DE69636728D1 - Neues protein und verfahren zu dessen herstellung - Google Patents

Neues protein und verfahren zu dessen herstellung

Info

Publication number
DE69636728D1
DE69636728D1 DE69636728A DE69636728A DE69636728D1 DE 69636728 D1 DE69636728 D1 DE 69636728D1 DE 69636728 A DE69636728 A DE 69636728A DE 69636728 A DE69636728 A DE 69636728A DE 69636728 D1 DE69636728 D1 DE 69636728D1
Authority
DE
Germany
Prior art keywords
protein
seq
purifying
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636728A
Other languages
English (en)
Other versions
DE69636728T4 (de
DE69636728T2 (de
Inventor
Fusao Makishima
Hiroyuki Takamatsu
Hideo Miki
Shinji Kawai
Michio Kimura
Tomoaki Matsumoto
Mieko Katsuura
Koichi Enomoto
Yusuke Satoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Original Assignee
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH filed Critical Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Application granted granted Critical
Publication of DE69636728D1 publication Critical patent/DE69636728D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69636728A 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung Expired - Lifetime DE69636728D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9366495 1995-04-19
JP32240395 1995-11-17
PCT/JP1996/001062 WO1996033215A1 (fr) 1995-04-19 1996-04-19 Proteine nouvelle et son procede de fabrication

Publications (1)

Publication Number Publication Date
DE69636728D1 true DE69636728D1 (de) 2007-01-04

Family

ID=26434967

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69636728A Expired - Lifetime DE69636728D1 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung
DE69636728T Expired - Lifetime DE69636728T4 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69636728T Expired - Lifetime DE69636728T4 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung

Country Status (18)

Country Link
US (3) US7235527B2 (de)
EP (1) EP0955313B1 (de)
AT (1) ATE325131T1 (de)
AU (1) AU704515C (de)
BR (1) BR9608019A (de)
CA (1) CA2216741C (de)
DE (2) DE69636728D1 (de)
DK (1) DK0955313T3 (de)
EA (1) EA000582B1 (de)
ES (1) ES2258774T3 (de)
HU (1) HU225424B1 (de)
NO (1) NO321153B1 (de)
NZ (1) NZ305472A (de)
OA (1) OA10528A (de)
PL (1) PL186518B1 (de)
PT (1) PT955313E (de)
UA (1) UA46767C2 (de)
WO (1) WO1996033215A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
ATE302021T1 (de) * 1997-01-30 2005-09-15 Bioph Biotech Entw Pharm Gmbh Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52
AU6267798A (en) † 1997-02-07 1998-08-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2006104306A1 (en) * 2005-03-30 2006-10-05 Jung Moon Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
KR100775958B1 (ko) 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20060286144A1 (en) * 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
DK1948689T3 (da) 2005-11-18 2012-07-23 Bioph Biotech Entw Pharm Gmbh Højaktivitetsvækstfaktormutanter
EP1880731A1 (de) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Menschlicher Wachstums und Differenzierungsfaktor GDF-5
AU2007234612B2 (en) * 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
ES2402672T3 (es) * 2007-01-25 2013-05-07 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Uso del GDF-5 para el mejoramiento o el mantenimiento del aspecto dérmico
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
CA2695697A1 (en) 2007-08-07 2009-02-12 Advanced Technologies And Regenerative Medicine, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
JP2009106163A (ja) * 2007-10-26 2009-05-21 Kyushu Univ 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
AU2009236459B2 (en) * 2008-04-14 2013-07-25 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
US9226898B1 (en) * 2009-11-18 2016-01-05 Richard C. K. Yen Submicron particles for the treatment of radiation damage in patients
AU2011284657B2 (en) 2010-07-30 2013-11-14 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
US20220387556A1 (en) 2019-12-18 2022-12-08 Merck Patent Gmbh Use of the gdf-5 mutant for the treatment of pain and cartilage destruction

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725234A (en) * 1985-08-15 1988-02-16 Ethridge Edwin C Alveolar bone grafting process with controlled surface active ceramics
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
UA48105C2 (uk) 1992-02-12 2002-08-15 Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Вон Фармака Мбх ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ)
EP1439190A1 (de) * 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
IL110589A0 (en) 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6248554B1 (en) 1993-11-24 2001-06-19 The Procter & Gamble Company DNA sequence coding for a BMP receptor
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
ATE319823T1 (de) * 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof

Also Published As

Publication number Publication date
EA199700329A1 (ru) 1998-04-30
CA2216741C (en) 2008-01-15
HU225424B1 (en) 2006-11-28
WO1996033215A1 (fr) 1996-10-24
EP0955313B1 (de) 2006-05-03
PL186518B1 (pl) 2004-01-30
US20020102633A1 (en) 2002-08-01
HUP9801697A3 (en) 2000-06-28
NO974812D0 (no) 1997-10-17
NO321153B1 (no) 2006-03-27
HUP9801697A2 (hu) 1998-10-28
AU5347096A (en) 1996-11-07
EA000582B1 (ru) 1999-12-29
DE69636728T4 (de) 2007-06-28
US7268114B2 (en) 2007-09-11
MX9708011A (es) 1998-03-31
DK0955313T3 (da) 2006-08-21
UA46767C2 (uk) 2002-06-17
AU704515C (en) 2002-03-28
AU704515B2 (en) 1999-04-22
NZ305472A (en) 1999-09-29
NO974812L (no) 1997-12-19
ATE325131T1 (de) 2006-06-15
PL322945A1 (en) 1998-03-02
DE69636728T2 (de) 2007-02-22
US7235527B2 (en) 2007-06-26
US7816103B2 (en) 2010-10-19
OA10528A (en) 2002-04-26
PT955313E (pt) 2006-07-31
US20030181378A1 (en) 2003-09-25
ES2258774T3 (es) 2006-09-01
EP0955313A4 (de) 2001-11-07
US20090325864A1 (en) 2009-12-31
CA2216741A1 (en) 1996-10-24
EP0955313A1 (de) 1999-11-10
BR9608019A (pt) 1999-11-30

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Legal Events

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