DE69718377D1 - Medizinisches Gerät mit einer an der Oberfläche gegerbten und mit Biomolekülen beschichteten Matrix - Google Patents

Medizinisches Gerät mit einer an der Oberfläche gegerbten und mit Biomolekülen beschichteten Matrix

Info

Publication number
DE69718377D1
DE69718377D1 DE69718377T DE69718377T DE69718377D1 DE 69718377 D1 DE69718377 D1 DE 69718377D1 DE 69718377 T DE69718377 T DE 69718377T DE 69718377 T DE69718377 T DE 69718377T DE 69718377 D1 DE69718377 D1 DE 69718377D1
Authority
DE
Germany
Prior art keywords
tanned
biomolecules
coated
medical device
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69718377T
Other languages
English (en)
Other versions
DE69718377T2 (de
Inventor
Marc Hendriks
Michel Verhoeven
Linda L Cahalan
Patrick T Cahalan
Benedicte Fouache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Application granted granted Critical
Publication of DE69718377D1 publication Critical patent/DE69718377D1/de
Publication of DE69718377T2 publication Critical patent/DE69718377T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/044—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0088—Chemical modification of the substrate by grafting of a monomer onto the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
DE69718377T 1996-05-31 1997-05-12 Medizinisches Gerät mit einer an der Oberfläche gegerbten und mit Biomolekülen beschichteten Matrix Expired - Lifetime DE69718377T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/656,614 US5811151A (en) 1996-05-31 1996-05-31 Method of modifying the surface of a medical device

Publications (2)

Publication Number Publication Date
DE69718377D1 true DE69718377D1 (de) 2003-02-20
DE69718377T2 DE69718377T2 (de) 2003-10-23

Family

ID=24633806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718377T Expired - Lifetime DE69718377T2 (de) 1996-05-31 1997-05-12 Medizinisches Gerät mit einer an der Oberfläche gegerbten und mit Biomolekülen beschichteten Matrix

Country Status (6)

Country Link
US (2) US5811151A (de)
EP (1) EP0809997B1 (de)
JP (1) JPH1052488A (de)
AU (1) AU713357B2 (de)
CA (1) CA2206147A1 (de)
DE (1) DE69718377T2 (de)

Families Citing this family (237)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063405A (en) * 1995-09-29 2000-05-16 L.A.M. Pharmaceuticals, Llc Sustained release delivery system
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6033719A (en) * 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
FR2758990B1 (fr) 1996-09-19 1999-05-28 Hospal Ind Appareil pour le traitement du sang par circulation extracorporelle et procede de fabrication
EP0860213A3 (de) * 1997-01-03 2002-10-16 Therapol SA Bioaktive Beschichtung von Oberflächen
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6146771A (en) 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US6221425B1 (en) * 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6395019B2 (en) 1998-02-09 2002-05-28 Trivascular, Inc. Endovascular graft
JP3936058B2 (ja) * 1998-03-12 2007-06-27 株式会社メニコン コンタクトレンズ用液剤
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6596401B1 (en) 1998-11-10 2003-07-22 C. R. Bard Inc. Silane copolymer compositions containing active agents
CA2350628A1 (en) * 1998-11-12 2000-05-18 Polymer Biosciences, Inc. Hemostatic polymer useful for rapid blood coagulation and hemostasis
US6340465B1 (en) 1999-04-12 2002-01-22 Edwards Lifesciences Corp. Lubricious coatings for medical devices
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6159531A (en) * 1999-08-30 2000-12-12 Cardiovasc, Inc. Coating having biological activity and medical implant having surface carrying the same and method
US8187303B2 (en) 2004-04-22 2012-05-29 Gmedelaware 2 Llc Anti-rotation fixation element for spinal prostheses
US6673116B2 (en) * 1999-10-22 2004-01-06 Mark A. Reiley Intramedullary guidance systems and methods for installing ankle replacement prostheses
EP1854433B1 (de) * 1999-10-22 2010-05-12 FSI Acquisition Sub, LLC Facettenarthroplastiegeräte
US8496712B2 (en) 1999-10-22 2013-07-30 Inbone Technologies, Inc. Systems and methods for installing ankle replacement prostheses
US7674293B2 (en) * 2004-04-22 2010-03-09 Facet Solutions, Inc. Crossbar spinal prosthesis having a modular design and related implantation methods
US7691145B2 (en) * 1999-10-22 2010-04-06 Facet Solutions, Inc. Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces
US6974478B2 (en) * 1999-10-22 2005-12-13 Archus Orthopedics, Inc. Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces
US6811567B2 (en) * 1999-10-22 2004-11-02 Archus Orthopedics Inc. Facet arthroplasty devices and methods
AU2118601A (en) * 1999-10-22 2001-05-08 Mark A. Reiley Ankle replacement system
US6733513B2 (en) 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US7300457B2 (en) 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US6936066B2 (en) * 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US7235092B2 (en) * 1999-11-19 2007-06-26 Advanced Bio Prosthetic Surfaces, Ltd. Guidewires and thin film catheter-sheaths and method of making same
US7736687B2 (en) 2006-01-31 2010-06-15 Advance Bio Prosthetic Surfaces, Ltd. Methods of making medical devices
US10172730B2 (en) 1999-11-19 2019-01-08 Vactronix Scientific, Llc Stents with metallic covers and methods of making same
US6726718B1 (en) * 1999-12-13 2004-04-27 St. Jude Medical, Inc. Medical articles prepared for cell adhesion
US6291428B1 (en) 1999-12-20 2001-09-18 The Hospital For Special Surgery Peptides which promote bone-forming cell attraction and adhesion
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
US7604663B1 (en) 1999-12-30 2009-10-20 St. Jude Medical, Inc. Medical devices with polymer/inorganic substrate composites
EP1645248B8 (de) * 2000-02-04 2010-06-16 Warsaw Orthopedic, Inc. Ausdehnbares interspinales Fusionsimplantat mit schwenkbarem Blocker
US6814756B1 (en) * 2000-02-04 2004-11-09 Gary K. Michelson Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion
US6743253B2 (en) * 2000-02-29 2004-06-01 Biomod Surfaces Polyurethane-sealed biocompatible device and method for its preparation
US7163712B2 (en) 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
US6444254B1 (en) * 2000-03-03 2002-09-03 Duke University Microstamping activated polymer surfaces
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US6444217B1 (en) * 2000-04-25 2002-09-03 University Of Washington Drug delivery devices, and methods of use
US6451050B1 (en) 2000-04-28 2002-09-17 Cardiovasc, Inc. Stent graft and method
US6520984B1 (en) 2000-04-28 2003-02-18 Cardiovasc, Inc. Stent graft assembly and method
US20030114918A1 (en) * 2000-04-28 2003-06-19 Garrison Michi E. Stent graft assembly and method
US8845713B2 (en) 2000-05-12 2014-09-30 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same
US20080177310A1 (en) * 2000-10-20 2008-07-24 Archus Orthopedics, Inc. Facet arthroplasty devices and methods
US6783793B1 (en) * 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
AU2002233936A1 (en) 2000-11-07 2002-05-21 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
US8372139B2 (en) * 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
US7083642B2 (en) * 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US6986772B2 (en) * 2001-03-01 2006-01-17 Michelson Gary K Dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine
EP1272130B1 (de) * 2001-02-04 2004-11-17 MICHELSON, Gary Karlin Instrument zum Einführen und Spreiten eines Zwischenwirbelfusionsimplantats
US6896680B2 (en) * 2001-03-01 2005-05-24 Gary K. Michelson Arcuate dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine
CA2434688A1 (en) 2001-03-01 2002-09-12 Gary Karlin Michelson Dynamic lordotic guard with movable extensions for creating an implantation space posteriorly in the lumbar spine and method for use thereof
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US6660034B1 (en) * 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US7186256B2 (en) * 2001-06-04 2007-03-06 Warsaw Orthopedic, Inc. Dynamic, modular, single-lock anterior cervical plate system having assembleable and movable segments
JP4286130B2 (ja) 2001-06-04 2009-06-24 ウォーソー・オーソペディック・インコーポレーテッド 椎体係合固定具および接続平板を有する前頚部平板システム、およびその据付方法
US7097645B2 (en) * 2001-06-04 2006-08-29 Sdgi Holdings, Inc. Dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments
EP1404243A4 (de) * 2001-06-04 2010-05-19 Warsaw Orthopedic Inc Dynamisches anteriores zervikalplattensystem mit beweglichen segmenten, instrumente und verfahren zu seiner anbringung
US7044952B2 (en) * 2001-06-06 2006-05-16 Sdgi Holdings, Inc. Dynamic multilock anterior cervical plate system having non-detachably fastened and moveable segments
US7041105B2 (en) * 2001-06-06 2006-05-09 Sdgi Holdings, Inc. Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US6787179B2 (en) * 2001-06-29 2004-09-07 Ethicon, Inc. Sterilization of bioactive coatings
WO2003008006A1 (en) * 2001-07-19 2003-01-30 Dempsey, Donald, J. Bioactive surface for titanium implants
ES2278952T3 (es) * 2001-07-26 2007-08-16 Avantec Vascular Corporation Dispositivos para administrar agentes terapeuticos con perfil de liberacion variable.
US20030055493A1 (en) * 2001-09-19 2003-03-20 Erin Carpenter Enhancement of stent radiopacity using anchors and tags
US7371258B2 (en) * 2001-10-26 2008-05-13 St. Jude Medical, Inc. Valved prosthesis with porous substrate
NL1019316C2 (nl) * 2001-11-06 2003-05-07 Tno Een vasculaire prothese.
DE10295443B4 (de) * 2001-11-23 2018-10-18 Feg Textiltechnik Forschungs- Und Entwicklungsgesellschaft Mbh Textiles Implantat mit Oberflächenmodifikation, und entsprechendes Verfahren zur Oberflächenmodifikation
EP1469865A4 (de) * 2001-12-31 2010-04-14 Crosslink D Inc Hämostatische zusammensetzungen und verfahren zur kontrolle von blutungen
US20030161938A1 (en) * 2002-02-22 2003-08-28 Bo Johnson Composition and method for coating medical devices
US6837903B2 (en) * 2002-03-22 2005-01-04 Clemson University Vascular biomaterial devices and methods
US20030195610A1 (en) * 2002-04-04 2003-10-16 Herrmann Robert A. Processes for producing polymer coatings through surface polymerization
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
CA2448513A1 (en) * 2002-06-29 2003-12-29 Aquanova German Solubilisate Technologies (Agt) Gmbh Isoflavone concentrates, as well as methods for their production
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
AU2003270817B2 (en) 2002-09-26 2009-09-17 Vactronix Scientific, Llc High strength vacuum deposited nitionol alloy films, medical thin film graft materials and method of making same
DE60300277T2 (de) 2002-11-08 2006-01-12 Howmedica Osteonics Corp. Lasererzeugte poröse Oberfläche
US20060147332A1 (en) 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US20040220534A1 (en) * 2003-04-29 2004-11-04 Martens Paul W. Medical device with antimicrobial layer
US20040230304A1 (en) * 2003-05-14 2004-11-18 Archus Orthopedics Inc. Prostheses, tools and methods for replacement of natural facet joints with artifical facet joint surfaces
US20040230201A1 (en) * 2003-05-14 2004-11-18 Archus Orthopedics Inc. Prostheses, tools and methods for replacement of natural facet joints with artifical facet joint surfaces
US7608104B2 (en) * 2003-05-14 2009-10-27 Archus Orthopedics, Inc. Prostheses, tools and methods for replacement of natural facet joints with artifical facet joint surfaces
DE10328816A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7074238B2 (en) * 2003-07-08 2006-07-11 Archus Orthopedics, Inc. Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US20050131406A1 (en) * 2003-12-15 2005-06-16 Archus Orthopedics, Inc. Polyaxial adjustment of facet joint prostheses
US20050147735A1 (en) * 2003-12-23 2005-07-07 Lowery Michael D. Lubricious, biocompatible coatings for medical devices
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
DE602005023714D1 (de) 2004-02-20 2010-11-04 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
CN100558415C (zh) * 2004-02-28 2009-11-11 汉莫堤克科技公司 药物表面的生物相容性涂层、方法和用途
US7406775B2 (en) * 2004-04-22 2008-08-05 Archus Orthopedics, Inc. Implantable orthopedic device component selection instrument and methods
US20080082171A1 (en) * 2004-04-22 2008-04-03 Kuiper Mark K Crossbar spinal prosthesis having a modular design and systems for treating spinal pathologies
US7051451B2 (en) * 2004-04-22 2006-05-30 Archus Orthopedics, Inc. Facet joint prosthesis measurement and implant tools
US20070093833A1 (en) * 2004-05-03 2007-04-26 Kuiper Mark K Crossbar spinal prosthesis having a modular design and related implantation methods
CA2576636A1 (en) * 2004-08-18 2006-03-02 Archus Orthopedics, Inc. Adjacent level facet arthroplasty devices, spine stabilization systems, and methods
US20060041311A1 (en) * 2004-08-18 2006-02-23 Mcleer Thomas J Devices and methods for treating facet joints
CA2579374A1 (en) 2004-09-07 2006-03-30 Archemix Corp. Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
US20070066551A1 (en) * 2004-09-07 2007-03-22 Keefe Anthony D Aptamer medicinal chemistry
US20060079895A1 (en) * 2004-09-30 2006-04-13 Mcleer Thomas J Methods and devices for improved bonding of devices to bone
US20060085075A1 (en) * 2004-10-04 2006-04-20 Archus Orthopedics, Inc. Polymeric joint complex and methods of use
US8221461B2 (en) 2004-10-25 2012-07-17 Gmedelaware 2 Llc Crossbar spinal prosthesis having a modular design and systems for treating spinal pathologies
JP4570445B2 (ja) * 2004-11-04 2010-10-27 独立行政法人科学技術振興機構 ハイブリット複合体を表面に備える体内留置型医療用デバイスの製造方法
US20060115514A1 (en) * 2004-11-26 2006-06-01 Stela Gengrinovitch Chelating and binding chemicals to a medical implant, medical device formed, and therapeutic applications
JP2008534063A (ja) * 2005-03-22 2008-08-28 アーカス・オーソペディクス・インコーポレーテッド 低侵襲性脊椎回復システム、装置、方法、及びキット
US8496686B2 (en) 2005-03-22 2013-07-30 Gmedelaware 2 Llc Minimally invasive spine restoration systems, devices, methods and kits
US8053078B2 (en) 2005-04-11 2011-11-08 Abbott Medical Optics Inc. Medical devices having soft, flexible lubricious coatings
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc
US7182783B2 (en) * 2005-04-25 2007-02-27 Sdgi Holdings, Inc. Selectively expandable composite structures for spinal arthroplasty
JP4613867B2 (ja) * 2005-05-26 2011-01-19 ソニー株式会社 コンテンツ処理装置及びコンテンツ処理方法、並びにコンピュータ・プログラム
DE102005032691A1 (de) * 2005-07-06 2007-01-18 Biotronik Vi Patent Ag Implantat mit immobilisierten Biokatalysatoren
US7771590B2 (en) * 2005-08-23 2010-08-10 Biomet Manufacturing Corp. Method and apparatus for collecting biological materials
US8048297B2 (en) 2005-08-23 2011-11-01 Biomet Biologics, Llc Method and apparatus for collecting biological materials
EP1962914B1 (de) 2005-11-14 2019-02-27 Biomet 3i, LLC Abscheidung von diskreten nanoteilchen auf einer implantatoberfläche
US8728387B2 (en) 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
WO2007126428A2 (en) * 2005-12-20 2007-11-08 Archus Orthopedics, Inc. Arthroplasty revision system and method
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
JP2009526862A (ja) * 2006-02-15 2009-07-23 マサチューセッツ・インスティテュート・オブ・テクノロジー 非滲出性抗菌ペプチドを含む医療デバイスおよびコーティング
WO2007106573A2 (en) * 2006-03-15 2007-09-20 Archus Orthopedics, Inc. Facet and disc arthroplasty systems and methods
US20070248653A1 (en) * 2006-04-20 2007-10-25 Cochrum Kent C Hemostatic compositions and methods for controlling bleeding
US20070254002A1 (en) * 2006-04-26 2007-11-01 Sheng-Qian Wu Biocompatible devices coated with activated protein C
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
US20070288021A1 (en) * 2006-06-07 2007-12-13 Howmedica Osteonics Corp. Flexible joint implant
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
JP2009541358A (ja) 2006-06-22 2009-11-26 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成を強化するためにｂｍｐ−２増幅因子／共活性化因子を送達するための組成物および方法
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
WO2008019397A2 (en) * 2006-08-11 2008-02-14 Archus Orthopedics, Inc. Angled washer polyaxial connection for dynamic spine prosthesis
US20080188936A1 (en) * 2007-02-02 2008-08-07 Tornier, Inc. System and method for repairing tendons and ligaments
TW200840554A (en) * 2007-02-28 2008-10-16 Alcon Inc Coated medical implants and lenses
US8114465B2 (en) * 2007-04-02 2012-02-14 Ension, Inc. Process for preparing a substrate coated with a biomolecule
US9693841B2 (en) 2007-04-02 2017-07-04 Ension, Inc. Surface treated staples, sutures and dental floss and methods of manufacturing the same
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2146794B1 (de) 2007-04-12 2016-10-19 Biomet Biologics, LLC Fraktionierungssystem für suspensionen mit trennungsschwimmer
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
WO2009014718A1 (en) 2007-07-24 2009-01-29 Porex Corporation Porous laser sintered articles
WO2009023276A1 (en) * 2007-08-15 2009-02-19 The Board Of Trustees Of The Leland Stanford Junior University Sequential coupling of biomolecule layers to polymers
US9247973B2 (en) * 2007-09-28 2016-02-02 DePuy Synthes Products, Inc. Anti-microbial implant
EP2192993A4 (de) * 2007-10-01 2012-02-15 Exogenesis Corp Verfahren und system zur beschichtung der oberfläche eines medizinischen gerätes mit einem therapeutischen wirkstoff und auf diese weise hergestellte wirkstofffreisetzende medizinische geräte
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8608049B2 (en) * 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
TWI391485B (zh) * 2007-10-31 2013-04-01 Forward Electronics Co Ltd 生物分子固定化之方法
US20090155335A1 (en) * 2007-12-05 2009-06-18 Semprus Biosciences Corp. Non-leaching non-fouling antimicrobial coatings
WO2009075788A1 (en) * 2007-12-05 2009-06-18 Semprus Biociences Corporation Synthetic non-fouling amino acids
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
EP2240116B1 (de) 2008-01-28 2015-07-01 Biomet 3I, LLC Implantatoberfläche mit erhöhter hydrophilie
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
EP2567692B1 (de) 2008-02-27 2016-04-06 Biomet Biologics, LLC Verwendung einer Vorrichtung zur Erzeugung Interleukin-1-rezeptorantagonistreicher Lösungen
EP2254991B1 (de) 2008-02-29 2018-08-22 Biomet Manufacturing, LLC System und verfahren zur trennung eines materials
US9095569B2 (en) 2008-04-18 2015-08-04 Collplant Ltd. Methods of generating and using procollagen
EP3045123B1 (de) 2008-06-16 2020-04-08 University Of Rochester Zusammensetzungen enthaltend fibroblasten-wachstumsfaktor (fgf) analoga und thrombopoietin zur verwendung zur behandlung von akuten strahlensyndroms
DE102008040787A1 (de) * 2008-07-28 2010-02-04 Biotronik Vi Patent Ag Biokorrodierbares Implantat mit einer Beschichtung enthaltend ein Hydrogel
DE102008040786A1 (de) * 2008-07-28 2010-02-04 Biotronik Vi Patent Ag Biokorrodierbares Implantat mit einer Beschichtung enthaltend eine wirkstofftragende Polymermatrix
CN102203173B (zh) 2008-09-19 2014-04-02 3M创新有限公司 配体接枝官能化基材
WO2010065958A1 (en) 2008-12-05 2010-06-10 Semprus Biosciences Corp. Layered non-fouling, antimicrobial, antithrombogenic coatings
BRPI0922266A2 (pt) * 2008-12-05 2019-09-24 Semprus Biosciences Corp composições de enxerto antitrombogênicas, antimicrobianas, anti-incrustantes
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
JP5464424B2 (ja) * 2010-01-15 2014-04-09 国立大学法人信州大学 防炎性繊維、防炎性繊維製品及び防炎性膜、並びにその製造方法
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
WO2011156603A2 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties
EP2579908A4 (de) 2010-06-09 2016-03-23 Arrow Int Inc Bewuchsfreie antimikrobielle antithrombogene graft-from-zusammensetzungen
CA2799786A1 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft compositions
EP2638879A3 (de) 2010-07-30 2018-05-16 Novartis AG Silikon-Hydrogel-Linsen mit wasserreichen Oberflächen
US9861814B2 (en) 2010-12-23 2018-01-09 Medtronic, Inc. Medical electrical lead having biological surface and methods of making and using same
EP2535062A1 (de) * 2011-06-13 2012-12-19 Dentsply IH AB Mit Kollagen beschichteter Artikel
WO2012173555A1 (en) 2011-06-13 2012-12-20 Dentsply Ih Ab Collagen coated article
HUE029018T2 (en) 2011-10-12 2017-02-28 Novartis Ag A method for producing UV absorbing contact lenses by coating
MX2014007202A (es) 2011-12-14 2015-03-09 Semprus Biosciences Corp Lentes de contacto modificadas en la superficie.
MX2014007204A (es) 2011-12-14 2015-04-14 Semprus Biosciences Corp Proceso de uv de multietapas para crear lentes de contacto modificadas en la superficie.
JP2015502437A (ja) 2011-12-14 2015-01-22 センプラス・バイオサイエンシーズ・コーポレイションＳｅｍｐｒｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐ． ランタニド又は遷移金属酸化剤を用いて改質したシリコーンヒドロゲルコンタクトレンズ
EP2791214A4 (de) 2011-12-14 2015-11-04 Semprus Biosciences Corp Redoxverfahren zur kontaktlinsenmodifikation
US9006359B2 (en) 2011-12-14 2015-04-14 Semprus Biosciences Corporation Imbibing process for contact lens surface modification
US9364896B2 (en) 2012-02-07 2016-06-14 Medical Modeling Inc. Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology
ES2671740T3 (es) 2012-03-20 2018-06-08 Biomet 3I, Llc Superficie de tratamiento para una superficie de implante
US9135374B2 (en) 2012-04-06 2015-09-15 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9180010B2 (en) 2012-04-06 2015-11-10 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
JP5956074B2 (ja) 2012-08-29 2016-07-20 カーディアック ペースメイカーズ， インコーポレイテッド 医療用リードのための向上した低摩擦コーティングおよび製造方法
AU2013347996B2 (en) 2012-11-21 2016-08-11 Cardiac Pacemakers, Inc. Medical electrodes with layered coatings
MY172901A (en) 2012-12-17 2019-12-13 Alcon Inc Method for making improved uv-absorbing ophthalmic lenses
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
WO2015009431A1 (en) * 2013-07-19 2015-01-22 Rarecyte, Inc. Solution and method for adhering suspension components to a substrate
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
CA2928629C (en) * 2013-11-28 2018-04-17 Toray Industries, Inc. Antithrombotic material
EP3083216B1 (de) 2013-12-17 2018-01-31 Novartis AG Silikonhydrogellinse mit vernetzter hydrophiler beschichtung
CA2948613A1 (en) * 2014-05-09 2015-11-12 Dci Donor Services, Inc. Tissue graft storage solutions and systems
EP2985043A1 (de) * 2014-08-14 2016-02-17 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Verfahren zur Herstellung eines medizinischen Geräts und hieraus hergestelltes Gerät
MY183678A (en) 2014-08-26 2021-03-08 Alcon Inc Method for applying stable coating on silicone hydrogel contact lenses
WO2016089966A1 (en) * 2014-12-02 2016-06-09 Rarecyte, Inc. Solution and method for adhering suspension components to a substrate
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings
WO2016159243A1 (ja) * 2015-03-31 2016-10-06 東レ株式会社 抗血栓性金属材料
EP3391101B1 (de) 2015-12-15 2020-07-08 Alcon Inc. Verfahren zum auftragen einer stabilen beschichtung auf silikonhydrogelkontaktlinsen
US20180296737A1 (en) * 2017-03-29 2018-10-18 Covalon Technologies Ltd. Coating compositions, polymeric coatings, and methods
KR102101936B1 (ko) * 2017-10-19 2020-04-17 서울대학교병원 의료용 임플란트 표면 개질용 조성물 및 그에 의해 표면 개질된 의료용 임플란트
US10830923B2 (en) 2017-12-13 2020-11-10 Alcon Inc. Method for producing MPS-compatible water gradient contact lenses
CN111569160B (zh) * 2020-05-26 2021-05-11 四川大学 基于重组人源胶原蛋白的多功能支架涂层及其制备方法
WO2024006522A1 (en) * 2022-07-01 2024-01-04 New York University Synthetic supracrestal dental implant fibers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
US5080924A (en) * 1989-04-24 1992-01-14 Drexel University Method of making biocompatible, surface modified materials
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
US5308641A (en) * 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces

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US5811151A (en) 1998-09-22
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US5866113A (en) 1999-02-02

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