composiciones para tratamiento anti-fibrinolitico.
WO2013165304A1 (en) 2012-04-30 2013-11-07 Yo Proteins Ab Methods for modification of tissues
US11045589B2 (en) 2017-09-22 2021-06-29 Becton, Dickinson And Company 4% trisodium citrate solution for use as a catheter lock solution

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54157816A (en) * 1978-05-27 1979-12-13 Unitika Ltd Fixing of bioactive substance to solid surface
US4610879A (en) * 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
US4813538A (en) * 1987-03-19 1989-03-21 Blackman Seymour N Re-usable sterile parenteral fluid medication administration kit
US5130143A (en) * 1988-11-04 1992-07-14 The Research Foundation Of State University Of New York Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy
SE462829B (sv) * 1989-01-10 1990-09-10 Kabigen Ab Trombolytiskt aktiva kompositioner innehaallande en modifierad plasminogenaktivator av vaevnadstyp samt en normal human t-pa, streptokinas eller humant urokinas
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
US5260060A (en) * 1991-08-09 1993-11-09 University Of Southern California Fibrinolytic enzymes
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer

Also Published As

Publication number Publication date
DE69631014T2 (de) 2004-09-16
EP0771146B1 (de) 2003-12-10
AU6145396A (en) 1996-11-29
US5922322A (en) 1999-07-13
WO1996036227A1 (en) 1996-11-21
ES2212802T3 (es) 2004-08-01
JPH10506925A (ja) 1998-07-07
ATE255904T1 (de) 2003-12-15
EP0771146A1 (de) 1997-05-07
US5830468A (en) 1998-11-03
EP0771146A4 (de) 2002-08-07
CA2194692A1 (en) 1996-11-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee