DE69636813D1 - Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion - Google Patents
Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren ProduktionInfo
- Publication number
- DE69636813D1 DE69636813D1 DE69636813T DE69636813T DE69636813D1 DE 69636813 D1 DE69636813 D1 DE 69636813D1 DE 69636813 T DE69636813 T DE 69636813T DE 69636813 T DE69636813 T DE 69636813T DE 69636813 D1 DE69636813 D1 DE 69636813D1
- Authority
- DE
- Germany
- Prior art keywords
- heparin
- methods
- production
- covalent conjugates
- conjugates containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/564,976 US6562781B1 (en) | 1995-11-30 | 1995-11-30 | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US564976 | 1995-11-30 | ||
PCT/CA1996/000799 WO1997019701A2 (en) | 1995-11-30 | 1996-11-29 | Glycosaminoglycan-antithrombin iii/heparin cofactor ii conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636813D1 true DE69636813D1 (de) | 2007-02-15 |
DE69636813T2 DE69636813T2 (de) | 2007-10-04 |
Family
ID=24256690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636813T Expired - Lifetime DE69636813T2 (de) | 1995-11-30 | 1996-11-29 | Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion |
Country Status (8)
Country | Link |
---|---|
US (2) | US6562781B1 (de) |
EP (1) | EP0863768B1 (de) |
JP (1) | JP4166275B2 (de) |
AT (1) | ATE350066T1 (de) |
AU (1) | AU7688396A (de) |
CA (1) | CA2237159C (de) |
DE (1) | DE69636813T2 (de) |
WO (1) | WO1997019701A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT405905B (de) * | 1997-03-25 | 1999-12-27 | Immuno Ag | Neue verwendung von antithrombin iii |
FI974321A0 (fi) | 1997-11-25 | 1997-11-25 | Jenny Ja Antti Wihurin Rahasto | Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa |
WO2000001406A1 (fr) * | 1998-07-07 | 2000-01-13 | Welfide Corporation | Utilisation medicinale du cofacteur ii de l'heparine |
WO2001005434A2 (en) * | 1999-07-20 | 2001-01-25 | Amgen Inc. | Hyaluronic acid-protein conjugates |
DE10132307A1 (de) * | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
CA2480790A1 (en) * | 2002-04-01 | 2003-10-16 | Kazunori Murakami | Use of antithrombin iii in treating acute lung injury |
EP1603601A1 (de) * | 2003-02-20 | 2005-12-14 | Hamilton Civic Hospitals Research Development, Inc. | Beschichtungszusammensetzung für polymerische oberflächen umfassend serpin und serpinderivate |
CA2535446A1 (en) * | 2003-08-12 | 2005-02-17 | Hamilton Civic Hospitals Research Development Inc. | Methods for preventing neurological events |
US7146034B2 (en) * | 2003-12-09 | 2006-12-05 | Superpower, Inc. | Tape manufacturing system |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
EP1835938B1 (de) | 2004-12-27 | 2013-08-07 | Baxter International Inc. | Polymer-von willebrand faktor-konjugate |
DK1841458T3 (da) * | 2005-01-06 | 2012-04-23 | Discovery Lab Inc | Behandlingsregime med overfladeaktivt stof til behandling eller forebyggelse af bronkopulmonal dysplasi |
US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
KR20080108147A (ko) | 2006-03-31 | 2008-12-11 | 백스터 인터내셔널 인코포레이티드 | 페질화된 인자 viii |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
EP2341941A4 (de) * | 2008-09-09 | 2014-12-10 | Univ Oklahoma | Heparosanpolymere sowie verfahren zu ihrer herstellung und verwendung zur verstärkung von therapeutika |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
ES2797649T3 (es) | 2011-07-12 | 2020-12-03 | Icu Medical Inc | Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico |
JPWO2015005459A1 (ja) * | 2013-07-10 | 2017-03-02 | 生化学工業株式会社 | 呼吸器投与用の医薬組成物 |
US10196625B2 (en) | 2013-09-30 | 2019-02-05 | Seikagaku Corporation | Method for improving blood persistence of protein |
GB201415062D0 (en) | 2014-08-26 | 2014-10-08 | Aplagon Oy | Therapeutic |
CA2960832A1 (en) * | 2014-09-18 | 2016-03-24 | Chondronest Sa | Composition containing glycosaminoglycans and proteins |
ES2828692T3 (es) * | 2015-01-09 | 2021-05-27 | Seikagaku Kogyo Co Ltd | Derivado de ácido condroitinsulfúrico y fármaco para tratar enfermedades de vejiga |
WO2016182822A1 (en) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
DK3525865T3 (da) | 2016-10-14 | 2022-10-24 | Icu Medical Inc | Desinficerende hætter til medicinsk konnektorer |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
EP3883638A1 (de) | 2018-11-21 | 2021-09-29 | ICU Medical, Inc. | Antimikrobielle vorrichtung mit einer kappe mit ring und einsatz |
EP4255552A1 (de) | 2020-12-07 | 2023-10-11 | ICU Medical, Inc. | Peritonealdialysekappen, systeme und verfahren |
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US2824092A (en) | 1955-01-04 | 1958-02-18 | Robert E Thompson | Process of preparation of a gelatincarboxymethyl cellulose complex |
US3616935A (en) | 1970-02-05 | 1971-11-02 | Dow Chemical Co | Preparation of antithrombogenic surfaces |
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SE392038B (sv) | 1971-09-08 | 1977-03-14 | Kabi Ab | Forfarande for isolering av antitrombin ur blod eller blodprodukter |
GB1479268A (en) | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
US4301153A (en) | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
JPS6040859B2 (ja) | 1977-07-27 | 1985-09-12 | 喜温 三浦 | 抗血栓性人工医療材料 |
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FR2472390A1 (fr) | 1979-05-04 | 1981-07-03 | Merieux Inst | Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus |
CA1171375A (en) | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
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-
1995
- 1995-11-30 US US08/564,976 patent/US6562781B1/en not_active Expired - Fee Related
-
1996
- 1996-11-29 WO PCT/CA1996/000799 patent/WO1997019701A2/en active IP Right Grant
- 1996-11-29 JP JP52003397A patent/JP4166275B2/ja not_active Expired - Fee Related
- 1996-11-29 AU AU76883/96A patent/AU7688396A/en not_active Abandoned
- 1996-11-29 EP EP96939779A patent/EP0863768B1/de not_active Expired - Lifetime
- 1996-11-29 DE DE69636813T patent/DE69636813T2/de not_active Expired - Lifetime
- 1996-11-29 AT AT96939779T patent/ATE350066T1/de not_active IP Right Cessation
- 1996-11-29 CA CA2237159A patent/CA2237159C/en not_active Expired - Lifetime
-
2002
- 2002-10-11 US US10/268,965 patent/US20030100487A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0863768B1 (de) | 2007-01-03 |
EP0863768A2 (de) | 1998-09-16 |
JP2000501082A (ja) | 2000-02-02 |
CA2237159C (en) | 2010-11-16 |
WO1997019701A2 (en) | 1997-06-05 |
WO1997019701A3 (en) | 1997-08-28 |
CA2237159A1 (en) | 1997-06-05 |
US20030100487A1 (en) | 2003-05-29 |
JP4166275B2 (ja) | 2008-10-15 |
ATE350066T1 (de) | 2007-01-15 |
US6562781B1 (en) | 2003-05-13 |
AU7688396A (en) | 1997-06-19 |
DE69636813T2 (de) | 2007-10-04 |
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