DE69713335T2 - Polymere zur abgabe von stickstoffoxide in vivo - Google Patents

Polymere zur abgabe von stickstoffoxide in vivo

Info

Publication number
DE69713335T2
DE69713335T2 DE69713335T DE69713335T DE69713335T2 DE 69713335 T2 DE69713335 T2 DE 69713335T2 DE 69713335 T DE69713335 T DE 69713335T DE 69713335 T DE69713335 T DE 69713335T DE 69713335 T2 DE69713335 T2 DE 69713335T2
Authority
DE
Germany
Prior art keywords
polymer
polymers
vivo
delivery
nitrosylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69713335T
Other languages
English (en)
Other versions
DE69713335D1 (de
Inventor
S Stamler
J Toone
S Stack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University Medical Center
Original Assignee
Duke University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University Medical Center filed Critical Duke University Medical Center
Publication of DE69713335D1 publication Critical patent/DE69713335D1/de
Application granted granted Critical
Publication of DE69713335T2 publication Critical patent/DE69713335T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
DE69713335T 1996-08-02 1997-07-28 Polymere zur abgabe von stickstoffoxide in vivo Expired - Lifetime DE69713335T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/691,862 US5770645A (en) 1996-08-02 1996-08-02 Polymers for delivering nitric oxide in vivo
PCT/US1997/013475 WO1998005689A1 (en) 1996-08-02 1997-07-28 Polymers for delivering nitric oxide in vivo

Publications (2)

Publication Number Publication Date
DE69713335D1 DE69713335D1 (de) 2002-07-18
DE69713335T2 true DE69713335T2 (de) 2003-02-13

Family

ID=24778280

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69713335T Expired - Lifetime DE69713335T2 (de) 1996-08-02 1997-07-28 Polymere zur abgabe von stickstoffoxide in vivo

Country Status (10)

Country Link
US (1) US5770645A (de)
EP (1) EP0914348B1 (de)
JP (1) JP4312263B2 (de)
KR (1) KR20000029774A (de)
AT (1) ATE219108T1 (de)
AU (1) AU714972B2 (de)
CA (1) CA2262922C (de)
DE (1) DE69713335T2 (de)
NZ (1) NZ334221A (de)
WO (1) WO1998005689A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232434B1 (en) * 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
ATE499343T1 (de) * 1997-07-03 2011-03-15 Us Gov Health & Human Serv Stickoxid freistetzende amidin- und enaminverwandte diazeniumdiolate, zubereitungen und verwendungen davon und verfahren zu ihrer herstellung
US5994444A (en) * 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
EP2221852B1 (de) 1998-01-15 2012-05-09 Cornell Research Foundation, Inc. Grabenisolation für mikromechanische Bauelemente
JP2002518351A (ja) * 1998-06-19 2002-06-25 オキシバイオ・インコーポレイテッド 抗感染および避妊特性を有する医療装置
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US20040043068A1 (en) * 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6838050B1 (en) 1999-06-04 2005-01-04 Oxibio, Inc. Methods and devices for providing anti-infective activity to a medical device
US6314956B1 (en) 1999-09-08 2001-11-13 Duke University Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
US7045152B2 (en) 1999-09-08 2006-05-16 Duke University Treating pulmonary disorders with gaseous agent causing repletion of GSNO
DE19945484A1 (de) * 1999-09-22 2001-04-05 Kolb Bachofen Victoria NO-freisetzende topisch applizierbare Zusammensetzung
US6737447B1 (en) * 1999-10-08 2004-05-18 The University Of Akron Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
US6613432B2 (en) * 1999-12-22 2003-09-02 Biosurface Engineering Technologies, Inc. Plasma-deposited coatings, devices and methods
MXPA02009236A (es) * 2000-03-20 2004-04-05 Novovascular Inc Matrices que contienen donadores de oxido nitrico y agentes reductores, y su uso.
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
US6417347B1 (en) * 2000-08-24 2002-07-09 Scimed Life Systems, Inc. High yield S-nitrosylation process
US6410622B1 (en) * 2000-09-11 2002-06-25 Gregory W. Endres Method of preventing fouling organisms in marine environments and polymer-bound nitric oxide/nitric oxide-releasing compositions usable therefor
US7049308B2 (en) * 2000-10-26 2006-05-23 Duke University C-nitroso compounds and use thereof
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US6398806B1 (en) * 2000-12-26 2002-06-04 Scimed Life Systems, Inc. Monolayer modification to gold coated stents to reduce adsorption of protein
US6706274B2 (en) 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
US7122027B2 (en) * 2001-05-25 2006-10-17 Medtronic, Inc. Implantable medical device with controllable gaseous agent release system
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US7135189B2 (en) * 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
US6673338B1 (en) 2001-09-10 2004-01-06 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same
WO2003026717A1 (en) * 2001-09-26 2003-04-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing coated medical devices and method of preparing same
US6703046B2 (en) * 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
AU2006252204B2 (en) * 2001-12-06 2010-07-08 Duke University Prevention of Flap Necrosis in Plastic Surgery
WO2003049593A2 (en) * 2001-12-06 2003-06-19 Duke University Prevention of flap necrosis in plastic surgery
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
EP1501563A1 (de) * 2002-05-03 2005-02-02 Duke University Medical Center Kohlenstoffnanoröhrchen zur speicherung von stickstoffoxid
US6949530B2 (en) * 2002-07-18 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
CA2497792C (en) 2002-09-06 2014-08-05 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
CN100348618C (zh) * 2002-09-11 2007-11-14 弗雷泽纽斯卡比德国有限公司 生产羟烷基淀粉衍生物的方法
US20030039697A1 (en) * 2002-09-12 2003-02-27 Yi-Ju Zhao Matrices containing nitric oxide donors and reducing agents and their use
FR2845090B1 (fr) * 2002-10-01 2004-12-24 Merck Sante Sas Nouveau polymere de nitrosation en synthese organique
US20040098106A1 (en) * 2002-11-14 2004-05-20 Williams Michael S. Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents
US7285287B2 (en) * 2002-11-14 2007-10-23 Synecor, Llc Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses
US6932930B2 (en) * 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
FR2852959B1 (fr) 2003-03-28 2008-02-15 Centre Nat Rech Scient Nouveaux derives de cyclodextrines, leur procede de preparation et leur utilisation notamment pour solubilisation de substances pharmacologiquement actives
EP1653978B1 (de) 2003-07-09 2020-06-03 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Vervendung von nitritsalzen zur behandlung von cardiovaskulären erkrankungen
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
SG145746A1 (en) * 2003-08-08 2008-09-29 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and g-csf
US8017074B2 (en) 2004-01-07 2011-09-13 Noxilizer, Inc. Sterilization system and device
CA2552735C (en) 2004-01-07 2012-09-11 Noxilizer, Inc. Sterilization system and device
JP2007526911A (ja) * 2004-01-22 2007-09-20 ザ ユニバーシティ オブ アクロン 医療装置および治療のためのポリマーｎｏ供与体プレドラッグナノファイバコーティング
US7829553B2 (en) * 2004-02-09 2010-11-09 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
WO2005092928A1 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
US8545950B2 (en) 2004-04-02 2013-10-01 Curwood, Inc. Method for distributing a myoglobin-containing food product
US8741402B2 (en) 2004-04-02 2014-06-03 Curwood, Inc. Webs with synergists that promote or preserve the desirable color of meat
US8470417B2 (en) 2004-04-02 2013-06-25 Curwood, Inc. Packaging inserts with myoglobin blooming agents, packages and methods for packaging
US8053047B2 (en) 2004-04-02 2011-11-08 Curwood, Inc. Packaging method that causes and maintains the preferred red color of fresh meat
US8029893B2 (en) 2004-04-02 2011-10-04 Curwood, Inc. Myoglobin blooming agent, films, packages and methods for packaging
US8110259B2 (en) 2004-04-02 2012-02-07 Curwood, Inc. Packaging articles, films and methods that promote or preserve the desirable color of meat
US7867531B2 (en) 2005-04-04 2011-01-11 Curwood, Inc. Myoglobin blooming agent containing shrink films, packages and methods for packaging
JP2007534389A (ja) * 2004-04-29 2007-11-29 キューブ・メディカル・アクティーゼルスカブ 血管形成に用いるバルーン
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
WO2006026412A2 (en) * 2004-08-31 2006-03-09 Vnus Medical Technologies, Inc. Apparatus and material composition for permanent occlusion of a hollow anatomical structure
CN101146484B (zh) 2005-01-25 2015-04-08 泰科医疗集团有限合伙公司 用于永久性闭塞中空解剖结构的结构
AU2006210952B2 (en) * 2005-01-31 2011-08-04 Mylan Laboratories, Inc. Pharmaceutical composition comprising hydroxylated nebivolol
SG175476A1 (en) 2005-01-31 2011-11-28 Mylan Lab Inc Glucuronidated nebivolol metabolites
WO2006084914A2 (en) * 2005-02-11 2006-08-17 Nolabs Ab Device for gastric treatment and manufacturing process for the same
EP1690532A1 (de) * 2005-02-11 2006-08-16 NOLabs AB Vorrichtung zur Behandlung vom Magen und ihr Verfahren zur Herstellung
EP1700611A1 (de) * 2005-02-11 2006-09-13 NOLabs AB Vorrichtung zur Behandlung von Krankheiten der Mundhöhle und deren Herstellungsprozess
JP5175107B2 (ja) * 2005-02-11 2013-04-03 ノーラブズ エービー 酸化窒素による神経障害の治療デバイス、方法および使用
EP1757278A1 (de) * 2005-08-23 2007-02-28 NOLabs AB Vorrichtung, System und Methode enthaltend eine verkapselte Flüssigkeit zur Stickstoffmonoxyd-Freisetzung von einem Polymer
EP1846009A2 (de) * 2005-02-11 2007-10-24 NOLabs AB Verbesserte vorrichtung zur anwendung von medikamenten, herstellungsverfahren dafür und behandlungsverfahren
PT1861130E (pt) * 2005-02-11 2008-12-02 Nolabs Ab Dispositivo e método para o tratamento de dermatomicose, e em particular de onicomicose
WO2006084913A2 (en) * 2005-02-11 2006-08-17 Nolabs Ab Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide
EP1690557A1 (de) * 2005-02-11 2006-08-16 NOLabs AB Vorrichtung zur Behandlung von rektalen Krankheiten und deren Herstellungsprozess
US8119840B2 (en) * 2005-03-04 2012-02-21 The University Of Akron Ethambutol based nitric oxide donors
CA2598528A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material
EP1704876A1 (de) * 2005-03-24 2006-09-27 NOLabs AB Kosmetische Behandlung, Vorrichtung zur Durchführung dieser Behandlung und deren Herstellungsmethode
PL1871433T3 (pl) 2005-03-24 2009-09-30 Nolabs Ab Zabieg kosmetyczny z tlenkiem azotu, urządzenie do wykonywania tego zabiegu i sposób jego wytwarzania
WO2006116014A2 (en) * 2005-04-21 2006-11-02 The University Of Akron Process for producing fibers and their uses
EP2669269B1 (de) 2005-05-27 2019-05-22 The University of North Carolina At Chapel Hill Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen
EP1731176A1 (de) 2005-06-01 2006-12-13 NOLabs AB Vorrichtung zur Vorbehandlung beinhaltend Stickstoffmonoxid
EP1728438A1 (de) 2005-06-01 2006-12-06 NOLabs AB Futtermittel
EP1764119A1 (de) 2005-09-09 2007-03-21 NOLabs AB Implantate mit verbesserter Osteointegration
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
US20090010989A1 (en) * 2005-09-12 2009-01-08 N0Labs Ab Coating For Implants and Implants With Improved Osteointegration, and Manufacturing Method
EP1790335A1 (de) 2005-11-14 2007-05-30 NOLabs AB Zusammensetzung und deren Verwendung für die Herstellung eines Medikamentes zur Behandlung, prophylaktischen Behandlung und Verhinderung von Krebs und/oder von Infektionskrankheiten in den Harnwegen
WO2007059311A2 (en) * 2005-11-16 2007-05-24 Nitromed, Inc. Furoxan compounds, compositions and methods of use
AU2006322035A1 (en) * 2005-12-06 2007-06-14 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US7993560B2 (en) * 2006-04-20 2011-08-09 Curwood, Inc. Process for introducing an additive into a polymer melt
US9017361B2 (en) 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
WO2007126344A1 (en) * 2006-04-27 2007-11-08 St. Jude Medical Ab Implantable medical device with releasing compound
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
BRPI0721507A2 (pt) * 2007-03-27 2013-01-08 Nolabs Ab dispositivo de dispensaÇço de àxido nÍtrico tàpico, kit, uso de àxido nÍtrico, e, mÉtodos de dispensaÇço tàpica de àxido nÍtrico e de tratamento
ITMI20071341A1 (it) 2007-07-05 2009-01-06 Fidia Farmaceutici Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no
CA2599082A1 (en) * 2007-08-27 2009-02-27 Ping I. Lee Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
WO2009065142A2 (en) 2007-11-15 2009-05-22 Biomedical Research Foundation Of Northwest Louisiana Use of nitrite salts in chronic ischemia
EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern
AU2008345034A1 (en) * 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide - donating compounds and uses thereof
US20090171455A1 (en) * 2007-12-31 2009-07-02 Boston Scientific Scimed, Inc. Biodegradable polymers
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
WO2010096766A1 (en) 2009-02-23 2010-08-26 Noxilizer, Inc. Device and method for gas sterilization
WO2010147742A2 (en) 2009-06-18 2010-12-23 Theravasc Inc. Use of nitrite salts in treating tissue damage
WO2011022680A2 (en) 2009-08-21 2011-02-24 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
EP2467127B1 (de) 2009-08-21 2023-08-02 Novan, Inc. Topische gele
US10463689B2 (en) * 2009-10-14 2019-11-05 Board Of Supervisors Of Louisiana State University Pharmaceutical formulations of nitrite and uses thereof
US20140073602A9 (en) 2010-07-09 2014-03-13 Fresenius Kabi Deutschland Gmbh Nitric oxide delivering hydroxyalkyl starch derivatives
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
ES2695173T3 (es) 2011-02-28 2019-01-02 Novan Inc Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas
EP2729131B1 (de) 2011-07-05 2020-04-15 Novan, Inc. Topische zusammensetzungen
CN103796704B (zh) 2011-07-12 2016-12-07 博讯瓦勒公司 用于将抗微生物剂递送到经皮导管中的装置
US20130046375A1 (en) 2011-08-17 2013-02-21 Meng Chen Plasma modified medical devices and methods
CN104520454B (zh) * 2012-08-09 2016-05-11 迪普格林工程有限公司 含锰材料的处理
JP6298818B2 (ja) * 2012-08-17 2018-03-20 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 水溶性一酸化窒素放出ポリグルコサミンおよびそれらの使用
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
AU2014218916A1 (en) 2013-02-20 2015-09-03 Theravasc Inc. Pharmaceutical formulations of nitrite and uses thereof
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US10206947B2 (en) 2013-08-08 2019-02-19 Novan, Inc. Topical compositions and methods of using the same
KR102321169B1 (ko) 2013-08-08 2021-11-02 노반, 인크. 국소 조성물 및 그의 사용 방법
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
JP7090549B2 (ja) 2016-03-02 2022-06-24 ノヴァン，インコーポレイテッド 炎症のための治療用組成物およびその治療方法
KR102426006B1 (ko) 2016-04-13 2022-07-29 노반, 인크. 감염 치료용 조성물, 시스템, 키트, 및 방법
WO2018067838A1 (en) 2016-10-07 2018-04-12 The University Of North Carolina At Chapel Hill S-nitrosothiol-mediated hyperbranched polyesters
JP7005609B2 (ja) 2016-10-14 2022-02-10 アイシーユー・メディカル・インコーポレーテッド 医療用コネクタのための浄化キャップ
EP3565848A4 (de) 2017-01-03 2020-09-02 The University of North Carolina at Chapel Hill Stickoxidfreisetzende alginate als biologisch abbaubare antibakterielle gerüste und zugehörige verfahren
CN110461338A (zh) 2017-03-28 2019-11-15 北卡罗来纳大学查佩尔希尔分校 作为可生物降解抗菌支架的释放一氧化氮的聚氨基糖苷类和其制备方法
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
WO2019173539A1 (en) * 2018-03-06 2019-09-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
AU2019384564B2 (en) 2018-11-21 2023-11-23 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
JP2022516461A (ja) 2018-12-28 2022-02-28 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 一酸化窒素放出抗菌性ポリマーおよびそれから製造された足場、ならびにそれに関する方法
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138535A (en) * 1970-05-25 1979-02-06 Schweiger Richard Georg Nitrite esters of polyhydroxy polymers
DE69008454T2 (de) * 1989-08-07 1994-08-25 Takeda Chemical Industries Ltd Nitrolsothiolderivate, ihre Herstellung und Verwendung.
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
US5114506A (en) * 1991-07-08 1992-05-19 The United States Of America As Represented By The Secretary Of The Navy Energetic composites of cyclodextrin nitrate esters and nitrate ester plasticizers
US5632981A (en) * 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5650447A (en) * 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
CA2106105C (en) * 1993-09-14 2008-03-18 Larry K. Keefer Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
DE69433478T2 (de) * 1993-09-17 2004-11-25 Brigham And Women's Hospital, Boston Verwendung von stickoxid-addukten zur verhütung von thrombosen auf artifiziellen und vaskulären oberflächen
US5482925A (en) * 1994-03-17 1996-01-09 Comedicus Incorporated Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
US5583101A (en) * 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
US5700830A (en) * 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
GB9424694D0 (en) * 1994-12-07 1995-02-01 Wellcome Found Compounds for use in medicine

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US5770645A (en) 1998-06-23
EP0914348A1 (de) 1999-05-12
WO1998005689A1 (en) 1998-02-12
JP4312263B2 (ja) 2009-08-12
ATE219108T1 (de) 2002-06-15
CA2262922C (en) 2007-06-05
AU3967797A (en) 1998-02-25
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CA2262922A1 (en) 1998-02-12

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