DE69637047D1 - Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäuren - Google Patents
Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäurenInfo
- Publication number
- DE69637047D1 DE69637047D1 DE69637047T DE69637047T DE69637047D1 DE 69637047 D1 DE69637047 D1 DE 69637047D1 DE 69637047 T DE69637047 T DE 69637047T DE 69637047 T DE69637047 T DE 69637047T DE 69637047 D1 DE69637047 D1 DE 69637047D1
- Authority
- DE
- Germany
- Prior art keywords
- detection
- extraction
- amplification
- nucleic acid
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/047—Additional chamber, reservoir
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/81—Tube, bottle, or dipstick
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88595P | 1995-07-13 | 1995-07-13 | |
US885P | 1995-07-13 | ||
PCT/US1996/011633 WO1997003348A1 (en) | 1995-07-13 | 1996-07-12 | Self-contained device integrating nucleic acid extraction, amplification and detection |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69637047D1 true DE69637047D1 (de) | 2007-06-06 |
DE69637047T2 DE69637047T2 (de) | 2007-12-27 |
Family
ID=21693436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637047T Expired - Lifetime DE69637047T2 (de) | 1995-07-13 | 1996-07-12 | Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäuren |
Country Status (8)
Country | Link |
---|---|
US (1) | US5955351A (de) |
EP (1) | EP0838025B1 (de) |
JP (1) | JPH11509100A (de) |
AT (1) | ATE360808T1 (de) |
AU (1) | AU718183B2 (de) |
CA (1) | CA2226717A1 (de) |
DE (1) | DE69637047T2 (de) |
WO (1) | WO1997003348A1 (de) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050123926A1 (en) * | 1994-01-13 | 2005-06-09 | Enzo Diagnostics, Inc., | In vitro process for producing multiple nucleic acid copies |
US20110097791A1 (en) * | 1999-04-16 | 2011-04-28 | Engelhardt Dean L | Novel process, construct and conjugate for producing multiple nucleic acid copies |
US6986985B1 (en) * | 1994-01-13 | 2006-01-17 | Enzo Life Sciences, Inc. | Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct |
US6153425A (en) * | 1995-07-13 | 2000-11-28 | Xtrana, Inc. | Self-contained device integrating nucleic acid extraction, amplification and detection |
US5989499A (en) * | 1997-05-02 | 1999-11-23 | Biomerieux, Inc. | Dual chamber disposable reaction vessel for amplification reactions |
US6429007B1 (en) | 1997-05-02 | 2002-08-06 | BIOMéRIEUX, INC. | Nucleic acid amplification reaction station for disposable test devices |
US6410275B1 (en) | 1997-05-02 | 2002-06-25 | Biomerieux, Inc. | Disposable test devices for performing nucleic acid amplification reactions |
ATE306324T1 (de) * | 1997-06-09 | 2005-10-15 | Hoffmann La Roche | Einweg-analysevorrichtung |
CA2312102C (en) | 1997-12-24 | 2007-09-04 | Cepheid | Integrated fluid manipulation cartridge |
EP1614474B1 (de) | 1998-05-01 | 2007-08-15 | Gen-Probe Incorporated | Inkubator für automatische Analysevorrichtung |
US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
US6413780B1 (en) | 1998-10-14 | 2002-07-02 | Abbott Laboratories | Structure and method for performing a determination of an item of interest in a sample |
CA2348054C (en) * | 1998-10-23 | 2012-06-19 | Qiagen Gesellschaft Mit Beschrankter Haftung | Processes and means for the isolation and purification of nucleic acids at surfaces |
US7914994B2 (en) | 1998-12-24 | 2011-03-29 | Cepheid | Method for separating an analyte from a sample |
US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
US8815521B2 (en) | 2000-05-30 | 2014-08-26 | Cepheid | Apparatus and method for cell disruption |
JP4022069B2 (ja) | 1999-05-28 | 2007-12-12 | シーフィード | 細胞破壊装置および方法 |
US9073053B2 (en) * | 1999-05-28 | 2015-07-07 | Cepheid | Apparatus and method for cell disruption |
US6159727A (en) * | 1999-06-04 | 2000-12-12 | Clontech Laboratories, Inc. | Hybridization chamber |
WO2000077253A1 (fr) * | 1999-06-16 | 2000-12-21 | Hitachi, Ltd. | Appareil et procede d'examen des genes |
US6664104B2 (en) | 1999-06-25 | 2003-12-16 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
DE19963032A1 (de) | 1999-12-24 | 2001-06-28 | Roche Diagnostics Gmbh | System zur Bearbeitung von Proben in einer Mehrkammeranordnung |
DE10006214A1 (de) | 2000-02-11 | 2001-08-16 | Roche Diagnostics Gmbh | System zur einfachen Nukleinsäureanalytik |
US20080260593A1 (en) * | 2000-03-22 | 2008-10-23 | Dewalch Norman Binz | Method and apparatus for processing substances in a single container |
AU2001249325A1 (en) * | 2000-03-22 | 2001-10-03 | Dewalch Technologies, Inc. | Method and apparatus for processing substances in a single container |
US6869532B2 (en) * | 2001-06-04 | 2005-03-22 | Cuno Incorporated | Nucleic acid binding matrix |
US20030098271A1 (en) * | 2001-11-26 | 2003-05-29 | Ralph Somack | Capsule and tray systems for combined sample collection, archiving, purification, and PCR |
US20040014097A1 (en) * | 2002-05-06 | 2004-01-22 | Mcglennen Ronald C. | Genetic test apparatus and method |
WO2004007078A1 (en) * | 2002-07-12 | 2004-01-22 | British Biocell International Limited | Lateral flow assay device and method |
US20060278242A1 (en) * | 2005-03-23 | 2006-12-14 | Mcglennen Ronald C | Apparatus and methods for medical testing |
US8594948B2 (en) * | 2002-09-18 | 2013-11-26 | Ronald C. McGlennen | Apparatus and methods for medical testing |
US7217542B2 (en) * | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
US7597936B2 (en) * | 2002-11-26 | 2009-10-06 | University Of Utah Research Foundation | Method of producing a pigmented composite microporous material |
WO2004048936A2 (en) * | 2002-11-26 | 2004-06-10 | University Of Utah Research Foundation | Microporous materials, methods, and articles for localizing and quantifying analytes |
DE102004021822B3 (de) * | 2004-04-30 | 2005-11-17 | Siemens Ag | Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien |
DE102004021780B4 (de) * | 2004-04-30 | 2008-10-02 | Siemens Ag | Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien |
US20060264714A1 (en) * | 2005-03-23 | 2006-11-23 | Mcglennen Ronald C | Apparatus and methods for medical testing |
GB0604973D0 (en) * | 2006-03-11 | 2006-04-19 | Central Science Lab Csl Of San | Purification method and kit |
US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
EP2049261B1 (de) | 2006-07-28 | 2018-07-04 | Diagnostics for the Real World, Ltd | Vorrichtung, system und verfahren zur verarbeitung einer probe |
US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
CN1888902B (zh) * | 2006-08-11 | 2011-05-18 | 杭州优思达生物技术有限公司 | 全封闭式靶核酸扩增物快速检测装置 |
US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
US7492312B2 (en) * | 2006-11-14 | 2009-02-17 | Fam Adly T | Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception |
GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
WO2009002447A1 (en) | 2007-06-21 | 2008-12-31 | Gen-Probe Incorporated | Instrument and receptacles for use in performing processes |
DE102007029772B4 (de) * | 2007-06-22 | 2011-12-08 | Aj Innuscreen Gmbh | Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen |
IL184183A0 (en) * | 2007-06-25 | 2007-10-31 | Benjamin Alspector | Bi directional transfer of an aliquot of fluid between compartments |
GB2456079B (en) | 2007-08-17 | 2010-07-14 | Diagnostics For The Real World | Device, system and method for processing a sample |
US8415141B2 (en) * | 2007-08-17 | 2013-04-09 | Qimin You | Enclosed unit for rapid detection of a target nucleic acid amplification product |
EP2207893B1 (de) | 2007-10-19 | 2011-12-28 | Becton, Dickinson and Company | Verfahren zum nachweis von beta-lactamase |
US9409166B2 (en) * | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
WO2009106838A1 (en) | 2008-02-29 | 2009-09-03 | Isis Innovation Limited | Diagnostic methods |
US9817001B2 (en) | 2008-05-27 | 2017-11-14 | Boston Heart Diagnostics Corporation | Methods for determining LDL cholesterol treatment |
US8470541B1 (en) * | 2008-09-27 | 2013-06-25 | Boston Heart Diagnostics Corporation | Methods for separation and immuno-detection of biomolecules, and apparatus related thereto |
WO2010047778A1 (en) * | 2008-10-20 | 2010-04-29 | Becton Dickinson And Company | Compositions for the detection of intracellular bacterial targets and other intracellular microorganism targets |
WO2010075025A2 (en) * | 2008-12-16 | 2010-07-01 | Shell Oil Company | Device for evaluating a heat exchange fluid |
US9121054B2 (en) * | 2009-12-08 | 2015-09-01 | Biohelix Corporation | Detection of nucleic acid amplification products in the presence of an internal control sequence on an immunochromatographic strip |
EP2596135A2 (de) | 2010-07-23 | 2013-05-29 | Beckman Coulter, Inc. | System und verfahren mit analyseeinheiten |
WO2012063877A1 (ja) * | 2010-11-09 | 2012-05-18 | 株式会社ジェイ・エム・エス | 分離容器および分離方法 |
WO2013056087A2 (en) | 2011-10-13 | 2013-04-18 | Boston Heart Diagnostics | Compositions and methods for treating and preventing coronary heart disease |
JP6165755B2 (ja) | 2011-11-07 | 2017-07-19 | ベックマン コールター, インコーポレイテッド | ロボットアーム |
JP6190380B2 (ja) | 2011-11-07 | 2017-08-30 | ベックマン コールター, インコーポレイテッド | 等分機システムおよびワークフロー |
BR112014011043A2 (pt) | 2011-11-07 | 2017-06-13 | Beckman Coulter Inc | detecção de recipiente de espécime |
WO2013070756A2 (en) | 2011-11-07 | 2013-05-16 | Beckman Coulter, Inc. | System and method for processing samples |
BR112014011046A2 (pt) | 2011-11-07 | 2017-06-13 | Beckman Coulter, Inc. | fluxo de trabalho e sistema de centrífuga |
EP2776847A1 (de) | 2011-11-07 | 2014-09-17 | Beckman Coulter, Inc. | Magnetische dämpfung für probentransportsystem |
AU2013203281A1 (en) | 2012-02-03 | 2013-08-22 | Axxin Pty Ltd | Nucleic acid amplification and detection apparatus and method |
WO2014000037A1 (en) * | 2012-06-26 | 2014-01-03 | Axxin Pty Ltd | Nucleic acid amplification and detection kit |
JP6166938B2 (ja) * | 2013-04-18 | 2017-07-19 | ローム株式会社 | マイクロチップ |
US9828624B2 (en) | 2013-07-24 | 2017-11-28 | Boston Heart Diagnostics Corporation | Driving patient compliance with therapy |
WO2015187849A2 (en) | 2014-06-04 | 2015-12-10 | Lucigen Corporation | Sample collection and analysis devices |
US10472620B2 (en) | 2014-07-01 | 2019-11-12 | General Electric Company | Method, substrate and device for separating nucleic acids |
US9593368B2 (en) | 2014-07-01 | 2017-03-14 | General Electric Company | Methods for amplifying nucleic acids on substrates |
US10870845B2 (en) | 2014-07-01 | 2020-12-22 | Global Life Sciences Solutions Operations UK Ltd | Methods for capturing nucleic acids |
ES2809600T3 (es) | 2014-11-14 | 2021-03-04 | Axxin Pty Ltd | Conjunto de recogida y almacenamiento de muestras biológicas |
CA2968221A1 (en) | 2014-11-17 | 2016-05-26 | Boston Heart Diagnostic Corporation | Cardiovascular disease risk assessment |
US11198122B2 (en) | 2015-07-17 | 2021-12-14 | Axxin Pty Ltd | Diagnostic test assembly, apparatus, method |
CN109563462B (zh) * | 2016-01-08 | 2022-04-22 | 先进诊疗公司 | 检测特定核酸序列的完全集成的手持式设备 |
WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
CN110621770B (zh) | 2017-04-19 | 2024-04-09 | 耶马都惠须龙株式会社 | Pcr用容器、装试剂的pcr用容器及试剂盒 |
BR112020006004A2 (pt) | 2017-09-27 | 2020-10-06 | Axxin Pty Ltd | sistema, montagem e método de teste de diagnóstico |
US20220010368A1 (en) * | 2018-11-19 | 2022-01-13 | Biocartis Nv | Enhanced detection of low-copy-number nucleic acids in an integrated workflow |
JP2022525322A (ja) | 2019-03-14 | 2022-05-12 | インシリクサ, インコーポレイテッド | 時間ゲート蛍光ベースの検出のための方法およびシステム |
EP4228813A1 (de) * | 2020-10-26 | 2023-08-23 | NAVARRO, Thierry | Vorrichtung und verfahren zur rna- oder dna-amplifikation |
CN113249214B (zh) * | 2021-07-05 | 2022-05-10 | 广州和实生物技术有限公司 | 一种可家庭自测的核酸检测装置、其使用方法及用途 |
Family Cites Families (36)
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US3715189A (en) * | 1970-06-15 | 1973-02-06 | Secretary Of The Treasury | Qualitative analysis device |
US4473530A (en) * | 1980-09-24 | 1984-09-25 | Villa Real Antony Euclid C | Compact sanitary urinalysis unit |
CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
US4458020A (en) * | 1982-11-15 | 1984-07-03 | Quidel | Integrated single tube plunger immunoassay system having plural reagent chambers |
US4687732A (en) * | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
DE3431536A1 (de) * | 1984-08-28 | 1986-03-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5310650A (en) * | 1986-09-29 | 1994-05-10 | Abbott Laboratoires | Method and device for improved reaction kinetics in nucleic acid hybridizations |
FR2612297B1 (fr) * | 1987-03-10 | 1990-10-05 | Pasteur Diagnostics | Dispositif de laboratoire pour analyse necessitant la mise en contact transitoire d'une phase solide et d'une phase liquide |
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DE3813278A1 (de) * | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | Verfahren zum nachweis von nukleinsaeuren |
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US5130238A (en) * | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
CA2031659A1 (en) * | 1990-01-26 | 1991-07-27 | John B. Findlay | Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods |
US5141850A (en) * | 1990-02-07 | 1992-08-25 | Hygeia Sciences, Inc. | Porous strip form assay device method |
SE465086B (sv) * | 1990-05-16 | 1991-07-22 | Mats Malmquist | Reagenskapillaerer, reaktionskaerl, beredningssaett och anvaendning daerav |
US5114858A (en) * | 1990-06-26 | 1992-05-19 | E. I. Du Pont De Nemours And Company | Cellular component extraction process in a disposable filtration vessel |
JPH04187077A (ja) * | 1990-11-22 | 1992-07-03 | Shimadzu Corp | 核酸の抽出精製装置 |
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DE4143639C2 (de) * | 1991-12-02 | 2002-10-24 | Qiagen Gmbh | Verfahren zur Isolierung und Reinigung von Nukleinsäuren |
US5244635A (en) * | 1992-06-19 | 1993-09-14 | Cirrus Diagnostics, Inc. | Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel |
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DE4420732A1 (de) * | 1994-06-15 | 1995-12-21 | Boehringer Mannheim Gmbh | Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe |
US5639428A (en) * | 1994-07-19 | 1997-06-17 | Becton Dickinson And Company | Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay |
DE19512369A1 (de) * | 1995-04-01 | 1996-10-02 | Boehringer Mannheim Gmbh | Vorrichtung zur Isolierung von Nukleinsäuren |
-
1996
- 1996-07-12 AU AU64580/96A patent/AU718183B2/en not_active Ceased
- 1996-07-12 WO PCT/US1996/011633 patent/WO1997003348A1/en active IP Right Grant
- 1996-07-12 EP EP96923760A patent/EP0838025B1/de not_active Expired - Lifetime
- 1996-07-12 DE DE69637047T patent/DE69637047T2/de not_active Expired - Lifetime
- 1996-07-12 US US08/679,522 patent/US5955351A/en not_active Expired - Lifetime
- 1996-07-12 JP JP9506006A patent/JPH11509100A/ja not_active Ceased
- 1996-07-12 AT AT96923760T patent/ATE360808T1/de not_active IP Right Cessation
- 1996-07-12 CA CA002226717A patent/CA2226717A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0838025B1 (de) | 2007-04-25 |
WO1997003348A1 (en) | 1997-01-30 |
EP0838025A4 (de) | 1999-10-06 |
US5955351A (en) | 1999-09-21 |
AU6458096A (en) | 1997-02-10 |
AU718183B2 (en) | 2000-04-06 |
EP0838025A1 (de) | 1998-04-29 |
DE69637047T2 (de) | 2007-12-27 |
ATE360808T1 (de) | 2007-05-15 |
CA2226717A1 (en) | 1997-01-30 |
JPH11509100A (ja) | 1999-08-17 |
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