DE69636728D1 - Neues protein und verfahren zu dessen herstellung - Google Patents

Neues protein und verfahren zu dessen herstellung

Info

Publication number
DE69636728D1
DE69636728D1 DE69636728A DE69636728A DE69636728D1 DE 69636728 D1 DE69636728 D1 DE 69636728D1 DE 69636728 A DE69636728 A DE 69636728A DE 69636728 A DE69636728 A DE 69636728A DE 69636728 D1 DE69636728 D1 DE 69636728D1
Authority
DE
Germany
Prior art keywords
protein
seq
purifying
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636728A
Other languages
English (en)
Other versions
DE69636728T2 (de
DE69636728T4 (de
Inventor
Fusao Makishima
Hiroyuki Takamatsu
Hideo Miki
Shinji Kawai
Michio Kimura
Tomoaki Matsumoto
Mieko Katsuura
Koichi Enomoto
Yusuke Satoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Original Assignee
Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH filed Critical Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
Application granted granted Critical
Publication of DE69636728D1 publication Critical patent/DE69636728D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69636728A 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung Expired - Lifetime DE69636728D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9366495 1995-04-19
JP32240395 1995-11-17
PCT/JP1996/001062 WO1996033215A1 (fr) 1995-04-19 1996-04-19 Proteine nouvelle et son procede de fabrication

Publications (1)

Publication Number Publication Date
DE69636728D1 true DE69636728D1 (de) 2007-01-04

Family

ID=26434967

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69636728T Expired - Lifetime DE69636728T4 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung
DE69636728A Expired - Lifetime DE69636728D1 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69636728T Expired - Lifetime DE69636728T4 (de) 1995-04-19 1996-04-19 Neues protein und verfahren zu dessen herstellung

Country Status (18)

Country Link
US (3) US7235527B2 (de)
EP (1) EP0955313B1 (de)
AT (1) ATE325131T1 (de)
AU (1) AU704515C (de)
BR (1) BR9608019A (de)
CA (1) CA2216741C (de)
DE (2) DE69636728T4 (de)
DK (1) DK0955313T3 (de)
EA (1) EA000582B1 (de)
ES (1) ES2258774T3 (de)
HU (1) HU225424B1 (de)
NO (1) NO321153B1 (de)
NZ (1) NZ305472A (de)
OA (1) OA10528A (de)
PL (1) PL186518B1 (de)
PT (1) PT955313E (de)
UA (1) UA46767C2 (de)
WO (1) WO1996033215A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
BR9807537B1 (pt) * 1997-01-30 2009-01-13 composição liofilizada de fator humano morfogenético ósseo mp52, bem como processo para sua preparação.
US6281195B1 (en) † 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
KR100775958B1 (ko) 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20070105762A1 (en) * 2005-03-30 2007-05-10 Jung Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
US20060286144A1 (en) * 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
CA2627370C (en) 2005-11-18 2016-02-23 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh High activity growth factor mutants
EP1880731A1 (de) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Menschlicher Wachstums und Differenzierungsfaktor GDF-5
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
WO2008089987A1 (en) * 2007-01-25 2008-07-31 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Use of gdf-5 for the improvement or maintenance of dermal appearance
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
WO2009020744A1 (en) 2007-08-07 2009-02-12 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
JP2009106163A (ja) * 2007-10-26 2009-05-21 Kyushu Univ 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
WO2009129101A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
US9226898B1 (en) * 2009-11-18 2016-01-05 Richard C. K. Yen Submicron particles for the treatment of radiation damage in patients
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
JP5837930B2 (ja) 2010-07-30 2015-12-24 ビオファーム・ゲゼルシャフト・ツァ・ビオテヒノロジッシェン・エントヴィックルング・フォン・ファルマカ・エムベーハー 創傷の治癒を加速する医薬送達装置及び増殖因子製剤
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
AU2020403846A1 (en) 2019-12-18 2022-08-11 Merck Patent Gmbh Use of the GDF-5 mutant for the treatment of pain and cartilage destruction

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725234A (en) * 1985-08-15 1988-02-16 Ethridge Edwin C Alveolar bone grafting process with controlled surface active ceramics
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
EP0625989B1 (de) * 1992-02-12 2000-01-19 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Dna-sequenzen kodierend für neuartige wachstums-/differentierungsfaktoren
EP0690871A4 (de) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
IL110589A0 (en) 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6248554B1 (en) 1993-11-24 2001-06-19 The Procter & Gamble Company DNA sequence coding for a BMP receptor
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
PT733109E (pt) * 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof

Also Published As

Publication number Publication date
EP0955313A1 (de) 1999-11-10
DE69636728T2 (de) 2007-02-22
US7235527B2 (en) 2007-06-26
WO1996033215A1 (fr) 1996-10-24
US7816103B2 (en) 2010-10-19
ES2258774T3 (es) 2006-09-01
US20090325864A1 (en) 2009-12-31
EA199700329A1 (ru) 1998-04-30
US20020102633A1 (en) 2002-08-01
NO974812D0 (no) 1997-10-17
ATE325131T1 (de) 2006-06-15
MX9708011A (es) 1998-03-31
HUP9801697A2 (hu) 1998-10-28
BR9608019A (pt) 1999-11-30
PL186518B1 (pl) 2004-01-30
DE69636728T4 (de) 2007-06-28
OA10528A (en) 2002-04-26
NO321153B1 (no) 2006-03-27
CA2216741A1 (en) 1996-10-24
CA2216741C (en) 2008-01-15
NO974812L (no) 1997-12-19
HUP9801697A3 (en) 2000-06-28
AU5347096A (en) 1996-11-07
PT955313E (pt) 2006-07-31
US20030181378A1 (en) 2003-09-25
NZ305472A (en) 1999-09-29
EP0955313B1 (de) 2006-05-03
US7268114B2 (en) 2007-09-11
EA000582B1 (ru) 1999-12-29
HU225424B1 (en) 2006-11-28
EP0955313A4 (de) 2001-11-07
DK0955313T3 (da) 2006-08-21
UA46767C2 (uk) 2002-06-17
PL322945A1 (en) 1998-03-02
AU704515B2 (en) 1999-04-22
AU704515C (en) 2002-03-28

Similar Documents

Publication Publication Date Title
DE69636728D1 (de) Neues protein und verfahren zu dessen herstellung
JP3762222B2 (ja) 改変型ＴＧＦ−βスーパーファミリータンパク質
AU656354B2 (en) Synthetic bioadhesive polypeptide
WO1995021919A3 (en) Protein having tpo activity
BG100236A (en) Sheared keratiocytic growth factor (kgf) of increased biological activity
CA2176942A1 (en) Bmp-12, bmp-13 and tendon-inducing compositions thereof
NO20065528L (no) Forbindelser som fremmer vevsvekst.
DE3587422D1 (de) Fuer ein hirudinaehnliches protein kodierende dns-sequenz und verfahren zur herstellung eines solchen proteins.
DE69012377T2 (de) Polypeptid und dessen Herstellung.
DE69530647D1 (de) Für biosynthetische Insulinvorstufen kodierende DNA-Sequenzen und Verfahren zur Herstellung von Insulin
CA2227204A1 (en) Human mp52 arg protein
EP0453456B1 (de) Pdgf-a, pdgf-aa, pdgf-ab, herstellungsverfahren und sie enthaltende arzneimittel
DE3767629D1 (de) Menschlicher b-zellen-differenzierungsfaktor und verfahren zu dessen herstellung.
Purchio et al. Synthesis of an active hybrid growth factor (GF) in bacteria: transforming GF-α/vaccinia GF fusion protein
MX9504057A (es) Proteina que tiene actividad tpo.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition