DE69706315T2 - Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an nicht-zielsequenzen in hybridisierungstests - Google Patents

Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an nicht-zielsequenzen in hybridisierungstests

Info

Publication number
DE69706315T2
DE69706315T2 DE69706315T DE69706315T DE69706315T2 DE 69706315 T2 DE69706315 T2 DE 69706315T2 DE 69706315 T DE69706315 T DE 69706315T DE 69706315 T DE69706315 T DE 69706315T DE 69706315 T2 DE69706315 T2 DE 69706315T2
Authority
DE
Germany
Prior art keywords
suppressing
binding
compositions
methods
target sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69706315T
Other languages
English (en)
Other versions
DE69706315D1 (de
Inventor
M Coull
J Hyldig-Nielsen
E Godtfredsen
J Fiandaca
Kyriaki Stefano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dako Denmark ApS
Boston Probes Inc
Original Assignee
Dako AS
Boston Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dako AS, Boston Probes Inc filed Critical Dako AS
Publication of DE69706315D1 publication Critical patent/DE69706315D1/de
Application granted granted Critical
Publication of DE69706315T2 publication Critical patent/DE69706315T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
DE69706315T 1996-12-04 1997-12-01 Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an nicht-zielsequenzen in hybridisierungstests Expired - Lifetime DE69706315T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3234996P 1996-12-04 1996-12-04
US93770997A 1997-09-25 1997-09-25
US08/963,472 US6110676A (en) 1996-12-04 1997-11-03 Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
PCT/US1997/021845 WO1998024933A1 (en) 1996-12-04 1997-12-01 Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays

Publications (2)

Publication Number Publication Date
DE69706315D1 DE69706315D1 (de) 2001-09-27
DE69706315T2 true DE69706315T2 (de) 2002-05-08

Family

ID=27364099

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69706315T Expired - Lifetime DE69706315T2 (de) 1996-12-04 1997-12-01 Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an nicht-zielsequenzen in hybridisierungstests

Country Status (6)

Country Link
US (2) US6110676A (de)
EP (1) EP0946750B1 (de)
AU (1) AU7625998A (de)
DE (1) DE69706315T2 (de)
DK (1) DK0946750T3 (de)
WO (1) WO1998024933A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4313861B2 (ja) * 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
GB9718921D0 (en) * 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
US6355421B1 (en) 1997-10-27 2002-03-12 Boston Probes, Inc. Methods, kits and compositions pertaining to PNA molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
AU748022B2 (en) * 1997-12-12 2002-05-30 Digene Corporation Universal collection medium
CA2320390C (en) 1998-02-11 2010-06-08 Perkin-Elmer Corporation Pna and dna conjugates and methods for preparation thereof
WO1999049293A2 (en) * 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
AU2006230730B2 (en) * 1998-05-01 2009-03-05 Gen-Probe Incorporated Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer
ATE363339T1 (de) 1998-05-01 2007-06-15 Gen Probe Inc Rührvorrichtung für den fluiden inhalt eines behälters
WO2000001850A2 (en) * 1998-07-02 2000-01-13 Gen-Probe Incorporated Molecular torches
US6952275B2 (en) 1998-07-06 2005-10-04 Creo Il. Ltd. System and method for efficient printing of variable information documents
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
WO2000077259A1 (en) * 1999-06-15 2000-12-21 Boston Probes, Inc. Probes, probe sets, methods and kits pertaining to the detection, identification and/or enumeration of yeast; particularly in wine
US7060432B1 (en) 1999-06-15 2006-06-13 Applera Corporation Methods for the detection, identification, and/or enumeration of yeast, particularly in wine
US7013221B1 (en) 1999-07-16 2006-03-14 Rosetta Inpharmatics Llc Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
CA2379212A1 (en) * 1999-07-16 2001-01-25 Rosetta Inpharmatics, Inc. Methods for determining the specificity and sensitivity of oligonucleotides for hybridization
US7371516B1 (en) 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US7078167B2 (en) 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US7122303B2 (en) 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US7115738B2 (en) 2000-03-14 2006-10-03 Active Motif Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
DE60141205D1 (de) * 2000-04-03 2010-03-18 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
DE60138916D1 (de) * 2000-09-26 2009-07-16 Boston Probes Inc Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
US20020142326A1 (en) * 2000-11-30 2002-10-03 Coull James M. Methods and compositions for sorting and/or determining organisms
EP1356113B1 (de) * 2000-12-15 2012-07-18 Life Technologies Corporation Verfahren zum nachweis von organismen
CA2439750A1 (en) * 2001-03-09 2002-09-19 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
US8026051B2 (en) 2001-05-18 2011-09-27 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of Candida
DE60223276T2 (de) * 2001-08-31 2008-08-14 Datascope Investment Corp. Verfahren zur Blockierung von unspezifischen Hybridisierungen von Nukleinsäuresequenzen
EP1432826B1 (de) 2001-09-24 2012-12-12 Life Technologies Corporation Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an zufällig verteillten repeat sequenzen in genomischen nukleinsäuren
US7101565B2 (en) 2002-02-05 2006-09-05 Corpak Medsystems, Inc. Probiotic/prebiotic composition and delivery method
AU2003230717A1 (en) * 2002-03-21 2003-10-08 Boston Probes, Inc. Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
AU2003228649A1 (en) * 2002-04-23 2003-11-10 U.S.Genomics, Inc. Compositions and methods related to two-arm nucleic acid probes
US7094537B2 (en) * 2002-04-30 2006-08-22 Agilent Technologies, Inc. Micro arrays with structured and unstructured probes
US6878523B2 (en) * 2002-05-08 2005-04-12 Gentel Bio Surfaces, Inc. Molecular interaction assays on a solid surface
US20040005611A1 (en) * 2002-05-17 2004-01-08 Hyldig-Nielsen Jens J. PNA probes, probe sets, methods and kits pertaining to the determination of Listeria
WO2004007692A2 (en) * 2002-07-17 2004-01-22 U.S.Genomics, Inc. Methods and compositions for analyzing polymers using chimeric tags
DE10237284A1 (de) * 2002-08-14 2004-03-04 Advalytix Ag Nukleinsäurenachweis
WO2004022578A2 (en) * 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
US20060110819A1 (en) * 2002-09-30 2006-05-25 Lomas Lee O Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces
AU2003286759A1 (en) * 2002-10-28 2004-05-25 Advandx, Inc. Peptide nucleic acid probes for analysis of enterococcus faecium
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2518904A1 (en) * 2003-03-12 2004-09-23 Cleveland State University Molecular haplotyping of genomic dna
US20040185451A1 (en) * 2003-03-21 2004-09-23 Leproust Eric M. Methods for detecting the presence of a nucleic acid analyte in a sample
ATE373729T1 (de) * 2003-07-03 2007-10-15 Danmarks Og Groenlands Geol Un Verfahren zur selektiven detektion einer zielnukleinsäure
EP1687451A2 (de) * 2003-09-30 2006-08-09 Applera Corporation Verfahren und kits zur hybridisierung mehrerer sondenlisten an nukleinsäureproben
EP1709204A1 (de) * 2004-01-23 2006-10-11 Lingvitae AS Verbesserung von polynukleotid-ligationsreaktionen
DE102004034343B4 (de) * 2004-07-10 2007-08-30 Olfert Landt Verfahren zum Nachweis von Spuren genomischer Varianten mittels Nukleinsäure-Amplifikationsreaktionen
BRPI0516955A (pt) * 2004-09-24 2008-09-30 Ingeneus Inc ensaio genÈmico
US20060160116A1 (en) * 2004-12-16 2006-07-20 The Regents Of The University Of California Repetitive sequence-free DNA libraries
US7932081B2 (en) 2005-03-10 2011-04-26 Gen-Probe Incorporated Signal measuring system for conducting real-time amplification assays
CA2610710C (en) * 2005-06-02 2016-10-11 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
JP2009518004A (ja) 2005-11-18 2009-05-07 ザ チルドレンズ マーシー ホスピタル 核酸ハイブリダイゼーションにおけるＣｏｔ−１ＤＮＡの歪みの低減
WO2007106690A2 (en) 2006-03-15 2007-09-20 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
KR100760525B1 (ko) * 2006-04-13 2007-10-04 김재만 병원성 미생물의 무증폭 다중 정량 검출킷트 및 검출방법
WO2008018305A1 (en) * 2006-08-08 2008-02-14 Arkray, Inc. Method of detecting variation and kit to be used therein
US20100120031A1 (en) * 2006-09-22 2010-05-13 The United States Of America, As Represented By The Secretary, Dept. Of Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate
JP5596894B2 (ja) * 2006-11-10 2014-09-24 キヤノン株式会社 プローブセット、プローブ固定担体及び遺伝子検査方法
US7820389B2 (en) * 2007-01-10 2010-10-26 Geneohm Sciences, Inc. Inhibition of mismatch hybridization by a universal competitor DNA
WO2008143972A2 (en) * 2007-05-18 2008-11-27 Advandx, Inc. Detection of methicillin-resistant staphylococcus aureus
US8288520B2 (en) * 2008-10-27 2012-10-16 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and system
US8680254B2 (en) 2009-01-14 2014-03-25 Philadelphia Health & Education Corporation Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
EP2385979B1 (de) * 2009-01-28 2017-08-16 QIAGEN Gaithersburg, Inc. Sequenzspezifisches verfahren zur vorbereitung grossvolumiger proben und assay
US9797000B2 (en) * 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
EP2270203A1 (de) 2009-06-29 2011-01-05 AIT Austrian Institute of Technology GmbH Oligonukleotid-Hybridisierungsverfahren
CA2773320C (en) 2009-09-14 2018-02-20 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
US9487839B2 (en) * 2009-09-29 2016-11-08 Case Western Reserve University Method for detecting single nucleotide polymorphisms
DE102010025496A1 (de) * 2009-10-09 2011-04-21 Universität Duisburg-Essen Verfahren zur Detektion von Genveränderungen, insbesondere Mutationen
US8927271B1 (en) 2010-01-21 2015-01-06 Jack T. Johansen Compositions and methods for detecting target analytes
WO2011094514A1 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
AU2011210748A1 (en) 2010-01-29 2012-08-09 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of HPV in a sample
EP2572001A2 (de) 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Verfahren und zusammensetzungen für sequenzspezifische reinigung und multiplex-analyse von nukleinsäuren
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
CN103551212B (zh) 2010-07-23 2016-01-20 贝克曼考尔特公司 试剂盒
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
US20130184184A1 (en) * 2010-11-22 2013-07-18 The University Of Chicago Methods and/or Use of Oligonucleotide Conjugates Having Varied Degrees of Labeling for Assays and Detections
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
CN103403533B (zh) 2011-02-24 2017-02-15 简.探针公司 用于分辨光信号检测器中不同调制频率的光信号的系统和方法
KR20140091032A (ko) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 검체 수송 시스템의 자기 감쇠
WO2013070755A2 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Centrifuge system and workflow
JP6062449B2 (ja) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド 標本コンテナ検出
ES2844324T3 (es) 2011-11-07 2021-07-21 Beckman Coulter Inc Brazo robótico
EP2776848B1 (de) 2011-11-07 2019-12-25 Beckman Coulter, Inc. System und verfahren zum transport von probenbehältern
BR112014011035A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter, Inc. sistema de aliquotagem e fluxo de trabalho
JP6433893B2 (ja) 2012-07-03 2018-12-05 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド Ｔｍ増強ブロッキングオリゴヌクレオチド、ならびに標的濃縮の改善およびオフターゲット選択の低減のためのベイト
US20150315636A1 (en) * 2012-10-31 2015-11-05 Becton, Dickinson And Company Selective amplification and real-time pcr detection of rare mutations
WO2014070540A1 (en) * 2012-11-01 2014-05-08 Siemens Healthcare Diagnostics Inc. Sequencing-based quantification of nucleic acid targets
EP2929050A1 (de) 2012-12-10 2015-10-14 AdvanDx, Inc. Verwendung von sonden zur massenspektrometrischen identifizierung von mikroorganismen oder zellen und relevanten erkrankungen von interesse
EP3964839B1 (de) 2013-03-15 2024-04-10 Abbott Laboratories Automatisierte diagnostische analysatoren mit rückwärtig zugänglichen führungsspursystemen und zugehörige verfahren
EP4109106A1 (de) 2013-03-15 2022-12-28 Abbott Laboratories Automatisierte diagnostische analysevorrichtungen mit vertikal angeordneten karussellen und zugehörige verfahren
EP2972402B1 (de) 2013-03-15 2023-12-20 Abbott Laboratories Diagnostische analysevorrichtung und vorbehandlungskarussells und zugehörige verfahren
US9416652B2 (en) 2013-08-08 2016-08-16 Vetco Gray Inc. Sensing magnetized portions of a wellhead system to monitor fatigue loading
JP6841609B2 (ja) 2015-07-10 2021-03-10 ３スキャン インコーポレイテッド 組織学的染色の空間的多重化
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
EP3505643A1 (de) * 2017-12-28 2019-07-03 Vito NV Verfahren zur detektion von nukleotidvarianten

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582970A (en) * 1982-11-03 1996-12-10 City Of Hope Competitive hybridization technique
US5723597A (en) * 1983-01-10 1998-03-03 Gen-Probe Incorporated Ribosomal nucleic acid probes for detecting organisms or groups of organisms
US5641632A (en) * 1983-01-10 1997-06-24 Gen-Probe Incorporated Method for preparing rRNA for hybridization with a probe
EP0756010B1 (de) * 1983-01-10 2001-07-04 Gen-Probe Incorporated Verfahren zum Nachweis, Identifizieren und Quantifizieren von Organismen und Viren
US5288611A (en) * 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US5756696A (en) * 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
AU588105B2 (en) * 1986-02-07 1989-09-07 Aluminum Company Of America System for on-line molten metal analysis
KR960002234B1 (ko) * 1987-07-31 1996-02-13 젠-프로우브 인코오퍼레이티드 바람직하지 못한 교차반응을 제거하기 위한 올리고뉴클레오티드를 사용하는 폴리뉴클레오티드에 대한 측정방법
EP0333465B1 (de) * 1988-03-18 1994-07-13 Baylor College Of Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5387510A (en) * 1991-10-02 1995-02-07 Eastman Kodak Company Detection of amplified nucleic acid using secondary capture oligonucleotides and test kit
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
CA2153387A1 (en) * 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
DE4341963C2 (de) * 1993-12-09 1999-09-23 Stihl Maschf Andreas Magnetzündanlage
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5849483A (en) * 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
CA2163393C (en) * 1994-11-30 2003-04-22 Colleen Marie Nycz Amplification and detection of mycobacteria nucleic acids
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
EP0837884A2 (de) * 1995-06-22 1998-04-29 Dako A/S Rekombinanter antikörper der fähig ist an pna/nukleinsäure-komplexen zu binden
US5612473A (en) * 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US5824476A (en) * 1996-02-28 1998-10-20 City Of Hope Competitive hybridization technique
US5723294A (en) * 1996-03-05 1998-03-03 Gull Laboratories Methods for detection and discrimination of multiple analytes using fluorescent technology
EP1164203B1 (de) * 1996-11-06 2007-10-10 Sequenom, Inc. DNA-Diagnostik mittels Massenspektrometrie

Also Published As

Publication number Publication date
EP0946750B1 (de) 2001-08-22
US20030124521A1 (en) 2003-07-03
DE69706315D1 (de) 2001-09-27
EP0946750A1 (de) 1999-10-06
WO1998024933A1 (en) 1998-06-11
DK0946750T3 (da) 2001-12-17
AU7625998A (en) 1998-06-29
US6110676A (en) 2000-08-29

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