DE69716474D1 - Thrombininhibitor-konjugate und endogene träger - Google Patents
Thrombininhibitor-konjugate und endogene trägerInfo
- Publication number
- DE69716474D1 DE69716474D1 DE69716474T DE69716474T DE69716474D1 DE 69716474 D1 DE69716474 D1 DE 69716474D1 DE 69716474 T DE69716474 T DE 69716474T DE 69716474 T DE69716474 T DE 69716474T DE 69716474 D1 DE69716474 D1 DE 69716474D1
- Authority
- DE
- Germany
- Prior art keywords
- thrombin
- thrombin inhibitor
- bloodstream
- activity
- compared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/674,315 US5840733A (en) | 1996-07-01 | 1996-07-01 | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| PCT/IB1997/001093 WO1998000171A2 (en) | 1996-07-01 | 1997-06-30 | Conjugates of thrombin inhibitors and endogenes carriers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69716474D1 true DE69716474D1 (de) | 2002-11-21 |
Family
ID=24706128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69716474T Expired - Lifetime DE69716474D1 (de) | 1996-07-01 | 1997-06-30 | Thrombininhibitor-konjugate und endogene träger |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US5840733A (de) |
| EP (1) | EP0956049B1 (de) |
| JP (1) | JP2000514795A (de) |
| KR (1) | KR20000022371A (de) |
| AT (1) | ATE226092T1 (de) |
| CA (1) | CA2258516A1 (de) |
| DE (1) | DE69716474D1 (de) |
| IL (1) | IL127712A0 (de) |
| WO (1) | WO1998000171A2 (de) |
Families Citing this family (49)
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|---|---|---|---|---|
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| US7033765B1 (en) | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
| ATE296115T1 (de) * | 1997-02-20 | 2005-06-15 | David S Dime | Ortsspezifische arzneimittel verabreichung |
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| CA2301799C (en) * | 1997-11-07 | 2007-08-07 | Conjuchem, Inc. | Novel conjugates of opioids and endogenous carriers |
| WO1999024075A2 (en) | 1997-11-07 | 1999-05-20 | Conjuchem, Inc. | Affinity markers for human serum albumin |
| US6107489A (en) * | 1998-03-17 | 2000-08-22 | Conjuchem, Inc. | Extended lifetimes in vivo renin inhibitors |
| US20030170250A1 (en) * | 1998-03-23 | 2003-09-11 | Ezrin Alan M. | Local delivery of long lasting therapeutic agents |
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| ES2347027T3 (es) | 1998-05-22 | 2010-10-22 | The Board Of Trustees Of The Leland Stanford Junior University | Moleculas bifuncionales y terapias basadas en las mismas. |
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| US7220552B1 (en) | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| AU2044001A (en) | 1999-11-19 | 2001-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Targeted bifunctional molecules and therapies based thereon |
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| RU2416393C2 (ru) * | 2005-09-01 | 2011-04-20 | Бакстер Интернэшнл Инк. | Препаративная форма аргатробана |
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| CN101384623B (zh) * | 2005-12-22 | 2013-07-24 | 常山凯捷健生物药物研发（河北）有限公司 | 白蛋白与治疗剂的预成型偶联物的制备方法 |
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| AU2012336036A1 (en) | 2011-11-07 | 2014-06-19 | Diakron Pharmaceuticals Inc. | An extended release formulation of a direct thrombin inhibitor |
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-
1996
- 1996-07-01 US US08/674,315 patent/US5840733A/en not_active Expired - Fee Related
-
1997
- 1997-06-30 CA CA002258516A patent/CA2258516A1/en not_active Abandoned
- 1997-06-30 WO PCT/IB1997/001093 patent/WO1998000171A2/en not_active Application Discontinuation
- 1997-06-30 JP JP10503954A patent/JP2000514795A/ja active Pending
- 1997-06-30 EP EP97937767A patent/EP0956049B1/de not_active Expired - Lifetime
- 1997-06-30 KR KR1019980710802A patent/KR20000022371A/ko not_active Application Discontinuation
- 1997-06-30 DE DE69716474T patent/DE69716474D1/de not_active Expired - Lifetime
- 1997-06-30 AT AT97937767T patent/ATE226092T1/de not_active IP Right Cessation
- 1997-06-30 IL IL12771297A patent/IL127712A0/xx unknown
-
1998
- 1998-07-01 US US09/108,534 patent/US5942620A/en not_active Expired - Fee Related
-
1999
- 1999-06-11 US US09/330,744 patent/US6087375A/en not_active Expired - Lifetime
-
2000
- 2000-06-22 US US09/599,379 patent/US6277863B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000022371A (ko) | 2000-04-25 |
| WO1998000171A3 (en) | 1998-06-04 |
| ATE226092T1 (de) | 2002-11-15 |
| US6277863B1 (en) | 2001-08-21 |
| EP0956049A2 (de) | 1999-11-17 |
| US5840733A (en) | 1998-11-24 |
| JP2000514795A (ja) | 2000-11-07 |
| WO1998000171A2 (en) | 1998-01-08 |
| US5942620A (en) | 1999-08-24 |
| IL127712A0 (en) | 1999-10-28 |
| EP0956049B1 (de) | 2002-10-16 |
| CA2258516A1 (en) | 1998-01-08 |
| US6087375A (en) | 2000-07-11 |
| AU4028397A (en) | 1998-01-21 |
| AU715746B2 (en) | 2000-02-10 |
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